Motif ID: PITX2

Z-value: 0.241


Transcription factors associated with PITX2:

Gene SymbolEntrez IDGene Name
PITX2 ENSG00000164093.11 PITX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544207_111544240-0.674.7e-02Click!


Activity profile for motif PITX2.

activity profile for motif PITX2


Sorted Z-values histogram for motif PITX2

Sorted Z-values for motif PITX2



Network of associatons between targets according to the STRING database.



First level regulatory network of PITX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_36429763 0.412 ENST00000379893.1
 DCLK1
doublecortin-like kinase 1
chr6_-_138893661 0.256 ENST00000427025.2
 NHSL1
NHS-like 1
chr10_-_61900762 0.181 ENST00000355288.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_-_69249863 0.172 ENST00000478263.1
ENST00000462512.1
 FRMD4B

FERM domain containing 4B

chr15_+_54901540 0.159 ENST00000539562.2
 UNC13C
unc-13 homolog C (C. elegans)
chr1_+_2407754 0.141 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
 PLCH2



phospholipase C, eta 2



chr12_+_6949964 0.140 ENST00000541978.1
ENST00000435982.2
 GNB3

guanine nucleotide binding protein (G protein), beta polypeptide 3

chr3_+_158787098 0.107 ENST00000397832.2
ENST00000451172.1
ENST00000482126.1
 IQCJ


IQ motif containing J


chr11_+_61522844 0.102 ENST00000265460.5
 MYRF
myelin regulatory factor
chr11_+_6942205 0.098 ENST00000317834.3
 OR2D3
olfactory receptor, family 2, subfamily D, member 3
chr21_-_19775973 0.088 ENST00000284885.3
 TMPRSS15
transmembrane protease, serine 15
chr14_+_75988768 0.081 ENST00000286639.6
 BATF
basic leucine zipper transcription factor, ATF-like
chr1_-_31230650 0.079 ENST00000294507.3
 LAPTM5
lysosomal protein transmembrane 5
chr2_-_65659762 0.073 ENST00000440972.1
 SPRED2
sprouty-related, EVH1 domain containing 2
chr11_-_119217365 0.065 ENST00000445041.2
ENST00000360167.4
ENST00000555262.1
ENST00000449574.2
 C1QTNF5
MFRP


C1q and tumor necrosis factor related protein 5
membrane frizzled-related protein


chr13_-_95131923 0.061 ENST00000377028.5
ENST00000446125.1
 DCT

dopachrome tautomerase

chr3_+_158787041 0.059 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
 IQCJ-SCHIP1


IQCJ-SCHIP1 readthrough


chr14_+_75988851 0.055 ENST00000555504.1
 BATF
basic leucine zipper transcription factor, ATF-like
chr15_+_41221536 0.054 ENST00000249749.5
 DLL4
delta-like 4 (Drosophila)
chr17_+_4643337 0.052 ENST00000592813.1
 ZMYND15
zinc finger, MYND-type containing 15
chr19_-_46142362 0.051 ENST00000586770.1
ENST00000591721.1
 EML2

echinoderm microtubule associated protein like 2

chr4_+_70916119 0.050 ENST00000246896.3
ENST00000511674.1
 HTN1

histatin 1

chr9_-_127358087 0.050 ENST00000475178.1
 NR6A1
nuclear receptor subfamily 6, group A, member 1
chr6_-_111804905 0.049 ENST00000358835.3
ENST00000435970.1
 REV3L

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

chr17_+_4643300 0.048 ENST00000433935.1
 ZMYND15
zinc finger, MYND-type containing 15
chr17_-_46657473 0.045 ENST00000332503.5
 HOXB4
homeobox B4
chr18_-_47017956 0.044 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
 RPL17-C18orf32

RPL17

RPL17-C18orf32 readthrough

ribosomal protein L17

chr8_+_123875624 0.042 ENST00000534247.1
 ZHX2
zinc fingers and homeoboxes 2
chr6_+_130339710 0.039 ENST00000526087.1
ENST00000533560.1
ENST00000361794.2
 L3MBTL3


l(3)mbt-like 3 (Drosophila)


chr8_-_10512569 0.037 ENST00000382483.3
 RP1L1
retinitis pigmentosa 1-like 1
chr13_+_73632897 0.036 ENST00000377687.4
 KLF5
Kruppel-like factor 5 (intestinal)
chr7_-_128415844 0.035 ENST00000249389.2
 OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr6_-_160209471 0.033 ENST00000539948.1
 TCP1
t-complex 1
chr22_-_30234218 0.032 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
 ASCC2


activating signal cointegrator 1 complex subunit 2


chr9_-_98268883 0.029 ENST00000551630.1
ENST00000548420.1
 PTCH1

patched 1

chr1_+_205538165 0.027 ENST00000536357.1
 MFSD4
major facilitator superfamily domain containing 4
chr7_+_73868439 0.025 ENST00000424337.2
 GTF2IRD1
GTF2I repeat domain containing 1
chr19_+_2476116 0.024 ENST00000215631.4
ENST00000587345.1
 GADD45B

growth arrest and DNA-damage-inducible, beta

chr3_-_50388522 0.023 ENST00000232501.3
 NPRL2
nitrogen permease regulator-like 2 (S. cerevisiae)
chr10_+_18240834 0.022 ENST00000377371.3
ENST00000539911.1
 SLC39A12

solute carrier family 39 (zinc transporter), member 12

chr21_-_34915147 0.022 ENST00000381831.3
ENST00000381839.3
 GART

phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase

chr2_+_3622893 0.020 ENST00000407445.3
ENST00000403564.1
 RPS7

ribosomal protein S7

chr3_+_139062838 0.019 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
 MRPS22


mitochondrial ribosomal protein S22


chr21_-_34915084 0.018 ENST00000426819.1
 GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr7_+_73868220 0.017 ENST00000455841.2
 GTF2IRD1
GTF2I repeat domain containing 1
chrX_-_6146876 0.017 ENST00000381095.3
 NLGN4X
neuroligin 4, X-linked
chrM_+_9207 0.017 ENST00000362079.2
 MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr19_-_19314162 0.016 ENST00000420605.3
ENST00000544883.1
ENST00000538165.2
ENST00000331552.7
 NR2C2AP



nuclear receptor 2C2-associated protein



chr10_+_18240753 0.014 ENST00000377369.2
 SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr1_+_92417716 0.013 ENST00000402388.1
 BRDT
bromodomain, testis-specific
chr3_+_119421849 0.013 ENST00000273390.5
ENST00000463700.1
 MAATS1

MYCBP-associated, testis expressed 1

chr17_-_10633535 0.012 ENST00000341871.3
 TMEM220
transmembrane protein 220
chr5_+_64920543 0.011 ENST00000399438.3
ENST00000510585.2
 TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr10_+_18240814 0.009 ENST00000377374.4
 SLC39A12
solute carrier family 39 (zinc transporter), member 12
chr20_+_44350968 0.009 ENST00000279058.3
 SPINT4
serine peptidase inhibitor, Kunitz type 4
chr18_-_3880051 0.008 ENST00000584874.1
 DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr12_-_323689 0.007 ENST00000428720.1
 SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr6_-_53013620 0.006 ENST00000259803.7
 GCM1
glial cells missing homolog 1 (Drosophila)
chrX_-_33357558 0.006 ENST00000288447.4
 DMD
dystrophin
chr9_+_34458771 0.006 ENST00000437363.1
ENST00000242317.4
 DNAI1

dynein, axonemal, intermediate chain 1

chr9_+_8858102 0.003 ENST00000447950.1
ENST00000430766.1
 RP11-75C9.1

RP11-75C9.1

chr3_-_49837254 0.002 ENST00000412678.2
ENST00000343366.4
ENST00000487256.1
 CDHR4


cadherin-related family member 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.3 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)