Motif ID: RELB
Z-value: 1.216
Transcription factors associated with RELB:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RELB | ENSG00000104856.9 | RELB |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RELB | hg19_v2_chr19_+_45504688_45504782 | -0.74 | 2.4e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 5.8 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.5 | 2.6 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.4 | 1.1 | GO:0006714 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) |
| 0.3 | 2.7 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.2 | 0.9 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.2 | 0.7 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.2 | 0.7 | GO:0002636 | positive regulation of germinal center formation(GO:0002636) |
| 0.2 | 0.6 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.2 | 0.5 | GO:0050787 | enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) negative regulation of ubiquitin-specific protease activity(GO:2000157) |
| 0.2 | 0.9 | GO:0035995 | skeletal muscle myosin thick filament assembly(GO:0030241) detection of muscle stretch(GO:0035995) |
| 0.2 | 1.6 | GO:0050859 | negative regulation of B cell receptor signaling pathway(GO:0050859) |
| 0.2 | 0.7 | GO:0001878 | response to yeast(GO:0001878) hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.2 | 0.5 | GO:0070446 | cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446) |
| 0.1 | 0.4 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) regulation of ovarian follicle development(GO:2000354) |
| 0.1 | 1.3 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.1 | 1.0 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.1 | 0.3 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.1 | 1.6 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 1.0 | GO:0019236 | response to pheromone(GO:0019236) |
| 0.1 | 0.4 | GO:0007497 | posterior midgut development(GO:0007497) endothelin receptor signaling pathway(GO:0086100) |
| 0.1 | 0.9 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 0.8 | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment(GO:2000329) |
| 0.1 | 0.4 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.1 | 0.4 | GO:0097187 | dentinogenesis(GO:0097187) |
| 0.1 | 0.5 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.1 | 0.2 | GO:1990535 | neuron projection maintenance(GO:1990535) |
| 0.1 | 1.6 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.1 | 0.4 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.1 | 0.7 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.1 | 0.1 | GO:0032240 | negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832) |
| 0.1 | 0.2 | GO:0090427 | activation of meiosis(GO:0090427) |
| 0.1 | 0.8 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.1 | 1.4 | GO:0060546 | negative regulation of necroptotic process(GO:0060546) |
| 0.1 | 0.7 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.1 | 0.3 | GO:1903347 | negative regulation of bicellular tight junction assembly(GO:1903347) |
| 0.1 | 0.9 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.1 | 0.6 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.1 | 0.3 | GO:0036343 | psychomotor behavior(GO:0036343) |
| 0.1 | 0.3 | GO:1904751 | positive regulation of protein localization to nucleolus(GO:1904751) |
| 0.0 | 0.2 | GO:2000174 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 1.3 | GO:1901741 | positive regulation of myoblast fusion(GO:1901741) |
| 0.0 | 0.1 | GO:0048203 | vesicle targeting, trans-Golgi to endosome(GO:0048203) |
| 0.0 | 1.1 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 0.4 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.0 | 0.5 | GO:2000580 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 0.0 | 0.3 | GO:0032484 | Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485) |
| 0.0 | 0.2 | GO:0046725 | negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) |
| 0.0 | 0.6 | GO:0060087 | relaxation of vascular smooth muscle(GO:0060087) |
| 0.0 | 0.3 | GO:0061086 | negative regulation of histone H3-K27 methylation(GO:0061086) |
| 0.0 | 0.3 | GO:0086046 | membrane depolarization during SA node cell action potential(GO:0086046) |
| 0.0 | 0.2 | GO:0044501 | modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032) |
| 0.0 | 0.4 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.3 | GO:1904338 | regulation of dopaminergic neuron differentiation(GO:1904338) |
| 0.0 | 0.4 | GO:0006689 | ganglioside catabolic process(GO:0006689) |
| 0.0 | 1.2 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.0 | 0.1 | GO:1901804 | beta-glucoside metabolic process(GO:1901804) beta-glucoside catabolic process(GO:1901805) positive regulation of neuronal action potential(GO:1904457) |
| 0.0 | 1.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.3 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.0 | 0.4 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) |
| 0.0 | 0.3 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.0 | 0.1 | GO:0006419 | alanyl-tRNA aminoacylation(GO:0006419) |
| 0.0 | 0.3 | GO:0009133 | nucleoside diphosphate biosynthetic process(GO:0009133) |
| 0.0 | 0.1 | GO:0002296 | T-helper 1 cell lineage commitment(GO:0002296) |
| 0.0 | 0.2 | GO:1901297 | positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068) |
| 0.0 | 0.5 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 2.0 | GO:0050885 | neuromuscular process controlling balance(GO:0050885) |
| 0.0 | 0.3 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.0 | 0.2 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 0.0 | 0.2 | GO:0048733 | sebaceous gland development(GO:0048733) |
| 0.0 | 0.7 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
| 0.0 | 0.2 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.0 | 0.1 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.7 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.0 | 0.2 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.0 | GO:0002232 | leukocyte chemotaxis involved in inflammatory response(GO:0002232) |
| 0.0 | 0.3 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.0 | 0.3 | GO:0001675 | acrosome assembly(GO:0001675) |
| 0.0 | 0.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.4 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.4 | GO:0001502 | cartilage condensation(GO:0001502) |
| 0.0 | 0.1 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.0 | 0.2 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 0.4 | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) |
| 0.0 | 0.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.0 | 0.3 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.4 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 1.3 | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092) |
| 0.0 | 0.2 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.0 | 0.3 | GO:0050901 | leukocyte tethering or rolling(GO:0050901) |
| 0.0 | 0.1 | GO:1905244 | regulation of modification of synaptic structure(GO:1905244) |
| 0.0 | 0.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.0 | 0.4 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.1 | GO:0036353 | histone H2A-K119 monoubiquitination(GO:0036353) aggresome assembly(GO:0070842) |
| 0.0 | 0.1 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
| 0.0 | 0.2 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.0 | 2.2 | GO:0048675 | axon extension(GO:0048675) |
| 0.0 | 0.0 | GO:0052151 | positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) |
| 0.0 | 0.3 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.0 | 0.3 | GO:1902083 | negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083) |
| 0.0 | 0.0 | GO:2000620 | positive regulation of histone H4-K16 acetylation(GO:2000620) |
| 0.0 | 0.6 | GO:1900048 | positive regulation of blood coagulation(GO:0030194) positive regulation of hemostasis(GO:1900048) |
| 0.0 | 0.1 | GO:0061470 | T follicular helper cell differentiation(GO:0061470) |
| 0.0 | 0.1 | GO:0042670 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.0 | 0.1 | GO:0034670 | chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.8 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.3 | 2.6 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.2 | 0.7 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.1 | 0.4 | GO:0002081 | outer acrosomal membrane(GO:0002081) |
| 0.1 | 0.7 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.4 | GO:0031592 | centrosomal corona(GO:0031592) |
| 0.1 | 0.4 | GO:0005889 | hydrogen:potassium-exchanging ATPase complex(GO:0005889) |
| 0.1 | 1.0 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 0.1 | 0.2 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.1 | 0.9 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 1.3 | GO:0012510 | trans-Golgi network transport vesicle membrane(GO:0012510) |
| 0.1 | 0.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 1.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.5 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 0.2 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.0 | 0.2 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.0 | 0.5 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 0.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 1.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 1.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.4 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 0.1 | GO:0016938 | kinesin I complex(GO:0016938) |
| 0.0 | 0.2 | GO:0019815 | B cell receptor complex(GO:0019815) |
| 0.0 | 0.2 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.0 | 0.1 | GO:1902560 | GMP reductase complex(GO:1902560) |
| 0.0 | 1.6 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.2 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
| 0.0 | 0.3 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.5 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 2.1 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.1 | GO:0098837 | postsynaptic recycling endosome(GO:0098837) |
| 0.0 | 0.1 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.2 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.3 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.0 | 0.1 | GO:0070765 | gamma-secretase complex(GO:0070765) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 5.8 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.4 | 1.1 | GO:0045550 | geranylgeranyl reductase activity(GO:0045550) |
| 0.3 | 2.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.3 | 1.0 | GO:0016503 | pheromone receptor activity(GO:0016503) |
| 0.2 | 0.7 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.2 | 0.5 | GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.1 | 0.4 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.1 | 0.4 | GO:0004962 | endothelin receptor activity(GO:0004962) |
| 0.1 | 0.5 | GO:0016532 | superoxide dismutase copper chaperone activity(GO:0016532) |
| 0.1 | 1.0 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 0.5 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.1 | 0.6 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 0.3 | GO:0098640 | integrin binding involved in cell-matrix adhesion(GO:0098640) |
| 0.1 | 1.5 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.1 | 0.7 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 0.1 | 1.0 | GO:0035005 | lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 0.4 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.1 | 0.9 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.1 | 0.7 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.3 | GO:0008384 | IkappaB kinase activity(GO:0008384) |
| 0.1 | 0.4 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.1 | 0.3 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473) |
| 0.1 | 0.6 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
| 0.1 | 0.3 | GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.1 | 0.8 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 0.2 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.0 | 0.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.0 | 0.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.2 | GO:0016971 | flavin-linked sulfhydryl oxidase activity(GO:0016971) |
| 0.0 | 0.9 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.4 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 0.3 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.0 | 0.3 | GO:0015252 | hydrogen ion channel activity(GO:0015252) |
| 0.0 | 0.3 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.0 | 0.4 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 0.9 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 2.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 0.1 | GO:0035650 | AP-1 adaptor complex binding(GO:0035650) |
| 0.0 | 0.4 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.0 | 0.2 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.0 | 0.5 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 0.7 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.2 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.1 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.0 | 0.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.5 | GO:0015232 | heme transporter activity(GO:0015232) |
| 0.0 | 0.5 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.0 | 0.1 | GO:0004583 | dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583) |
| 0.0 | 0.1 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.0 | 0.5 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.0 | 0.4 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.0 | 0.0 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
| 0.0 | 0.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 0.1 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.0 | 0.1 | GO:0016657 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 0.1 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 1.3 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.0 | 0.5 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.2 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.0 | 1.4 | GO:0032813 | tumor necrosis factor receptor superfamily binding(GO:0032813) |
| 0.0 | 0.3 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.1 | GO:0005471 | ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207) |
| 0.0 | 0.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.7 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.3 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 0.2 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 1.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.3 | GO:0001054 | RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055) |
| 0.0 | 0.1 | GO:0008440 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) |
| 0.0 | 0.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.0 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.0 | 0.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.2 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.0 | 0.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 0.1 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.0 | 0.1 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.0 | 0.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.8 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 3.2 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.0 | 0.6 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 1.3 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
| 0.0 | 0.2 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 2.2 | PID_AJDISS_2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.5 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.4 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
| 0.0 | 0.5 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.6 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 1.3 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 1.1 | REACTOME_REGULATION_OF_IFNA_SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.0 | 0.3 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 0.7 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 1.5 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.9 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 3.9 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.3 | REACTOME_FGFR2C_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 0.8 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 1.1 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.4 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.1 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.3 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 0.3 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.4 | REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.4 | REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.5 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.0 | 0.2 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.3 | REACTOME_RNA_POL_III_CHAIN_ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
