Motif ID: NFKB2
Z-value: 0.313
Transcription factors associated with NFKB2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NFKB2 | ENSG00000077150.13 | NFKB2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg19_v2_chr10_+_104154229_104154354 | -0.50 | 1.7e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:1902228 | mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141) |
| 0.1 | 0.3 | GO:0043449 | cellular alkene metabolic process(GO:0043449) |
| 0.0 | 0.2 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.0 | 0.1 | GO:0031548 | regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548) |
| 0.0 | 0.1 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
| 0.0 | 0.2 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.0 | 0.1 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 0.0 | 0.1 | GO:0042264 | peptidyl-aspartic acid hydroxylation(GO:0042264) |
| 0.0 | 0.1 | GO:0033277 | abortive mitotic cell cycle(GO:0033277) |
| 0.0 | 0.1 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000563) |
| 0.0 | 0.1 | GO:0032849 | positive regulation of cellular pH reduction(GO:0032849) dipeptide transport(GO:0042938) |
| 0.0 | 0.1 | GO:0032764 | negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294) |
| 0.0 | 0.0 | GO:0007037 | vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830) |
| 0.0 | 0.1 | GO:1905167 | positive regulation of lysosomal protein catabolic process(GO:1905167) |
| 0.0 | 0.0 | GO:0003220 | left ventricular cardiac muscle tissue morphogenesis(GO:0003220) |
| 0.0 | 0.1 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.0 | 0.3 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.2 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.1 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.0 | 0.0 | GO:0034553 | respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032) |
| 0.0 | 0.0 | GO:0033140 | negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140) |
| 0.0 | 0.0 | GO:1990535 | neuron projection maintenance(GO:1990535) |
| 0.0 | 0.0 | GO:0050787 | detoxification of mercury ion(GO:0050787) |
| 0.0 | 0.1 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.0 | 0.0 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 0.1 | GO:0002084 | protein depalmitoylation(GO:0002084) |
| 0.0 | 0.1 | GO:0032218 | riboflavin transport(GO:0032218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:1990682 | CSF1-CSF1R complex(GO:1990682) |
| 0.0 | 0.2 | GO:0032010 | phagolysosome(GO:0032010) |
| 0.0 | 0.1 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.0 | 0.1 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.1 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.0 | GO:0045160 | myosin I complex(GO:0045160) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.0 | 0.2 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.0 | 0.1 | GO:0052856 | NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857) |
| 0.0 | 0.3 | GO:0035005 | lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.0 | 0.1 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.0 | 0.1 | GO:0016964 | alpha-2 macroglobulin receptor activity(GO:0016964) |
| 0.0 | 0.1 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.0 | 0.1 | GO:0008457 | beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256) |
| 0.0 | 0.0 | GO:0050659 | N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659) |
| 0.0 | 0.1 | GO:0038131 | neuregulin receptor activity(GO:0038131) |
| 0.0 | 0.3 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 0.1 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.0 | 0.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.0 | 0.1 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.0 | 0.2 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 0.1 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.0 | 0.2 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.1 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 0.1 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.0 | 0.1 | GO:0032217 | riboflavin transporter activity(GO:0032217) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.5 | REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
