Motif ID: LEF1

Z-value: 0.503


Transcription factors associated with LEF1:

Gene SymbolEntrez IDGene Name
LEF1 ENSG00000138795.5 LEF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
LEF1hg19_v2_chr4_-_109088940_1090890370.703.6e-02Click!


Activity profile for motif LEF1.

activity profile for motif LEF1


Sorted Z-values histogram for motif LEF1

Sorted Z-values for motif LEF1



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_41742697 0.649 ENST00000242208.4
INHBA
inhibin, beta A
chrX_-_138287168 0.642 ENST00000436198.1
FGF13
fibroblast growth factor 13
chrX_-_32173579 0.589 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD




dystrophin




chr8_+_85095769 0.444 ENST00000518566.1
RALYL
RALY RNA binding protein-like
chr13_-_36429763 0.433 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr6_+_43968306 0.418 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223


chromosome 6 open reading frame 223


chr1_-_200992827 0.369 ENST00000332129.2
ENST00000422435.2
KIF21B

kinesin family member 21B

chr12_+_54378923 0.348 ENST00000303460.4
HOXC10
homeobox C10
chr4_-_186877502 0.346 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2


sorbin and SH3 domain containing 2


chr19_-_6690723 0.329 ENST00000601008.1
C3
complement component 3
chr6_-_79315735 0.322 ENST00000449463.1
RP3-390M24.1
RP3-390M24.1
chr1_-_219615984 0.295 ENST00000420762.1
RP11-95P13.1
RP11-95P13.1
chr9_-_102582155 0.292 ENST00000427039.1
RP11-554F20.1
RP11-554F20.1
chrX_-_124097620 0.291 ENST00000371130.3
ENST00000422452.2
TENM1

teneurin transmembrane protein 1

chr17_-_46682321 0.287 ENST00000225648.3
ENST00000484302.2
HOXB6

homeobox B6

chr10_-_61900762 0.282 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr17_-_46623441 0.282 ENST00000330070.4
HOXB2
homeobox B2
chr6_+_12958137 0.280 ENST00000457702.2
ENST00000379345.2
PHACTR1

phosphatase and actin regulator 1

chr13_-_72441315 0.268 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1


dachshund homolog 1 (Drosophila)


chr12_+_54378849 0.254 ENST00000515593.1
HOXC10
homeobox C10
chr8_+_85095497 0.248 ENST00000522455.1
ENST00000521695.1
RALYL

RALY RNA binding protein-like

chr17_-_56406117 0.244 ENST00000268893.6
ENST00000355701.3
BZRAP1

benzodiazepine receptor (peripheral) associated protein 1

chr4_-_186877481 0.242 ENST00000444781.1
ENST00000432655.1
SORBS2

sorbin and SH3 domain containing 2

chr16_+_29150963 0.241 ENST00000563477.1
RP11-426C22.5
RP11-426C22.5
chr8_+_55467072 0.238 ENST00000602362.1
RP11-53M11.3
RP11-53M11.3
chr6_-_11807277 0.236 ENST00000379415.2
ADTRP
androgen-dependent TFPI-regulating protein
chr2_-_67442409 0.235 ENST00000414404.1
ENST00000433133.1
AC078941.1

AC078941.1

chr1_+_203096831 0.223 ENST00000337894.4
ADORA1
adenosine A1 receptor
chr15_+_73344791 0.221 ENST00000261908.6
NEO1
neogenin 1
chr6_+_114178512 0.221 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr11_+_7273181 0.220 ENST00000318881.6
SYT9
synaptotagmin IX
chr7_+_28452130 0.210 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr1_+_213123862 0.208 ENST00000366966.2
ENST00000366964.3
VASH2

vasohibin 2

chr12_+_7167980 0.208 ENST00000360817.5
ENST00000402681.3
C1S

complement component 1, s subcomponent

chr3_+_29323043 0.205 ENST00000452462.1
ENST00000456853.1
RBMS3

RNA binding motif, single stranded interacting protein 3

chr3_+_111260980 0.202 ENST00000438817.2
CD96
CD96 molecule
chr3_+_123813509 0.201 ENST00000460856.1
ENST00000240874.3
KALRN

kalirin, RhoGEF kinase

chr6_-_127840048 0.199 ENST00000467753.1
SOGA3
SOGA family member 3
chr18_-_53089723 0.193 ENST00000561992.1
ENST00000562512.2
TCF4

transcription factor 4

chr14_+_24837226 0.193 ENST00000554050.1
ENST00000554903.1
ENST00000554779.1
ENST00000250373.4
ENST00000553708.1
NFATC4




nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4




chr10_-_33405600 0.191 ENST00000414308.1
RP11-342D11.3
RP11-342D11.3
chr13_-_72440901 0.190 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr14_+_69726864 0.189 ENST00000448469.3
GALNT16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr16_+_50582222 0.189 ENST00000268459.3
NKD1
naked cuticle homolog 1 (Drosophila)
chr15_-_79103757 0.186 ENST00000388820.4
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr22_+_37959647 0.181 ENST00000415670.1
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr3_-_99569821 0.180 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr4_-_176733377 0.177 ENST00000505375.1
GPM6A
glycoprotein M6A
chr10_-_14050522 0.177 ENST00000342409.2
FRMD4A
FERM domain containing 4A
chrX_+_135229559 0.176 ENST00000394155.2
FHL1
four and a half LIM domains 1
chrX_+_135229600 0.176 ENST00000370690.3
FHL1
four and a half LIM domains 1
chr14_-_38064198 0.174 ENST00000250448.2
FOXA1
forkhead box A1
chr15_+_63335899 0.173 ENST00000561266.1
TPM1
tropomyosin 1 (alpha)
chr14_+_69726968 0.171 ENST00000553669.1
GALNT16
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16
chr13_-_30160925 0.170 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr12_+_94071341 0.167 ENST00000542893.2
CRADD
CASP2 and RIPK1 domain containing adaptor with death domain
chr10_-_17171785 0.166 ENST00000377823.1
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr2_-_72375167 0.160 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr6_-_11779403 0.156 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr17_-_47308128 0.154 ENST00000413580.1
ENST00000511066.1
PHOSPHO1

phosphatase, orphan 1

chr6_-_11779840 0.153 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr14_-_37051798 0.152 ENST00000258829.5
NKX2-8
NK2 homeobox 8
chr2_-_74780176 0.152 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chrX_+_37545012 0.151 ENST00000378616.3
XK
X-linked Kx blood group (McLeod syndrome)
chr13_-_95131923 0.151 ENST00000377028.5
ENST00000446125.1
DCT

dopachrome tautomerase

chr3_+_123813543 0.149 ENST00000360013.3
KALRN
kalirin, RhoGEF kinase
chr1_+_213123976 0.148 ENST00000366965.2
ENST00000366967.2
VASH2

vasohibin 2

chr11_+_92085707 0.147 ENST00000525166.1
FAT3
FAT atypical cadherin 3
chr12_+_8849773 0.146 ENST00000541044.1
RIMKLB
ribosomal modification protein rimK-like family member B
chr2_-_72374948 0.145 ENST00000546307.1
ENST00000474509.1
CYP26B1

cytochrome P450, family 26, subfamily B, polypeptide 1

chr16_-_4323015 0.144 ENST00000204517.6
TFAP4
transcription factor AP-4 (activating enhancer binding protein 4)
chr7_-_84122033 0.143 ENST00000424555.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr21_+_18811205 0.143 ENST00000440664.1
C21orf37
chromosome 21 open reading frame 37
chr17_-_47308100 0.142 ENST00000503902.1
ENST00000512250.1
PHOSPHO1

phosphatase, orphan 1

chr6_-_11779174 0.141 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr6_-_127840021 0.141 ENST00000465909.2
SOGA3
SOGA family member 3
chr2_-_224467002 0.141 ENST00000421386.1
ENST00000433889.1
SCG2

secretogranin II

chr6_+_78400375 0.140 ENST00000602452.2
MEI4
meiosis-specific 4 homolog (S. cerevisiae)
chr2_+_27665232 0.139 ENST00000543753.1
ENST00000288873.3
KRTCAP3

keratinocyte associated protein 3

chr14_+_59100774 0.139 ENST00000556859.1
ENST00000421793.1
DACT1

dishevelled-binding antagonist of beta-catenin 1

chr3_+_111578583 0.138 ENST00000478922.1
ENST00000477695.1
PHLDB2

pleckstrin homology-like domain, family B, member 2

chr2_+_85360499 0.136 ENST00000282111.3
TCF7L1
transcription factor 7-like 1 (T-cell specific, HMG-box)
chr3_+_111260954 0.136 ENST00000283285.5
CD96
CD96 molecule
chr11_+_92085262 0.135 ENST00000298047.6
ENST00000409404.2
ENST00000541502.1
FAT3


FAT atypical cadherin 3


chr18_-_52989217 0.135 ENST00000570287.2
TCF4
transcription factor 4
chr20_-_52645231 0.132 ENST00000448484.1
BCAS1
breast carcinoma amplified sequence 1
chr3_+_111260856 0.132 ENST00000352690.4
CD96
CD96 molecule
chr18_+_6729698 0.132 ENST00000383472.4
ARHGAP28
Rho GTPase activating protein 28
chr15_+_96869165 0.132 ENST00000421109.2
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr4_+_54966198 0.132 ENST00000326902.2
ENST00000503800.1
GSX2

GS homeobox 2

chr14_-_67981916 0.131 ENST00000357461.2
TMEM229B
transmembrane protein 229B
chr18_+_6774000 0.130 ENST00000532723.1
ARHGAP28
Rho GTPase activating protein 28
chr21_-_32931290 0.130 ENST00000286827.3
TIAM1
T-cell lymphoma invasion and metastasis 1
chr6_-_127840336 0.129 ENST00000525778.1
SOGA3
SOGA family member 3
chr1_+_213123915 0.128 ENST00000366968.4
ENST00000490792.1
VASH2

vasohibin 2

chr13_-_110959478 0.128 ENST00000543140.1
ENST00000375820.4
COL4A1

collagen, type IV, alpha 1

chr1_+_53793885 0.128 ENST00000445039.2
RP4-784A16.5
RP4-784A16.5
chr6_-_112575838 0.124 ENST00000455073.1
LAMA4
laminin, alpha 4
chr4_-_186682716 0.122 ENST00000445343.1
SORBS2
sorbin and SH3 domain containing 2
chr8_-_124553437 0.121 ENST00000517956.1
ENST00000443022.2
FBXO32

F-box protein 32

chr9_-_97356075 0.119 ENST00000375337.3
FBP2
fructose-1,6-bisphosphatase 2
chr21_+_17791648 0.119 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
LINC00478


long intergenic non-protein coding RNA 478


chr3_-_149375783 0.118 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WWTR1


WW domain containing transcription regulator 1


chr6_-_134639180 0.118 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr10_-_17171817 0.115 ENST00000377833.4
CUBN
cubilin (intrinsic factor-cobalamin receptor)
chr14_-_67981870 0.114 ENST00000555994.1
TMEM229B
transmembrane protein 229B
chr12_+_54426637 0.112 ENST00000312492.2
HOXC5
homeobox C5
chr2_+_171571827 0.112 ENST00000375281.3
SP5
Sp5 transcription factor
chr21_+_39628852 0.111 ENST00000398938.2
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr1_+_16085244 0.111 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr6_-_127840453 0.109 ENST00000556132.1
SOGA3
SOGA family member 3
chr12_+_94071129 0.109 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
CRADD



CASP2 and RIPK1 domain containing adaptor with death domain



chr12_+_9066472 0.107 ENST00000538657.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr6_+_12008986 0.106 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr7_+_120628731 0.105 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr1_+_16085263 0.105 ENST00000483633.2
ENST00000502739.1
ENST00000431771.2
FBLIM1


filamin binding LIM protein 1


chr2_-_74781061 0.104 ENST00000264094.3
ENST00000393937.2
ENST00000409986.1
LOXL3


lysyl oxidase-like 3


chr9_+_116638630 0.104 ENST00000452710.1
ENST00000374124.4
ZNF618

zinc finger protein 618

chr12_-_31477072 0.103 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr1_-_156051789 0.101 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr3_+_141105235 0.101 ENST00000503809.1
ZBTB38
zinc finger and BTB domain containing 38
chr12_-_81763184 0.099 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2


protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


chr9_+_82186872 0.099 ENST00000376544.3
ENST00000376520.4
TLE4

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

chr1_-_213020991 0.098 ENST00000332912.3
C1orf227
chromosome 1 open reading frame 227
chrX_-_138724677 0.098 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2


MCF.2 cell line derived transforming sequence


chr1_+_144339738 0.098 ENST00000538264.1
AL592284.1
Protein LOC642441
chr12_+_54422142 0.098 ENST00000243108.4
HOXC6
homeobox C6
chr15_-_72564906 0.097 ENST00000566844.1
PARP6
poly (ADP-ribose) polymerase family, member 6
chr5_+_132009675 0.096 ENST00000231449.2
ENST00000350025.2
IL4

interleukin 4

chr2_+_172950227 0.096 ENST00000341900.6
DLX1
distal-less homeobox 1
chr2_-_100721801 0.096 ENST00000424600.1
ENST00000441400.1
AFF3

AF4/FMR2 family, member 3

chr13_+_32605437 0.095 ENST00000380250.3
FRY
furry homolog (Drosophila)
chr3_+_39509070 0.094 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
MOBP





myelin-associated oligodendrocyte basic protein





chr7_+_20370746 0.093 ENST00000222573.4
ITGB8
integrin, beta 8
chr12_+_79258547 0.093 ENST00000457153.2
SYT1
synaptotagmin I
chr7_+_20370300 0.090 ENST00000537992.1
ITGB8
integrin, beta 8
chr11_-_6677018 0.090 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr21_+_30672433 0.090 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr19_+_13906250 0.090 ENST00000254323.2
ZSWIM4
zinc finger, SWIM-type containing 4
chr3_-_134093395 0.089 ENST00000249883.5
AMOTL2
angiomotin like 2
chr18_-_52989525 0.089 ENST00000457482.3
TCF4
transcription factor 4
chr3_-_71353892 0.089 ENST00000484350.1
FOXP1
forkhead box P1
chr9_+_128510454 0.089 ENST00000491787.3
ENST00000447726.2
PBX3

pre-B-cell leukemia homeobox 3

chr14_+_75746664 0.088 ENST00000557139.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr18_-_53089538 0.087 ENST00000566777.1
TCF4
transcription factor 4
chrX_-_39956656 0.087 ENST00000397354.3
ENST00000378444.4
BCOR

BCL6 corepressor

chr17_-_44896047 0.086 ENST00000225512.5
WNT3
wingless-type MMTV integration site family, member 3
chr3_+_151531810 0.086 ENST00000232892.7
AADAC
arylacetamide deacetylase
chr5_+_36606992 0.086 ENST00000505202.1
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr12_-_81763127 0.085 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr17_-_38020392 0.085 ENST00000346872.3
ENST00000439167.2
ENST00000377945.3
ENST00000394189.2
ENST00000377944.3
ENST00000377958.2
ENST00000535189.1
ENST00000377952.2
IKZF3







IKAROS family zinc finger 3 (Aiolos)







chr7_-_84121858 0.085 ENST00000448879.1
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr1_+_110026544 0.084 ENST00000369870.3
ATXN7L2
ataxin 7-like 2
chr18_+_55712915 0.082 ENST00000592846.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr12_+_9067123 0.082 ENST00000543824.1
PHC1
polyhomeotic homolog 1 (Drosophila)
chr4_-_109090106 0.081 ENST00000379951.2
LEF1
lymphoid enhancer-binding factor 1
chr14_-_81425828 0.081 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
CEP128


centrosomal protein 128kDa


chr17_-_41738931 0.080 ENST00000329168.3
ENST00000549132.1
MEOX1

mesenchyme homeobox 1

chr17_+_38337491 0.080 ENST00000538981.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chr10_-_126138622 0.080 ENST00000451024.3
NKX1-2
NK1 homeobox 2
chr4_-_157892498 0.079 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr14_+_65182395 0.079 ENST00000554088.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr2_+_11679963 0.079 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr9_+_116638562 0.078 ENST00000374126.5
ENST00000288466.7
ZNF618

zinc finger protein 618

chr12_-_16761117 0.077 ENST00000538051.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr5_+_34757309 0.077 ENST00000397449.1
RAI14
retinoic acid induced 14
chr18_-_53019208 0.077 ENST00000562607.1
TCF4
transcription factor 4
chr17_-_41623691 0.076 ENST00000545954.1
ETV4
ets variant 4
chr9_-_4299874 0.076 ENST00000381971.3
ENST00000477901.1
GLIS3

GLIS family zinc finger 3

chr3_-_134093738 0.076 ENST00000506107.1
AMOTL2
angiomotin like 2
chr2_+_27665289 0.076 ENST00000407293.1
KRTCAP3
keratinocyte associated protein 3
chr3_+_119013185 0.076 ENST00000264245.4
ARHGAP31
Rho GTPase activating protein 31
chr17_-_7297833 0.076 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3



TMEM256-PLSCR3 readthrough (NMD candidate)



chr3_+_29322933 0.076 ENST00000273139.9
ENST00000383766.2
RBMS3

RNA binding motif, single stranded interacting protein 3

chr15_-_70388943 0.076 ENST00000559048.1
ENST00000560939.1
ENST00000440567.3
ENST00000557907.1
ENST00000558379.1
ENST00000451782.2
ENST00000559929.1
TLE3






transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)






chr6_-_134639042 0.076 ENST00000461976.2
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_122240792 0.075 ENST00000541657.1
ENST00000545885.1
ENST00000542933.1
ENST00000428029.2
ENST00000541694.1
ENST00000536662.1
ENST00000535643.1
RHOF
AC084018.1





ras homolog family member F (in filopodia)
AC084018.1





chr2_-_97534312 0.075 ENST00000442264.1
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr18_+_9136758 0.074 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12


ankyrin repeat domain 12


chr4_+_146403912 0.074 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
SMAD1


SMAD family member 1


chr21_+_17443521 0.073 ENST00000456342.1
LINC00478
long intergenic non-protein coding RNA 478
chr3_+_29322803 0.073 ENST00000396583.3
ENST00000383767.2
RBMS3

RNA binding motif, single stranded interacting protein 3

chr12_-_95611149 0.073 ENST00000549499.1
ENST00000343958.4
ENST00000546711.1
FGD6


FYVE, RhoGEF and PH domain containing 6


chr3_-_47823298 0.073 ENST00000254480.5
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr8_+_85095553 0.073 ENST00000521268.1
RALYL
RALY RNA binding protein-like
chr3_-_71777824 0.073 ENST00000469524.1
EIF4E3
eukaryotic translation initiation factor 4E family member 3
chrX_-_45629661 0.072 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2

RP6-99M1.2

chr11_+_114128522 0.072 ENST00000535401.1
NNMT
nicotinamide N-methyltransferase
chr17_-_41623716 0.072 ENST00000319349.5
ETV4
ets variant 4
chr17_+_38673270 0.071 ENST00000578280.1
RP5-1028K7.2
RP5-1028K7.2
chr19_-_50316517 0.071 ENST00000313777.4
ENST00000445575.2
FUZ

fuzzy planar cell polarity protein

chr18_+_55888767 0.071 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase


chr4_-_109089573 0.071 ENST00000265165.1
LEF1
lymphoid enhancer-binding factor 1
chr1_+_66796401 0.070 ENST00000528771.1
PDE4B
phosphodiesterase 4B, cAMP-specific
chr12_-_122018114 0.070 ENST00000539394.1
KDM2B
lysine (K)-specific demethylase 2B
chr18_+_72922710 0.070 ENST00000322038.5
TSHZ1
teashirt zinc finger homeobox 1
chr20_-_23066953 0.069 ENST00000246006.4
CD93
CD93 molecule
chr11_-_58378759 0.069 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr3_+_141106643 0.069 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_+_11539204 0.069 ENST00000294484.6
ENST00000389575.3
PTCHD2

patched domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 0.5 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.1 0.3 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.1 0.6 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.3 GO:2001037 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.2 GO:0032242 regulation of nucleoside transport(GO:0032242)
0.1 0.3 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 0.2 GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1 0.2 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.2 GO:0031133 cellular magnesium ion homeostasis(GO:0010961) regulation of axon diameter(GO:0031133)
0.1 0.2 GO:0090299 regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.0 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.6 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.5 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.4 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.0 0.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
0.0 0.3 GO:0021546 rhombomere development(GO:0021546)
0.0 0.1 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 0.1 GO:0009956 radial pattern formation(GO:0009956)
0.0 0.1 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.1 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 0.1 GO:0071288 cellular response to mercury ion(GO:0071288)
0.0 0.1 GO:0061075 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.1 GO:0003192 mitral valve formation(GO:0003192)
0.0 0.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.1 GO:0007388 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.0 0.2 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0 0.2 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0 0.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.0 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.1 GO:1902910 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.0 0.1 GO:0000415 negative regulation of histone H3-K36 methylation(GO:0000415)
0.0 0.1 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0 0.2 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 0.3 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.0 0.0 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.2 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.2 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.0 0.1 GO:0007499 ectoderm and mesoderm interaction(GO:0007499) female genitalia morphogenesis(GO:0048807) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529)
0.0 0.1 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.0 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.0 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.1 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.0 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.2 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.0 GO:1903625 negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.0 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.4 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1 0.2 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.1 0.2 GO:0042585 female germ cell nucleus(GO:0001674) germinal vesicle(GO:0042585)
0.0 0.6 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.2 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.0 0.6 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 0.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.0 GO:0044305 calyx of Held(GO:0044305)
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0034711 inhibin binding(GO:0034711)
0.1 0.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.1 GO:0072591 citrate-L-glutamate ligase activity(GO:0072591)
0.0 0.3 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.5 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.3 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0030350 iron-responsive element binding(GO:0030350)
0.0 0.2 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.1 GO:0019150 D-ribulokinase activity(GO:0019150)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.0 0.2 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.0 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.0 0.1 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0070513 death domain binding(GO:0070513)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.0 GO:1904713 beta-catenin destruction complex binding(GO:1904713)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0030348 syntaxin-3 binding(GO:0030348)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.8 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion