Motif ID: NKX1-1

Z-value: 0.186


Transcription factors associated with NKX1-1:

Gene SymbolEntrez IDGene Name
NKX1-1 ENSG00000235608.1 NKX1-1



Activity profile for motif NKX1-1.

activity profile for motif NKX1-1


Sorted Z-values histogram for motif NKX1-1

Sorted Z-values for motif NKX1-1



Network of associatons between targets according to the STRING database.



First level regulatory network of NKX1-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_134201768 0.262 ENST00000535456.2
ENST00000339772.7
 GLB1L2

galactosidase, beta 1-like 2

chr2_+_8822113 0.240 ENST00000396290.1
ENST00000331129.3
 ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

chr10_+_5238793 0.114 ENST00000263126.1
 AKR1C4
aldo-keto reductase family 1, member C4
chr12_+_16500599 0.113 ENST00000535309.1
ENST00000540056.1
ENST00000396209.1
ENST00000540126.1
 MGST1



microsomal glutathione S-transferase 1



chr8_+_26371763 0.112 ENST00000521913.1
 DPYSL2
dihydropyrimidinase-like 2
chr4_+_87515454 0.112 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
 PTPN13


protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)


chr12_+_16500037 0.107 ENST00000536371.1
ENST00000010404.2
 MGST1

microsomal glutathione S-transferase 1

chr12_+_16500571 0.102 ENST00000543076.1
ENST00000396210.3
 MGST1

microsomal glutathione S-transferase 1

chr5_-_115890554 0.099 ENST00000509665.1
 SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_-_40337470 0.079 ENST00000293330.1
 HCRT
hypocretin (orexin) neuropeptide precursor
chr4_+_66536248 0.074 ENST00000514260.1
ENST00000507117.1
 RP11-807H7.1

RP11-807H7.1

chr20_-_17662705 0.068 ENST00000455029.2
 RRBP1
ribosome binding protein 1
chrX_-_153363188 0.066 ENST00000303391.6
 MECP2
methyl CpG binding protein 2 (Rett syndrome)
chr17_-_27418537 0.061 ENST00000408971.2
 TIAF1
TGFB1-induced anti-apoptotic factor 1
chr10_-_56561022 0.061 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
 PCDH15













protocadherin-related 15













chr1_-_221915418 0.058 ENST00000323825.3
ENST00000366899.3
 DUSP10

dual specificity phosphatase 10

chr3_-_105587879 0.057 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr7_+_2559399 0.055 ENST00000222725.5
ENST00000359574.3
 LFNG

LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

chr3_-_105588231 0.054 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr1_-_21620877 0.047 ENST00000527991.1
 ECE1
endothelin converting enzyme 1
chr3_+_186288454 0.045 ENST00000265028.3
 DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr14_-_24711806 0.044 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
 TINF2



TERF1 (TRF1)-interacting nuclear factor 2



chr7_-_122339162 0.043 ENST00000340112.2
 RNF133
ring finger protein 133
chr14_-_24711865 0.042 ENST00000399423.4
ENST00000267415.7
 TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr2_+_217524323 0.041 ENST00000456764.1
 IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr8_+_22132810 0.039 ENST00000356766.6
 PIWIL2
piwi-like RNA-mediated gene silencing 2
chr14_-_24711764 0.039 ENST00000557921.1
ENST00000558476.1
 TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr4_-_103682145 0.039 ENST00000226578.4
 MANBA
mannosidase, beta A, lysosomal
chr9_+_116225999 0.038 ENST00000317613.6
 RGS3
regulator of G-protein signaling 3
chrX_-_153363125 0.035 ENST00000407218.1
ENST00000453960.2
 MECP2

methyl CpG binding protein 2 (Rett syndrome)

chr1_+_62439037 0.035 ENST00000545929.1
 INADL
InaD-like (Drosophila)
chr2_-_167232484 0.034 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
 SCN9A


sodium channel, voltage-gated, type IX, alpha subunit


chr14_-_24711470 0.034 ENST00000559969.1
 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr8_-_94928861 0.034 ENST00000607097.1
 MIR378D2
microRNA 378d-2
chr5_-_159546396 0.033 ENST00000523662.1
ENST00000456329.3
ENST00000307063.7
 PWWP2A


PWWP domain containing 2A


chr4_-_66536196 0.032 ENST00000511294.1
 EPHA5
EPH receptor A5
chr21_-_37914898 0.029 ENST00000399136.1
 CLDN14
claudin 14
chrX_+_72783026 0.029 ENST00000373504.6
ENST00000373502.5
 CHIC1

cysteine-rich hydrophobic domain 1

chr6_+_34204642 0.029 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1




high mobility group AT-hook 1




chrX_+_55026763 0.028 ENST00000374987.3
 APEX2
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr19_+_32897009 0.027 ENST00000342179.5
ENST00000586427.1
 DPY19L3

dpy-19-like 3 (C. elegans)

chr11_-_124981475 0.026 ENST00000532156.1
ENST00000532407.1
ENST00000279968.4
ENST00000527766.1
ENST00000529583.1
ENST00000524373.1
ENST00000527271.1
ENST00000526175.1
ENST00000529609.1
ENST00000533273.1
ENST00000531909.1
ENST00000529530.1
 TMEM218











transmembrane protein 218











chr13_+_78315295 0.025 ENST00000351546.3
 SLAIN1
SLAIN motif family, member 1
chr19_+_32896697 0.025 ENST00000586987.1
 DPY19L3
dpy-19-like 3 (C. elegans)
chr9_+_124329336 0.024 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
 DAB2IP


DAB2 interacting protein


chr7_+_99647411 0.023 ENST00000438937.1
 ZSCAN21
zinc finger and SCAN domain containing 21
chr13_+_78315348 0.023 ENST00000441784.1
 SLAIN1
SLAIN motif family, member 1
chr12_-_23737534 0.021 ENST00000396007.2
 SOX5
SRY (sex determining region Y)-box 5
chr2_-_239197201 0.020 ENST00000254658.3
 PER2
period circadian clock 2
chr2_-_239197238 0.019 ENST00000254657.3
 PER2
period circadian clock 2
chr2_-_97405775 0.019 ENST00000264963.4
ENST00000537039.1
ENST00000377079.4
ENST00000426463.2
ENST00000534882.1
 LMAN2L




lectin, mannose-binding 2-like




chr4_-_66536057 0.017 ENST00000273854.3
 EPHA5
EPH receptor A5
chr8_+_22132847 0.017 ENST00000521356.1
 PIWIL2
piwi-like RNA-mediated gene silencing 2
chr10_-_56560939 0.017 ENST00000373955.1
 PCDH15
protocadherin-related 15
chr4_+_128554081 0.016 ENST00000335251.6
ENST00000296461.5
 INTU

inturned planar cell polarity protein

chr12_+_64798826 0.014 ENST00000540203.1
 XPOT
exportin, tRNA
chr12_+_7013897 0.014 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr1_+_100818156 0.012 ENST00000336454.3
 CDC14A
cell division cycle 14A
chr2_+_187371440 0.012 ENST00000445547.1
 ZC3H15
zinc finger CCCH-type containing 15
chr1_-_28969517 0.012 ENST00000263974.4
ENST00000373824.4
 TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr1_+_100818009 0.012 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
 CDC14A


cell division cycle 14A


chr7_+_12726623 0.010 ENST00000439721.1
 ARL4A
ADP-ribosylation factor-like 4A
chr2_-_47142884 0.010 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
 MCFD2



multiple coagulation factor deficiency 2



chr11_-_59383617 0.009 ENST00000263847.1
 OSBP
oxysterol binding protein
chr4_-_89442940 0.009 ENST00000527353.1
 PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr7_+_12727250 0.009 ENST00000404894.1
 ARL4A
ADP-ribosylation factor-like 4A
chr12_-_50790267 0.009 ENST00000327337.5
ENST00000543111.1
 FAM186A

family with sequence similarity 186, member A

chr1_-_190446759 0.009 ENST00000367462.3
 BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr2_-_47143160 0.009 ENST00000409800.1
ENST00000409218.1
 MCFD2

multiple coagulation factor deficiency 2

chr11_-_4629367 0.009 ENST00000533021.1
 TRIM68
tripartite motif containing 68
chr17_-_44657017 0.008 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
 ARL17A





ADP-ribosylation factor-like 17A





chr1_-_51796226 0.008 ENST00000451380.1
ENST00000371747.3
ENST00000439482.1
 TTC39A


tetratricopeptide repeat domain 39A


chr2_+_105050794 0.008 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
 AC013402.2


long intergenic non-protein coding RNA 1102


chr10_+_120789223 0.008 ENST00000425699.1
 NANOS1
nanos homolog 1 (Drosophila)
chr7_+_50348268 0.007 ENST00000438033.1
ENST00000439701.1
 IKZF1

IKAROS family zinc finger 1 (Ikaros)

chr7_+_99647389 0.007 ENST00000543588.1
ENST00000292450.4
ENST00000456748.2
 ZSCAN21


zinc finger and SCAN domain containing 21


chr8_+_98656693 0.007 ENST00000519934.1
 MTDH
metadherin
chr19_+_42811093 0.007 ENST00000595750.1
 PRR19
proline rich 19
chr17_-_45266542 0.006 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
 CDC27




cell division cycle 27




chr11_-_4629388 0.006 ENST00000526337.1
ENST00000300747.5
 TRIM68

tripartite motif containing 68

chr14_+_32798547 0.006 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6


A kinase (PRKA) anchor protein 6


chr12_-_117175819 0.005 ENST00000261318.3
ENST00000536380.1
 C12orf49

chromosome 12 open reading frame 49

chr3_+_186560476 0.005 ENST00000320741.2
ENST00000444204.2
 ADIPOQ

adiponectin, C1Q and collagen domain containing

chr11_-_62521614 0.005 ENST00000527994.1
ENST00000394807.3
 ZBTB3

zinc finger and BTB domain containing 3

chr18_-_33709268 0.005 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr17_+_59489112 0.005 ENST00000335108.2
 C17orf82
chromosome 17 open reading frame 82
chr14_-_88200641 0.005 ENST00000556168.1
 RP11-1152H15.1
RP11-1152H15.1
chr3_+_186560462 0.004 ENST00000412955.2
 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr6_+_26501449 0.004 ENST00000244513.6
 BTN1A1
butyrophilin, subfamily 1, member A1
chr1_+_46972668 0.004 ENST00000371956.4
ENST00000360032.3
 DMBX1

diencephalon/mesencephalon homeobox 1

chr1_+_222910625 0.004 ENST00000360827.2
 FAM177B
family with sequence similarity 177, member B
chrX_-_47509994 0.004 ENST00000343894.4
 ELK1
ELK1, member of ETS oncogene family
chr12_+_7014064 0.004 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr17_-_44439084 0.003 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
 ARL17B





ADP-ribosylation factor-like 17B





chr10_+_99205959 0.003 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
 ZDHHC16



zinc finger, DHHC-type containing 16



chr11_-_105892937 0.002 ENST00000301919.4
ENST00000534458.1
ENST00000530108.1
ENST00000530788.1
 MSANTD4



Myb/SANT-like DNA-binding domain containing 4 with coiled-coils



chrX_-_47509887 0.002 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
 ELK1


ELK1, member of ETS oncogene family


chr22_-_39151463 0.002 ENST00000405510.1
ENST00000433561.1
 SUN2

Sad1 and UNC84 domain containing 2

chr10_+_99205894 0.002 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
 ZDHHC16



zinc finger, DHHC-type containing 16



chr11_+_72983246 0.001 ENST00000393590.2
 P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr19_-_14228541 0.001 ENST00000590853.1
ENST00000308677.4
 PRKACA

protein kinase, cAMP-dependent, catalytic, alpha

chr12_-_6961050 0.001 ENST00000538862.2
 CDCA3
cell division cycle associated 3
chr12_+_48499252 0.001 ENST00000549003.1
ENST00000550924.1
 PFKM

phosphofructokinase, muscle

chr11_+_72983450 0.001 ENST00000536225.1
 P2RY6
pyrimidinergic receptor P2Y, G-protein coupled, 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0071449 cellular response to lipid hydroperoxide(GO:0071449)
0.1 0.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0019230 pathogenesis(GO:0009405) proprioception(GO:0019230)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.1 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0010370 perinucleolar chromocenter(GO:0010370)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.3 GO:0043295 glutathione binding(GO:0043295)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)