Motif ID: MEF2C
Z-value: 0.563
Transcription factors associated with MEF2C:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| MEF2C | ENSG00000081189.9 | MEF2C |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MEF2C | hg19_v2_chr5_-_88179302_88179319 | -0.78 | 1.3e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0050894 | determination of affect(GO:0050894) |
| 0.3 | 1.6 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.3 | 1.5 | GO:0045200 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 0.2 | 0.5 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.1 | 0.3 | GO:0032242 | regulation of nucleoside transport(GO:0032242) |
| 0.1 | 0.6 | GO:0044027 | hypermethylation of CpG island(GO:0044027) |
| 0.1 | 0.4 | GO:0032971 | regulation of muscle filament sliding(GO:0032971) |
| 0.1 | 1.1 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 0.9 | GO:0061669 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.1 | 0.6 | GO:0098735 | positive regulation of the force of heart contraction(GO:0098735) |
| 0.1 | 0.3 | GO:0061053 | somite development(GO:0061053) |
| 0.1 | 0.2 | GO:1904425 | negative regulation of GTP binding(GO:1904425) |
| 0.1 | 0.1 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) |
| 0.1 | 2.4 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 0.3 | GO:0015793 | glycerol transport(GO:0015793) |
| 0.0 | 0.1 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.0 | 0.1 | GO:0040040 | thermosensory behavior(GO:0040040) |
| 0.0 | 0.1 | GO:0060629 | regulation of homologous chromosome segregation(GO:0060629) |
| 0.0 | 0.2 | GO:0036309 | protein localization to M-band(GO:0036309) |
| 0.0 | 0.4 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.0 | 0.1 | GO:0060708 | positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141) spongiotrophoblast differentiation(GO:0060708) |
| 0.0 | 0.6 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 0.1 | GO:0033058 | directional locomotion(GO:0033058) |
| 0.0 | 0.2 | GO:1905150 | regulation of voltage-gated sodium channel activity(GO:1905150) |
| 0.0 | 0.3 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.3 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) ERK5 cascade(GO:0070375) |
| 0.0 | 0.1 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
| 0.0 | 0.3 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.1 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.0 | 0.1 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.0 | 0.1 | GO:0038091 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) |
| 0.0 | 0.3 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.1 | GO:0015840 | urea transport(GO:0015840) |
| 0.0 | 0.1 | GO:0055129 | L-proline biosynthetic process(GO:0055129) |
| 0.0 | 0.0 | GO:1905051 | regulation of base-excision repair(GO:1905051) positive regulation of base-excision repair(GO:1905053) |
| 0.0 | 0.1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 0.5 | GO:2000615 | regulation of histone H3-K9 acetylation(GO:2000615) |
| 0.0 | 0.1 | GO:0009257 | 10-formyltetrahydrofolate biosynthetic process(GO:0009257) |
| 0.0 | 0.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.3 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 0.0 | GO:0060382 | regulation of DNA strand elongation(GO:0060382) |
| 0.0 | 0.0 | GO:1901656 | glycoside transport(GO:1901656) |
| 0.0 | 0.0 | GO:0003219 | cardiac right ventricle formation(GO:0003219) |
| 0.0 | 0.0 | GO:0071676 | negative regulation of mononuclear cell migration(GO:0071676) allantois development(GO:1905069) |
| 0.0 | 0.2 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 0.0 | 0.1 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.0 | 0.7 | GO:0055010 | ventricular cardiac muscle tissue morphogenesis(GO:0055010) |
| 0.0 | 0.1 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.0 | 0.1 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:1990584 | cardiac Troponin complex(GO:1990584) |
| 0.1 | 0.4 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 1.9 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 0.1 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 0.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 0.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 0.1 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.0 | 0.9 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.1 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 1.1 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 0.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.1 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) junctional membrane complex(GO:0030314) |
| 0.0 | 1.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 3.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.5 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.0 | 0.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.0 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
| 0.0 | 0.0 | GO:0071159 | NF-kappaB complex(GO:0071159) |
| 0.0 | 0.0 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) |
| 0.0 | 0.2 | GO:0032591 | dendritic spine membrane(GO:0032591) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
| 0.1 | 0.7 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.1 | 0.3 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 0.3 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.1 | 0.4 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 2.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.3 | GO:0015254 | glycerol channel activity(GO:0015254) |
| 0.1 | 0.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 0.5 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.1 | 0.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 0.2 | GO:0051373 | FATZ binding(GO:0051373) |
| 0.0 | 0.1 | GO:0005146 | leukemia inhibitory factor receptor binding(GO:0005146) |
| 0.0 | 0.2 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.0 | 0.1 | GO:0005018 | platelet-derived growth factor alpha-receptor activity(GO:0005018) |
| 0.0 | 1.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 1.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.1 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.0 | 0.2 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 0.1 | GO:0046538 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.0 | 0.2 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 0.6 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.3 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.0 | 0.1 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.0 | 0.0 | GO:0017130 | poly(C) RNA binding(GO:0017130) |
| 0.0 | 0.0 | GO:0015168 | glycerol transmembrane transporter activity(GO:0015168) |
| 0.0 | 0.3 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.1 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.0 | 0.2 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 0.1 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 0.3 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 1.2 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 1.3 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.0 | PID_HDAC_CLASSII_PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.7 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 0.3 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.0 | 1.3 | REACTOME_PIP3_ACTIVATES_AKT_SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.4 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
