Motif ID: RUNX3_BCL11A

Z-value: 0.458

Transcription factors associated with RUNX3_BCL11A:

Gene SymbolEntrez IDGene Name
BCL11A ENSG00000119866.16 BCL11A
RUNX3 ENSG00000020633.14 RUNX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RUNX3hg19_v2_chr1_-_25256368_25256476-0.636.9e-02Click!
BCL11Ahg19_v2_chr2_-_60780607_60780634-0.609.0e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of RUNX3_BCL11A

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_12246664 0.476 ENST00000449986.1
AC096559.1
AC096559.1
chr3_+_98250743 0.409 ENST00000284311.3
GPR15
G protein-coupled receptor 15
chr6_+_45296048 0.331 ENST00000465038.2
ENST00000352853.5
ENST00000541979.1
ENST00000371438.1
RUNX2



runt-related transcription factor 2



chrX_+_37639302 0.327 ENST00000545017.1
ENST00000536160.1
CYBB

cytochrome b-245, beta polypeptide

chr1_+_239882842 0.317 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr5_+_133451254 0.304 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7







transcription factor 7 (T-cell specific, HMG-box)







chr1_+_110453608 0.303 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chrX_+_37639264 0.296 ENST00000378588.4
CYBB
cytochrome b-245, beta polypeptide
chr1_+_110453514 0.294 ENST00000369802.3
ENST00000420111.2
CSF1

colony stimulating factor 1 (macrophage)

chr1_+_110453462 0.293 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr6_+_45296391 0.290 ENST00000371436.6
ENST00000576263.1
RUNX2

runt-related transcription factor 2

chr1_+_110453203 0.282 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1


colony stimulating factor 1 (macrophage)


chr10_+_25463951 0.275 ENST00000376351.3
GPR158
G protein-coupled receptor 158
chr19_+_36203830 0.274 ENST00000262630.3
ZBTB32
zinc finger and BTB domain containing 32
chr1_+_110453109 0.271 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chrX_+_48542168 0.270 ENST00000376701.4
WAS
Wiskott-Aldrich syndrome
chr4_+_71091786 0.267 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr1_-_39395165 0.263 ENST00000372985.3
RHBDL2
rhomboid, veinlet-like 2 (Drosophila)
chr6_+_27925019 0.258 ENST00000244623.1
OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr11_+_121447469 0.252 ENST00000532694.1
ENST00000534286.1
SORL1

sortilin-related receptor, L(DLR class) A repeats containing

chr6_-_34524093 0.244 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr4_-_48116540 0.243 ENST00000506073.1
TXK
TXK tyrosine kinase
chr6_-_34524049 0.233 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr3_+_187957646 0.231 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_159895275 0.214 ENST00000517927.1
MIR146A
microRNA 146a
chr6_-_46048116 0.209 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr2_+_33359473 0.200 ENST00000432635.1
LTBP1
latent transforming growth factor beta binding protein 1
chr8_-_72274355 0.199 ENST00000388741.2
EYA1
eyes absent homolog 1 (Drosophila)
chr1_+_164528866 0.198 ENST00000420696.2
PBX1
pre-B-cell leukemia homeobox 1
chr2_+_33359687 0.195 ENST00000402934.1
ENST00000404525.1
ENST00000407925.1
LTBP1


latent transforming growth factor beta binding protein 1


chr2_+_33359646 0.189 ENST00000390003.4
ENST00000418533.2
LTBP1

latent transforming growth factor beta binding protein 1

chr2_+_37571717 0.187 ENST00000338415.3
ENST00000404976.1
QPCT

glutaminyl-peptide cyclotransferase

chr1_+_196621002 0.185 ENST00000367429.4
ENST00000439155.2
CFH

complement factor H

chr8_-_72274095 0.185 ENST00000303824.7
EYA1
eyes absent homolog 1 (Drosophila)
chr11_-_58345569 0.172 ENST00000528954.1
ENST00000528489.1
LPXN

leupaxin

chr2_-_152830441 0.171 ENST00000534999.1
ENST00000397327.2
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr9_+_118916082 0.168 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr2_+_37571845 0.167 ENST00000537448.1
QPCT
glutaminyl-peptide cyclotransferase
chr8_-_72274467 0.164 ENST00000340726.3
EYA1
eyes absent homolog 1 (Drosophila)
chr2_+_182850551 0.161 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr13_-_62001982 0.159 ENST00000409186.1
PCDH20
protocadherin 20
chr2_+_169658928 0.158 ENST00000317647.7
ENST00000445023.2
NOSTRIN

nitric oxide synthase trafficking

chr1_+_196621156 0.158 ENST00000359637.2
CFH
complement factor H
chr1_+_164528437 0.157 ENST00000485769.1
PBX1
pre-B-cell leukemia homeobox 1
chr7_-_16844611 0.153 ENST00000401412.1
ENST00000419304.2
AGR2

anterior gradient 2

chr10_+_115511434 0.151 ENST00000369312.4
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr2_+_169659121 0.151 ENST00000397206.2
ENST00000397209.2
ENST00000421711.2
NOSTRIN


nitric oxide synthase trafficking


chr20_+_43343886 0.149 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr2_-_152830479 0.146 ENST00000360283.6
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr1_-_153517473 0.144 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr12_-_24103954 0.140 ENST00000441133.2
ENST00000545921.1
SOX5

SRY (sex determining region Y)-box 5

chr11_-_58275578 0.134 ENST00000360374.2
OR5B21
olfactory receptor, family 5, subfamily B, member 21
chr5_+_173763250 0.131 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
RP11-267A15.1


RP11-267A15.1


chr8_-_11325047 0.129 ENST00000531804.1
FAM167A
family with sequence similarity 167, member A
chr13_-_103053946 0.129 ENST00000376131.4
FGF14
fibroblast growth factor 14
chr4_-_57976544 0.128 ENST00000295666.4
ENST00000537922.1
IGFBP7

insulin-like growth factor binding protein 7

chr8_-_17555164 0.127 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr7_-_73184588 0.126 ENST00000395145.2
CLDN3
claudin 3
chr8_-_60031762 0.124 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr10_+_115511213 0.123 ENST00000361048.1
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr2_-_207078154 0.123 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chr2_-_207078086 0.122 ENST00000442134.1
GPR1
G protein-coupled receptor 1
chr6_-_152623231 0.119 ENST00000540663.1
ENST00000537033.1
SYNE1

spectrin repeat containing, nuclear envelope 1

chr1_+_164528616 0.119 ENST00000340699.3
PBX1
pre-B-cell leukemia homeobox 1
chr20_+_43343476 0.115 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr3_+_96533621 0.113 ENST00000542517.1
ENST00000506569.1
EPHA6

EPH receptor A6

chr10_+_112404132 0.112 ENST00000369519.3
RBM20
RNA binding motif protein 20
chr12_-_58145889 0.112 ENST00000547853.1
CDK4
cyclin-dependent kinase 4
chr8_-_19540086 0.109 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr20_-_25062767 0.108 ENST00000429762.3
ENST00000444511.2
ENST00000376707.3
VSX1


visual system homeobox 1


chr1_+_156211753 0.108 ENST00000368272.4
BGLAP
bone gamma-carboxyglutamate (gla) protein
chr6_+_31514622 0.107 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr8_-_19540266 0.107 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr20_+_43343517 0.106 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr9_-_95166841 0.105 ENST00000262551.4
OGN
osteoglycin
chr1_-_207095324 0.104 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chr10_+_24738355 0.104 ENST00000307544.6
KIAA1217
KIAA1217
chr5_+_35856951 0.098 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
IL7R



interleukin 7 receptor



chr6_-_75912508 0.097 ENST00000416123.2
COL12A1
collagen, type XII, alpha 1
chr9_+_35806082 0.096 ENST00000447210.1
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr1_-_207095212 0.095 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr17_-_41836153 0.095 ENST00000301691.2
SOST
sclerostin
chr15_+_81225699 0.093 ENST00000560027.1
KIAA1199
KIAA1199
chr8_+_31497271 0.092 ENST00000520407.1
NRG1
neuregulin 1
chr2_-_158300556 0.092 ENST00000264192.3
CYTIP
cytohesin 1 interacting protein
chr8_-_17533838 0.092 ENST00000400046.1
MTUS1
microtubule associated tumor suppressor 1
chr17_+_38599693 0.092 ENST00000542955.1
ENST00000269593.4
IGFBP4

insulin-like growth factor binding protein 4

chr17_-_39183452 0.091 ENST00000361883.5
KRTAP1-5
keratin associated protein 1-5
chr9_-_95166884 0.089 ENST00000375561.5
OGN
osteoglycin
chr12_+_93130311 0.088 ENST00000344636.3
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr2_+_30455016 0.086 ENST00000401506.1
ENST00000407930.2
LBH

limb bud and heart development

chr5_-_35938674 0.086 ENST00000397366.1
ENST00000513623.1
ENST00000514524.1
ENST00000397367.2
CAPSL



calcyphosine-like



chr13_-_99910673 0.085 ENST00000397473.2
ENST00000397470.2
GPR18

G protein-coupled receptor 18

chr1_-_184006829 0.081 ENST00000361927.4
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr9_+_35805527 0.081 ENST00000421267.1
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr5_+_140579162 0.079 ENST00000536699.1
ENST00000354757.3
PCDHB11

protocadherin beta 11

chr5_-_94417562 0.076 ENST00000505465.1
MCTP1
multiple C2 domains, transmembrane 1
chr2_-_47382414 0.075 ENST00000294947.2
C2orf61
chromosome 2 open reading frame 61
chr1_-_98511756 0.074 ENST00000602984.1
ENST00000602852.1
MIR137HG

MIR137 host gene (non-protein coding)

chr1_-_217250231 0.074 ENST00000493748.1
ENST00000463665.1
ESRRG

estrogen-related receptor gamma

chr3_+_9944303 0.074 ENST00000421412.1
ENST00000295980.3
IL17RE

interleukin 17 receptor E

chr2_-_152955537 0.074 ENST00000201943.5
ENST00000539935.1
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr5_-_94417314 0.074 ENST00000505208.1
MCTP1
multiple C2 domains, transmembrane 1
chr1_+_9299895 0.073 ENST00000602477.1
H6PD
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
chr5_+_67535647 0.073 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_+_72204755 0.072 ENST00000512686.1
ENST00000340595.3
SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr2_+_111562758 0.072 ENST00000433706.1
ACOXL
acyl-CoA oxidase-like
chr1_-_184006611 0.072 ENST00000546159.1
COLGALT2
collagen beta(1-O)galactosyltransferase 2
chr2_-_61389240 0.070 ENST00000606876.1
RP11-493E12.1
RP11-493E12.1
chr17_-_34417479 0.070 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr5_-_94417339 0.070 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1


multiple C2 domains, transmembrane 1


chr11_+_62475130 0.070 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr17_-_29648761 0.069 ENST00000247270.3
ENST00000462804.2
EVI2A

ecotropic viral integration site 2A

chr17_-_34524157 0.068 ENST00000378354.4
ENST00000394484.1
CCL3L3

chemokine (C-C motif) ligand 3-like 3

chr5_+_131409476 0.068 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr7_-_115670792 0.068 ENST00000265440.7
ENST00000393485.1
TFEC

transcription factor EC

chr5_-_94417186 0.067 ENST00000312216.8
ENST00000512425.1
MCTP1

multiple C2 domains, transmembrane 1

chrX_-_128788914 0.066 ENST00000429967.1
ENST00000307484.6
APLN

apelin

chr8_+_92261516 0.065 ENST00000276609.3
ENST00000309536.2
SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr1_-_149889382 0.064 ENST00000369145.1
ENST00000369146.3
SV2A

synaptic vesicle glycoprotein 2A

chr6_+_31515337 0.064 ENST00000376148.4
ENST00000376145.4
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr14_+_85996471 0.063 ENST00000330753.4
FLRT2
fibronectin leucine rich transmembrane protein 2
chr4_-_84035905 0.063 ENST00000311507.4
PLAC8
placenta-specific 8
chr8_+_30496078 0.063 ENST00000517349.1
SMIM18
small integral membrane protein 18
chr17_-_10017864 0.063 ENST00000323816.4
GAS7
growth arrest-specific 7
chr6_-_52109335 0.061 ENST00000336123.4
IL17F
interleukin 17F
chr5_+_148206156 0.061 ENST00000305988.4
ADRB2
adrenoceptor beta 2, surface
chr22_+_40440804 0.061 ENST00000441751.1
ENST00000301923.9
TNRC6B

trinucleotide repeat containing 6B

chr18_-_35145689 0.061 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CELF4


CUGBP, Elav-like family member 4


chrX_+_22050546 0.060 ENST00000379374.4
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr1_-_206945830 0.059 ENST00000423557.1
IL10
interleukin 10
chr1_+_12524965 0.059 ENST00000471923.1
VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr11_-_94965667 0.058 ENST00000542176.1
ENST00000278499.2
SESN3

sestrin 3

chr14_+_85996507 0.058 ENST00000554746.1
FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_-_42418999 0.056 ENST00000340840.2
ENST00000354325.2
TRERF1

transcriptional regulating factor 1

chr5_-_71803177 0.055 ENST00000414109.2
ZNF366
zinc finger protein 366
chr4_-_84035868 0.055 ENST00000426923.2
ENST00000509973.1
PLAC8

placenta-specific 8

chr12_-_10542617 0.054 ENST00000240618.6
KLRK1
killer cell lectin-like receptor subfamily K, member 1
chr6_-_46424599 0.054 ENST00000405162.1
RCAN2
regulator of calcineurin 2
chr18_-_35145593 0.054 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CELF4


CUGBP, Elav-like family member 4


chr2_-_214016314 0.054 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chr1_-_151798546 0.053 ENST00000356728.6
RORC
RAR-related orphan receptor C
chr18_-_35145728 0.053 ENST00000361795.5
ENST00000603232.1
CELF4

CUGBP, Elav-like family member 4

chr21_+_35553045 0.052 ENST00000416145.1
ENST00000430922.1
ENST00000419881.2
LINC00310


long intergenic non-protein coding RNA 310


chr6_+_151358048 0.051 ENST00000450635.1
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr13_-_44735393 0.050 ENST00000400419.1
SMIM2
small integral membrane protein 2
chr2_+_103035102 0.050 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr18_-_58040000 0.049 ENST00000299766.3
MC4R
melanocortin 4 receptor
chr17_+_40119801 0.049 ENST00000585452.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr1_-_24469602 0.049 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr7_-_115670804 0.049 ENST00000320239.7
TFEC
transcription factor EC
chr19_+_13135439 0.049 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_-_42636543 0.048 ENST00000528894.4
ENST00000560804.2
ENST00000560558.1
ENST00000560398.1
ENST00000526816.2
POU2F2




POU class 2 homeobox 2




chr2_-_55646957 0.048 ENST00000263630.8
CCDC88A
coiled-coil domain containing 88A
chr3_+_136676851 0.048 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr16_-_68482394 0.048 ENST00000561749.1
SMPD3
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
chr3_+_136676707 0.048 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr2_-_55647057 0.048 ENST00000436346.1
CCDC88A
coiled-coil domain containing 88A
chr16_+_28505955 0.047 ENST00000564831.1
ENST00000328423.5
ENST00000431282.1
APOBR


apolipoprotein B receptor


chr14_+_62584197 0.047 ENST00000334389.4
LINC00643
long intergenic non-protein coding RNA 643
chr1_+_23695680 0.047 ENST00000454117.1
ENST00000335648.3
ENST00000518821.1
ENST00000437367.2
C1orf213



chromosome 1 open reading frame 213



chr8_+_30244580 0.047 ENST00000523115.1
ENST00000519647.1
RBPMS

RNA binding protein with multiple splicing

chrX_+_101478829 0.046 ENST00000372763.1
ENST00000372758.1
NXF2

nuclear RNA export factor 2

chr5_+_145316120 0.046 ENST00000359120.4
SH3RF2
SH3 domain containing ring finger 2
chr19_+_46367518 0.045 ENST00000302177.2
FOXA3
forkhead box A3
chr1_+_156338993 0.045 ENST00000368249.1
ENST00000368246.2
ENST00000537040.1
ENST00000400992.2
ENST00000255013.3
ENST00000451864.2
RHBG





Rh family, B glycoprotein (gene/pseudogene)





chr5_-_137878887 0.045 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1



eukaryotic translation termination factor 1



chr1_-_235098861 0.045 ENST00000458044.1
RP11-443B7.1
RP11-443B7.1
chr3_-_98241760 0.044 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1










claudin domain containing 1










chr18_+_3448455 0.044 ENST00000549780.1
TGIF1
TGFB-induced factor homeobox 1
chr19_-_44285401 0.044 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr12_-_24103841 0.044 ENST00000541847.1
SOX5
SRY (sex determining region Y)-box 5
chr15_-_33447055 0.044 ENST00000559047.1
ENST00000561249.1
FMN1

formin 1

chr14_+_23563952 0.044 ENST00000319074.4
C14orf119
chromosome 14 open reading frame 119
chr1_+_6615241 0.043 ENST00000333172.6
ENST00000328191.4
ENST00000351136.3
TAS1R1


taste receptor, type 1, member 1


chr17_-_36884451 0.043 ENST00000595377.1
AC006449.1
NS5ATP13TP1; Uncharacterized protein
chr19_-_42636617 0.043 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2




POU class 2 homeobox 2




chr3_+_188889737 0.042 ENST00000345063.3
TPRG1
tumor protein p63 regulated 1
chr2_+_112813134 0.042 ENST00000452614.1
TMEM87B
transmembrane protein 87B
chr5_-_56778635 0.041 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr2_+_228678550 0.041 ENST00000409189.3
ENST00000358813.4
CCL20

chemokine (C-C motif) ligand 20

chrX_-_54209640 0.041 ENST00000375180.2
ENST00000328235.4
ENST00000477084.1
FAM120C


family with sequence similarity 120C


chr20_-_22665932 0.040 ENST00000437696.1
RP11-359G22.2
RP11-359G22.2
chr4_+_89299994 0.039 ENST00000264346.7
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr4_+_89299885 0.038 ENST00000380265.5
ENST00000273960.3
HERC6

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

chr14_+_64680854 0.038 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr4_-_156297919 0.038 ENST00000450097.1
MAP9
microtubule-associated protein 9
chr6_+_37787262 0.038 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr3_+_189507460 0.037 ENST00000434928.1
TP63
tumor protein p63
chr14_-_35183886 0.037 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr1_-_173174681 0.037 ENST00000367718.1
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr5_+_131993856 0.037 ENST00000304506.3
IL13
interleukin 13
chr2_+_173955327 0.037 ENST00000422149.1
MLTK
Mitogen-activated protein kinase kinase kinase MLT
chr6_+_30029008 0.036 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
ZNRD1



zinc ribbon domain containing 1



chr14_-_21493884 0.036 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2






NDRG family member 2






chr12_+_57916584 0.036 ENST00000546632.1
ENST00000549623.1
ENST00000431731.2
MBD6


methyl-CpG binding domain protein 6


chr4_-_10686475 0.036 ENST00000226951.6
CLNK
cytokine-dependent hematopoietic cell linker
chr19_-_14064114 0.035 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1



podocan-like 1



chr12_+_57916466 0.035 ENST00000355673.3
MBD6
methyl-CpG binding domain protein 6
chr5_+_75699040 0.035 ENST00000274364.6
IQGAP2
IQ motif containing GTPase activating protein 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.1 0.6 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.4 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.1 0.7 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.3 GO:1905246 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.3 GO:0002625 regulation of T cell antigen processing and presentation(GO:0002625)
0.1 0.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.1 0.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.3 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.6 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.2 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.2 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.0 0.1 GO:2000053 regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0 0.1 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.1 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0051466 positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.1 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.0 0.2 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0 0.1 GO:0051414 response to cortisol(GO:0051414)
0.0 0.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.1 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.0 0.2 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.0 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.0 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.5 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.0 GO:0030473 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration(GO:0021817) nuclear migration along microtubule(GO:0030473) nuclear migration along microfilament(GO:0031022)
0.0 0.1 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.0 GO:2000501 regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.2 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.6 GO:0050436 microfibril binding(GO:0050436)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.0 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.1 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.2 GO:0042835 BRE binding(GO:0042835)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.4 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.1 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.0 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.3 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.3 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.3 GO:0043274 phospholipase binding(GO:0043274)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)