Motif ID: REST

Z-value: 0.458


Transcription factors associated with REST:

Gene SymbolEntrez IDGene Name
REST ENSG00000084093.11 REST

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.703.4e-02Click!


Activity profile for motif REST.

activity profile for motif REST


Sorted Z-values histogram for motif REST

Sorted Z-values for motif REST



Network of associatons between targets according to the STRING database.



First level regulatory network of REST

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_99609996 0.828 ENST00000370602.1
 GOLGA7B
golgin A7 family, member B
chr14_-_51561784 0.482 ENST00000360392.4
 TRIM9
tripartite motif containing 9
chr14_-_51562037 0.335 ENST00000338969.5
 TRIM9
tripartite motif containing 9
chrX_-_153141302 0.285 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM




L1 cell adhesion molecule




chr15_-_72612470 0.272 ENST00000287202.5
 CELF6
CUGBP, Elav-like family member 6
chrX_-_153141434 0.270 ENST00000407935.2
ENST00000439496.1
 L1CAM

L1 cell adhesion molecule

chr7_+_8474150 0.212 ENST00000602349.1
 NXPH1
neurexophilin 1
chr9_-_139096955 0.210 ENST00000371748.5
 LHX3
LIM homeobox 3
chr17_+_42385927 0.197 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
 RUNDC3A


RUN domain containing 3A


chr11_-_6677018 0.196 ENST00000299441.3
 DCHS1
dachsous cadherin-related 1
chr12_-_57871853 0.183 ENST00000549602.1
ENST00000430041.2
 ARHGAP9

Rho GTPase activating protein 9

chr3_-_8686479 0.180 ENST00000544814.1
ENST00000427408.1
 SSUH2

ssu-2 homolog (C. elegans)

chr19_-_55691472 0.168 ENST00000537500.1
 SYT5
synaptotagmin V
chr10_-_79398250 0.161 ENST00000286627.5
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr20_-_62284766 0.155 ENST00000370053.1
 STMN3
stathmin-like 3
chr1_-_241520385 0.154 ENST00000366564.1
 RGS7
regulator of G-protein signaling 7
chr15_+_75287861 0.152 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
 SCAMP5







secretory carrier membrane protein 5







chr12_-_57871825 0.146 ENST00000548139.1
 ARHGAP9
Rho GTPase activating protein 9
chr17_+_72667239 0.144 ENST00000402449.4
 RAB37
RAB37, member RAS oncogene family
chr12_-_12837423 0.140 ENST00000540510.1
 GPR19
G protein-coupled receptor 19
chr20_+_30555805 0.133 ENST00000562532.2
 XKR7
XK, Kell blood group complex subunit-related family, member 7
chr9_+_135457530 0.132 ENST00000263610.2
 BARHL1
BarH-like homeobox 1
chr19_+_4769117 0.129 ENST00000540211.1
ENST00000317292.3
ENST00000586721.1
ENST00000592709.1
ENST00000588711.1
ENST00000589639.1
ENST00000591008.1
ENST00000592663.1
ENST00000588758.1
 MIR7-3HG








MIR7-3 host gene (non-protein coding)








chr19_-_55691377 0.115 ENST00000589172.1
 SYT5
synaptotagmin V
chr19_-_45926739 0.113 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
 ERCC1



excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)



chr16_+_3019309 0.112 ENST00000576565.1
 PAQR4
progestin and adipoQ receptor family member IV
chr12_-_57871567 0.111 ENST00000551452.1
 ARHGAP9
Rho GTPase activating protein 9
chr3_+_149531607 0.107 ENST00000468648.1
ENST00000459632.1
 RNF13

ring finger protein 13

chr1_+_210111534 0.104 ENST00000422431.1
ENST00000534859.1
ENST00000399639.2
ENST00000537238.1
 SYT14



synaptotagmin XIV



chr19_-_39402798 0.103 ENST00000571838.1
 CTC-360G5.1
coiled-coil glutamate-rich protein 2
chr3_+_62304648 0.099 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
 C3orf14


chromosome 3 open reading frame 14


chr15_-_83378526 0.099 ENST00000535348.1
ENST00000535359.1
 AP3B2

adaptor-related protein complex 3, beta 2 subunit

chr16_+_3019246 0.099 ENST00000318782.8
ENST00000293978.8
 PAQR4

progestin and adipoQ receptor family member IV

chr3_+_62304712 0.092 ENST00000494481.1
 C3orf14
chromosome 3 open reading frame 14
chr19_-_45927097 0.090 ENST00000340192.7
 ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr12_-_57871620 0.090 ENST00000552604.1
 ARHGAP9
Rho GTPase activating protein 9
chr6_+_158957431 0.088 ENST00000367090.3
 TMEM181
transmembrane protein 181
chr15_-_32162833 0.088 ENST00000560598.1
 OTUD7A
OTU domain containing 7A
chr15_+_68117844 0.087 ENST00000554054.1
 SKOR1
SKI family transcriptional corepressor 1
chr1_+_210111570 0.086 ENST00000367019.1
ENST00000472886.1
 SYT14

synaptotagmin XIV

chr9_+_135458021 0.084 ENST00000542090.1
 BARHL1
BarH-like homeobox 1
chr2_-_47798044 0.083 ENST00000327876.4
 KCNK12
potassium channel, subfamily K, member 12
chr10_-_79398127 0.081 ENST00000372443.1
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr13_-_111214015 0.079 ENST00000267328.3
 RAB20
RAB20, member RAS oncogene family
chr15_+_68117872 0.078 ENST00000380035.2
ENST00000389002.1
 SKOR1

SKI family transcriptional corepressor 1

chr19_-_11639910 0.077 ENST00000588998.1
ENST00000586149.1
 ECSIT

ECSIT signalling integrator

chr2_-_27531313 0.076 ENST00000296099.2
 UCN
urocortin
chr5_-_176037105 0.073 ENST00000303991.4
 GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr18_-_40857493 0.071 ENST00000255224.3
 SYT4
synaptotagmin IV
chr1_-_40105617 0.068 ENST00000372852.3
 HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr14_+_93897272 0.066 ENST00000393151.2
 UNC79
unc-79 homolog (C. elegans)
chr4_-_175750364 0.064 ENST00000340217.5
ENST00000274093.3
 GLRA3

glycine receptor, alpha 3

chr14_+_93897199 0.064 ENST00000553484.1
 UNC79
unc-79 homolog (C. elegans)
chr19_-_45927622 0.064 ENST00000300853.3
ENST00000589165.1
 ERCC1

excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)

chr19_-_11639931 0.063 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
 ECSIT





ECSIT signalling integrator





chr2_+_131513864 0.062 ENST00000458606.1
ENST00000423981.1
 AMER3

APC membrane recruitment protein 3

chr11_-_75141206 0.060 ENST00000376292.4
 KLHL35
kelch-like family member 35
chr12_+_113229737 0.060 ENST00000551052.1
ENST00000415485.3
 RPH3A

rabphilin 3A homolog (mouse)

chr15_-_83378638 0.059 ENST00000261722.3
 AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr11_-_72492878 0.057 ENST00000535054.1
ENST00000545082.1
 STARD10

StAR-related lipid transfer (START) domain containing 10

chr3_+_9745487 0.056 ENST00000383832.3
 CPNE9
copine family member IX
chr9_-_104357277 0.053 ENST00000374806.1
 PPP3R2
protein phosphatase 3, regulatory subunit B, beta
chr5_+_33936491 0.051 ENST00000330120.3
 RXFP3
relaxin/insulin-like family peptide receptor 3
chr20_+_62327996 0.051 ENST00000369996.1
 TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr10_+_89419370 0.050 ENST00000361175.4
ENST00000456849.1
 PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

chr3_-_48700310 0.049 ENST00000164024.4
ENST00000544264.1
 CELSR3

cadherin, EGF LAG seven-pass G-type receptor 3

chr9_+_138606400 0.048 ENST00000486577.2
 KCNT1
potassium channel, subfamily T, member 1
chr6_+_25652432 0.047 ENST00000377961.2
 SCGN
secretagogin, EF-hand calcium binding protein
chr2_-_51259641 0.044 ENST00000406316.2
ENST00000405581.1
 NRXN1

neurexin 1

chr3_+_9745510 0.044 ENST00000383831.3
 CPNE9
copine family member IX
chr9_-_123812542 0.042 ENST00000223642.1
 C5
complement component 5
chr1_-_102462565 0.037 ENST00000370103.4
 OLFM3
olfactomedin 3
chr16_+_5008290 0.036 ENST00000251170.7
 SEC14L5
SEC14-like 5 (S. cerevisiae)
chr8_-_145752390 0.035 ENST00000529415.2
ENST00000533758.1
 LRRC24

leucine rich repeat containing 24

chr20_+_5892147 0.033 ENST00000455042.1
 CHGB
chromogranin B (secretogranin 1)
chr1_+_65775204 0.033 ENST00000371069.4
 DNAJC6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_+_35773070 0.031 ENST00000373853.1
ENST00000360215.1
 LHFPL5

lipoma HMGIC fusion partner-like 5

chr12_+_113796347 0.031 ENST00000545182.2
ENST00000280800.3
 PLBD2

phospholipase B domain containing 2

chr22_+_31199037 0.022 ENST00000424224.1
 OSBP2
oxysterol binding protein 2
chr11_+_45907177 0.022 ENST00000241014.2
 MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr20_+_44657807 0.019 ENST00000372315.1
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_-_55691614 0.018 ENST00000592470.1
ENST00000354308.3
 SYT5

synaptotagmin V

chr2_-_51259528 0.017 ENST00000404971.1
 NRXN1
neurexin 1
chr12_+_113229452 0.016 ENST00000389385.4
 RPH3A
rabphilin 3A homolog (mouse)
chr20_+_44657845 0.016 ENST00000243964.3
 SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr19_+_39759154 0.016 ENST00000331982.5
 IFNL2
interferon, lambda 2
chr7_-_65113280 0.016 ENST00000593865.1
 AC104057.1
Protein LOC100996407
chr10_+_26505594 0.016 ENST00000259271.3
 GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_+_212606219 0.016 ENST00000366988.3
 NENF
neudesin neurotrophic factor
chr18_-_5197501 0.015 ENST00000580650.1
 C18orf42
chromosome 18 open reading frame 42
chrX_-_153237258 0.014 ENST00000310441.7
 HCFC1
host cell factor C1 (VP16-accessory protein)
chr5_+_167956121 0.014 ENST00000338333.4
 FBLL1
fibrillarin-like 1
chr2_-_51259292 0.014 ENST00000401669.2
 NRXN1
neurexin 1
chr1_-_151689259 0.014 ENST00000420342.1
ENST00000290583.4
 CELF3

CUGBP, Elav-like family member 3

chr2_-_51259229 0.012 ENST00000405472.3
 NRXN1
neurexin 1
chr19_+_41036371 0.010 ENST00000392023.1
 SPTBN4
spectrin, beta, non-erythrocytic 4
chr17_-_27332931 0.009 ENST00000442608.3
ENST00000335960.6
 SEZ6

seizure related 6 homolog (mouse)

chr12_-_99288536 0.009 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
 ANKS1B


ankyrin repeat and sterile alpha motif domain containing 1B


chr6_+_25652501 0.008 ENST00000334979.6
 SCGN
secretagogin, EF-hand calcium binding protein
chr12_+_113229543 0.007 ENST00000447659.2
 RPH3A
rabphilin 3A homolog (mouse)
chr17_-_27333311 0.006 ENST00000317338.12
ENST00000585644.1
 SEZ6

seizure related 6 homolog (mouse)

chr12_-_29936731 0.005 ENST00000552618.1
ENST00000539277.1
ENST00000551659.1
 TMTC1


transmembrane and tetratricopeptide repeat containing 1


chr11_+_64808675 0.005 ENST00000529996.1
 SAC3D1
SAC3 domain containing 1
chr1_+_154540246 0.000 ENST00000368476.3
 CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.1 0.2 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.2 GO:0003192 mitral valve formation(GO:0003192)
0.1 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.1 GO:0035482 gastric motility(GO:0035482) gastric emptying(GO:0035483) negative regulation of gastric acid secretion(GO:0060455)
0.0 0.2 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.0 GO:0040040 thermosensory behavior(GO:0040040)
0.0 0.0 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:1990742 dense core granule membrane(GO:0032127) microvesicle(GO:1990742)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.6 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0043196 varicosity(GO:0043196)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.3 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.0 0.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins