Motif ID: PRDM14

Z-value: 0.605


Transcription factors associated with PRDM14:

Gene SymbolEntrez IDGene Name
PRDM14 ENSG00000147596.3 PRDM14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_709835620.274.8e-01Click!


Activity profile for motif PRDM14.

activity profile for motif PRDM14


Sorted Z-values histogram for motif PRDM14

Sorted Z-values for motif PRDM14



Network of associatons between targets according to the STRING database.



First level regulatory network of PRDM14

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_10458982 2.005 ENST00000326756.3
ZNF518B
zinc finger protein 518B
chr4_-_10459009 1.549 ENST00000507515.1
ZNF518B
zinc finger protein 518B
chr17_-_19651668 1.167 ENST00000494157.2
ENST00000225740.6
ALDH3A1

aldehyde dehydrogenase 3 family, member A1

chr17_-_19651654 1.060 ENST00000395555.3
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr17_-_19651598 0.802 ENST00000570414.1
ALDH3A1
aldehyde dehydrogenase 3 family, member A1
chr2_-_145277882 0.675 ENST00000465070.1
ENST00000444559.1
ZEB2

zinc finger E-box binding homeobox 2

chr2_-_145278475 0.627 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr14_-_54425475 0.601 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr7_-_124405681 0.562 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr5_+_32711419 0.511 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr5_+_32710736 0.433 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr16_-_55866997 0.270 ENST00000360526.3
ENST00000361503.4
CES1

carboxylesterase 1

chr14_+_21492331 0.263 ENST00000533984.1
ENST00000532213.2
AL161668.5

AL161668.5

chr11_+_62475130 0.242 ENST00000294117.5
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chrX_+_51636629 0.179 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1


melanoma antigen family D, 1


chr2_-_192711968 0.159 ENST00000304141.4
SDPR
serum deprivation response
chr1_+_156052354 0.142 ENST00000368301.2
LMNA
lamin A/C
chr20_-_3154162 0.125 ENST00000360342.3
LZTS3
Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr18_+_57567180 0.116 ENST00000316660.6
ENST00000269518.9
PMAIP1

phorbol-12-myristate-13-acetate-induced protein 1

chr11_+_64879317 0.115 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
TM7SF2










transmembrane 7 superfamily member 2










chr4_+_4861385 0.115 ENST00000382723.4
MSX1
msh homeobox 1
chr5_-_135528822 0.113 ENST00000607574.1
AC009014.3
AC009014.3
chr5_-_108063949 0.106 ENST00000606054.1
LINC01023
long intergenic non-protein coding RNA 1023
chr11_+_85566422 0.101 ENST00000342404.3
CCDC83
coiled-coil domain containing 83
chr19_+_49838653 0.100 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37





CD37 molecule





chr10_+_12171721 0.091 ENST00000379020.4
ENST00000379017.3
SEC61A2

Sec61 alpha 2 subunit (S. cerevisiae)

chr3_-_143567262 0.084 ENST00000474151.1
ENST00000316549.6
SLC9A9

solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9

chr10_+_12171636 0.083 ENST00000379051.1
ENST00000379033.3
ENST00000441368.1
ENST00000298428.9
ENST00000304267.8
SEC61A2




Sec61 alpha 2 subunit (S. cerevisiae)




chr4_-_103266626 0.073 ENST00000356736.4
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr7_-_139763521 0.072 ENST00000263549.3
PARP12
poly (ADP-ribose) polymerase family, member 12
chr1_-_31845914 0.070 ENST00000373713.2
FABP3
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr7_-_30066233 0.065 ENST00000222803.5
FKBP14
FK506 binding protein 14, 22 kDa
chr5_-_16936340 0.064 ENST00000507288.1
ENST00000513610.1
MYO10

myosin X

chr1_-_33642151 0.062 ENST00000543586.1
TRIM62
tripartite motif containing 62
chr1_+_36621174 0.062 ENST00000429533.2
MAP7D1
MAP7 domain containing 1
chr17_+_47653178 0.057 ENST00000328741.5
NXPH3
neurexophilin 3
chr17_+_36873677 0.054 ENST00000471200.1
MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr2_+_101437487 0.053 ENST00000427413.1
ENST00000542504.1
NPAS2

neuronal PAS domain protein 2

chr1_+_36621529 0.052 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr1_+_109102652 0.052 ENST00000370035.3
ENST00000405454.1
FAM102B

family with sequence similarity 102, member B

chr1_-_27216729 0.052 ENST00000431781.2
ENST00000374135.4
GPN2

GPN-loop GTPase 2

chr3_-_155394152 0.045 ENST00000494598.1
PLCH1
phospholipase C, eta 1
chr4_+_141677577 0.042 ENST00000609937.1
RP11-102N12.3
RP11-102N12.3
chr22_-_29457832 0.040 ENST00000216071.4
C22orf31
chromosome 22 open reading frame 31
chr12_+_72332618 0.039 ENST00000333850.3
TPH2
tryptophan hydroxylase 2
chr3_-_155394099 0.037 ENST00000414191.1
PLCH1
phospholipase C, eta 1
chr7_-_44580861 0.033 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1



NPC1-like 1



chr12_+_56325812 0.032 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
DGKA





diacylglycerol kinase, alpha 80kDa





chr11_-_62439727 0.032 ENST00000528862.1
C11orf48
chromosome 11 open reading frame 48
chr17_-_46691990 0.028 ENST00000576562.1
HOXB8
homeobox B8
chr11_-_62474803 0.027 ENST00000533982.1
ENST00000360796.5
BSCL2

Berardinelli-Seip congenital lipodystrophy 2 (seipin)

chr12_-_52967600 0.025 ENST00000549343.1
ENST00000305620.2
KRT74

keratin 74

chr4_-_157563459 0.018 ENST00000504237.1
ENST00000511399.1
RP11-171N4.2

Uncharacterized protein

chr2_+_113033164 0.017 ENST00000409871.1
ENST00000343936.4
ZC3H6

zinc finger CCCH-type containing 6

chr15_+_69850521 0.015 ENST00000558781.1
RP11-279F6.1
RP11-279F6.1
chr17_-_46692287 0.013 ENST00000239144.4
HOXB8
homeobox B8
chr19_+_38880252 0.010 ENST00000586301.1
SPRED3
sprouty-related, EVH1 domain containing 3
chr17_+_41924536 0.010 ENST00000317310.4
CD300LG
CD300 molecule-like family member g
chr14_-_21492113 0.009 ENST00000554094.1
NDRG2
NDRG family member 2
chr11_-_105892937 0.004 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
MSANTD4



Myb/SANT-like DNA-binding domain containing 4 with coiled-coils



chr7_+_150211918 0.003 ENST00000313543.4
GIMAP7
GTPase, IMAP family member 7
chr9_+_132597722 0.002 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
USP20


ubiquitin specific peptidase 20


chr4_+_81187753 0.002 ENST00000312465.7
ENST00000456523.3
FGF5

fibroblast growth factor 5

chr12_-_49351303 0.001 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr2_-_37193606 0.001 ENST00000379213.2
ENST00000263918.4
STRN

striatin, calmodulin binding protein

chrX_+_119292467 0.001 ENST00000371388.3
RHOXF2
Rhox homeobox family, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.6 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.3 GO:0090119 vesicle-mediated cholesterol transport(GO:0090119)
0.1 0.9 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.6 GO:0045964 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.1 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.0 3.0 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.1 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.9 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.0 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 0.1 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
0.0 0.1 GO:0070538 oleic acid binding(GO:0070538)
0.0 1.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis