• All motifs sorted by activity significance
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• Mean activities
• All promoters sorted by FOV

• Activities table
• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
• Download the whole report

Motif ID: MAFA

Z-value: 0.229

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_-_153517473	0.278	ENST00000368715.1	S100A4	S100 calcium binding protein A4
chr14_-_54317532	0.275	ENST00000418927.1	AL162759.1	AL162759.1
chr4_+_15005391	0.182	ENST00000507071.1 ENST00000345451.3 ENST00000259997.5 ENST00000382395.3 ENST00000382401.3	CPEB2	cytoplasmic polyadenylation element binding protein 2
chrX_-_43741594	0.150	ENST00000536181.1 ENST00000378069.4	MAOB	monoamine oxidase B
chr2_+_85811525	0.138	ENST00000306384.4	VAMP5	vesicle-associated membrane protein 5
chr11_-_70507901	0.119	ENST00000449833.2 ENST00000357171.3 ENST00000449116.2	SHANK2	SH3 and multiple ankyrin repeat domains 2
chr11_+_72929319	0.117	ENST00000393597.2 ENST00000311131.2	P2RY2	purinergic receptor P2Y, G-protein coupled, 2
chr4_+_72052964	0.115	ENST00000264485.5 ENST00000425175.1	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr1_-_57045228	0.115	ENST00000371250.3	PPAP2B	phosphatidic acid phosphatase type 2B
chr11_+_72929402	0.114	ENST00000393596.2	P2RY2	purinergic receptor P2Y, G-protein coupled, 2
chr12_+_53817633	0.108	ENST00000257863.4 ENST00000550311.1 ENST00000379791.3	AMHR2	anti-Mullerian hormone receptor, type II
chr9_-_130712995	0.105	ENST00000373084.4	FAM102A	family with sequence similarity 102, member A
chr22_-_27014043	0.099	ENST00000215939.2	CRYBB1	crystallin, beta B1
chr4_+_72053017	0.097	ENST00000351898.6	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr3_+_75955817	0.092	ENST00000487694.3 ENST00000602589.1	ROBO2	roundabout, axon guidance receptor, homolog 2 (Drosophila)
chr3_-_196439065	0.091	ENST00000399942.4 ENST00000409690.3	CEP19	centrosomal protein 19kDa
chr5_-_179285785	0.089	ENST00000520698.1 ENST00000518235.1 ENST00000376931.2 ENST00000518219.1 ENST00000521333.1 ENST00000523084.1	C5orf45	chromosome 5 open reading frame 45
chr9_+_2622085	0.089	ENST00000382099.2	VLDLR	very low density lipoprotein receptor
chr2_+_33172221	0.088	ENST00000354476.3	LTBP1	latent transforming growth factor beta binding protein 1
chr6_+_7727030	0.087	ENST00000283147.6	BMP6	bone morphogenetic protein 6
chr8_-_63998590	0.083	ENST00000260116.4	TTPA	tocopherol (alpha) transfer protein
chr6_+_97372645	0.082	ENST00000536676.1 ENST00000544166.1	KLHL32	kelch-like family member 32
chr12_-_22487588	0.077	ENST00000381424.3	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr9_+_125133467	0.076	ENST00000426608.1	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr3_+_184016986	0.075	ENST00000417952.1	PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr2_+_102624977	0.072	ENST00000441002.1	IL1R2	interleukin 1 receptor, type II
chr5_-_179285848	0.071	ENST00000403396.2 ENST00000292586.6	C5orf45	chromosome 5 open reading frame 45
chr10_+_124221036	0.071	ENST00000368984.3	HTRA1	HtrA serine peptidase 1
chrX_+_3189861	0.067	ENST00000457435.1 ENST00000420429.2	CXorf28	chromosome X open reading frame 28
chr5_-_94620239	0.065	ENST00000515393.1	MCTP1	multiple C2 domains, transmembrane 1
chr9_+_97488939	0.064	ENST00000277198.2 ENST00000297979.5	C9orf3	chromosome 9 open reading frame 3
chr8_-_9762871	0.064	ENST00000521242.1	LINC00599	long intergenic non-protein coding RNA 599
chr3_+_185304059	0.063	ENST00000427465.2	SENP2	SUMO1/sentrin/SMT3 specific peptidase 2
chr9_+_2621950	0.062	ENST00000382096.1	VLDLR	very low density lipoprotein receptor
chr17_-_17109579	0.061	ENST00000321560.3	PLD6	phospholipase D family, member 6
chr2_+_103236004	0.061	ENST00000233969.2	SLC9A2	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr5_-_114505624	0.059	ENST00000513154.1	TRIM36	tripartite motif containing 36
chr16_+_28996572	0.058	ENST00000360872.5 ENST00000566177.1 ENST00000354453.4	LAT	linker for activation of T cells
chr5_-_114505591	0.058	ENST00000508894.1	TRIM36	tripartite motif containing 36
chrX_-_53310791	0.057	ENST00000375365.2	IQSEC2	IQ motif and Sec7 domain 2
chr6_+_97372734	0.054	ENST00000539200.1	KLHL32	kelch-like family member 32
chr17_-_39781054	0.054	ENST00000463128.1	KRT17	keratin 17
chr4_-_22517620	0.050	ENST00000502482.1 ENST00000334304.5	GPR125	G protein-coupled receptor 125
chr6_+_97372596	0.047	ENST00000369261.4	KLHL32	kelch-like family member 32
chr10_-_75676400	0.045	ENST00000412307.2	C10orf55	chromosome 10 open reading frame 55
chrY_-_1461617	0.043	ENSTR0000381401.5	SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr17_+_38465441	0.042	ENST00000577646.1 ENST00000254066.5	RARA	retinoic acid receptor, alpha
chr9_-_100000957	0.042	ENST00000366109.2 ENST00000607322.1	RP11-498P14.5	RP11-498P14.5
chrX_-_1511617	0.040	ENST00000381401.5	SLC25A6	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr16_+_28996364	0.040	ENST00000564277.1	LAT	linker for activation of T cells
chr9_+_2621798	0.039	ENST00000382100.3	VLDLR	very low density lipoprotein receptor
chr18_-_2982869	0.039	ENST00000584915.1	LPIN2	lipin 2
chr12_-_22487618	0.038	ENST00000404299.3 ENST00000396037.4	ST8SIA1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr4_-_10118348	0.035	ENST00000502702.1	WDR1	WD repeat domain 1
chr6_-_24489842	0.033	ENST00000230036.1	GPLD1	glycosylphosphatidylinositol specific phospholipase D1
chr18_+_77623668	0.033	ENST00000316249.3	KCNG2	potassium voltage-gated channel, subfamily G, member 2
chr4_+_106067943	0.032	ENST00000380013.4 ENST00000394764.1 ENST00000413648.2	TET2	tet methylcytosine dioxygenase 2
chr3_+_196439170	0.032	ENST00000392391.3 ENST00000314118.4	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X
chr11_-_66103932	0.031	ENST00000311320.4	RIN1	Ras and Rab interactor 1
chr15_+_80696666	0.030	ENST00000303329.4	ARNT2	aryl-hydrocarbon receptor nuclear translocator 2
chr4_+_6784401	0.029	ENST00000425103.1 ENST00000307659.5	KIAA0232	KIAA0232
chr19_-_37958318	0.027	ENST00000316950.6 ENST00000591710.1	ZNF569	zinc finger protein 569
chr3_+_196439275	0.027	ENST00000296333.5	PIGX	phosphatidylinositol glycan anchor biosynthesis, class X
chr2_+_118846008	0.027	ENST00000245787.4	INSIG2	insulin induced gene 2
chr1_-_13331692	0.027	ENST00000353410.5 ENST00000376173.3	PRAMEF3	PRAME family member 3
chr7_-_22234381	0.025	ENST00000458533.1	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr20_-_43743790	0.025	ENST00000307971.4 ENST00000372789.4	WFDC5	WAP four-disulfide core domain 5
chr12_+_21654714	0.024	ENST00000542038.1 ENST00000540141.1 ENST00000229314.5	GOLT1B	golgi transport 1B
chr11_-_66103867	0.023	ENST00000424433.2	RIN1	Ras and Rab interactor 1
chr11_-_57518848	0.023	ENST00000436147.3	BTBD18	BTB (POZ) domain containing 18
chr17_+_25936862	0.023	ENST00000582410.1	KSR1	kinase suppressor of ras 1
chr12_-_123215306	0.022	ENST00000356987.2 ENST00000436083.2	HCAR1	hydroxycarboxylic acid receptor 1
chr19_+_18451391	0.021	ENST00000269919.6 ENST00000604499.2 ENST00000595066.1 ENST00000252813.5	PGPEP1	pyroglutamyl-peptidase I
chr19_-_33182616	0.021	ENST00000592431.1	CTD-2538C1.2	CTD-2538C1.2
chr4_+_2470664	0.021	ENST00000314289.8 ENST00000541204.1 ENST00000502316.1 ENST00000507247.1 ENST00000509258.1 ENST00000511859.1	RNF4	ring finger protein 4
chr15_+_90744533	0.020	ENST00000411539.2	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr16_+_22524844	0.020	ENST00000538606.1 ENST00000424340.1 ENST00000517539.1 ENST00000528249.1	NPIPB5	nuclear pore complex interacting protein family, member B5
chr15_+_98503922	0.019	ENST00000268042.6	ARRDC4	arrestin domain containing 4
chr2_+_191745560	0.019	ENST00000338435.4	GLS	glutaminase
chr19_+_18451439	0.019	ENST00000597431.2	PGPEP1	pyroglutamyl-peptidase I
chr10_-_81708854	0.018	ENST00000372292.3	SFTPD	surfactant protein D
chr10_-_135171510	0.018	ENST00000278025.4 ENST00000368552.3	FUOM	fucose mutarotase
chr17_+_41363854	0.017	ENST00000588693.1 ENST00000588659.1 ENST00000541594.1 ENST00000536052.1 ENST00000331615.3	TMEM106A	transmembrane protein 106A
chr7_-_151433342	0.017	ENST00000433631.2	PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr19_-_43099070	0.016	ENST00000244336.5	CEACAM8	carcinoembryonic antigen-related cell adhesion molecule 8
chr8_-_89339705	0.016	ENST00000286614.6	MMP16	matrix metallopeptidase 16 (membrane-inserted)
chr3_+_107241882	0.016	ENST00000416476.2	BBX	bobby sox homolog (Drosophila)
chr7_-_73133959	0.016	ENST00000395155.3 ENST00000395154.3 ENST00000222812.3 ENST00000395156.3	STX1A	syntaxin 1A (brain)
chr3_+_172361483	0.015	ENST00000598405.1	AC007919.2	HCG1787166; PRO1163; Uncharacterized protein
chr16_-_21436459	0.015	ENST00000448012.2 ENST00000504841.2 ENST00000419180.2	NPIPB3	nuclear pore complex interacting protein family, member B3
chr16_-_29415350	0.015	ENST00000524087.1	NPIPB11	nuclear pore complex interacting protein family, member B11
chr1_-_45956822	0.014	ENST00000372086.3 ENST00000341771.6	TESK2	testis-specific kinase 2
chr1_-_45956800	0.013	ENST00000538496.1	TESK2	testis-specific kinase 2
chr16_-_21868739	0.013	ENST00000415645.2	NPIPB4	nuclear pore complex interacting protein family, member B4
chr10_-_135171178	0.013	ENST00000368551.1	FUOM	fucose mutarotase
chr19_-_4124079	0.013	ENST00000394867.4 ENST00000262948.5	MAP2K2	mitogen-activated protein kinase kinase 2
chr16_-_29517141	0.012	ENST00000550665.1	RP11-231C14.4	Uncharacterized protein
chr19_+_38880695	0.012	ENST00000587947.1 ENST00000338502.4	SPRED3	sprouty-related, EVH1 domain containing 3
chr5_+_179286013	0.012	ENST00000499601.2	CTC-241N9.1	Uncharacterized protein
chrX_-_47509887	0.011	ENST00000247161.3 ENST00000592066.1 ENST00000376983.3	ELK1	ELK1, member of ETS oncogene family
chr15_+_90744745	0.011	ENST00000558051.1	SEMA4B	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
chr5_-_118324200	0.011	ENST00000515439.3 ENST00000510708.1	DTWD2	DTW domain containing 2
chr1_-_32403370	0.010	ENST00000534796.1	PTP4A2	protein tyrosine phosphatase type IVA, member 2
chr14_+_24605389	0.010	ENST00000382708.3 ENST00000561435.1	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr3_+_107241783	0.010	ENST00000415149.2 ENST00000402543.1 ENST00000325805.8 ENST00000427402.1	BBX	bobby sox homolog (Drosophila)
chr20_+_306177	0.010	ENST00000544632.1	SOX12	SRY (sex determining region Y)-box 12
chr12_+_56546363	0.010	ENST00000551834.1 ENST00000552568.1	MYL6B	myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr19_+_6740888	0.008	ENST00000596673.1	TRIP10	thyroid hormone receptor interactor 10
chr1_+_78354243	0.008	ENST00000294624.8	NEXN	nexilin (F actin binding protein)
chr19_+_12949251	0.008	ENST00000251472.4	MAST1	microtubule associated serine/threonine kinase 1
chr20_+_306221	0.007	ENST00000342665.2	SOX12	SRY (sex determining region Y)-box 12
chr19_-_2050852	0.007	ENST00000541165.1 ENST00000591601.1	MKNK2	MAP kinase interacting serine/threonine kinase 2
chr1_-_38325256	0.007	ENST00000373036.4	MTF1	metal-regulatory transcription factor 1
chr6_+_42896865	0.006	ENST00000372836.4 ENST00000394142.3	CNPY3	canopy FGF signaling regulator 3
chr5_+_60933634	0.006	ENST00000505642.1	C5orf64	chromosome 5 open reading frame 64
chr15_-_23086259	0.006	ENST00000538684.1	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1
chrX_-_47509994	0.006	ENST00000343894.4	ELK1	ELK1, member of ETS oncogene family
chr5_+_139739772	0.005	ENST00000506757.2 ENST00000230993.6 ENST00000506545.1 ENST00000432095.2 ENST00000507527.1	SLC4A9	solute carrier family 4, sodium bicarbonate cotransporter, member 9
chr1_-_32403903	0.005	ENST00000344035.6 ENST00000356536.3	PTP4A2	protein tyrosine phosphatase type IVA, member 2
chr11_+_111411384	0.005	ENST00000375615.3 ENST00000525126.1 ENST00000436913.2 ENST00000533265.1	LAYN	layilin
chr1_-_45956868	0.005	ENST00000451835.2	TESK2	testis-specific kinase 2
chr14_+_81421921	0.005	ENST00000554263.1 ENST00000554435.1	TSHR	thyroid stimulating hormone receptor
chr11_+_111412053	0.004	ENST00000530962.1	LAYN	layilin
chr1_+_206858328	0.004	ENST00000367103.3	MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2
chr15_-_23086394	0.004	ENST00000337435.4	NIPA1	non imprinted in Prader-Willi/Angelman syndrome 1
chr11_+_107462471	0.003	ENST00000600612.1	AP000889.3	HCG2032453; Uncharacterized protein; cDNA FLJ25337 fis, clone TST00714
chr2_+_191745535	0.003	ENST00000320717.3	GLS	glutaminase
chr6_+_22221010	0.003	ENST00000567753.1	RP11-524C21.2	RP11-524C21.2
chr16_+_70258261	0.003	ENST00000594734.1	FKSG63	FKSG63
chr2_+_26915584	0.002	ENST00000302909.3	KCNK3	potassium channel, subfamily K, member 3
chr9_-_130889990	0.002	ENST00000449878.1	PTGES2	prostaglandin E synthase 2
chr11_-_93276514	0.002	ENST00000526869.1	SMCO4	single-pass membrane protein with coiled-coil domains 4
chr14_+_81421355	0.001	ENST00000541158.2	TSHR	thyroid stimulating hormone receptor
chr21_+_44589118	0.001	ENST00000291554.2	CRYAA	crystallin, alpha A
chr19_+_54641444	0.001	ENST00000221232.5 ENST00000358389.3	CNOT3	CCR4-NOT transcription complex, subunit 3
chr14_+_36295638	0.001	ENST00000543183.1	BRMS1L	breast cancer metastasis-suppressor 1-like
chr8_-_114389353	0.000	ENST00000343508.3	CSMD3	CUB and Sushi multiple domains 3
chr7_+_100860949	0.000	ENST00000305105.2	ZNHIT1	zinc finger, HIT-type containing 1
chr9_+_100000717	0.000	ENST00000375205.2 ENST00000357054.1 ENST00000395220.1 ENST00000375202.2 ENST00000411667.2	CCDC180	coiled-coil domain containing 180

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	GO:1900248	cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.0	0.1	GO:0052553	induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.0	0.2	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.2	GO:0014063	negative regulation of serotonin secretion(GO:0014063)
0.0	0.1	GO:0097187	dentinogenesis(GO:0097187)
0.0	0.1	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0050712	negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0	0.1	GO:0090031	positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0	0.1	GO:0061364	negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
0.0	0.2	GO:0070257	positive regulation of mucus secretion(GO:0070257)
0.0	0.1	GO:0010636	positive regulation of mitochondrial fusion(GO:0010636)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:0034515	proteasome storage granule(GO:0034515)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	GO:0034189	very-low-density lipoprotein particle binding(GO:0034189)
0.0	0.1	GO:0005026	transforming growth factor beta receptor activity, type II(GO:0005026)
0.0	0.2	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0005471	ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.0	0.1	GO:0008431	vitamin E binding(GO:0008431)
0.0	0.2	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0	0.1	GO:0050436	microfibril binding(GO:0050436)
0.0	0.1	GO:0004910	interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0	0.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.1	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	REACTOME_P2Y_RECEPTORS	Genes involved in P2Y receptors

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