Motif ID: RORC

Z-value: 0.224


Transcription factors associated with RORC:

Gene SymbolEntrez IDGene Name
RORC ENSG00000143365.12 RORC

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151804222_151804228-0.206.1e-01Click!


Activity profile for motif RORC.

activity profile for motif RORC


Sorted Z-values histogram for motif RORC

Sorted Z-values for motif RORC



Network of associatons between targets according to the STRING database.



First level regulatory network of RORC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_54418598 0.179 ENST00000609748.1
ENST00000558961.1
 BMP4

bone morphogenetic protein 4

chr6_-_46922659 0.171 ENST00000265417.7
 GPR116
G protein-coupled receptor 116
chr1_-_153522562 0.140 ENST00000368714.1
 S100A4
S100 calcium binding protein A4
chrX_-_43832711 0.140 ENST00000378062.5
 NDP
Norrie disease (pseudoglioma)
chr17_-_42992856 0.116 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
 GFAP






glial fibrillary acidic protein






chr4_-_87770416 0.088 ENST00000273905.6
 SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr14_-_23451845 0.080 ENST00000262713.2
 AJUBA
ajuba LIM protein
chr12_+_13061894 0.078 ENST00000540125.1
 GPRC5A
G protein-coupled receptor, family C, group 5, member A
chr14_-_23451467 0.071 ENST00000361265.4
ENST00000555074.1
 AJUBA
RP11-298I3.5
ajuba LIM protein
RP11-298I3.5
chr3_+_187461442 0.071 ENST00000450760.1
 RP11-211G3.2
RP11-211G3.2
chr3_+_185304059 0.069 ENST00000427465.2
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr10_-_105845536 0.066 ENST00000393211.3
 COL17A1
collagen, type XVII, alpha 1
chr3_+_185303962 0.064 ENST00000296257.5
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr4_-_159094194 0.052 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
 FAM198B


family with sequence similarity 198, member B


chr9_-_110251836 0.047 ENST00000374672.4
 KLF4
Kruppel-like factor 4 (gut)
chr1_-_211752073 0.043 ENST00000367001.4
 SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr11_-_19223523 0.042 ENST00000265968.3
 CSRP3
cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr3_-_65583561 0.041 ENST00000460329.2
 MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr4_-_1188922 0.041 ENST00000515004.1
ENST00000502483.1
 SPON2

spondin 2, extracellular matrix protein

chr12_+_56414795 0.038 ENST00000431367.2
 IKZF4
IKAROS family zinc finger 4 (Eos)
chr1_+_104198377 0.035 ENST00000370083.4
 AMY1A
amylase, alpha 1A (salivary)
chr6_+_44094627 0.033 ENST00000259746.9
 TMEM63B
transmembrane protein 63B
chr12_+_56623827 0.032 ENST00000424625.1
ENST00000419753.1
ENST00000454355.2
ENST00000417965.1
ENST00000436633.1
 SLC39A5




solute carrier family 39 (zinc transporter), member 5




chr6_+_43738444 0.031 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
 VEGFA








vascular endothelial growth factor A








chr12_-_39734783 0.030 ENST00000552961.1
 KIF21A
kinesin family member 21A
chr14_+_23025534 0.027 ENST00000557595.1
 AE000662.92
Uncharacterized protein
chr1_+_159796589 0.027 ENST00000368104.4
 SLAMF8
SLAM family member 8
chr4_+_169633310 0.026 ENST00000510998.1
 PALLD
palladin, cytoskeletal associated protein
chr1_+_236849754 0.025 ENST00000542672.1
ENST00000366578.4
 ACTN2

actinin, alpha 2

chr13_+_109248500 0.024 ENST00000356711.2
 MYO16
myosin XVI
chrX_-_102531717 0.022 ENST00000372680.1
 TCEAL5
transcription elongation factor A (SII)-like 5
chr21_+_17553910 0.022 ENST00000428669.2
 LINC00478
long intergenic non-protein coding RNA 478
chr2_-_148778323 0.022 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
 ORC4



origin recognition complex, subunit 4



chr4_+_85504075 0.021 ENST00000295887.5
 CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr8_-_95449155 0.018 ENST00000481490.2
 FSBP
fibrinogen silencer binding protein
chr12_+_7167980 0.017 ENST00000360817.5
ENST00000402681.3
 C1S

complement component 1, s subcomponent

chr16_+_16326352 0.016 ENST00000399336.4
ENST00000263012.6
ENST00000538468.1
 NOMO3


NODAL modulator 3


chr9_-_35042824 0.015 ENST00000595331.1
 FLJ00273
FLJ00273
chr15_+_31508174 0.015 ENST00000559292.2
ENST00000557928.1
 RP11-16E12.1

RP11-16E12.1

chr8_+_71485681 0.014 ENST00000391684.1
 AC120194.1
AC120194.1
chr19_-_8567478 0.014 ENST00000255612.3
 PRAM1
PML-RARA regulated adaptor molecule 1
chr7_+_97736197 0.014 ENST00000297293.5
 LMTK2
lemur tyrosine kinase 2
chr20_-_44007014 0.013 ENST00000372726.3
ENST00000537995.1
 TP53TG5

TP53 target 5

chr7_-_128415844 0.013 ENST00000249389.2
 OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr19_-_46580352 0.013 ENST00000601672.1
 IGFL4
IGF-like family member 4
chr2_+_162016827 0.012 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
 TANK


TRAF family member-associated NFKB activator


chr1_+_67632083 0.012 ENST00000347310.5
ENST00000371002.1
 IL23R

interleukin 23 receptor

chr4_-_120243545 0.012 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr12_+_56624436 0.012 ENST00000266980.4
ENST00000437277.1
 SLC39A5

solute carrier family 39 (zinc transporter), member 5

chr14_+_21785693 0.012 ENST00000382933.4
ENST00000557351.1
 RPGRIP1

retinitis pigmentosa GTPase regulator interacting protein 1

chr16_-_1821496 0.012 ENST00000564628.1
ENST00000563498.1
 NME3

NME/NM23 nucleoside diphosphate kinase 3

chr20_-_33732952 0.011 ENST00000541621.1
 EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr7_-_43965937 0.009 ENST00000455877.1
ENST00000223341.7
ENST00000447717.3
ENST00000426198.1
 URGCP



upregulator of cell proliferation



chr19_-_49140692 0.009 ENST00000222122.5
 DBP
D site of albumin promoter (albumin D-box) binding protein
chr2_+_162016804 0.008 ENST00000392749.2
ENST00000440506.1
 TANK

TRAF family member-associated NFKB activator

chr1_+_205197304 0.008 ENST00000358024.3
 TMCC2
transmembrane and coiled-coil domain family 2
chr1_+_26869597 0.007 ENST00000530003.1
 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr2_-_30144432 0.006 ENST00000389048.3
 ALK
anaplastic lymphoma receptor tyrosine kinase
chr19_+_12780512 0.006 ENST00000242796.4
 WDR83
WD repeat domain 83
chr7_+_20686946 0.006 ENST00000443026.2
ENST00000406935.1
 ABCB5

ATP-binding cassette, sub-family B (MDR/TAP), member 5

chr2_+_162016916 0.006 ENST00000405852.1
 TANK
TRAF family member-associated NFKB activator
chr1_+_159796534 0.005 ENST00000289707.5
 SLAMF8
SLAM family member 8
chr1_-_62190793 0.003 ENST00000371177.2
ENST00000606498.1
 TM2D1

TM2 domain containing 1

chr2_+_160590469 0.003 ENST00000409591.1
 MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr11_+_65292884 0.003 ENST00000527009.1
 SCYL1
SCY1-like 1 (S. cerevisiae)
chr1_-_1763721 0.003 ENST00000437146.1
 GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1
chr3_-_164914640 0.002 ENST00000241274.3
 SLITRK3
SLIT and NTRK-like family, member 3
chr2_+_148778570 0.002 ENST00000407073.1
 MBD5
methyl-CpG binding domain protein 5
chr7_+_112063192 0.001 ENST00000005558.4
 IFRD1
interferon-related developmental regulator 1
chr14_-_68157084 0.000 ENST00000557564.1
 RP11-1012A1.4
RP11-1012A1.4
chr17_-_59940705 0.000 ENST00000577913.1
 BRIP1
BRCA1 interacting protein C-terminal helicase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.0 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)