Motif ID: NFATC2_NFATC3

Z-value: 0.612

Transcription factors associated with NFATC2_NFATC3:

Gene SymbolEntrez IDGene Name
NFATC2 ENSG00000101096.15 NFATC2
NFATC3 ENSG00000072736.14 NFATC3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC2hg19_v2_chr20_-_50179368_50179392-0.472.0e-01Click!
NFATC3hg19_v2_chr16_+_68119440_68119561-0.314.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC2_NFATC3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_41742697 1.181 ENST00000242208.4
INHBA
inhibin, beta A
chr13_-_46716969 0.856 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr3_+_25469724 0.817 ENST00000437042.2
RARB
retinoic acid receptor, beta
chr19_+_36346734 0.714 ENST00000586102.3
KIRREL2
kin of IRRE like 2 (Drosophila)
chr5_-_64777733 0.583 ENST00000381055.3
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr18_+_43405471 0.568 ENST00000389474.3
SIGLEC15
sialic acid binding Ig-like lectin 15
chr17_-_47287928 0.562 ENST00000507680.1
GNGT2
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
chrX_-_139866723 0.552 ENST00000370532.2
CDR1
cerebellar degeneration-related protein 1, 34kDa
chr1_+_38022513 0.527 ENST00000296218.7
DNALI1
dynein, axonemal, light intermediate chain 1
chr14_+_24837226 0.465 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4




nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4




chr17_+_47287749 0.440 ENST00000419580.2
ABI3
ABI family, member 3
chr3_+_25469802 0.364 ENST00000330688.4
RARB
retinoic acid receptor, beta
chr14_+_63671577 0.362 ENST00000555125.1
RHOJ
ras homolog family member J
chrX_-_133792480 0.360 ENST00000359237.4
PLAC1
placenta-specific 1
chr14_-_25479811 0.344 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr17_+_74372662 0.342 ENST00000591651.1
ENST00000545180.1
SPHK1

sphingosine kinase 1

chr3_+_140981456 0.335 ENST00000504264.1
ACPL2
acid phosphatase-like 2
chr7_+_28452130 0.328 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chrX_-_138304939 0.304 ENST00000448673.1
FGF13
fibroblast growth factor 13
chr14_+_63671105 0.303 ENST00000316754.3
RHOJ
ras homolog family member J
chr3_-_100565249 0.287 ENST00000495591.1
ENST00000383691.4
ENST00000466947.1
ABI3BP


ABI family, member 3 (NESH) binding protein


chr7_+_120629085 0.281 ENST00000428526.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr6_-_13290684 0.280 ENST00000606393.1
RP1-257A7.5
RP1-257A7.5
chr20_+_44637526 0.275 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr2_-_227050079 0.263 ENST00000423838.1
AC068138.1
AC068138.1
chr6_+_106535455 0.245 ENST00000424894.1
PRDM1
PR domain containing 1, with ZNF domain
chr5_-_64777685 0.236 ENST00000536360.1
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr5_+_135394840 0.229 ENST00000503087.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr3_-_9595480 0.223 ENST00000287585.6
LHFPL4
lipoma HMGIC fusion partner-like 4
chr19_+_41281060 0.214 ENST00000594436.1
ENST00000597784.1
MIA

melanoma inhibitory activity

chr6_+_138188378 0.213 ENST00000420009.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr6_+_116832789 0.211 ENST00000368599.3
FAM26E
family with sequence similarity 26, member E
chr3_+_111578027 0.211 ENST00000431670.2
ENST00000412622.1
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr3_+_111578131 0.210 ENST00000498699.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr14_-_80677815 0.207 ENST00000557125.1
ENST00000555750.1
DIO2

deiodinase, iodothyronine, type II

chr1_+_45274154 0.207 ENST00000450269.1
ENST00000453418.1
ENST00000409335.2
BTBD19


BTB (POZ) domain containing 19


chr17_-_41977964 0.206 ENST00000377184.3
MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr11_+_131240373 0.204 ENST00000374791.3
ENST00000436745.1
NTM

neurotrimin

chr12_+_54447637 0.203 ENST00000609810.1
ENST00000430889.2
HOXC4
HOXC4
homeobox C4
Homeobox protein Hox-C4
chr1_+_247579451 0.201 ENST00000391828.3
ENST00000366497.2
NLRP3

NLR family, pyrin domain containing 3

chr19_+_41281282 0.198 ENST00000263369.3
MIA
melanoma inhibitory activity
chr7_+_150706010 0.198 ENST00000475017.1
NOS3
nitric oxide synthase 3 (endothelial cell)
chr8_+_85618155 0.197 ENST00000523850.1
ENST00000521376.1
RALYL

RALY RNA binding protein-like

chr4_-_186733363 0.196 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
SORBS2


sorbin and SH3 domain containing 2


chr13_-_33780133 0.196 ENST00000399365.3
STARD13
StAR-related lipid transfer (START) domain containing 13
chr17_-_46623441 0.196 ENST00000330070.4
HOXB2
homeobox B2
chr16_-_85969774 0.190 ENST00000598933.1
RP11-542M13.3
RP11-542M13.3
chr3_+_164924716 0.190 ENST00000470138.1
ENST00000498616.1
RP11-85M11.2

RP11-85M11.2

chr14_-_80677970 0.189 ENST00000438257.4
DIO2
deiodinase, iodothyronine, type II
chr14_-_103589246 0.187 ENST00000558224.1
ENST00000560742.1
LINC00677

long intergenic non-protein coding RNA 677

chr12_-_21487829 0.180 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
SLCO1A2




solute carrier organic anion transporter family, member 1A2




chr9_-_97356075 0.180 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr14_+_65170820 0.177 ENST00000555982.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr14_-_80677613 0.176 ENST00000556811.1
DIO2
deiodinase, iodothyronine, type II
chr17_-_46657473 0.176 ENST00000332503.5
HOXB4
homeobox B4
chr6_+_151662815 0.174 ENST00000359755.5
AKAP12
A kinase (PRKA) anchor protein 12
chr6_-_134495992 0.172 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
SGK1


serum/glucocorticoid regulated kinase 1


chr18_+_61442629 0.167 ENST00000398019.2
ENST00000540675.1
SERPINB7

serpin peptidase inhibitor, clade B (ovalbumin), member 7

chr4_+_33883237 0.167 ENST00000505326.1
ENST00000506650.1
RP11-79E3.2

RP11-79E3.2

chrX_+_133941218 0.166 ENST00000370784.4
ENST00000370785.3
FAM122C

family with sequence similarity 122C

chr14_-_92413353 0.165 ENST00000556154.1
FBLN5
fibulin 5
chr5_+_132009675 0.163 ENST00000231449.2
ENST00000350025.2
IL4

interleukin 4

chr3_+_111718173 0.163 ENST00000494932.1
TAGLN3
transgelin 3
chr5_-_53115506 0.162 ENST00000511953.1
ENST00000504552.1
CTD-2081C10.1

CTD-2081C10.1

chr18_-_53070913 0.159 ENST00000568186.1
ENST00000564228.1
TCF4

transcription factor 4

chr11_+_131240593 0.157 ENST00000539799.1
NTM
neurotrimin
chr19_+_41281416 0.157 ENST00000597140.1
MIA
melanoma inhibitory activity
chr6_+_138188351 0.154 ENST00000421450.1
TNFAIP3
tumor necrosis factor, alpha-induced protein 3
chr3_-_114035026 0.153 ENST00000570269.1
RP11-553L6.5
RP11-553L6.5
chr4_-_71532339 0.153 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr18_+_77155942 0.151 ENST00000397790.2
NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
chr18_-_53257027 0.151 ENST00000568740.1
ENST00000564403.2
ENST00000537578.1
TCF4


transcription factor 4


chr1_+_239882842 0.151 ENST00000448020.1
CHRM3
cholinergic receptor, muscarinic 3
chr16_+_67381263 0.150 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36


leucine rich repeat containing 36


chr4_-_186877502 0.149 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2


sorbin and SH3 domain containing 2


chr3_-_195310802 0.147 ENST00000421243.1
ENST00000453131.1
APOD

apolipoprotein D

chr14_-_51863853 0.147 ENST00000556762.1
RP11-255G12.3
RP11-255G12.3
chr20_+_1875110 0.146 ENST00000400068.3
SIRPA
signal-regulatory protein alpha
chr19_-_55881741 0.146 ENST00000264563.2
ENST00000590625.1
ENST00000585513.1
IL11


interleukin 11


chr5_+_131993856 0.145 ENST00000304506.3
IL13
interleukin 13
chr3_+_99357319 0.144 ENST00000452013.1
ENST00000261037.3
ENST00000273342.4
COL8A1


collagen, type VIII, alpha 1


chr16_+_15528332 0.142 ENST00000566490.1
C16orf45
chromosome 16 open reading frame 45
chr3_-_156878482 0.142 ENST00000295925.4
CCNL1
cyclin L1
chr6_-_11779840 0.141 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr7_+_140373619 0.141 ENST00000483369.1
ADCK2
aarF domain containing kinase 2
chr6_+_31105426 0.141 ENST00000547221.1
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr6_+_158733692 0.140 ENST00000367094.2
ENST00000367097.3
TULP4

tubby like protein 4

chr7_+_120629653 0.140 ENST00000450913.2
ENST00000340646.5
CPED1

cadherin-like and PC-esterase domain containing 1

chr9_+_129097520 0.139 ENST00000436593.3
MVB12B
multivesicular body subunit 12B
chr12_+_50690489 0.139 ENST00000598429.1
AC140061.12
Uncharacterized protein
chr5_+_173930710 0.138 ENST00000511707.1
RP11-267A15.1
RP11-267A15.1
chr1_-_149908710 0.135 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11


myotubularin related protein 11


chr2_-_113594279 0.134 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B


interleukin 1, beta


chr2_-_190044480 0.132 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr7_+_134551583 0.132 ENST00000435928.1
CALD1
caldesmon 1
chr3_-_156878540 0.131 ENST00000461804.1
CCNL1
cyclin L1
chr18_+_77155856 0.131 ENST00000253506.5
ENST00000591814.1
NFATC1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

chr6_-_11779403 0.131 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr10_+_118305435 0.130 ENST00000369221.2
PNLIP
pancreatic lipase
chr9_-_35691017 0.129 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr6_-_32191834 0.128 ENST00000375023.3
NOTCH4
notch 4
chr12_+_52203789 0.128 ENST00000599343.1
AC068987.1
HCG1997999; cDNA FLJ33996 fis, clone DFNES2008881
chr14_+_65171315 0.128 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr3_-_149051194 0.127 ENST00000470080.1
TM4SF18
transmembrane 4 L six family member 18
chr3_-_134092561 0.127 ENST00000510560.1
ENST00000504234.1
ENST00000515172.1
AMOTL2


angiomotin like 2


chr2_-_238322770 0.126 ENST00000472056.1
COL6A3
collagen, type VI, alpha 3
chr5_+_173930676 0.125 ENST00000504512.1
RP11-267A15.1
RP11-267A15.1
chr19_+_51226573 0.125 ENST00000250340.4
CLEC11A
C-type lectin domain family 11, member A
chr14_-_92413727 0.124 ENST00000267620.10
FBLN5
fibulin 5
chr18_-_53089723 0.123 ENST00000561992.1
ENST00000562512.2
TCF4

transcription factor 4

chr7_+_120628731 0.123 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr13_-_33924755 0.122 ENST00000439831.1
ENST00000567873.1
STARD13

StAR-related lipid transfer (START) domain containing 13

chr17_-_61776522 0.122 ENST00000582055.1
LIMD2
LIM domain containing 2
chrX_+_52780318 0.122 ENST00000375515.3
ENST00000276049.6
SSX2B

synovial sarcoma, X breakpoint 2B

chr12_+_52450298 0.120 ENST00000550582.2
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr1_+_186265399 0.120 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4






proteoglycan 4






chr3_-_71632894 0.120 ENST00000493089.1
FOXP1
forkhead box P1
chr6_+_106534192 0.119 ENST00000369091.2
ENST00000369096.4
PRDM1

PR domain containing 1, with ZNF domain

chr14_+_65171099 0.117 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr18_+_50278430 0.117 ENST00000578080.1
ENST00000582875.1
ENST00000412726.1
DCC


deleted in colorectal carcinoma


chr10_-_61899124 0.117 ENST00000373815.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_-_179691866 0.115 ENST00000464614.1
ENST00000476138.1
ENST00000463761.1
PEX5L


peroxisomal biogenesis factor 5-like


chr8_-_133637624 0.113 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr2_+_11696464 0.113 ENST00000234142.5
GREB1
growth regulation by estrogen in breast cancer 1
chr4_-_186877806 0.113 ENST00000355634.5
SORBS2
sorbin and SH3 domain containing 2
chr2_-_74667612 0.113 ENST00000305557.5
ENST00000233330.6
RTKN

rhotekin

chr17_-_17740325 0.112 ENST00000338854.5
SREBF1
sterol regulatory element binding transcription factor 1
chr9_-_79267432 0.112 ENST00000424866.1
PRUNE2
prune homolog 2 (Drosophila)
chr17_+_39261584 0.111 ENST00000391415.1
KRTAP4-9
keratin associated protein 4-9
chr10_-_82049424 0.110 ENST00000372213.3
MAT1A
methionine adenosyltransferase I, alpha
chr8_-_16035454 0.110 ENST00000355282.2
MSR1
macrophage scavenger receptor 1
chr15_+_59730348 0.110 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
FAM81A



family with sequence similarity 81, member A



chr2_-_238322800 0.109 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
COL6A3





collagen, type VI, alpha 3





chr17_+_79953310 0.108 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr22_+_24990746 0.108 ENST00000456869.1
ENST00000411974.1
GGT1

gamma-glutamyltransferase 1

chr3_-_112360116 0.107 ENST00000206423.3
ENST00000439685.2
CCDC80

coiled-coil domain containing 80

chr12_-_122240792 0.107 ENST00000541657.1
ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
RHOF
AC084018.1





ras homolog family member F (in filopodia)
AC084018.1





chr1_+_159557607 0.107 ENST00000255040.2
APCS
amyloid P component, serum
chr12_+_79258547 0.105 ENST00000457153.2
SYT1
synaptotagmin I
chr1_-_161207986 0.105 ENST00000506209.1
ENST00000367980.2
NR1I3

nuclear receptor subfamily 1, group I, member 3

chr13_+_103459704 0.104 ENST00000602836.1
BIVM-ERCC5
BIVM-ERCC5 readthrough
chr14_-_60097524 0.103 ENST00000342503.4
RTN1
reticulon 1
chr6_-_11779174 0.102 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr12_-_71031185 0.102 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB


protein tyrosine phosphatase, receptor type, B


chr21_-_16374688 0.102 ENST00000411932.1
NRIP1
nuclear receptor interacting protein 1
chr15_+_63334831 0.101 ENST00000288398.6
ENST00000358278.3
ENST00000560445.1
ENST00000403994.3
ENST00000357980.4
ENST00000559556.1
ENST00000559397.1
ENST00000267996.7
ENST00000560970.1
TPM1








tropomyosin 1 (alpha)








chr17_-_46688334 0.101 ENST00000239165.7
HOXB7
homeobox B7
chr14_+_103589789 0.101 ENST00000558056.1
ENST00000560869.1
TNFAIP2

tumor necrosis factor, alpha-induced protein 2

chr11_+_33563821 0.100 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L


KIAA1549-like


chr12_+_79258444 0.100 ENST00000261205.4
SYT1
synaptotagmin I
chr9_+_135285579 0.100 ENST00000343036.2
ENST00000393216.2
C9orf171

chromosome 9 open reading frame 171

chr4_-_186578674 0.100 ENST00000438278.1
SORBS2
sorbin and SH3 domain containing 2
chr7_-_111424462 0.099 ENST00000437129.1
DOCK4
dedicator of cytokinesis 4
chr12_+_122459757 0.097 ENST00000261822.4
BCL7A
B-cell CLL/lymphoma 7A
chr3_+_111630451 0.097 ENST00000495180.1
PHLDB2
pleckstrin homology-like domain, family B, member 2
chr19_+_13134772 0.097 ENST00000587760.1
ENST00000585575.1
NFIX

nuclear factor I/X (CCAAT-binding transcription factor)

chr20_-_34025999 0.097 ENST00000374369.3
GDF5
growth differentiation factor 5
chr6_+_106546808 0.097 ENST00000369089.3
PRDM1
PR domain containing 1, with ZNF domain
chr9_+_129097479 0.096 ENST00000402437.2
MVB12B
multivesicular body subunit 12B
chr14_+_21538517 0.096 ENST00000298693.3
ARHGEF40
Rho guanine nucleotide exchange factor (GEF) 40
chr17_+_42925270 0.096 ENST00000253410.2
ENST00000587021.1
HIGD1B

HIG1 hypoxia inducible domain family, member 1B

chr1_-_55352834 0.095 ENST00000371269.3
DHCR24
24-dehydrocholesterol reductase
chr18_+_13382553 0.095 ENST00000586222.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr3_-_71353892 0.094 ENST00000484350.1
FOXP1
forkhead box P1
chr11_+_58938903 0.094 ENST00000532982.1
DTX4
deltex homolog 4 (Drosophila)
chr5_+_154393260 0.093 ENST00000435029.4
KIF4B
kinesin family member 4B
chr6_-_131384347 0.093 ENST00000530481.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr5_+_140514782 0.092 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr15_+_96869165 0.091 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr7_+_112262421 0.091 ENST00000453459.1
AC002463.3
AC002463.3
chr14_-_60097297 0.091 ENST00000395090.1
RTN1
reticulon 1
chr16_+_67381289 0.091 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr17_-_7080227 0.091 ENST00000574330.1
ASGR1
asialoglycoprotein receptor 1
chr17_+_48912744 0.090 ENST00000311378.4
WFIKKN2
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2
chr7_-_156803329 0.090 ENST00000252971.6
MNX1
motor neuron and pancreas homeobox 1
chr17_+_67759813 0.090 ENST00000587241.1
AC003051.1
AC003051.1
chr2_-_238323007 0.090 ENST00000295550.4
COL6A3
collagen, type VI, alpha 3
chr13_+_77522632 0.090 ENST00000377462.1
IRG1
immunoresponsive 1 homolog (mouse)
chr6_-_131384373 0.090 ENST00000392427.3
ENST00000525271.1
ENST00000527411.1
EPB41L2


erythrocyte membrane protein band 4.1-like 2


chr12_+_14369524 0.089 ENST00000538329.1
RP11-134N1.2
RP11-134N1.2
chr10_-_24770632 0.089 ENST00000596413.1
AL353583.1
AL353583.1
chrX_+_56259316 0.089 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr13_+_47127322 0.088 ENST00000389798.3
LRCH1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr11_+_7626950 0.087 ENST00000530181.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_+_49961990 0.087 ENST00000551063.1
PRPF40B
PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)
chr15_+_63188009 0.085 ENST00000557900.1
RP11-1069G10.2
RP11-1069G10.2
chr17_-_74528128 0.085 ENST00000590175.1
CYGB
cytoglobin
chr14_-_21562671 0.085 ENST00000554923.1
ZNF219
zinc finger protein 219
chr4_-_141074123 0.084 ENST00000502696.1
MAML3
mastermind-like 3 (Drosophila)
chr17_+_4853442 0.084 ENST00000522301.1
ENO3
enolase 3 (beta, muscle)
chr17_-_7120498 0.084 ENST00000485100.1
DLG4
discs, large homolog 4 (Drosophila)
chr6_-_131384412 0.084 ENST00000445890.2
ENST00000368128.2
ENST00000337057.3
EPB41L2


erythrocyte membrane protein band 4.1-like 2


chr20_+_55204351 0.084 ENST00000201031.2
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr18_+_55888767 0.083 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase


chr12_-_71031220 0.082 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr18_-_53253112 0.082 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4


transcription factor 4


chr13_-_30160925 0.082 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr6_-_134639042 0.081 ENST00000461976.2
SGK1
serum/glucocorticoid regulated kinase 1
chr13_-_86373536 0.081 ENST00000400286.2
SLITRK6
SLIT and NTRK-like family, member 6
chr12_+_79371565 0.080 ENST00000551304.1
SYT1
synaptotagmin I

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 0.5 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.1 0.4 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)
0.1 0.3 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 1.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.3 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.4 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.1 0.3 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.3 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.3 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.0 0.2 GO:0021965 spinal cord ventral commissure morphogenesis(GO:0021965)
0.0 0.2 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.6 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.2 GO:0014740 negative regulation of muscle hyperplasia(GO:0014740)
0.0 0.3 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.3 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.6 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.2 GO:0019075 virus maturation(GO:0019075)
0.0 0.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.0 GO:0060560 developmental growth involved in morphogenesis(GO:0060560)
0.0 0.3 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.0 0.1 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.0 0.2 GO:0021546 rhombomere development(GO:0021546)
0.0 0.1 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.1 GO:0014805 smooth muscle adaptation(GO:0014805)
0.0 0.1 GO:0044793 negative regulation by host of viral process(GO:0044793)
0.0 0.1 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.0 0.2 GO:0032621 interleukin-18 production(GO:0032621)
0.0 0.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.0 0.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.6 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.1 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025)
0.0 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.1 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.1 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.0 0.1 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.1 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.1 GO:1990051 activation of protein kinase C activity(GO:1990051)
0.0 0.1 GO:1901207 regulation of heart looping(GO:1901207)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0019082 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.0 0.1 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.1 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.1 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.1 GO:0045065 cytotoxic T cell differentiation(GO:0045065)
0.0 0.1 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.0 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.0 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.0 0.3 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 0.1 GO:0072186 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.0 0.1 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0070295 transformation of host cell by virus(GO:0019087) renal water absorption(GO:0070295)
0.0 0.0 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.1 GO:0072255 metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.0 0.1 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.1 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.0 0.1 GO:2000402 negative regulation of lymphocyte migration(GO:2000402)
0.0 0.1 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.0 0.0 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.0 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.0 0.0 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.0 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.0 0.1 GO:0060157 urinary bladder development(GO:0060157)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.3 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.1 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0042585 female germ cell nucleus(GO:0001674) germinal vesicle(GO:0042585)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:1904724 tertiary granule(GO:0070820) tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.2 GO:0098839 postsynaptic density membrane(GO:0098839)
0.0 0.3 GO:0008091 spectrin(GO:0008091)
0.0 0.0 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.2 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.4 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0034711 inhibin binding(GO:0034711)
0.1 0.6 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 1.2 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 1.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.3 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.1 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 0.1 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.0 0.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.1 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.0 0.3 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 0.1 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0 0.1 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.0 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 0.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.0 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.0 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 0.1 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 0.0 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.0 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 1.0 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.0 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 0.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.5 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.2 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.0 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction