Motif ID: NKX3-1
Z-value: 0.718
Transcription factors associated with NKX3-1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NKX3-1 | ENSG00000167034.9 | NKX3-1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX3-1 | hg19_v2_chr8_-_23540402_23540466 | -0.82 | 6.9e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.2 | 0.7 | GO:0042418 | epinephrine biosynthetic process(GO:0042418) |
| 0.2 | 1.6 | GO:0043305 | negative regulation of mast cell degranulation(GO:0043305) |
| 0.1 | 0.8 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.1 | 2.3 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.1 | 0.6 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.1 | 0.6 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.7 | GO:0019255 | glucose 1-phosphate metabolic process(GO:0019255) |
| 0.1 | 0.3 | GO:0006421 | asparaginyl-tRNA aminoacylation(GO:0006421) |
| 0.1 | 0.9 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.1 | 0.2 | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) |
| 0.1 | 0.2 | GO:0006579 | amino-acid betaine catabolic process(GO:0006579) |
| 0.1 | 1.4 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 0.5 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.1 | 0.3 | GO:1901979 | regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159) |
| 0.0 | 0.2 | GO:0044053 | translocation of peptides or proteins into host(GO:0042000) translocation of peptides or proteins into host cell cytoplasm(GO:0044053) translocation of molecules into host(GO:0044417) translocation of peptides or proteins into other organism involved in symbiotic interaction(GO:0051808) translocation of molecules into other organism involved in symbiotic interaction(GO:0051836) |
| 0.0 | 0.1 | GO:0006147 | guanine catabolic process(GO:0006147) |
| 0.0 | 0.7 | GO:0045636 | positive regulation of melanocyte differentiation(GO:0045636) |
| 0.0 | 0.2 | GO:0021523 | somatic motor neuron differentiation(GO:0021523) protein localization to ciliary transition zone(GO:1904491) |
| 0.0 | 0.7 | GO:0010886 | positive regulation of cholesterol storage(GO:0010886) |
| 0.0 | 0.2 | GO:0010752 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 0.0 | 0.2 | GO:0010643 | cell communication by chemical coupling(GO:0010643) |
| 0.0 | 0.1 | GO:0035948 | positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) |
| 0.0 | 0.2 | GO:1903490 | regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490) |
| 0.0 | 0.4 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.2 | GO:0097500 | receptor localization to nonmotile primary cilium(GO:0097500) |
| 0.0 | 0.1 | GO:0035936 | testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845) |
| 0.0 | 0.2 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.0 | 0.2 | GO:0010032 | meiotic chromosome condensation(GO:0010032) |
| 0.0 | 0.9 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.1 | GO:1903285 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470) |
| 0.0 | 0.1 | GO:0071475 | cellular hyperosmotic salinity response(GO:0071475) |
| 0.0 | 0.1 | GO:0021943 | formation of radial glial scaffolds(GO:0021943) |
| 0.0 | 0.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 0.1 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.0 | 0.1 | GO:0018171 | peptidyl-cysteine oxidation(GO:0018171) |
| 0.0 | 0.1 | GO:0035617 | stress granule disassembly(GO:0035617) |
| 0.0 | 0.2 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.0 | 0.1 | GO:1902499 | positive regulation of protein autoubiquitination(GO:1902499) |
| 0.0 | 0.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) |
| 0.0 | 0.1 | GO:0042670 | retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549) |
| 0.0 | 0.1 | GO:0006447 | regulation of translational initiation by iron(GO:0006447) |
| 0.0 | 0.1 | GO:0071963 | establishment or maintenance of cell polarity regulating cell shape(GO:0071963) |
| 0.0 | 0.1 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.0 | 0.1 | GO:0035995 | detection of muscle stretch(GO:0035995) |
| 0.0 | 0.4 | GO:0042789 | mRNA transcription from RNA polymerase II promoter(GO:0042789) |
| 0.0 | 0.2 | GO:0051382 | kinetochore assembly(GO:0051382) |
| 0.0 | 0.1 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
| 0.0 | 0.2 | GO:1904424 | regulation of GTP binding(GO:1904424) |
| 0.0 | 0.1 | GO:0015705 | iodide transport(GO:0015705) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.1 | 0.9 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.1 | 0.3 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.1 | 0.3 | GO:0030934 | anchoring collagen complex(GO:0030934) |
| 0.0 | 0.3 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.0 | 0.2 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.0 | 0.1 | GO:1990876 | cytoplasmic side of nuclear pore(GO:1990876) |
| 0.0 | 0.7 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.0 | 0.1 | GO:0031262 | Ndc80 complex(GO:0031262) |
| 0.0 | 0.6 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 0.1 | GO:0043564 | Ku70:Ku80 complex(GO:0043564) |
| 0.0 | 0.2 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.2 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.0 | 0.2 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 0.0 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.0 | 0.2 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 0.2 | GO:0036038 | MKS complex(GO:0036038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0004603 | phenylethanolamine N-methyltransferase activity(GO:0004603) |
| 0.1 | 0.7 | GO:0051748 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.1 | 0.2 | GO:0008281 | sulfonylurea receptor activity(GO:0008281) |
| 0.1 | 1.4 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.1 | 0.3 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.0 | 0.1 | GO:0019781 | NEDD8 activating enzyme activity(GO:0019781) |
| 0.0 | 0.1 | GO:0008892 | guanine deaminase activity(GO:0008892) |
| 0.0 | 0.9 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 0.2 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 0.2 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.0 | 0.2 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.0 | 0.8 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.3 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.0 | 0.3 | GO:1902282 | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282) |
| 0.0 | 0.2 | GO:0015526 | hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513) |
| 0.0 | 0.1 | GO:0070336 | flap-structured DNA binding(GO:0070336) |
| 0.0 | 0.1 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.0 | 0.1 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.0 | 0.3 | GO:0008097 | 5S rRNA binding(GO:0008097) |
| 0.0 | 0.1 | GO:0015111 | iodide transmembrane transporter activity(GO:0015111) |
| 0.0 | 0.1 | GO:0030760 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 0.0 | 0.3 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.0 | 0.0 | GO:0052836 | inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839) |
| 0.0 | 0.4 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.1 | GO:0051032 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.0 | 0.1 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.0 | 0.8 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 0.0 | GO:0036361 | racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661) |
| 0.0 | 0.1 | GO:0051575 | 5'-deoxyribose-5-phosphate lyase activity(GO:0051575) |
| 0.0 | 0.1 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 0.2 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.2 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 2.7 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 1.8 | GO:0004896 | cytokine receptor activity(GO:0004896) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 2.3 | PID_FCER1_PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.0 | 0.4 | PID_ARF6_DOWNSTREAM_PATHWAY | Arf6 downstream pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.7 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.0 | 0.7 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.6 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.0 | 1.0 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.6 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.3 | REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
