Motif ID: PBX3

Z-value: 0.646


Transcription factors associated with PBX3:

Gene SymbolEntrez IDGene Name
PBX3 ENSG00000167081.12 PBX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
PBX3hg19_v2_chr9_+_128509663_1285097330.844.4e-03Click!


Activity profile for motif PBX3.

activity profile for motif PBX3


Sorted Z-values histogram for motif PBX3

Sorted Z-values for motif PBX3



Network of associatons between targets according to the STRING database.



First level regulatory network of PBX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_39975544 0.848 ENST00000544340.1
FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_39975455 0.846 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr3_+_111718173 0.807 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_111717511 0.785 ENST00000478951.1
ENST00000393917.2
TAGLN3

transgelin 3

chr3_+_111717600 0.743 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111718036 0.703 ENST00000455401.2
TAGLN3
transgelin 3
chr5_+_167181917 0.633 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr16_+_89238149 0.590 ENST00000289746.2
CDH15
cadherin 15, type 1, M-cadherin (myotubule)
chr4_-_89205350 0.564 ENST00000509340.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr4_-_6202247 0.503 ENST00000409021.3
ENST00000409371.3
JAKMIP1

janus kinase and microtubule interacting protein 1

chr4_-_6202291 0.488 ENST00000282924.5
JAKMIP1
janus kinase and microtubule interacting protein 1
chr10_+_99609996 0.452 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr8_+_105235572 0.435 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr5_+_121647764 0.387 ENST00000261368.8
ENST00000379533.2
ENST00000379536.2
ENST00000379538.3
SNCAIP



synuclein, alpha interacting protein



chr21_-_16437126 0.386 ENST00000318948.4
NRIP1
nuclear receptor interacting protein 1
chr21_-_16437255 0.386 ENST00000400199.1
ENST00000400202.1
NRIP1

nuclear receptor interacting protein 1

chr19_+_51728316 0.365 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33



CD33 molecule



chr5_+_166711804 0.363 ENST00000518659.1
ENST00000545108.1
TENM2

teneurin transmembrane protein 2

chr1_-_156786634 0.344 ENST00000392306.2
ENST00000368199.3
SH2D2A

SH2 domain containing 2A

chr21_-_32716556 0.340 ENST00000455508.1
TIAM1
T-cell lymphoma invasion and metastasis 1
chr1_-_156786530 0.334 ENST00000368198.3
SH2D2A
SH2 domain containing 2A
chr21_+_47540424 0.326 ENST00000413758.1
COL6A2
collagen, type VI, alpha 2
chr2_+_63277927 0.326 ENST00000282549.2
OTX1
orthodenticle homeobox 1
chr5_+_121647924 0.323 ENST00000414317.2
SNCAIP
synuclein, alpha interacting protein
chr17_+_48243352 0.308 ENST00000344627.6
ENST00000262018.3
ENST00000543315.1
ENST00000451235.2
ENST00000511303.1
SGCA




sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)




chr2_-_71062938 0.301 ENST00000410009.3
CD207
CD207 molecule, langerin
chr19_-_474880 0.299 ENST00000382696.3
ENST00000315489.4
ODF3L2

outer dense fiber of sperm tails 3-like 2

chr17_+_6926339 0.290 ENST00000293805.5
BCL6B
B-cell CLL/lymphoma 6, member B
chr5_+_121647386 0.287 ENST00000542191.1
ENST00000506272.1
ENST00000508681.1
ENST00000509154.2
SNCAIP



synuclein, alpha interacting protein



chr17_-_8534067 0.280 ENST00000360416.3
ENST00000269243.4
MYH10

myosin, heavy chain 10, non-muscle

chr2_+_66662510 0.276 ENST00000272369.9
ENST00000407092.2
MEIS1

Meis homeobox 1

chr17_-_8534031 0.273 ENST00000411957.1
ENST00000396239.1
ENST00000379980.4
MYH10


myosin, heavy chain 10, non-muscle


chr19_+_13906250 0.272 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr14_+_37131058 0.266 ENST00000361487.6
PAX9
paired box 9
chr2_+_66662690 0.251 ENST00000488550.1
MEIS1
Meis homeobox 1
chr2_+_66662249 0.248 ENST00000560281.2
MEIS1
Meis homeobox 1
chr2_+_113670548 0.247 ENST00000263326.3
ENST00000352179.3
ENST00000349806.3
ENST00000353225.3
IL37



interleukin 37



chr5_+_53686658 0.237 ENST00000512618.1
LINC01033
long intergenic non-protein coding RNA 1033
chr3_+_30648066 0.224 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr16_-_79634595 0.223 ENST00000326043.4
ENST00000393350.1
MAF

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

chr6_-_119031228 0.221 ENST00000392500.3
ENST00000368488.5
ENST00000434604.1
CEP85L


centrosomal protein 85kDa-like


chr17_-_13505219 0.220 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr3_+_111393659 0.220 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr10_-_48332197 0.219 ENST00000454672.1
RP11-463P17.1
RP11-463P17.1
chr3_-_52486841 0.218 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr18_-_67624160 0.208 ENST00000581982.1
ENST00000280200.4
CD226

CD226 molecule

chr2_-_61765732 0.206 ENST00000443240.1
ENST00000436018.1
XPO1

exportin 1 (CRM1 homolog, yeast)

chr12_-_42983478 0.206 ENST00000345127.3
ENST00000547113.1
PRICKLE1

prickle homolog 1 (Drosophila)

chr2_-_61765315 0.205 ENST00000406957.1
ENST00000401558.2
XPO1

exportin 1 (CRM1 homolog, yeast)

chr3_+_48481658 0.204 ENST00000438607.2
TMA7
translation machinery associated 7 homolog (S. cerevisiae)
chr19_+_2977444 0.203 ENST00000246112.4
ENST00000453329.1
ENST00000482627.1
ENST00000452088.1
TLE6



transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)



chr13_+_113656047 0.203 ENST00000375597.4
MCF2L
MCF.2 cell line derived transforming sequence-like
chr11_-_71159458 0.200 ENST00000355527.3
DHCR7
7-dehydrocholesterol reductase
chr16_-_53537105 0.199 ENST00000568596.1
ENST00000570004.1
ENST00000564497.1
ENST00000300245.4
ENST00000394657.7
AKTIP




AKT interacting protein




chr9_+_34652164 0.198 ENST00000441545.2
ENST00000553620.1
IL11RA

interleukin 11 receptor, alpha

chr10_-_76868866 0.198 ENST00000607487.1
DUSP13
dual specificity phosphatase 13
chr3_+_30647994 0.197 ENST00000295754.5
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr13_-_31191642 0.196 ENST00000405805.1
HMGB1
high mobility group box 1
chr8_+_101349823 0.193 ENST00000519566.1
KB-1991G8.1
KB-1991G8.1
chr10_-_76868931 0.190 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
DUSP13




dual specificity phosphatase 13




chr5_+_149569520 0.187 ENST00000230671.2
ENST00000524041.1
SLC6A7

solute carrier family 6 (neurotransmitter transporter), member 7

chr11_+_46354455 0.185 ENST00000343674.6
DGKZ
diacylglycerol kinase, zeta
chr11_-_71159380 0.185 ENST00000525346.1
ENST00000531364.1
ENST00000529990.1
ENST00000527316.1
ENST00000407721.2
DHCR7




7-dehydrocholesterol reductase




chr3_-_186080012 0.185 ENST00000544847.1
ENST00000265022.3
DGKG

diacylglycerol kinase, gamma 90kDa

chr2_+_74685527 0.182 ENST00000393972.3
ENST00000409737.1
ENST00000428943.1
WBP1


WW domain binding protein 1


chr10_+_102891048 0.181 ENST00000467928.2
TLX1
T-cell leukemia homeobox 1
chr5_-_179780312 0.181 ENST00000253778.8
GFPT2
glutamine-fructose-6-phosphate transaminase 2
chr17_-_44896047 0.177 ENST00000225512.5
WNT3
wingless-type MMTV integration site family, member 3
chr13_-_33780133 0.177 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_+_37782955 0.176 ENST00000580825.1
PPP1R1B
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr14_-_91526922 0.175 ENST00000418736.2
ENST00000261991.3
RPS6KA5

ribosomal protein S6 kinase, 90kDa, polypeptide 5

chr17_-_42019836 0.175 ENST00000225992.3
PPY
pancreatic polypeptide
chr13_+_113656022 0.172 ENST00000423482.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr3_-_33482002 0.172 ENST00000283628.5
ENST00000456378.1
UBP1

upstream binding protein 1 (LBP-1a)

chr20_+_55204351 0.172 ENST00000201031.2
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr12_+_49209348 0.172 ENST00000536187.2
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr2_+_74685413 0.170 ENST00000233615.2
WBP1
WW domain binding protein 1
chrX_-_153210107 0.170 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
RENBP


renin binding protein


chr10_+_67330096 0.169 ENST00000433152.4
ENST00000601979.1
ENST00000599409.1
ENST00000608678.1
RP11-222A11.1



RP11-222A11.1



chr7_+_100183927 0.169 ENST00000241071.6
ENST00000360609.2
FBXO24

F-box protein 24

chr3_-_25706368 0.168 ENST00000424225.1
TOP2B
topoisomerase (DNA) II beta 180kDa
chr16_-_2260834 0.167 ENST00000562360.1
ENST00000566018.1
BRICD5

BRICHOS domain containing 5

chr3_+_111393501 0.165 ENST00000393934.3
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr21_+_39628852 0.165 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr3_-_15643060 0.163 ENST00000414979.1
ENST00000435217.2
ENST00000456194.2
ENST00000457447.2
HACL1



2-hydroxyacyl-CoA lyase 1



chr22_-_37571089 0.162 ENST00000453962.1
ENST00000429622.1
ENST00000445595.1
IL2RB


interleukin 2 receptor, beta


chr22_-_24126145 0.159 ENST00000598975.1
AP000349.1
Uncharacterized protein
chr22_+_36784632 0.159 ENST00000424761.1
RP4-633O19__A.1
RP4-633O19__A.1
chr3_-_15643090 0.156 ENST00000451445.2
ENST00000421993.1
HACL1

2-hydroxyacyl-CoA lyase 1

chr14_-_65346555 0.148 ENST00000542895.1
ENST00000556626.1
SPTB

spectrin, beta, erythrocytic

chr10_-_99258135 0.147 ENST00000327238.10
ENST00000327277.7
ENST00000355839.6
ENST00000437002.1
ENST00000422685.1
MMS19




MMS19 nucleotide excision repair homolog (S. cerevisiae)




chr9_+_116327326 0.146 ENST00000342620.5
RGS3
regulator of G-protein signaling 3
chr11_+_58938903 0.145 ENST00000532982.1
DTX4
deltex homolog 4 (Drosophila)
chr18_+_44526744 0.142 ENST00000585469.1
KATNAL2
katanin p60 subunit A-like 2
chr9_+_82186872 0.141 ENST00000376544.3
ENST00000376520.4
TLE4

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

chr3_-_113415441 0.140 ENST00000491165.1
ENST00000316407.4
KIAA2018

KIAA2018

chr7_-_42276612 0.140 ENST00000395925.3
ENST00000437480.1
GLI3

GLI family zinc finger 3

chr17_+_38673270 0.139 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr19_+_41869894 0.138 ENST00000413014.2
TMEM91
transmembrane protein 91
chr7_-_149470297 0.138 ENST00000484747.1
ZNF467
zinc finger protein 467
chr7_+_21467642 0.138 ENST00000222584.3
ENST00000432066.2
SP4

Sp4 transcription factor

chr19_+_46498704 0.136 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
CCDC61


coiled-coil domain containing 61


chr6_-_131321863 0.134 ENST00000528282.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr7_-_38389573 0.134 ENST00000390344.2
TRGV5
T cell receptor gamma variable 5
chr17_+_19314432 0.131 ENST00000575165.2
RNF112
ring finger protein 112
chr3_-_3221358 0.131 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
CRBN



cereblon



chr10_+_114710211 0.130 ENST00000349937.2
ENST00000369397.4
TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box)

chr12_+_19389814 0.129 ENST00000536974.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr13_-_21348050 0.128 ENST00000382754.4
N6AMT2
N-6 adenine-specific DNA methyltransferase 2 (putative)
chr1_-_247171347 0.126 ENST00000339986.7
ENST00000487338.2
ZNF695

zinc finger protein 695

chr4_-_57687847 0.125 ENST00000504762.1
ENST00000248701.4
ENST00000506738.1
SPINK2


serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)


chr2_-_45236540 0.122 ENST00000303077.6
SIX2
SIX homeobox 2
chr17_+_58755184 0.121 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3


breast carcinoma amplified sequence 3


chr9_-_33264676 0.121 ENST00000472232.3
ENST00000379704.2
BAG1

BCL2-associated athanogene

chr3_-_195163584 0.121 ENST00000439666.1
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr13_-_21348066 0.120 ENST00000382758.1
N6AMT2
N-6 adenine-specific DNA methyltransferase 2 (putative)
chr15_-_37392086 0.119 ENST00000561208.1
MEIS2
Meis homeobox 2
chr8_-_7274385 0.119 ENST00000318157.2
DEFB4B
defensin, beta 4B
chr2_-_220436248 0.119 ENST00000265318.4
OBSL1
obscurin-like 1
chr17_+_6918354 0.118 ENST00000552775.1
C17orf49
chromosome 17 open reading frame 49
chr11_-_128457446 0.118 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr10_-_69425399 0.118 ENST00000330298.6
CTNNA3
catenin (cadherin-associated protein), alpha 3
chr1_-_182558374 0.115 ENST00000367559.3
ENST00000539397.1
RNASEL

ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)

chr16_+_1728257 0.114 ENST00000248098.3
ENST00000562684.1
ENST00000561516.1
ENST00000382711.5
ENST00000566742.1
HN1L




hematological and neurological expressed 1-like




chr7_+_64838712 0.114 ENST00000328747.7
ENST00000431504.1
ENST00000357512.2
ZNF92


zinc finger protein 92


chr8_-_37411648 0.114 ENST00000519738.1
RP11-150O12.1
RP11-150O12.1
chr13_-_102068769 0.114 ENST00000376196.3
NALCN
sodium leak channel, non-selective
chr13_+_31191920 0.114 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr19_+_11485333 0.113 ENST00000312423.2
SWSAP1
SWIM-type zinc finger 7 associated protein 1
chr8_-_80680078 0.113 ENST00000337919.5
ENST00000354724.3
HEY1

hes-related family bHLH transcription factor with YRPW motif 1

chr7_+_64838786 0.113 ENST00000450302.2
ZNF92
zinc finger protein 92
chr17_+_8191815 0.112 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF



RAN guanine nucleotide release factor



chr10_+_99258625 0.112 ENST00000370664.3
UBTD1
ubiquitin domain containing 1
chr11_-_115127611 0.111 ENST00000545094.1
CADM1
cell adhesion molecule 1
chr2_-_220435963 0.111 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
OBSL1




obscurin-like 1




chr9_-_35689900 0.110 ENST00000378300.5
ENST00000329305.2
ENST00000360958.2
TPM2


tropomyosin 2 (beta)


chr16_+_1728305 0.110 ENST00000569765.1
HN1L
hematological and neurological expressed 1-like
chr7_+_128355439 0.110 ENST00000315184.5
FAM71F1
family with sequence similarity 71, member F1
chr11_+_112832202 0.109 ENST00000534015.1
NCAM1
neural cell adhesion molecule 1
chr12_+_2921788 0.109 ENST00000228799.2
ENST00000419778.2
ENST00000542548.1
ITFG2


integrin alpha FG-GAP repeat containing 2


chr8_+_7752151 0.109 ENST00000302247.2
DEFB4A
defensin, beta 4A
chr17_+_79369249 0.109 ENST00000574717.2
RP11-1055B8.6
Uncharacterized protein
chr7_-_27702455 0.108 ENST00000265395.2
HIBADH
3-hydroxyisobutyrate dehydrogenase
chr12_-_121342170 0.107 ENST00000353487.2
SPPL3
signal peptide peptidase like 3
chr9_-_131940526 0.107 ENST00000372491.2
IER5L
immediate early response 5-like
chr6_-_116989916 0.107 ENST00000368576.3
ENST00000368573.1
ZUFSP

zinc finger with UFM1-specific peptidase domain

chr7_+_55433131 0.107 ENST00000254770.2
LANCL2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr2_-_77749336 0.105 ENST00000409282.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr1_-_112106578 0.105 ENST00000369717.4
ADORA3
adenosine A3 receptor
chr9_-_99180597 0.105 ENST00000375256.4
ZNF367
zinc finger protein 367
chrX_+_69674943 0.104 ENST00000542398.1
DLG3
discs, large homolog 3 (Drosophila)
chr17_+_61699766 0.104 ENST00000579585.1
ENST00000584573.1
ENST00000361733.3
ENST00000361357.3
MAP3K3



mitogen-activated protein kinase kinase kinase 3



chr17_+_61571746 0.103 ENST00000579409.1
ACE
angiotensin I converting enzyme
chr19_+_55591743 0.103 ENST00000588359.1
ENST00000245618.5
EPS8L1

EPS8-like 1

chr9_+_82186682 0.103 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr3_+_37035289 0.101 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1




mutL homolog 1




chr1_-_155177677 0.100 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3


thrombospondin 3


chr10_+_99400443 0.100 ENST00000370631.3
PI4K2A
phosphatidylinositol 4-kinase type 2 alpha
chrX_+_70503037 0.100 ENST00000535149.1
NONO
non-POU domain containing, octamer-binding
chrX_-_40036520 0.100 ENST00000406200.2
ENST00000378455.4
ENST00000342274.4
BCOR


BCL6 corepressor


chrX_+_70503526 0.100 ENST00000413858.1
ENST00000450092.1
NONO

non-POU domain containing, octamer-binding

chr3_-_48481518 0.099 ENST00000412398.2
ENST00000395696.1
CCDC51

coiled-coil domain containing 51

chr19_-_50083822 0.099 ENST00000596358.1
NOSIP
nitric oxide synthase interacting protein
chr13_-_20437648 0.099 ENST00000382907.4
ENST00000382905.4
ZMYM5

zinc finger, MYM-type 5

chr19_+_4474846 0.098 ENST00000589486.1
ENST00000592691.1
HDGFRP2

Hepatoma-derived growth factor-related protein 2

chr3_+_158362299 0.098 ENST00000478576.1
ENST00000264263.5
ENST00000464732.1
GFM1


G elongation factor, mitochondrial 1


chrX_+_102631248 0.098 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
NGFRAP1


nerve growth factor receptor (TNFRSF16) associated protein 1


chr1_+_218683438 0.097 ENST00000443836.1
C1orf143
chromosome 1 open reading frame 143
chr13_-_100624012 0.097 ENST00000267294.4
ZIC5
Zic family member 5
chr9_+_34989638 0.096 ENST00000453597.3
ENST00000335998.3
ENST00000312316.5
DNAJB5


DnaJ (Hsp40) homolog, subfamily B, member 5


chr19_-_23941639 0.096 ENST00000395385.3
ENST00000531570.1
ENST00000528059.1
ZNF681


zinc finger protein 681


chr4_-_106817137 0.095 ENST00000510876.1
INTS12
integrator complex subunit 12
chr13_+_73632897 0.095 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr19_-_50083803 0.095 ENST00000391853.3
ENST00000339093.3
NOSIP

nitric oxide synthase interacting protein

chr6_+_111195973 0.093 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1



adenosylmethionine decarboxylase 1



chr19_+_10736183 0.093 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2


solute carrier family 44 (choline transporter), member 2


chrX_+_70503433 0.093 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
NONO



non-POU domain containing, octamer-binding



chr3_-_33481835 0.092 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr2_+_220094479 0.092 ENST00000323348.5
ENST00000453432.1
ENST00000409849.1
ENST00000416565.1
ENST00000410034.3
ENST00000447157.1
ANKZF1





ankyrin repeat and zinc finger domain containing 1





chr3_+_52489606 0.091 ENST00000488380.1
ENST00000420808.2
NISCH

nischarin

chr22_-_17640110 0.091 ENST00000399852.3
ENST00000336737.4
CECR5

cat eye syndrome chromosome region, candidate 5

chr22_-_32022280 0.091 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chr22_+_31477296 0.091 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
SMTN




smoothelin




chr3_-_48481434 0.091 ENST00000395694.2
ENST00000447018.1
ENST00000442740.1
CCDC51


coiled-coil domain containing 51


chr14_+_77582905 0.090 ENST00000557408.1
TMEM63C
transmembrane protein 63C
chr13_+_52586517 0.089 ENST00000523764.1
ENST00000521508.1
ALG11

ALG11, alpha-1,2-mannosyltransferase

chr12_-_50101165 0.089 ENST00000352151.5
ENST00000335154.5
ENST00000293590.5
FMNL3


formin-like 3


chr6_-_85474219 0.088 ENST00000369663.5
TBX18
T-box 18
chr2_-_77749387 0.087 ENST00000409884.1
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr19_-_12551849 0.087 ENST00000301547.5
ENST00000595562.1
ZNF443
CTD-3105H18.16
zinc finger protein 443
Uncharacterized protein
chr8_+_107738343 0.087 ENST00000521592.1
OXR1
oxidation resistance 1
chr8_+_107738240 0.086 ENST00000449762.2
ENST00000297447.6
OXR1

oxidation resistance 1

chr1_+_6105974 0.086 ENST00000378083.3
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr6_+_10723148 0.086 ENST00000541412.1
ENST00000229563.5
TMEM14C

transmembrane protein 14C

chrX_-_70474910 0.086 ENST00000373988.1
ENST00000373998.1
ZMYM3

zinc finger, MYM-type 3

chr4_+_74347400 0.086 ENST00000226355.3
AFM
afamin
chr16_-_84538218 0.085 ENST00000562447.1
ENST00000565765.1
ENST00000535580.1
ENST00000343629.6
TLDC1



TBC/LysM-associated domain containing 1



chr12_+_28343353 0.084 ENST00000539107.1
CCDC91
coiled-coil domain containing 91
chr5_+_157602404 0.084 ENST00000522975.1
CTC-436K13.1
CTC-436K13.1
chr15_-_37391614 0.083 ENST00000219869.9
MEIS2
Meis homeobox 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.3 0.8 GO:0001543 ovarian follicle rupture(GO:0001543)
0.1 0.4 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 0.6 GO:0021592 fourth ventricle development(GO:0021592)
0.1 0.4 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 0.2 GO:0060061 Spemann organizer formation(GO:0060061)
0.1 0.3 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.2 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 0.3 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
0.0 0.2 GO:0032072 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.0 0.1 GO:0021775 optic nerve morphogenesis(GO:0021631) smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) mammary gland specification(GO:0060594)
0.0 0.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.0 1.0 GO:0097264 self proteolysis(GO:0097264)
0.0 0.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.1 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.2 GO:2000691 regulation of cardiac muscle cell myoblast differentiation(GO:2000690) negative regulation of cardiac muscle cell myoblast differentiation(GO:2000691)
0.0 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.8 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 0.1 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0 0.3 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.1 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.0 0.1 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.0 0.4 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.0 0.3 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0070895 transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
0.0 0.2 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164)
0.0 0.1 GO:0060823 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.3 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 1.0 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.1 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 0.1 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.0 0.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.0 0.1 GO:0050976 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976)
0.0 0.1 GO:0061075 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.3 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.7 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.1 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.0 0.1 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.0 0.3 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.1 GO:0032796 uropod organization(GO:0032796)
0.0 0.1 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0030578 PML body organization(GO:0030578)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 0.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.0 0.0 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.0 0.0 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.1 GO:0009794 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.1 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.1 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.0 GO:0009080 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) L-alanine metabolic process(GO:0042851) L-alanine catabolic process(GO:0042853)
0.0 0.1 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.0 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.3 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.0 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.0 0.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0044565 dendritic cell proliferation(GO:0044565)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0097513 myosin II filament(GO:0097513)
0.1 0.2 GO:0070695 FHF complex(GO:0070695)
0.1 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0071817 MMXD complex(GO:0071817)
0.0 0.5 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.1 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.3 GO:1990393 3M complex(GO:1990393)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.3 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.3 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.1 GO:1990031 pinceau fiber(GO:1990031)
0.0 0.0 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.0 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.2 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.1 0.3 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.1 0.2 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 1.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.1 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 1.0 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0004911 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.1 GO:0015361 low-affinity sodium:dicarboxylate symporter activity(GO:0015361)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.2 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.3 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0030984 kininogen binding(GO:0030984)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0008431 vitamin E binding(GO:0008431)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.1 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.1 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 0.1 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.0 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0004473 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.1 GO:0031711 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711)
0.0 0.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 0.0 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.0 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.0 GO:0052836 inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.8 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.0 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation