• All motifs sorted by activity significance
• All samples sorted alphabetically
• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: RFX5

Z-value: 0.462

---

Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr5_-_149792295	1.286	ENST00000518797.1 ENST00000524315.1 ENST00000009530.7 ENST00000377795.3	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_-_32557610	1.064	ENST00000360004.5	HLA-DRB1	major histocompatibility complex, class II, DR beta 1
chr6_+_33043703	0.670	ENST00000418931.2 ENST00000535465.1	HLA-DPB1	major histocompatibility complex, class II, DP beta 1
chr6_-_32908792	0.623	ENST00000418107.2	HLA-DMB	major histocompatibility complex, class II, DM beta
chr6_-_32498046	0.608	ENST00000374975.3	HLA-DRB5	major histocompatibility complex, class II, DR beta 5
chr6_-_32920794	0.449	ENST00000395305.3 ENST00000395303.3 ENST00000374843.4 ENST00000429234.1	HLA-DMA XXbac-BPG181M17.5	major histocompatibility complex, class II, DM alpha Uncharacterized protein
chr6_-_32634425	0.337	ENST00000399082.3 ENST00000399079.3 ENST00000374943.4 ENST00000434651.2	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1
chr1_+_150254936	0.296	ENST00000447007.1 ENST00000369095.1 ENST00000369094.1	C1orf51	chromosome 1 open reading frame 51
chr6_-_32908765	0.173	ENST00000416244.2	HLA-DMB	major histocompatibility complex, class II, DM beta
chr1_-_53608249	0.148	ENST00000371494.4	SLC1A7	solute carrier family 1 (glutamate transporter), member 7
chr6_-_32784687	0.122	ENST00000447394.1 ENST00000438763.2	HLA-DOB	major histocompatibility complex, class II, DO beta
chr17_+_38137050	0.116	ENST00000264639.4	PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr1_+_181003067	0.115	ENST00000434571.2 ENST00000367579.3 ENST00000282990.6 ENST00000367580.5	MR1	major histocompatibility complex, class I-related
chr17_+_38137073	0.113	ENST00000541736.1	PSMD3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr10_+_82116529	0.111	ENST00000411538.1 ENST00000256039.2	DYDC2	DPY30 domain containing 2
chr2_-_201599892	0.107	ENST00000452787.1	AC007163.3	AC007163.3
chr1_-_208417620	0.105	ENST00000367033.3	PLXNA2	plexin A2
chr16_+_57844549	0.102	ENST00000564282.1	CTD-2600O9.1	uncharacterized protein LOC388282
chr1_-_53608289	0.096	ENST00000371491.4	SLC1A7	solute carrier family 1 (glutamate transporter), member 7
chr6_+_26440700	0.095	ENST00000494393.1 ENST00000482451.1 ENST00000244519.2 ENST00000339789.4 ENST00000471353.1 ENST00000361232.3 ENST00000487627.1 ENST00000496719.1 ENST00000490254.1 ENST00000487272.1	BTN3A3	butyrophilin, subfamily 3, member A3
chr8_+_101170134	0.089	ENST00000520643.1	SPAG1	sperm associated antigen 1
chr9_-_69380597	0.089	ENST00000414341.2	CR769776.1	LOC441426 protein; Uncharacterized protein
chr6_+_26458152	0.086	ENST00000312541.5	BTN2A1	butyrophilin, subfamily 2, member A1
chr17_+_30348024	0.079	ENST00000327564.7 ENST00000584368.1 ENST00000394713.3 ENST00000341671.7	LRRC37B	leucine rich repeat containing 37B
chr6_+_26458171	0.079	ENST00000493173.1 ENST00000541522.1 ENST00000429381.1 ENST00000469185.1	BTN2A1	butyrophilin, subfamily 2, member A1
chr3_+_196466710	0.074	ENST00000327134.3	PAK2	p21 protein (Cdc42/Rac)-activated kinase 2
chr6_-_24667180	0.073	ENST00000545995.1	TDP2	tyrosyl-DNA phosphodiesterase 2
chr6_-_24666819	0.067	ENST00000341060.3	TDP2	tyrosyl-DNA phosphodiesterase 2
chr6_-_30181156	0.063	ENST00000418026.1 ENST00000416596.1 ENST00000453195.1	TRIM26	tripartite motif containing 26
chr6_-_30181133	0.057	ENST00000454678.2 ENST00000434785.1	TRIM26	tripartite motif containing 26
chr6_-_32731299	0.056	ENST00000435145.2 ENST00000437316.2	HLA-DQB2	major histocompatibility complex, class II, DQ beta 2
chr1_-_202936394	0.053	ENST00000367249.4	CYB5R1	cytochrome b5 reductase 1
chr9_+_135937365	0.050	ENST00000372080.4 ENST00000351304.7	CEL	carboxyl ester lipase
chr10_-_82116497	0.048	ENST00000372204.3	DYDC1	DPY30 domain containing 1
chr5_+_119799927	0.047	ENST00000407149.2 ENST00000379551.2	PRR16	proline rich 16
chr6_-_133079022	0.043	ENST00000525289.1 ENST00000326499.6	VNN2	vanin 2
chr20_+_42875935	0.040	ENST00000438466.1 ENST00000372952.3 ENST00000537864.1 ENST00000445952.1	GDAP1L1	ganglioside induced differentiation associated protein 1-like 1
chr6_+_26383404	0.039	ENST00000416795.2 ENST00000494184.1	BTN2A2	butyrophilin, subfamily 2, member A2
chr19_+_19496728	0.036	ENST00000537887.1 ENST00000417582.2	GATAD2A	GATA zinc finger domain containing 2A
chr3_+_9850199	0.036	ENST00000452597.1	TTLL3	tubulin tyrosine ligase-like family, member 3
chr9_+_43135095	0.033	ENST00000377437.2	AL513478.1	Uncharacterized protein
chr3_+_9851384	0.031	ENST00000419081.1 ENST00000438596.1 ENST00000417065.1 ENST00000439814.1 ENST00000418745.1	TTLL3	tubulin tyrosine ligase-like family, member 3
chr20_+_306177	0.030	ENST00000544632.1	SOX12	SRY (sex determining region Y)-box 12
chr5_-_55412774	0.028	ENST00000434982.2	ANKRD55	ankyrin repeat domain 55
chr3_+_9851558	0.026	ENST00000430718.1	TTLL3	tubulin tyrosine ligase-like family, member 3
chr20_+_306221	0.021	ENST00000342665.2	SOX12	SRY (sex determining region Y)-box 12
chr11_+_111385497	0.020	ENST00000375618.4 ENST00000529167.1 ENST00000332814.6	C11orf88	chromosome 11 open reading frame 88
chr12_-_123565834	0.019	ENST00000546049.1	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2
chrX_-_40594755	0.019	ENST00000324817.1	MED14	mediator complex subunit 14
chr19_+_19496624	0.018	ENST00000494516.2 ENST00000360315.3 ENST00000252577.5	GATAD2A	GATA zinc finger domain containing 2A
chr6_+_26383318	0.018	ENST00000469230.1 ENST00000490025.1 ENST00000356709.4 ENST00000352867.2 ENST00000493275.1 ENST00000472507.1 ENST00000482536.1 ENST00000432533.2 ENST00000482842.1	BTN2A2	butyrophilin, subfamily 2, member A2
chr16_-_74808710	0.018	ENST00000219368.3 ENST00000544337.1	FA2H	fatty acid 2-hydroxylase
chr8_+_101170257	0.017	ENST00000251809.3	SPAG1	sperm associated antigen 1
chr1_+_114473350	0.015	ENST00000503968.1	HIPK1	homeodomain interacting protein kinase 1
chr4_-_83719884	0.013	ENST00000282709.4 ENST00000273908.4	SCD5	stearoyl-CoA desaturase 5
chr2_+_242089046	0.012	ENST00000407025.1 ENST00000272983.8	PPP1R7	protein phosphatase 1, regulatory subunit 7
chr11_-_72433346	0.009	ENST00000334211.8	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_-_126467906	0.008	ENST00000507313.1 ENST00000545784.1	LINC00939	long intergenic non-protein coding RNA 939
chr10_+_14880287	0.007	ENST00000437161.2	HSPA14	heat shock 70kDa protein 14
chr19_-_6057282	0.006	ENST00000592281.1	RFX2	regulatory factor X, 2 (influences HLA class II expression)
chr6_-_30658745	0.005	ENST00000376420.5 ENST00000376421.5	NRM	nurim (nuclear envelope membrane protein)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	2.3	GO:0002399	MHC class II protein complex assembly(GO:0002399)
0.3	1.3	GO:0002901	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	0.1	GO:0002586	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	1.7	GO:0031295	T cell costimulation(GO:0031295)
0.0	0.1	GO:0044240	multicellular organism lipid catabolic process(GO:0044240)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	5.4	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.2	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.3	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	2.4	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.1	0.4	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	0.1	GO:0070260	tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.0	1.3	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0070736	protein-glycine ligase activity, initiating(GO:0070736)
0.0	0.2	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.1	GO:0032393	MHC class I receptor activity(GO:0032393)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	PID_IL12_STAT4_PATHWAY	IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	2.7	REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION	Genes involved in MHC class II antigen presentation

---