Motif ID: NR1D1

Z-value: 0.356


Transcription factors associated with NR1D1:

Gene SymbolEntrez IDGene Name
NR1D1 ENSG00000126368.5 NR1D1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_38256990-0.742.2e-02Click!


Activity profile for motif NR1D1.

activity profile for motif NR1D1


Sorted Z-values histogram for motif NR1D1

Sorted Z-values for motif NR1D1



Network of associatons between targets according to the STRING database.



First level regulatory network of NR1D1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_51220176 0.741 ENST00000359082.3
ENST00000293441.1
SHANK1

SH3 and multiple ankyrin repeat domains 1

chr8_+_105235572 0.336 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chrX_-_138304939 0.336 ENST00000448673.1
FGF13
fibroblast growth factor 13
chr1_-_240906911 0.259 ENST00000431139.2
RP11-80B9.4
RP11-80B9.4
chr22_-_37880543 0.242 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_+_2398876 0.206 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr11_+_7534999 0.205 ENST00000528947.1
ENST00000299492.4
PPFIBP2

PTPRF interacting protein, binding protein 2 (liprin beta 2)

chr22_-_20138302 0.189 ENST00000540078.1
ENST00000439765.2
AC006547.14

uncharacterized protein LOC388849

chr1_+_200863949 0.155 ENST00000413687.2
C1orf106
chromosome 1 open reading frame 106
chr2_-_64371546 0.143 ENST00000358912.4
PELI1
pellino E3 ubiquitin protein ligase 1
chr13_+_113622757 0.133 ENST00000375604.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr18_-_44336998 0.132 ENST00000315087.7
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr2_+_63816087 0.129 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1



malate dehydrogenase 1, NAD (soluble)



chr2_+_63816295 0.126 ENST00000539945.1
ENST00000544381.1
MDH1

malate dehydrogenase 1, NAD (soluble)

chr5_-_43313574 0.126 ENST00000325110.6
ENST00000433297.2
HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr2_+_63816269 0.124 ENST00000432309.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr15_+_65903680 0.124 ENST00000537259.1
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr3_+_48413709 0.123 ENST00000296438.5
ENST00000436231.1
ENST00000445170.1
ENST00000415155.1
FBXW12



F-box and WD repeat domain containing 12



chr2_+_63816126 0.121 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr2_+_242755144 0.121 ENST00000428592.1
NEU4
sialidase 4
chr2_-_63815860 0.119 ENST00000272321.7
ENST00000431065.1
WDPCP

WD repeat containing planar cell polarity effector

chr13_+_113622810 0.117 ENST00000397030.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr13_+_113623509 0.117 ENST00000535094.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr2_-_73053126 0.116 ENST00000272427.6
ENST00000410104.1
EXOC6B

exocyst complex component 6B

chr15_-_65903512 0.115 ENST00000567923.1
VWA9
von Willebrand factor A domain containing 9
chr5_-_43313269 0.112 ENST00000511774.1
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr1_-_6557156 0.108 ENST00000537245.1
PLEKHG5
pleckstrin homology domain containing, family G (with RhoGef domain) member 5
chr3_-_52002194 0.100 ENST00000466412.1
PCBP4
poly(rC) binding protein 4
chr15_-_65903574 0.100 ENST00000420799.2
ENST00000313182.2
ENST00000431261.2
ENST00000442903.3
VWA9



von Willebrand factor A domain containing 9



chr3_-_52002403 0.095 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4



poly(rC) binding protein 4



chr15_-_65903407 0.095 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
VWA9





von Willebrand factor A domain containing 9





chr16_+_71392616 0.091 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2


calbindin 2


chr1_-_41131326 0.085 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr3_-_45957088 0.074 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr6_+_76458909 0.074 ENST00000369981.3
ENST00000369985.4
MYO6

myosin VI

chr6_+_76458990 0.072 ENST00000369977.3
MYO6
myosin VI
chr16_+_67233412 0.071 ENST00000477898.1
ELMO3
engulfment and cell motility 3
chr22_+_38321840 0.071 ENST00000454685.1
MICALL1
MICAL-like 1
chr17_+_79968655 0.069 ENST00000583744.1
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr7_+_64126535 0.068 ENST00000344930.3
ZNF107
zinc finger protein 107
chr6_-_135424186 0.068 ENST00000529882.1
HBS1L
HBS1-like (S. cerevisiae)
chr16_+_67233007 0.066 ENST00000360833.1
ENST00000393997.2
ELMO3

engulfment and cell motility 3

chr11_-_327537 0.065 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr11_+_46740730 0.062 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2


coagulation factor II (thrombin)


chr8_+_101162812 0.056 ENST00000353107.3
ENST00000522439.1
POLR2K

polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa

chr14_+_74815116 0.055 ENST00000256362.4
VRTN
vertebrae development associated
chr6_+_99282570 0.053 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr13_+_100741269 0.052 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA


propionyl CoA carboxylase, alpha polypeptide


chr12_-_7125770 0.046 ENST00000261407.4
LPCAT3
lysophosphatidylcholine acyltransferase 3
chr3_-_48723268 0.045 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCKIPSD



NCK interacting protein with SH3 domain



chrX_-_49089771 0.045 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F


calcium channel, voltage-dependent, L type, alpha 1F subunit


chr9_+_103790991 0.045 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr14_+_100789669 0.044 ENST00000361529.3
ENST00000557052.1
SLC25A47

solute carrier family 25, member 47

chr9_+_139221880 0.041 ENST00000392945.3
ENST00000440944.1
GPSM1

G-protein signaling modulator 1

chr17_-_18546151 0.038 ENST00000575211.1
TBC1D28
TBC1 domain family, member 28
chr17_-_3599492 0.037 ENST00000435558.1
ENST00000345901.3
P2RX5

purinergic receptor P2X, ligand-gated ion channel, 5

chr10_-_103880209 0.036 ENST00000425280.1
LDB1
LIM domain binding 1
chr17_-_3599327 0.036 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5


purinergic receptor P2X, ligand-gated ion channel, 5


chr1_-_168513229 0.034 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chr12_+_57854274 0.033 ENST00000528432.1
GLI1
GLI family zinc finger 1
chr1_-_26232522 0.033 ENST00000399728.1
STMN1
stathmin 1
chr11_+_46366918 0.033 ENST00000528615.1
ENST00000395574.3
DGKZ

diacylglycerol kinase, zeta

chr22_-_28316116 0.032 ENST00000415296.1
PITPNB
phosphatidylinositol transfer protein, beta
chr9_+_136243264 0.032 ENST00000371955.1
C9orf96
chromosome 9 open reading frame 96
chr1_+_203764742 0.032 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A




zinc finger CCCH-type containing 11A




chr22_+_20905269 0.031 ENST00000457322.1
MED15
mediator complex subunit 15
chr11_+_46366799 0.031 ENST00000532868.2
DGKZ
diacylglycerol kinase, zeta
chr22_+_37415728 0.031 ENST00000404802.3
MPST
mercaptopyruvate sulfurtransferase
chr16_-_18468926 0.031 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr12_-_110883346 0.029 ENST00000547365.1
ARPC3
actin related protein 2/3 complex, subunit 3, 21kDa
chr22_+_37415700 0.028 ENST00000397129.1
MPST
mercaptopyruvate sulfurtransferase
chr1_-_26232951 0.028 ENST00000426559.2
ENST00000455785.2
STMN1

stathmin 1

chr9_-_37592561 0.028 ENST00000544379.1
ENST00000377773.5
ENST00000401811.3
ENST00000321301.6
TOMM5



translocase of outer mitochondrial membrane 5 homolog (yeast)



chr7_+_64126503 0.027 ENST00000360117.3
ZNF107
zinc finger protein 107
chr12_-_123755639 0.026 ENST00000535979.1
CDK2AP1
cyclin-dependent kinase 2 associated protein 1
chr17_-_56358287 0.026 ENST00000225275.3
ENST00000340482.3
MPO

myeloperoxidase

chr1_-_111991850 0.026 ENST00000411751.2
WDR77
WD repeat domain 77
chr11_-_64013663 0.025 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_+_111992064 0.025 ENST00000483994.1
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr14_-_94595993 0.025 ENST00000238609.3
IFI27L2
interferon, alpha-inducible protein 27-like 2
chr9_-_136242956 0.025 ENST00000371989.3
ENST00000485435.2
SURF4

surfeit 4

chr10_+_90346519 0.024 ENST00000371939.3
LIPJ
lipase, family member J
chr19_+_21688366 0.024 ENST00000358491.4
ENST00000597078.1
ZNF429

zinc finger protein 429

chr22_+_37415776 0.023 ENST00000341116.3
ENST00000429360.2
ENST00000404393.1
MPST


mercaptopyruvate sulfurtransferase


chr17_-_76128488 0.021 ENST00000322914.3
TMC6
transmembrane channel-like 6
chr19_+_39647271 0.021 ENST00000599657.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr1_+_168545711 0.021 ENST00000367818.3
XCL1
chemokine (C motif) ligand 1
chr1_+_161719552 0.020 ENST00000367943.4
DUSP12
dual specificity phosphatase 12
chr16_+_77225071 0.020 ENST00000439557.2
ENST00000545553.1
MON1B

MON1 secretory trafficking family member B

chr16_+_30006615 0.019 ENST00000563197.1
INO80E
INO80 complex subunit E
chr9_-_136242909 0.018 ENST00000371991.3
ENST00000545297.1
SURF4

surfeit 4

chr22_+_45898712 0.017 ENST00000455233.1
ENST00000348697.2
ENST00000402984.3
ENST00000262722.7
ENST00000327858.6
ENST00000442170.2
ENST00000340923.5
ENST00000439835.1
FBLN1







fibulin 1







chr17_-_59940705 0.017 ENST00000577913.1
BRIP1
BRCA1 interacting protein C-terminal helicase 1
chr1_-_147245445 0.017 ENST00000430508.1
GJA5
gap junction protein, alpha 5, 40kDa
chr15_-_81282133 0.016 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr9_-_131155773 0.015 ENST00000608502.1
MIR219-2
microRNA 219-2
chr1_-_111991908 0.015 ENST00000235090.5
WDR77
WD repeat domain 77
chr19_-_38806540 0.014 ENST00000592694.1
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr19_-_12833361 0.013 ENST00000592287.1
TNPO2
transportin 2
chr17_+_6899366 0.013 ENST00000251535.6
ALOX12
arachidonate 12-lipoxygenase
chr19_-_38806390 0.013 ENST00000589247.1
ENST00000329420.8
ENST00000591784.1
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr19_-_12833164 0.013 ENST00000356861.5
TNPO2
transportin 2
chr16_+_1832902 0.012 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2





nucleotide binding protein 2





chr7_-_128695147 0.012 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3


transportin 3


chr19_-_38806560 0.012 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr1_-_147245484 0.011 ENST00000271348.2
GJA5
gap junction protein, alpha 5, 40kDa
chr19_-_19932501 0.010 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
ZNF506







CTC-559E9.4
zinc finger protein 506







CTC-559E9.4
chr7_-_30009542 0.010 ENST00000438497.1
SCRN1
secernin 1
chr19_+_21203426 0.009 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430


zinc finger protein 430


chr6_+_31543334 0.009 ENST00000449264.2
TNF
tumor necrosis factor
chr19_-_42927251 0.009 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chr9_+_91150016 0.008 ENST00000375854.3
ENST00000375855.3
NXNL2

nucleoredoxin-like 2

chr17_-_38074859 0.008 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
GSDMB


gasdermin B


chr11_-_117170403 0.007 ENST00000504995.1
BACE1
beta-site APP-cleaving enzyme 1
chr7_+_114562616 0.007 ENST00000448022.1
MDFIC
MyoD family inhibitor domain containing
chr1_-_26233423 0.006 ENST00000357865.2
STMN1
stathmin 1
chr17_-_7145475 0.006 ENST00000571129.1
ENST00000571253.1
ENST00000573928.1
GABARAP


GABA(A) receptor-associated protein


chr7_-_128694927 0.006 ENST00000471166.1
ENST00000265388.5
TNPO3

transportin 3

chr7_+_139025875 0.006 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chrX_+_68725084 0.006 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr1_+_159796534 0.005 ENST00000289707.5
SLAMF8
SLAM family member 8
chr14_-_50999373 0.005 ENST00000554273.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr17_-_72588422 0.004 ENST00000375352.1
CD300LD
CD300 molecule-like family member d
chr14_-_23770683 0.003 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E




protein phosphatase 1, regulatory subunit 3E




chr7_+_94139105 0.003 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr19_+_21264943 0.003 ENST00000597424.1
ZNF714
zinc finger protein 714
chr1_-_156918806 0.002 ENST00000315174.8
ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr16_+_4606347 0.001 ENST00000444310.4
C16orf96
chromosome 16 open reading frame 96
chr19_-_22605136 0.001 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
ZNF98


zinc finger protein 98


chr11_+_125365110 0.001 ENST00000527818.1
AP000708.1
AP000708.1
chr10_-_105156198 0.001 ENST00000369815.1
ENST00000309579.3
ENST00000337003.4
USMG5


up-regulated during skeletal muscle growth 5 homolog (mouse)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0050894 determination of affect(GO:0050894)
0.1 0.3 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.5 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.3 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.0 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.1 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
0.0 0.1 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.4 GO:0009642 response to light intensity(GO:0009642)
0.0 0.2 GO:0032494 response to peptidoglycan(GO:0032494)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.5 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.1 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)