Motif ID: NKX2-8

Z-value: 0.592


Transcription factors associated with NKX2-8:

Gene SymbolEntrez IDGene Name
NKX2-8 ENSG00000136327.6 NKX2-8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-8hg19_v2_chr14_-_37051798_370518310.501.7e-01Click!


Activity profile for motif NKX2-8.

activity profile for motif NKX2-8


Sorted Z-values histogram for motif NKX2-8

Sorted Z-values for motif NKX2-8



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-8

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_-_56296182 1.180 ENST00000361673.3
ALPK2
alpha-kinase 2
chr13_-_46756351 1.049 ENST00000323076.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_43968306 0.632 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223


chromosome 6 open reading frame 223


chr3_+_111717600 0.595 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 0.588 ENST00000478951.1
ENST00000393917.2
TAGLN3

transgelin 3

chrX_-_32173579 0.482 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD




dystrophin




chr18_+_43304092 0.472 ENST00000321925.4
ENST00000587601.1
SLC14A1

solute carrier family 14 (urea transporter), member 1 (Kidd blood group)

chr5_+_156607829 0.437 ENST00000422843.3
ITK
IL2-inducible T-cell kinase
chr3_+_67048721 0.389 ENST00000295568.4
ENST00000484414.1
ENST00000460576.1
ENST00000417314.2
KBTBD8



kelch repeat and BTB (POZ) domain containing 8



chr4_-_153601136 0.376 ENST00000504064.1
ENST00000304385.3
TMEM154

transmembrane protein 154

chr7_+_100318423 0.375 ENST00000252723.2
EPO
erythropoietin
chr16_+_8807419 0.370 ENST00000565016.1
ENST00000567812.1
ABAT

4-aminobutyrate aminotransferase

chr11_-_5364809 0.338 ENST00000300773.2
OR51B5
olfactory receptor, family 51, subfamily B, member 5
chr14_+_63671577 0.322 ENST00000555125.1
RHOJ
ras homolog family member J
chr22_-_30925150 0.317 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr5_+_140474181 0.316 ENST00000194155.4
PCDHB2
protocadherin beta 2
chr11_-_133826852 0.294 ENST00000533871.2
ENST00000321016.8
IGSF9B

immunoglobulin superfamily, member 9B

chr1_+_16083123 0.276 ENST00000510393.1
ENST00000430076.1
FBLIM1

filamin binding LIM protein 1

chr3_+_126423045 0.270 ENST00000290913.3
ENST00000508789.1
CHCHD6

coiled-coil-helix-coiled-coil-helix domain containing 6

chr14_+_21569245 0.237 ENST00000556585.2
TMEM253
transmembrane protein 253
chr22_+_31518938 0.232 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J






inositol polyphosphate-5-phosphatase J






chr1_+_154401791 0.231 ENST00000476006.1
IL6R
interleukin 6 receptor
chr1_+_16083098 0.231 ENST00000496928.2
ENST00000508310.1
FBLIM1

filamin binding LIM protein 1

chr11_-_107590383 0.230 ENST00000525934.1
ENST00000531293.1
SLN

sarcolipin

chr7_-_99277610 0.229 ENST00000343703.5
ENST00000222982.4
ENST00000439761.1
ENST00000339843.2
CYP3A5



cytochrome P450, family 3, subfamily A, polypeptide 5



chr7_+_129847688 0.204 ENST00000297819.3
SSMEM1
serine-rich single-pass membrane protein 1
chr3_+_47021168 0.203 ENST00000450053.3
ENST00000292309.5
ENST00000383740.2
NBEAL2


neurobeachin-like 2


chr2_+_62132781 0.196 ENST00000311832.5
COMMD1
copper metabolism (Murr1) domain containing 1
chr12_-_12837423 0.195 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr2_+_62132800 0.192 ENST00000538736.1
COMMD1
copper metabolism (Murr1) domain containing 1
chr16_+_89696692 0.185 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr12_-_102591604 0.183 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr12_-_5352315 0.180 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr11_-_72353494 0.180 ENST00000544570.1
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr17_+_39994032 0.180 ENST00000293303.4
ENST00000438813.1
KLHL10

kelch-like family member 10

chr2_-_25451065 0.177 ENST00000606328.1
RP11-458N5.1
RP11-458N5.1
chr11_-_72353451 0.177 ENST00000376450.3
PDE2A
phosphodiesterase 2A, cGMP-stimulated
chr2_-_133429091 0.173 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr15_-_60683326 0.167 ENST00000559350.1
ENST00000558986.1
ENST00000560389.1
ANXA2


annexin A2


chr10_-_118032979 0.167 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr17_-_8198636 0.160 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35


solute carrier family 25, member 35


chr3_-_16524357 0.158 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr1_-_155006224 0.154 ENST00000368424.3
DCST2
DC-STAMP domain containing 2
chr10_-_118032697 0.149 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr1_+_76251912 0.146 ENST00000370826.3
RABGGTB
Rab geranylgeranyltransferase, beta subunit
chr15_-_56757329 0.145 ENST00000260453.3
MNS1
meiosis-specific nuclear structural 1
chr6_-_131299929 0.142 ENST00000531356.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr17_+_37784749 0.140 ENST00000394265.1
ENST00000394267.2
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chr3_-_114790179 0.140 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_176708533 0.140 ENST00000507520.1
GPM6A
glycoprotein M6A
chr18_-_72920372 0.137 ENST00000581620.1
ENST00000582437.1
ZADH2

zinc binding alcohol dehydrogenase domain containing 2

chr7_-_156803329 0.132 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1
chr6_+_149539106 0.131 ENST00000443992.1
RP1-111D6.3
RP1-111D6.3
chr17_+_67590125 0.129 ENST00000591334.1
AC003051.1
AC003051.1
chr12_+_121837905 0.129 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34



ring finger protein 34, E3 ubiquitin protein ligase



chr11_+_18720316 0.127 ENST00000280734.2
TMEM86A
transmembrane protein 86A
chr12_+_121416489 0.121 ENST00000541395.1
ENST00000544413.1
HNF1A

HNF1 homeobox A

chr3_-_114343039 0.120 ENST00000481632.1
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_371994 0.119 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13



solute carrier family 6 (neurotransmitter transporter), member 13



chr11_+_59705928 0.118 ENST00000398992.1
OOSP1
oocyte secreted protein 1
chr1_+_120839412 0.118 ENST00000355228.4
FAM72B
family with sequence similarity 72, member B
chr1_+_55464600 0.117 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr11_-_128457446 0.115 ENST00000392668.4
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr8_+_27182862 0.114 ENST00000521164.1
ENST00000346049.5
PTK2B

protein tyrosine kinase 2 beta

chr13_-_23949671 0.113 ENST00000402364.1
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr1_-_220101944 0.112 ENST00000366926.3
ENST00000536992.1
SLC30A10

solute carrier family 30, member 10

chr9_-_128412696 0.112 ENST00000420643.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr13_+_28712614 0.111 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr9_+_109685630 0.108 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr13_+_46039037 0.108 ENST00000349995.5
COG3
component of oligomeric golgi complex 3
chr4_-_119274121 0.105 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr18_-_44336998 0.104 ENST00000315087.7
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr2_+_11752379 0.101 ENST00000396123.1
GREB1
growth regulation by estrogen in breast cancer 1
chr15_-_75248954 0.101 ENST00000499788.2
RPP25
ribonuclease P/MRP 25kDa subunit
chr16_+_23194033 0.101 ENST00000300061.2
SCNN1G
sodium channel, non-voltage-gated 1, gamma subunit
chr3_+_39093481 0.101 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WDR48



WD repeat domain 48



chr6_+_143772060 0.100 ENST00000367591.4
PEX3
peroxisomal biogenesis factor 3
chr19_-_11347173 0.100 ENST00000587656.1
DOCK6
dedicator of cytokinesis 6
chr7_-_766879 0.099 ENST00000537384.1
ENST00000417852.1
PRKAR1B

protein kinase, cAMP-dependent, regulatory, type I, beta

chr16_+_88872176 0.099 ENST00000569140.1
CDT1
chromatin licensing and DNA replication factor 1
chr6_-_133084580 0.099 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
VNN2


vanin 2


chrX_-_9754333 0.099 ENST00000447366.1
GPR143
G protein-coupled receptor 143
chr3_-_53290016 0.098 ENST00000423525.2
ENST00000423516.1
ENST00000296289.6
ENST00000462138.1
TKT



transketolase



chr16_-_3767506 0.096 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr8_+_107593198 0.096 ENST00000517686.1
OXR1
oxidation resistance 1
chr17_-_46703826 0.096 ENST00000550387.1
ENST00000311177.5
HOXB9

homeobox B9

chr1_-_33786699 0.095 ENST00000442999.3
A3GALT2
alpha 1,3-galactosyltransferase 2
chr5_+_3596168 0.095 ENST00000302006.3
IRX1
iroquois homeobox 1
chr5_-_179107975 0.094 ENST00000376974.4
CBY3
chibby homolog 3 (Drosophila)
chr1_+_173793777 0.092 ENST00000239457.5
DARS2
aspartyl-tRNA synthetase 2, mitochondrial
chr6_+_158957431 0.092 ENST00000367090.3
TMEM181
transmembrane protein 181
chrX_+_144908928 0.091 ENST00000408967.2
TMEM257
transmembrane protein 257
chr12_+_101962128 0.088 ENST00000550514.1
MYBPC1
myosin binding protein C, slow type
chr15_-_70387120 0.088 ENST00000539550.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr6_+_111408698 0.087 ENST00000368851.5
SLC16A10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr15_-_77363375 0.087 ENST00000559494.1
TSPAN3
tetraspanin 3
chr16_-_3767551 0.087 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr19_-_3600549 0.085 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr4_+_76481258 0.085 ENST00000311623.4
ENST00000435974.2
C4orf26

chromosome 4 open reading frame 26

chr4_-_70080449 0.082 ENST00000446444.1
UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr13_-_103346854 0.081 ENST00000267273.6
METTL21C
methyltransferase like 21C
chr15_-_77363513 0.081 ENST00000267970.4
TSPAN3
tetraspanin 3
chr17_+_8191815 0.080 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF



RAN guanine nucleotide release factor



chr16_-_30441293 0.079 ENST00000565758.1
ENST00000567983.1
ENST00000319285.4
DCTPP1


dCTP pyrophosphatase 1


chr17_+_73455788 0.077 ENST00000581519.1
KIAA0195
KIAA0195
chr22_+_32754139 0.075 ENST00000382088.3
RFPL3
ret finger protein-like 3
chr1_-_155006254 0.075 ENST00000295536.5
DCST2
DC-STAMP domain containing 2
chr15_-_77363441 0.074 ENST00000346495.2
ENST00000424443.3
ENST00000561277.1
TSPAN3


tetraspanin 3


chr8_+_67405755 0.074 ENST00000521495.1
C8orf46
chromosome 8 open reading frame 46
chr21_+_33671160 0.074 ENST00000303645.5
MRAP
melanocortin 2 receptor accessory protein
chr1_+_10057274 0.073 ENST00000294435.7
RBP7
retinol binding protein 7, cellular
chr3_-_121740969 0.070 ENST00000393631.1
ENST00000273691.3
ENST00000344209.5
ILDR1


immunoglobulin-like domain containing receptor 1


chr3_+_137728842 0.070 ENST00000183605.5
CLDN18
claudin 18
chr3_-_53164423 0.068 ENST00000467048.1
ENST00000394738.3
ENST00000296292.3
RFT1


RFT1 homolog (S. cerevisiae)


chr17_+_73642315 0.068 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr1_-_94147385 0.066 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chrX_+_118533269 0.065 ENST00000336249.7
SLC25A43
solute carrier family 25, member 43
chr11_-_77348796 0.064 ENST00000263309.3
ENST00000525064.1
CLNS1A

chloride channel, nucleotide-sensitive, 1A

chr12_-_75603236 0.062 ENST00000540018.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr12_-_75603482 0.061 ENST00000341669.3
ENST00000298972.1
ENST00000350228.2
KCNC2


potassium voltage-gated channel, Shaw-related subfamily, member 2


chr5_+_68665608 0.060 ENST00000509734.1
ENST00000354868.5
ENST00000521422.1
ENST00000354312.3
ENST00000345306.6
RAD17




RAD17 homolog (S. pombe)




chr15_+_74911430 0.059 ENST00000562670.1
ENST00000564096.1
CLK3

CDC-like kinase 3

chr6_-_87804815 0.059 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr17_-_9808887 0.059 ENST00000226193.5
RCVRN
recoverin
chr16_+_58426296 0.059 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3


GINS complex subunit 3 (Psf3 homolog)


chr22_+_32753854 0.059 ENST00000249007.4
RFPL3
ret finger protein-like 3
chr11_+_925824 0.058 ENST00000525796.1
ENST00000534328.1
ENST00000448903.2
ENST00000332231.5
AP2A2



adaptor-related protein complex 2, alpha 2 subunit



chr8_-_61429315 0.058 ENST00000530725.1
ENST00000532232.1
RP11-163N6.2

RP11-163N6.2

chr17_+_73642486 0.058 ENST00000579469.1
SMIM6
small integral membrane protein 6
chr15_+_40453204 0.058 ENST00000287598.6
ENST00000412359.3
BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr1_+_179050512 0.058 ENST00000367627.3
TOR3A
torsin family 3, member A
chr15_+_86686953 0.058 ENST00000421325.2
AGBL1
ATP/GTP binding protein-like 1
chr15_+_51973680 0.057 ENST00000542355.2
SCG3
secretogranin III
chr3_-_108836977 0.057 ENST00000232603.5
MORC1
MORC family CW-type zinc finger 1
chr12_-_75603202 0.057 ENST00000393288.2
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chrX_-_109590174 0.057 ENST00000372054.1
GNG5P2
guanine nucleotide binding protein (G protein), gamma 5 pseudogene 2
chr11_-_77348821 0.056 ENST00000528364.1
ENST00000532069.1
ENST00000525428.1
CLNS1A


chloride channel, nucleotide-sensitive, 1A


chr5_+_176692466 0.055 ENST00000508029.1
ENST00000503056.1
NSD1

nuclear receptor binding SET domain protein 1

chr20_-_43936937 0.054 ENST00000342716.4
ENST00000353917.5
ENST00000360607.6
ENST00000372751.4
MATN4



matrilin 4



chr3_-_114343768 0.054 ENST00000393785.2
ZBTB20
zinc finger and BTB domain containing 20
chr9_+_131873659 0.054 ENST00000452489.2
ENST00000347048.4
ENST00000357197.4
ENST00000445241.1
ENST00000355007.3
ENST00000414331.1
PPP2R4





protein phosphatase 2A activator, regulatory subunit 4





chr22_+_29834572 0.053 ENST00000354373.2
RFPL1
ret finger protein-like 1
chr11_-_104827425 0.052 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_75603643 0.052 ENST00000549446.1
KCNC2
potassium voltage-gated channel, Shaw-related subfamily, member 2
chr15_-_35047166 0.052 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chr1_+_42922173 0.050 ENST00000455780.1
ENST00000372560.3
ENST00000372561.3
ENST00000372556.3
PPCS



phosphopantothenoylcysteine synthetase



chr1_-_217262969 0.050 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chr5_+_35852797 0.048 ENST00000508941.1
IL7R
interleukin 7 receptor
chr4_-_69111401 0.048 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chrX_+_123094369 0.047 ENST00000455404.1
ENST00000218089.9
STAG2

stromal antigen 2

chr6_-_132272504 0.047 ENST00000367976.3
CTGF
connective tissue growth factor
chr15_+_51973550 0.046 ENST00000220478.3
SCG3
secretogranin III
chr12_+_9144626 0.046 ENST00000543895.1
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chrX_+_123094672 0.045 ENST00000354548.5
ENST00000458700.1
STAG2

stromal antigen 2

chr12_-_118406777 0.045 ENST00000339824.5
KSR2
kinase suppressor of ras 2
chr4_+_37245799 0.044 ENST00000309447.5
KIAA1239
KIAA1239
chr17_+_71228793 0.044 ENST00000426147.2
C17orf80
chromosome 17 open reading frame 80
chr22_+_20877924 0.043 ENST00000445189.1
MED15
mediator complex subunit 15
chrX_+_115567767 0.043 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr11_+_18417948 0.043 ENST00000542179.1
LDHA
lactate dehydrogenase A
chr7_+_135242652 0.042 ENST00000285968.6
ENST00000440390.2
NUP205

nucleoporin 205kDa

chr3_-_196242233 0.042 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr19_+_2249308 0.042 ENST00000592877.1
ENST00000221496.4
AMH

anti-Mullerian hormone

chr1_-_217262933 0.041 ENST00000359162.2
ESRRG
estrogen-related receptor gamma
chr14_-_36990354 0.040 ENST00000518149.1
NKX2-1
NK2 homeobox 1
chr5_-_78808617 0.040 ENST00000282260.6
ENST00000508576.1
ENST00000535690.1
HOMER1


homer homolog 1 (Drosophila)


chr16_-_18468926 0.040 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr1_+_228337553 0.040 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr1_-_115292591 0.039 ENST00000438362.2
CSDE1
cold shock domain containing E1, RNA-binding
chr22_+_38609538 0.038 ENST00000407965.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr2_-_68547061 0.038 ENST00000263655.3
CNRIP1
cannabinoid receptor interacting protein 1
chr9_-_22009297 0.038 ENST00000276925.6
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
chr1_-_68698222 0.037 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS



wntless Wnt ligand secretion mediator



chr8_-_125551278 0.037 ENST00000519232.1
ENST00000523888.1
ENST00000522810.1
ENST00000519548.1
ENST00000517678.1
ENST00000605953.1
ENST00000276692.6
TATDN1






TatD DNase domain containing 1






chr2_-_36779411 0.037 ENST00000406220.1
AC007401.2
Uncharacterized protein
chr7_-_137686791 0.037 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2


cAMP responsive element binding protein 3-like 2


chr12_+_49658855 0.037 ENST00000549183.1
TUBA1C
tubulin, alpha 1c
chr6_-_32806506 0.036 ENST00000374897.2
ENST00000452392.2
TAP2
TAP2
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr12_+_25205155 0.036 ENST00000550945.1
LRMP
lymphoid-restricted membrane protein
chr3_+_63953415 0.036 ENST00000484332.1
ATXN7
ataxin 7
chr14_+_58894706 0.036 ENST00000261244.5
KIAA0586
KIAA0586
chr19_+_36486078 0.034 ENST00000378887.2
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr7_+_18330035 0.034 ENST00000413509.2
HDAC9
histone deacetylase 9
chr2_-_136288740 0.033 ENST00000264159.6
ENST00000536680.1
ZRANB3

zinc finger, RAN-binding domain containing 3

chrM_+_8527 0.033 ENST00000361899.2
MT-ATP6
mitochondrially encoded ATP synthase 6
chr12_-_10320190 0.033 ENST00000543993.1
ENST00000339968.6
OLR1

oxidized low density lipoprotein (lectin-like) receptor 1

chr19_+_32836499 0.033 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507


zinc finger protein 507


chr9_+_131873842 0.032 ENST00000417728.1
PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr8_+_67341239 0.032 ENST00000320270.2
RRS1
RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
chr17_-_79623597 0.031 ENST00000574024.1
ENST00000331056.5
PDE6G

phosphodiesterase 6G, cGMP-specific, rod, gamma

chr13_-_46964177 0.031 ENST00000389908.3
KIAA0226L
KIAA0226-like
chr12_-_11548496 0.031 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2

PRB1
proline-rich protein BstNI subfamily 2

proline-rich protein BstNI subfamily 1
chr3_-_87039662 0.031 ENST00000494229.1
VGLL3
vestigial like 3 (Drosophila)
chr17_+_58755184 0.031 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3


breast carcinoma amplified sequence 3


chr17_+_73472575 0.031 ENST00000375248.5
KIAA0195
KIAA0195
chr8_+_105602961 0.030 ENST00000521923.1
RP11-127H5.1
Uncharacterized protein
chr3_+_10183447 0.030 ENST00000345392.2
VHL
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
chr11_-_10828892 0.030 ENST00000525681.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr2_-_152118352 0.028 ENST00000331426.5
RBM43
RNA binding motif protein 43
chr4_+_15341442 0.028 ENST00000397700.2
ENST00000295297.4
C1QTNF7

C1q and tumor necrosis factor related protein 7


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.1 0.2 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1 0.4 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.1 0.2 GO:0016999 antibiotic metabolic process(GO:0016999)
0.1 0.2 GO:0009386 translational attenuation(GO:0009386)
0.1 0.5 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.2 GO:0002384 hepatic immune response(GO:0002384)
0.1 0.2 GO:0009822 alkaloid catabolic process(GO:0009822)
0.1 0.4 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.2 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.2 GO:0052214 multi-organism catabolic process(GO:0044035) development of symbiont involved in interaction with host(GO:0044115) modulation of development of symbiont involved in interaction with host(GO:0044145) negative regulation of development of symbiont involved in interaction with host(GO:0044147) metabolism of substance in other organism involved in symbiotic interaction(GO:0052214) catabolism of substance in other organism involved in symbiotic interaction(GO:0052227) metabolism of macromolecule in other organism involved in symbiotic interaction(GO:0052229) catabolism by host of symbiont macromolecule(GO:0052360) catabolism by organism of macromolecule in other organism involved in symbiotic interaction(GO:0052361) catabolism by host of symbiont protein(GO:0052362) catabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052363) catabolism by host of substance in symbiont(GO:0052364) metabolism by host of symbiont macromolecule(GO:0052416) metabolism by host of symbiont protein(GO:0052417) metabolism by organism of protein in other organism involved in symbiotic interaction(GO:0052418) metabolism by host of substance in symbiont(GO:0052419)
0.0 1.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0035623 renal glucose absorption(GO:0035623)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.4 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.1 GO:0006726 eye pigment biosynthetic process(GO:0006726) eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474)
0.0 0.1 GO:0009405 pathogenesis(GO:0009405)
0.0 0.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.2 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 0.3 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0046166 xylulose metabolic process(GO:0005997) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.4 GO:0014029 neural crest formation(GO:0014029)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.1 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.1 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.0 0.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.3 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0030578 PML body organization(GO:0030578) positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.0 GO:0007506 gonadal mesoderm development(GO:0007506)
0.0 0.0 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.0 GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.0 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.0 GO:0032203 telomere formation via telomerase(GO:0032203)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.2 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.0 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0070852 cell body fiber(GO:0070852)
0.0 0.0 GO:0044611 nuclear pore inner ring(GO:0044611)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.3 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 0.2 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.1 0.4 GO:0032145 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.1 0.5 GO:0015265 urea channel activity(GO:0015265)
0.1 0.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.4 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.1 GO:0072544 L-DOPA receptor activity(GO:0035643) L-DOPA binding(GO:0072544)
0.0 0.1 GO:0070996 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) type 1 melanocortin receptor binding(GO:0070996)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.1 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.0 0.1 GO:0004802 transketolase activity(GO:0004802)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
0.0 0.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0 0.2 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.1 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.1 GO:0030250 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) phosphatidic acid binding(GO:0070300)
0.0 0.0 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.0 GO:0010698 acetyltransferase activator activity(GO:0010698)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST_STAT3_PATHWAY STAT3 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.2 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation