Motif ID: NFATC1

Z-value: 0.520


Transcription factors associated with NFATC1:

Gene SymbolEntrez IDGene Name
NFATC1 ENSG00000131196.13 NFATC1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
NFATC1hg19_v2_chr18_+_77155942_77155951-0.881.6e-03Click!


Activity profile for motif NFATC1.

activity profile for motif NFATC1


Sorted Z-values histogram for motif NFATC1

Sorted Z-values for motif NFATC1



Network of associatons between targets according to the STRING database.



First level regulatory network of NFATC1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_153517473 0.964 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr11_+_34642656 0.854 ENST00000257831.3
ENST00000450654.2
EHF

ets homologous factor

chr6_+_32407619 0.782 ENST00000395388.2
ENST00000374982.5
HLA-DRA

major histocompatibility complex, class II, DR alpha

chr12_-_52685312 0.732 ENST00000327741.5
KRT81
keratin 81
chr4_-_73434498 0.679 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr1_-_111743285 0.651 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr2_+_33701286 0.538 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr2_+_33701707 0.536 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3


RAS guanyl releasing protein 3 (calcium and DAG-regulated)


chr11_+_34654011 0.467 ENST00000531794.1
EHF
ets homologous factor
chr5_-_88179302 0.461 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr7_+_139529040 0.457 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr14_-_54418598 0.426 ENST00000609748.1
ENST00000558961.1
BMP4

bone morphogenetic protein 4

chr7_+_1126437 0.419 ENST00000413368.1
ENST00000397092.1
GPER1

G protein-coupled estrogen receptor 1

chr1_+_46640750 0.402 ENST00000372003.1
TSPAN1
tetraspanin 1
chr7_+_1126461 0.400 ENST00000297469.3
GPER1
G protein-coupled estrogen receptor 1
chrX_-_43832711 0.379 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr1_+_82266053 0.371 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2






latrophilin 2






chr4_-_168155577 0.369 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3





sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3





chr8_-_17555164 0.359 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr11_+_65190245 0.356 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1


nuclear paraspeckle assembly transcript 1 (non-protein coding)


chr5_+_140729649 0.350 ENST00000523390.1
PCDHGB1
protocadherin gamma subfamily B, 1
chr6_-_32920794 0.345 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chr10_-_105212059 0.345 ENST00000260743.5
CALHM2
calcium homeostasis modulator 2
chr10_-_105212141 0.330 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr10_-_92681033 0.325 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr5_+_32788945 0.321 ENST00000326958.1
AC026703.1
AC026703.1
chr8_+_106331769 0.300 ENST00000520492.1
ZFPM2
zinc finger protein, FOG family member 2
chr4_-_74847800 0.298 ENST00000296029.3
PF4
platelet factor 4
chr14_+_75761099 0.293 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5

RP11-293M10.5

chr17_-_39780634 0.292 ENST00000577817.2
KRT17
keratin 17
chr17_-_39780819 0.290 ENST00000311208.8
KRT17
keratin 17
chr1_+_948803 0.281 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr4_-_168155417 0.277 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr1_+_150254936 0.274 ENST00000447007.1
ENST00000369095.1
ENST00000369094.1
C1orf51


chromosome 1 open reading frame 51


chr2_-_145278475 0.269 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr3_-_185270342 0.269 ENST00000424591.2
LIPH
lipase, member H
chr1_-_203320617 0.255 ENST00000354955.4
FMOD
fibromodulin
chr17_-_39781054 0.253 ENST00000463128.1
KRT17
keratin 17
chrX_-_13835461 0.250 ENST00000316715.4
ENST00000356942.5
GPM6B

glycoprotein M6B

chr1_+_15853308 0.250 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
DNAJC16


DnaJ (Hsp40) homolog, subfamily C, member 16


chr8_-_110615669 0.246 ENST00000533394.1
SYBU
syntabulin (syntaxin-interacting)
chr12_-_66275350 0.245 ENST00000536648.1
RP11-366L20.2
Uncharacterized protein
chr4_-_168155169 0.244 ENST00000534949.1
ENST00000535728.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr4_+_110834033 0.239 ENST00000509793.1
ENST00000265171.5
EGF

epidermal growth factor

chr7_+_139529085 0.238 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr10_-_43762329 0.237 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr12_-_92536433 0.232 ENST00000551563.2
ENST00000546975.1
ENST00000549802.1
C12orf79


chromosome 12 open reading frame 79


chr1_+_79115503 0.229 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
IFI44


interferon-induced protein 44


chr8_-_30706608 0.219 ENST00000256246.2
TEX15
testis expressed 15
chr7_-_80548493 0.215 ENST00000536800.1
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr3_+_184530173 0.213 ENST00000453056.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr13_-_62001982 0.213 ENST00000409186.1
PCDH20
protocadherin 20
chr6_-_56716686 0.206 ENST00000520645.1
DST
dystonin
chr4_+_86748898 0.206 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr4_-_38806404 0.205 ENST00000308979.2
ENST00000505940.1
ENST00000515861.1
TLR1


toll-like receptor 1


chr19_-_44388116 0.201 ENST00000587539.1
ZNF404
zinc finger protein 404
chr3_+_46395219 0.201 ENST00000445132.2
ENST00000292301.4
CCR2

chemokine (C-C motif) receptor 2

chr10_+_11206925 0.199 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2


CUGBP, Elav-like family member 2


chr12_-_11287243 0.198 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr1_+_204042723 0.196 ENST00000367204.1
SOX13
SRY (sex determining region Y)-box 13
chr3_-_182817297 0.195 ENST00000539926.1
ENST00000476176.1
MCCC1

methylcrotonoyl-CoA carboxylase 1 (alpha)

chr4_-_52883786 0.190 ENST00000343457.3
LRRC66
leucine rich repeat containing 66
chr3_+_69812877 0.190 ENST00000457080.1
ENST00000328528.6
MITF

microphthalmia-associated transcription factor

chr3_-_182817367 0.185 ENST00000265594.4
MCCC1
methylcrotonoyl-CoA carboxylase 1 (alpha)
chr8_-_72268968 0.185 ENST00000388740.3
EYA1
eyes absent homolog 1 (Drosophila)
chr10_+_11207088 0.183 ENST00000608830.1
CELF2
CUGBP, Elav-like family member 2
chr13_-_67804445 0.182 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
PCDH9


protocadherin 9


chr4_+_86749045 0.181 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chrX_-_13835147 0.169 ENST00000493677.1
ENST00000355135.2
GPM6B

glycoprotein M6B

chr6_+_71104588 0.169 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr4_-_168155300 0.169 ENST00000541637.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr20_-_17539456 0.166 ENST00000544874.1
ENST00000377868.2
BFSP1

beaded filament structural protein 1, filensin

chr3_-_185270383 0.165 ENST00000296252.4
LIPH
lipase, member H
chr17_-_29648761 0.163 ENST00000247270.3
ENST00000462804.2
EVI2A

ecotropic viral integration site 2A

chr3_+_178866199 0.160 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr7_-_100493744 0.158 ENST00000428317.1
ENST00000441605.1
ACHE

acetylcholinesterase (Yt blood group)

chr15_+_38964048 0.157 ENST00000560203.1
ENST00000557946.1
RP11-275I4.2

RP11-275I4.2

chr5_+_118691008 0.156 ENST00000504642.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr3_-_178976996 0.156 ENST00000485523.1
KCNMB3
potassium large conductance calcium-activated channel, subfamily M beta member 3
chr10_+_115511434 0.155 ENST00000369312.4
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr3_+_178865887 0.154 ENST00000477735.1
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr14_-_92247032 0.151 ENST00000556661.1
ENST00000553676.1
ENST00000554560.1
CATSPERB


catsper channel auxiliary subunit beta


chr2_-_211168332 0.151 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr17_-_39677971 0.150 ENST00000393976.2
KRT15
keratin 15
chr6_+_10528560 0.146 ENST00000379597.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr3_-_178789220 0.146 ENST00000414084.1
ZMAT3
zinc finger, matrin-type 3
chr2_+_204732487 0.145 ENST00000302823.3
CTLA4
cytotoxic T-lymphocyte-associated protein 4
chr7_-_122342988 0.142 ENST00000434824.1
RNF148
ring finger protein 148
chr20_+_42574317 0.142 ENST00000358131.5
TOX2
TOX high mobility group box family member 2
chr8_+_55471630 0.142 ENST00000522001.1
RP11-53M11.3
RP11-53M11.3
chr18_-_25739260 0.142 ENST00000413878.1
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr4_+_41614909 0.141 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1


LIM and calponin homology domains 1


chrX_-_48827976 0.140 ENST00000218176.3
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr17_-_27503770 0.140 ENST00000533112.1
MYO18A
myosin XVIIIA
chr11_-_27723158 0.138 ENST00000395980.2
BDNF
brain-derived neurotrophic factor
chr4_-_159094194 0.136 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B


family with sequence similarity 198, member B


chr3_-_24536222 0.136 ENST00000415021.1
ENST00000447875.1
THRB

thyroid hormone receptor, beta

chr10_+_115511213 0.135 ENST00000361048.1
PLEKHS1
pleckstrin homology domain containing, family S member 1
chr2_-_214016314 0.135 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chr3_+_185304059 0.133 ENST00000427465.2
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr8_-_13372395 0.133 ENST00000276297.4
ENST00000511869.1
DLC1

deleted in liver cancer 1

chr8_-_95274536 0.132 ENST00000297596.2
ENST00000396194.2
GEM

GTP binding protein overexpressed in skeletal muscle

chr6_+_41021027 0.132 ENST00000244669.2
APOBEC2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr2_-_211179883 0.131 ENST00000352451.3
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr2_-_230786032 0.131 ENST00000428959.1
TRIP12
thyroid hormone receptor interactor 12
chr5_+_118690466 0.131 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr2_-_157198860 0.129 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr6_-_24799117 0.128 ENST00000565469.1
RP3-369A17.5
chromosome 6 open reading frame 229
chr2_+_28618532 0.127 ENST00000545753.1
FOSL2
FOS-like antigen 2
chr4_-_122148620 0.127 ENST00000509841.1
TNIP3
TNFAIP3 interacting protein 3
chr3_+_185303962 0.127 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr2_+_17721920 0.127 ENST00000295156.4
VSNL1
visinin-like 1
chrX_+_154254960 0.126 ENST00000369498.3
FUNDC2
FUN14 domain containing 2
chr2_-_159237472 0.126 ENST00000409187.1
CCDC148
coiled-coil domain containing 148
chr4_-_11431389 0.120 ENST00000002596.5
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr3_-_188665428 0.120 ENST00000444488.1
TPRG1-AS1
TPRG1 antisense RNA 1
chr17_+_79495397 0.117 ENST00000417245.2
ENST00000334850.7
FSCN2

fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)

chr5_-_94417339 0.117 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
MCTP1


multiple C2 domains, transmembrane 1


chr14_+_51026926 0.116 ENST00000557735.1
ATL1
atlastin GTPase 1
chr9_-_14314566 0.114 ENST00000397579.2
NFIB
nuclear factor I/B
chr4_-_87770416 0.111 ENST00000273905.6
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr1_-_186649543 0.111 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr12_-_11214893 0.109 ENST00000533467.1
TAS2R46
taste receptor, type 2, member 46
chr19_+_38779778 0.109 ENST00000590738.1
ENST00000587519.2
ENST00000591889.1
SPINT2
CTB-102L5.4

serine peptidase inhibitor, Kunitz type, 2
CTB-102L5.4

chrX_-_48056199 0.107 ENST00000311798.1
ENST00000347757.1
SSX5

synovial sarcoma, X breakpoint 5

chr16_+_24621546 0.107 ENST00000566108.1
CTD-2540M10.1
CTD-2540M10.1
chr5_-_94417562 0.106 ENST00000505465.1
MCTP1
multiple C2 domains, transmembrane 1
chr9_-_14314518 0.106 ENST00000397581.2
NFIB
nuclear factor I/B
chr3_-_178984759 0.105 ENST00000349697.2
ENST00000497599.1
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chrX_+_105412290 0.104 ENST00000357175.2
ENST00000337685.2
MUM1L1

melanoma associated antigen (mutated) 1-like 1

chr19_-_55150343 0.104 ENST00000456337.1
AC009892.10
Uncharacterized protein
chr14_-_92413353 0.102 ENST00000556154.1
FBLN5
fibulin 5
chr12_-_123560608 0.101 ENST00000541244.1
PITPNM2
phosphatidylinositol transfer protein, membrane-associated 2
chr12_-_13529594 0.098 ENST00000539026.1
C12orf36
chromosome 12 open reading frame 36
chr11_-_102401469 0.097 ENST00000260227.4
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)
chr4_+_88571429 0.095 ENST00000339673.6
ENST00000282479.7
DMP1

dentin matrix acidic phosphoprotein 1

chrX_-_10544942 0.095 ENST00000380779.1
MID1
midline 1 (Opitz/BBB syndrome)
chr12_-_7245018 0.094 ENST00000543835.1
ENST00000535233.2
C1R

complement component 1, r subcomponent

chr13_-_49975632 0.094 ENST00000457041.1
ENST00000355854.4
CAB39L

calcium binding protein 39-like

chr14_+_51026743 0.093 ENST00000358385.6
ENST00000357032.3
ENST00000354525.4
ATL1


atlastin GTPase 1


chr3_+_14444063 0.092 ENST00000454876.2
ENST00000360861.3
ENST00000416216.2
SLC6A6


solute carrier family 6 (neurotransmitter transporter), member 6


chr12_+_48225126 0.091 ENST00000550909.1
ENST00000550720.1
ENST00000548564.1
RP5-1057I20.2


RP5-1057I20.2


chr12_-_13529642 0.091 ENST00000318426.2
C12orf36
chromosome 12 open reading frame 36
chr17_+_36584662 0.090 ENST00000431231.2
ENST00000437668.3
ARHGAP23

Rho GTPase activating protein 23

chr14_+_51026844 0.090 ENST00000554886.1
ATL1
atlastin GTPase 1
chr17_-_39743139 0.088 ENST00000167586.6
KRT14
keratin 14
chr2_+_46926326 0.086 ENST00000394861.2
SOCS5
suppressor of cytokine signaling 5
chr6_-_15663198 0.086 ENST00000338950.5
ENST00000511762.2
ENST00000355917.3
ENST00000344537.5
DTNBP1



dystrobrevin binding protein 1



chr22_-_43355858 0.083 ENST00000402229.1
ENST00000407585.1
ENST00000453079.1
PACSIN2


protein kinase C and casein kinase substrate in neurons 2


chr11_-_58611957 0.083 ENST00000532258.1
GLYATL2
glycine-N-acyltransferase-like 2
chr2_+_33701684 0.082 ENST00000442390.1
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr18_-_25616519 0.082 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chrX_+_10031499 0.081 ENST00000454666.1
WWC3
WWC family member 3
chr12_-_15815626 0.080 ENST00000540613.1
EPS8
epidermal growth factor receptor pathway substrate 8
chr4_-_80994471 0.080 ENST00000295465.4
ANTXR2
anthrax toxin receptor 2
chr2_+_65663812 0.080 ENST00000606978.1
ENST00000377977.3
ENST00000536804.1
AC074391.1


AC074391.1


chr14_+_23564700 0.079 ENST00000554203.1
C14orf119
chromosome 14 open reading frame 119
chr8_-_145754428 0.079 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82


chromosome 8 open reading frame 82


chr12_-_10605929 0.079 ENST00000347831.5
ENST00000359151.3
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr17_-_40264321 0.078 ENST00000430773.1
ENST00000413196.2
DHX58

DEXH (Asp-Glu-X-His) box polypeptide 58

chr2_-_230786378 0.077 ENST00000430954.1
TRIP12
thyroid hormone receptor interactor 12
chr8_-_81787006 0.077 ENST00000327835.3
ZNF704
zinc finger protein 704
chr9_+_124062071 0.077 ENST00000373818.4
GSN
gelsolin
chr4_+_39046615 0.076 ENST00000261425.3
ENST00000508137.2
KLHL5

kelch-like family member 5

chr2_-_161349909 0.076 ENST00000392753.3
RBMS1
RNA binding motif, single stranded interacting protein 1
chr1_+_87595433 0.075 ENST00000469312.2
ENST00000490006.2
RP5-1052I5.1

long intergenic non-protein coding RNA 1140

chr1_-_36020531 0.075 ENST00000440579.1
ENST00000494948.1
KIAA0319L

KIAA0319-like

chr3_-_36986534 0.075 ENST00000429976.2
ENST00000301807.6
TRANK1

tetratricopeptide repeat and ankyrin repeat containing 1

chr12_-_21928515 0.074 ENST00000537950.1
KCNJ8
potassium inwardly-rectifying channel, subfamily J, member 8
chr12_-_11150474 0.072 ENST00000538986.1
TAS2R20
taste receptor, type 2, member 20
chr1_-_27226928 0.072 ENST00000361720.5
GPATCH3
G patch domain containing 3
chr6_+_42989344 0.072 ENST00000244496.5
RRP36
ribosomal RNA processing 36 homolog (S. cerevisiae)
chr6_+_152011628 0.071 ENST00000404742.1
ENST00000440973.1
ESR1

estrogen receptor 1

chr11_+_128563652 0.069 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr8_+_30496078 0.069 ENST00000517349.1
SMIM18
small integral membrane protein 18
chr6_+_129204337 0.069 ENST00000421865.2
LAMA2
laminin, alpha 2
chr1_+_86046433 0.068 ENST00000451137.2
CYR61
cysteine-rich, angiogenic inducer, 61
chr14_+_35591509 0.068 ENST00000604073.1
KIAA0391
KIAA0391
chr4_+_169633310 0.068 ENST00000510998.1
PALLD
palladin, cytoskeletal associated protein
chr1_-_212588157 0.068 ENST00000261455.4
ENST00000535273.1
TMEM206

transmembrane protein 206

chr4_-_80994619 0.067 ENST00000404191.1
ANTXR2
anthrax toxin receptor 2
chr14_+_78227105 0.066 ENST00000439131.2
ENST00000355883.3
ENST00000557011.1
ENST00000556047.1
C14orf178



chromosome 14 open reading frame 178



chr21_-_22175341 0.065 ENST00000416768.1
ENST00000452561.1
ENST00000419299.1
ENST00000437238.1
LINC00320



long intergenic non-protein coding RNA 320



chr3_+_46395579 0.063 ENST00000421659.1
CCR2
chemokine (C-C motif) receptor 2
chr3_-_65583561 0.063 ENST00000460329.2
MAGI1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr2_-_122262593 0.063 ENST00000418989.1
CLASP1
cytoplasmic linker associated protein 1
chr1_+_156254070 0.062 ENST00000405535.2
ENST00000456810.1
TMEM79

transmembrane protein 79

chr6_-_119670919 0.062 ENST00000368468.3
MAN1A1
mannosidase, alpha, class 1A, member 1
chr15_-_66545995 0.062 ENST00000395614.1
ENST00000288745.3
ENST00000422354.1
ENST00000395625.2
ENST00000360698.4
ENST00000409699.2
MEGF11





multiple EGF-like-domains 11





chr14_+_32547434 0.062 ENST00000556191.1
ENST00000554090.1
ARHGAP5

Rho GTPase activating protein 5

chr9_-_19065082 0.062 ENST00000415524.1
HAUS6
HAUS augmin-like complex, subunit 6
chr1_+_11866207 0.061 ENST00000312413.6
ENST00000346436.6
CLCN6

chloride channel, voltage-sensitive 6

chr7_-_122342966 0.061 ENST00000447240.1
RNF148
ring finger protein 148
chr1_-_155880672 0.061 ENST00000609492.1
ENST00000368322.3
RIT1

Ras-like without CAAX 1

chr6_-_43595039 0.061 ENST00000307114.7
GTPBP2
GTP binding protein 2
chr17_-_35969409 0.060 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG







synergin, gamma







chr19_-_30199516 0.059 ENST00000591243.1
C19orf12
chromosome 19 open reading frame 12
chr22_-_43398442 0.058 ENST00000422336.1
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr2_+_204732666 0.058 ENST00000295854.6
ENST00000472206.1
CTLA4

cytotoxic T-lymphocyte-associated protein 4

chr15_-_30685752 0.057 ENST00000299847.2
ENST00000397827.3
CHRFAM7A

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.3 0.8 GO:2000724 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.1 0.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.3 GO:0007506 gonadal mesoderm development(GO:0007506)
0.1 0.3 GO:1902567 astrocyte chemotaxis(GO:0035700) negative regulation of eosinophil activation(GO:1902567) positive regulation of T cell extravasation(GO:2000409) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.1 0.3 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.1 0.4 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.3 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.5 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.4 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.1 0.2 GO:0034130 toll-like receptor 1 signaling pathway(GO:0034130)
0.1 0.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 0.2 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.3 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 1.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.2 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986) general adaptation syndrome(GO:0051866)
0.0 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.9 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.7 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.3 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.0 0.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.2 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.2 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.2 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.0 0.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.1 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.1 GO:0070173 regulation of enamel mineralization(GO:0070173)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.1 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0009972 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.1 GO:0070836 caveola assembly(GO:0070836)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.1 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.1 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.2 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.0 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.1 GO:0042335 cuticle development(GO:0042335)
0.0 0.0 GO:0006480 N-terminal protein amino acid methylation(GO:0006480)
0.0 0.0 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
0.1 0.4 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.1 1.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 1.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0031673 H zone(GO:0031673)
0.0 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.2 0.7 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 1.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 0.3 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.4 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.0 1.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.0 1.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.3 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.2 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.0 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.0 GO:0071885 N-terminal protein N-methyltransferase activity(GO:0071885)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_BETA_DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.6 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6