Motif ID: NKX2-1

Z-value: 0.582


Transcription factors associated with NKX2-1:

Gene SymbolEntrez IDGene Name
NKX2-1 ENSG00000136352.13 NKX2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36989427_369894420.781.4e-02Click!


Activity profile for motif NKX2-1.

activity profile for motif NKX2-1


Sorted Z-values histogram for motif NKX2-1

Sorted Z-values for motif NKX2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX2-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_31360887 0.958 ENST00000420311.2
ENST00000356174.3
ENST00000324589.5
GALNT14


UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)


chr6_+_43968306 0.691 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223


chromosome 6 open reading frame 223


chrX_-_83442915 0.661 ENST00000262752.2
ENST00000543399.1
RPS6KA6

ribosomal protein S6 kinase, 90kDa, polypeptide 6

chrX_-_32173579 0.652 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD




dystrophin




chr21_+_45773515 0.627 ENST00000397932.2
ENST00000300481.9
TRPM2

transient receptor potential cation channel, subfamily M, member 2

chr5_-_172662230 0.588 ENST00000424406.2
NKX2-5
NK2 homeobox 5
chr5_-_172662303 0.556 ENST00000517440.1
ENST00000329198.4
NKX2-5

NK2 homeobox 5

chr5_-_172662197 0.555 ENST00000521848.1
NKX2-5
NK2 homeobox 5
chr22_+_24999114 0.402 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
GGT1










gamma-glutamyltransferase 1










chr16_+_66638003 0.383 ENST00000562357.1
ENST00000360086.4
ENST00000562707.1
ENST00000361909.4
ENST00000460097.1
ENST00000565666.1
CMTM3





CKLF-like MARVEL transmembrane domain containing 3





chr14_+_63671577 0.354 ENST00000555125.1
RHOJ
ras homolog family member J
chr16_+_66638616 0.299 ENST00000564060.1
ENST00000565922.1
CMTM3

CKLF-like MARVEL transmembrane domain containing 3

chr2_-_225266743 0.268 ENST00000409685.3
FAM124B
family with sequence similarity 124B
chr16_+_28303804 0.266 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr16_+_66638567 0.227 ENST00000567572.1
CMTM3
CKLF-like MARVEL transmembrane domain containing 3
chr10_+_80027105 0.218 ENST00000461034.1
ENST00000476909.1
ENST00000459633.1
LINC00595


long intergenic non-protein coding RNA 595


chr1_+_206643806 0.208 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr1_+_206643787 0.205 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr20_-_36793663 0.202 ENST00000536701.1
ENST00000536724.1
TGM2

transglutaminase 2

chr22_-_30925150 0.192 ENST00000437871.1
SEC14L6
SEC14-like 6 (S. cerevisiae)
chr22_-_30968839 0.187 ENST00000445645.1
ENST00000416358.1
ENST00000423371.1
ENST00000411821.1
ENST00000448604.1
GAL3ST1




galactose-3-O-sulfotransferase 1




chr2_+_168043793 0.185 ENST00000409273.1
ENST00000409605.1
XIRP2

xin actin-binding repeat containing 2

chr6_-_113953705 0.181 ENST00000452675.1
RP11-367G18.1
RP11-367G18.1
chr1_-_92952433 0.177 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr12_-_5352315 0.159 ENST00000536518.1
RP11-319E16.1
RP11-319E16.1
chr19_+_24009879 0.157 ENST00000354585.4
RPSAP58
ribosomal protein SA pseudogene 58
chr8_+_37654693 0.150 ENST00000412232.2
GPR124
G protein-coupled receptor 124
chr2_-_225266711 0.150 ENST00000389874.3
FAM124B
family with sequence similarity 124B
chr17_+_61554829 0.147 ENST00000582627.1
ACE
angiotensin I converting enzyme
chr17_+_61571746 0.140 ENST00000579409.1
ACE
angiotensin I converting enzyme
chr14_-_73360796 0.138 ENST00000556509.1
ENST00000541685.1
ENST00000546183.1
DPF3


D4, zinc and double PHD fingers, family 3


chr17_-_1508379 0.137 ENST00000412517.3
SLC43A2
solute carrier family 43 (amino acid system L transporter), member 2
chr2_-_225266802 0.137 ENST00000243806.2
FAM124B
family with sequence similarity 124B
chr6_-_39399087 0.136 ENST00000229913.5
ENST00000541946.1
ENST00000394362.1
KIF6


kinesin family member 6


chr20_-_56285595 0.135 ENST00000395816.3
ENST00000347215.4
PMEPA1

prostate transmembrane protein, androgen induced 1

chr1_-_33786699 0.134 ENST00000442999.3
A3GALT2
alpha 1,3-galactosyltransferase 2
chr17_-_8198636 0.132 ENST00000577745.1
ENST00000579192.1
ENST00000396278.1
SLC25A35


solute carrier family 25, member 35


chr1_-_38397384 0.130 ENST00000373027.1
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr16_+_58533951 0.128 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
NDRG4










NDRG family member 4










chr1_-_156051789 0.127 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr17_+_37784749 0.126 ENST00000394265.1
ENST00000394267.2
PPP1R1B

protein phosphatase 1, regulatory (inhibitor) subunit 1B

chrX_-_108976449 0.122 ENST00000469857.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr9_-_4299874 0.120 ENST00000381971.3
ENST00000477901.1
GLIS3

GLIS family zinc finger 3

chr2_-_133429091 0.117 ENST00000345008.6
LYPD1
LY6/PLAUR domain containing 1
chr1_-_228604328 0.111 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
TRIM17




tripartite motif containing 17




chr1_+_55464600 0.109 ENST00000371265.4
BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr9_+_133986782 0.108 ENST00000372301.2
AIF1L
allograft inflammatory factor 1-like
chr3_-_11685345 0.108 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr20_+_30407105 0.107 ENST00000375994.2
MYLK2
myosin light chain kinase 2
chr3_-_16524357 0.107 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr18_+_42260861 0.103 ENST00000282030.5
SETBP1
SET binding protein 1
chr20_+_30407151 0.103 ENST00000375985.4
MYLK2
myosin light chain kinase 2
chr12_+_121416489 0.103 ENST00000541395.1
ENST00000544413.1
HNF1A

HNF1 homeobox A

chr10_+_63808970 0.092 ENST00000309334.5
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr8_-_80680078 0.092 ENST00000337919.5
ENST00000354724.3
HEY1

hes-related family bHLH transcription factor with YRPW motif 1

chr18_+_72166564 0.092 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP2


CNDP dipeptidase 2 (metallopeptidase M20 family)


chr22_-_30968813 0.090 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1


galactose-3-O-sulfotransferase 1


chr19_-_36231437 0.090 ENST00000591748.1
IGFLR1
IGF-like family receptor 1
chr12_+_101962128 0.089 ENST00000550514.1
MYBPC1
myosin binding protein C, slow type
chr9_-_128246769 0.088 ENST00000444226.1
MAPKAP1
mitogen-activated protein kinase associated protein 1
chr18_+_13382553 0.087 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr2_-_25451065 0.086 ENST00000606328.1
RP11-458N5.1
RP11-458N5.1
chr21_-_36421401 0.084 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr7_+_127881325 0.084 ENST00000308868.4
LEP
leptin
chr16_-_21170762 0.082 ENST00000261383.3
ENST00000415178.1
DNAH3

dynein, axonemal, heavy chain 3

chr1_-_220101944 0.082 ENST00000366926.3
ENST00000536992.1
SLC30A10

solute carrier family 30, member 10

chr3_-_52029830 0.082 ENST00000492277.1
ENST00000475248.1
ENST00000479017.1
ENST00000495383.1
ENST00000466397.1
ENST00000481629.1
RPL29





ribosomal protein L29





chr11_-_104827425 0.079 ENST00000393150.3
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr12_-_102591604 0.077 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr3_-_114790179 0.077 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chrX_-_108976410 0.077 ENST00000504980.1
ACSL4
acyl-CoA synthetase long-chain family member 4
chr3_-_52029958 0.076 ENST00000294189.6
RPL29
ribosomal protein L29
chr11_-_65325203 0.076 ENST00000526927.1
ENST00000536982.1
LTBP3

latent transforming growth factor beta binding protein 3

chr15_+_74911430 0.076 ENST00000562670.1
ENST00000564096.1
CLK3

CDC-like kinase 3

chr12_+_121837905 0.076 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
RNF34



ring finger protein 34, E3 ubiquitin protein ligase



chr10_+_102222798 0.075 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr3_-_113464906 0.073 ENST00000477813.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr12_+_50478977 0.073 ENST00000381513.4
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr15_+_57511609 0.072 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
TCF12


transcription factor 12


chr19_+_39903185 0.071 ENST00000409794.3
PLEKHG2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr12_+_50479109 0.071 ENST00000550477.1
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr11_-_65325430 0.071 ENST00000322147.4
LTBP3
latent transforming growth factor beta binding protein 3
chr17_-_76778339 0.070 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
CYTH1



cytohesin 1



chr4_+_55524085 0.069 ENST00000412167.2
ENST00000288135.5
KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr17_-_79623597 0.068 ENST00000574024.1
ENST00000331056.5
PDE6G

phosphodiesterase 6G, cGMP-specific, rod, gamma

chr3_+_32726774 0.068 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr12_+_50479101 0.067 ENST00000551966.1
SMARCD1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr1_+_228337553 0.066 ENST00000366714.2
GJC2
gap junction protein, gamma 2, 47kDa
chr14_+_74815116 0.066 ENST00000256362.4
VRTN
vertebrae development associated
chrX_-_70473957 0.065 ENST00000373984.3
ENST00000314425.5
ENST00000373982.1
ZMYM3


zinc finger, MYM-type 3


chr14_+_81421861 0.063 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr10_+_82300575 0.062 ENST00000313455.4
SH2D4B
SH2 domain containing 4B
chr9_-_7800067 0.062 ENST00000358227.4
TMEM261
transmembrane protein 261
chr11_+_46193466 0.060 ENST00000533793.1
RP11-702F3.3
RP11-702F3.3
chr11_-_86383650 0.060 ENST00000526944.1
ENST00000530335.1
ENST00000543262.1
ENST00000524826.1
ME3



malic enzyme 3, NADP(+)-dependent, mitochondrial



chr1_-_17338386 0.059 ENST00000341676.5
ENST00000452699.1
ATP13A2

ATPase type 13A2

chr10_-_103454876 0.058 ENST00000331272.7
FBXW4
F-box and WD repeat domain containing 4
chrX_-_70474499 0.058 ENST00000353904.2
ZMYM3
zinc finger, MYM-type 3
chrX_-_119693745 0.057 ENST00000371323.2
CUL4B
cullin 4B
chr16_+_2022036 0.057 ENST00000568546.1
TBL3
transducin (beta)-like 3
chrX_-_70474377 0.056 ENST00000373978.1
ENST00000373981.1
ZMYM3

zinc finger, MYM-type 3

chr18_+_56806701 0.056 ENST00000587834.1
SEC11C
SEC11 homolog C (S. cerevisiae)
chr14_+_81421710 0.055 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr17_-_47492236 0.052 ENST00000434917.2
ENST00000300408.3
ENST00000511832.1
ENST00000419140.2
PHB



prohibitin



chr15_+_40453204 0.052 ENST00000287598.6
ENST00000412359.3
BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr1_-_41487415 0.051 ENST00000372611.1
SLFNL1
schlafen-like 1
chr9_+_109685630 0.051 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr14_+_81421355 0.050 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr17_-_47492164 0.050 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
PHB


prohibitin


chr17_-_60005365 0.048 ENST00000444766.3
INTS2
integrator complex subunit 2
chr1_-_115259337 0.046 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr6_+_31674639 0.046 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
LY6G6F

MEGT1
lymphocyte antigen 6 complex, locus G6F

HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr16_+_1359138 0.045 ENST00000325437.5
UBE2I
ubiquitin-conjugating enzyme E2I
chr1_-_25291475 0.045 ENST00000338888.3
ENST00000399916.1
RUNX3

runt-related transcription factor 3

chr22_+_35653445 0.044 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4



HMG box domain containing 4



chr6_-_87804815 0.044 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr19_+_38924316 0.044 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
RYR1


ryanodine receptor 1 (skeletal)


chr6_-_149806105 0.044 ENST00000389942.5
ENST00000416573.2
ENST00000542614.1
ENST00000409806.3
ZC3H12D



zinc finger CCCH-type containing 12D



chr8_+_118147498 0.043 ENST00000519688.1
ENST00000456015.2
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr21_+_45432174 0.043 ENST00000380221.3
ENST00000291574.4
TRAPPC10

trafficking protein particle complex 10

chr19_+_1942453 0.041 ENST00000591752.1
CSNK1G2
casein kinase 1, gamma 2
chr17_-_60005329 0.041 ENST00000251334.6
INTS2
integrator complex subunit 2
chr16_+_57126482 0.039 ENST00000537605.1
ENST00000535318.2
CPNE2

copine II

chr5_-_58571935 0.038 ENST00000503258.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr18_-_58040000 0.037 ENST00000299766.3
MC4R
melanocortin 4 receptor
chr16_+_57126428 0.037 ENST00000290776.8
CPNE2
copine II
chr10_+_80027085 0.036 ENST00000415959.1
LINC00595
long intergenic non-protein coding RNA 595
chr11_-_18813353 0.034 ENST00000358540.2
ENST00000396171.4
ENST00000396167.2
PTPN5


protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)


chr17_+_66521936 0.034 ENST00000592800.1
PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha
chr12_+_25205628 0.033 ENST00000554942.1
LRMP
lymphoid-restricted membrane protein
chr10_-_98031265 0.033 ENST00000224337.5
ENST00000371176.2
BLNK

B-cell linker

chr11_+_66512089 0.033 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80





chromosome 11 open reading frame 80





chr14_+_67707826 0.032 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr6_-_55739542 0.032 ENST00000446683.2
BMP5
bone morphogenetic protein 5
chr3_+_172361483 0.032 ENST00000598405.1
AC007919.2
HCG1787166; PRO1163; Uncharacterized protein
chr16_-_28223166 0.032 ENST00000304658.5
XPO6
exportin 6
chr12_+_93772326 0.031 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
NUDT4



nudix (nucleoside diphosphate linked moiety X)-type motif 4



chr2_+_99797636 0.031 ENST00000409145.1
MRPL30
mitochondrial ribosomal protein L30
chr2_+_99797542 0.031 ENST00000338148.3
ENST00000512183.2
MRPL30
C2orf15
mitochondrial ribosomal protein L30
chromosome 2 open reading frame 15
chr7_-_105332084 0.030 ENST00000472195.1
ATXN7L1
ataxin 7-like 1
chr1_-_41487383 0.030 ENST00000302946.8
ENST00000372613.2
ENST00000439569.2
ENST00000397197.2
SLFNL1



schlafen-like 1



chr12_+_6961279 0.029 ENST00000229268.8
ENST00000389231.5
ENST00000542087.1
USP5


ubiquitin specific peptidase 5 (isopeptidase T)


chr18_-_13915530 0.029 ENST00000327606.3
MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr12_+_41582103 0.028 ENST00000402685.2
PDZRN4
PDZ domain containing ring finger 4
chr1_-_153599426 0.028 ENST00000392622.1
S100A13
S100 calcium binding protein A13
chrX_+_131157290 0.028 ENST00000394334.2
MST4
Serine/threonine-protein kinase MST4
chr14_+_81421921 0.027 ENST00000554263.1
ENST00000554435.1
TSHR

thyroid stimulating hormone receptor

chr17_+_46048376 0.027 ENST00000338399.4
CDK5RAP3
CDK5 regulatory subunit associated protein 3
chr6_+_31554779 0.026 ENST00000376090.2
LST1
leukocyte specific transcript 1
chrX_+_78003204 0.025 ENST00000435339.3
ENST00000514744.1
LPAR4

lysophosphatidic acid receptor 4

chr15_+_69452959 0.025 ENST00000261858.2
GLCE
glucuronic acid epimerase
chr8_-_114389353 0.024 ENST00000343508.3
CSMD3
CUB and Sushi multiple domains 3
chr15_+_77287426 0.024 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1


proline-serine-threonine phosphatase interacting protein 1


chr17_+_73642486 0.024 ENST00000579469.1
SMIM6
small integral membrane protein 6
chrX_+_131157322 0.024 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
MST4


Serine/threonine-protein kinase MST4


chrX_-_153237258 0.024 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr20_-_35724388 0.024 ENST00000344359.3
ENST00000373664.3
RBL1

retinoblastoma-like 1 (p107)

chr8_-_144679296 0.023 ENST00000317198.6
EEF1D
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr3_+_121311966 0.023 ENST00000338040.4
FBXO40
F-box protein 40
chr8_-_141810634 0.023 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2


protein tyrosine kinase 2


chr16_+_71929397 0.022 ENST00000537613.1
ENST00000424485.2
ENST00000606369.1
ENST00000329908.8
ENST00000538850.1
ENST00000541918.1
ENST00000534994.1
ENST00000378798.5
ENST00000539186.1
IST1








increased sodium tolerance 1 homolog (yeast)








chr8_+_70404996 0.022 ENST00000402687.4
ENST00000419716.3
SULF1

sulfatase 1

chr11_+_66512303 0.022 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr12_+_93772402 0.022 ENST00000546925.1
NUDT4
nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr16_+_640201 0.022 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr1_+_202431859 0.022 ENST00000391959.3
ENST00000367270.4
PPP1R12B

protein phosphatase 1, regulatory subunit 12B

chr7_+_99156249 0.021 ENST00000449244.1
ZNF655
zinc finger protein 655
chr12_-_21810765 0.021 ENST00000450584.1
ENST00000350669.1
LDHB

lactate dehydrogenase B

chr3_+_23847432 0.020 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr14_+_67708137 0.020 ENST00000556345.1
ENST00000555925.1
ENST00000557783.1
MPP5


membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)


chr7_+_99156212 0.019 ENST00000454654.1
ZNF655
zinc finger protein 655
chr11_-_18813110 0.019 ENST00000396168.1
PTPN5
protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
chr17_+_76210267 0.019 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5



baculoviral IAP repeat containing 5



chr19_-_10679644 0.019 ENST00000393599.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr19_-_54804173 0.019 ENST00000391744.3
ENST00000251390.3
LILRA3

leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3

chr8_+_132916318 0.018 ENST00000254624.5
ENST00000522709.1
EFR3A

EFR3 homolog A (S. cerevisiae)

chr17_+_73642315 0.018 ENST00000556126.2
SMIM6
small integral membrane protein 6
chr16_+_12995614 0.018 ENST00000423335.2
SHISA9
shisa family member 9
chr9_-_72374848 0.018 ENST00000377200.5
ENST00000340434.4
ENST00000472967.2
PTAR1


protein prenyltransferase alpha subunit repeat containing 1


chr1_+_214163033 0.017 ENST00000607425.1
PROX1
prospero homeobox 1
chr18_+_54814288 0.017 ENST00000585477.1
BOD1L2
biorientation of chromosomes in cell division 1-like 2
chr12_-_21810726 0.017 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr1_+_207277590 0.016 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr17_+_46048471 0.015 ENST00000578018.1
ENST00000579175.1
CDK5RAP3

CDK5 regulatory subunit associated protein 3

chr21_+_33671264 0.015 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr3_-_56950407 0.015 ENST00000496106.1
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr1_-_68698222 0.015 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS



wntless Wnt ligand secretion mediator



chr11_+_105948216 0.014 ENST00000278618.4
AASDHPPT
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr12_+_18414446 0.014 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr11_-_113318443 0.013 ENST00000543292.1
DRD2
dopamine receptor D2
chr3_+_4535155 0.013 ENST00000544951.1
ITPR1
inositol 1,4,5-trisphosphate receptor, type 1
chr20_+_58152524 0.012 ENST00000359926.3
PHACTR3
phosphatase and actin regulator 3
chr15_+_89181974 0.012 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr15_+_89182156 0.012 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr6_+_25652501 0.012 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr22_+_50986462 0.011 ENST00000395676.2
KLHDC7B
kelch domain containing 7B
chr17_-_10452929 0.011 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2


myosin, heavy chain 2, skeletal muscle, adult


chr4_-_79860506 0.011 ENST00000295462.3
ENST00000380645.4
ENST00000512733.1
PAQR3


progestin and adipoQ receptor family member III


chr17_-_34195889 0.010 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr17_+_26646175 0.010 ENST00000583381.1
ENST00000582113.1
ENST00000582384.1
TMEM97


transmembrane protein 97



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0060929 Purkinje myocyte differentiation(GO:0003168) septum secundum development(GO:0003285) cardiac pacemaker cell fate commitment(GO:0060927) atrioventricular node cell fate commitment(GO:0060929)
0.1 0.7 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 0.2 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.1 0.3 GO:1903597 negative regulation of gap junction assembly(GO:1903597)
0.1 0.2 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.1 0.6 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.1 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.0 0.9 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.2 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.0 0.4 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0070662 mast cell proliferation(GO:0070662)
0.0 0.1 GO:0035623 renal glucose absorption(GO:0035623)
0.0 0.1 GO:1990051 activation of protein kinase C activity(GO:1990051)
0.0 0.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.0 0.3 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.2 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.0 0.1 GO:1905166 negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166)
0.0 0.1 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.1 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.0 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676) allantois development(GO:1905069)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.2 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0010736 serum response element binding(GO:0010736)
0.1 0.4 GO:0036435 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.1 0.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.3 GO:0031711 tripeptidyl-peptidase activity(GO:0008240) bradykinin receptor binding(GO:0031711)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.1 GO:0031751 D4 dopamine receptor binding(GO:0031751)
0.0 0.3 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.7 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 1.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.7 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.4 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.1 GO:0004803 transposase activity(GO:0004803)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.4 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction