Motif ID: KLF12

Z-value: 0.985


Transcription factors associated with KLF12:

Gene SymbolEntrez IDGene Name
KLF12 ENSG00000118922.12 KLF12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
KLF12hg19_v2_chr13_-_74708372_74708409-0.127.6e-01Click!


Activity profile for motif KLF12.

activity profile for motif KLF12


Sorted Z-values histogram for motif KLF12

Sorted Z-values for motif KLF12



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_46716969 2.074 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_47841485 1.209 ENST00000506156.1
ENST00000240364.2
FAM117A

family with sequence similarity 117, member A

chr13_-_36429763 1.090 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr1_+_153750622 0.916 ENST00000532853.1
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr12_+_72666407 0.906 ENST00000261180.4
TRHDE
thyrotropin-releasing hormone degrading enzyme
chr14_+_63671105 0.895 ENST00000316754.3
RHOJ
ras homolog family member J
chr6_+_116832789 0.859 ENST00000368599.3
FAM26E
family with sequence similarity 26, member E
chr11_+_117070037 0.792 ENST00000392951.4
ENST00000525531.1
ENST00000278968.6
TAGLN


transgelin


chr9_-_117568365 0.761 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr20_+_44637526 0.747 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr17_+_1665345 0.737 ENST00000576406.1
ENST00000571149.1
SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

chr14_+_63671577 0.731 ENST00000555125.1
RHOJ
ras homolog family member J
chr11_-_5323226 0.722 ENST00000380224.1
OR51B4
olfactory receptor, family 51, subfamily B, member 4
chr7_-_137039191 0.706 ENST00000438969.2
AC078842.3
AC078842.3
chr11_+_7534999 0.704 ENST00000528947.1
ENST00000299492.4
PPFIBP2

PTPRF interacting protein, binding protein 2 (liprin beta 2)

chr1_-_49242553 0.693 ENST00000371833.3
BEND5
BEN domain containing 5
chr12_+_54379569 0.676 ENST00000513209.1
RP11-834C11.12
RP11-834C11.12
chr5_+_167181917 0.639 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr6_-_138833630 0.598 ENST00000533765.1
NHSL1
NHS-like 1
chr5_+_167182003 0.582 ENST00000520394.1
TENM2
teneurin transmembrane protein 2
chrX_-_112084043 0.566 ENST00000304758.1
AMOT
angiomotin
chrX_-_84634708 0.564 ENST00000373145.3
POF1B
premature ovarian failure, 1B
chr1_-_55341551 0.562 ENST00000537443.1
DHCR24
24-dehydrocholesterol reductase
chr2_-_73511407 0.561 ENST00000520530.2
FBXO41
F-box protein 41
chr6_-_138820624 0.547 ENST00000343505.5
NHSL1
NHS-like 1
chr2_-_74780176 0.538 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr17_+_1665306 0.526 ENST00000571360.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr16_+_87636474 0.521 ENST00000284262.2
JPH3
junctophilin 3
chr9_+_35673853 0.514 ENST00000378357.4
CA9
carbonic anhydrase IX
chr14_+_52313833 0.497 ENST00000553560.1
GNG2
guanine nucleotide binding protein (G protein), gamma 2
chr11_-_568369 0.494 ENST00000534540.1
ENST00000528245.1
ENST00000500447.1
ENST00000533920.1
MIR210HG



MIR210 host gene (non-protein coding)



chr1_-_45672221 0.488 ENST00000359600.5
ZSWIM5
zinc finger, SWIM-type containing 5
chrX_-_84634737 0.478 ENST00000262753.4
POF1B
premature ovarian failure, 1B
chr5_+_34656331 0.470 ENST00000265109.3
RAI14
retinoic acid induced 14
chr19_-_5785630 0.464 ENST00000590343.1
ENST00000586012.1
DUS3L
CTB-54O9.9
dihydrouridine synthase 3-like (S. cerevisiae)
Uncharacterized protein
chr16_+_30194916 0.462 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
CORO1A


coronin, actin binding protein, 1A


chr19_-_55686399 0.456 ENST00000587067.1
SYT5
synaptotagmin V
chr2_+_74710194 0.454 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31


tetratricopeptide repeat domain 31


chr2_+_89952792 0.446 ENST00000390265.2
IGKV1D-33
immunoglobulin kappa variable 1D-33
chr19_+_48898132 0.436 ENST00000263269.3
GRIN2D
glutamate receptor, ionotropic, N-methyl D-aspartate 2D
chr5_-_19988288 0.435 ENST00000502796.1
ENST00000511273.1
CDH18

cadherin 18, type 2

chr2_-_225266743 0.427 ENST00000409685.3
FAM124B
family with sequence similarity 124B
chr16_-_67978016 0.424 ENST00000264005.5
LCAT
lecithin-cholesterol acyltransferase
chr3_-_8686479 0.423 ENST00000544814.1
ENST00000427408.1
SSUH2

ssu-2 homolog (C. elegans)

chr3_+_29322803 0.418 ENST00000396583.3
ENST00000383767.2
RBMS3

RNA binding motif, single stranded interacting protein 3

chr20_-_31071239 0.406 ENST00000359676.5
C20orf112
chromosome 20 open reading frame 112
chr5_+_34656529 0.405 ENST00000513974.1
ENST00000512629.1
RAI14

retinoic acid induced 14

chr8_+_21914477 0.401 ENST00000517804.1
DMTN
dematin actin binding protein
chr8_+_21914348 0.396 ENST00000520174.1
DMTN
dematin actin binding protein
chr14_+_65170820 0.390 ENST00000555982.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr5_+_34656569 0.389 ENST00000428746.2
RAI14
retinoic acid induced 14
chr5_-_19988339 0.381 ENST00000382275.1
CDH18
cadherin 18, type 2
chr3_+_46924829 0.381 ENST00000313049.5
PTH1R
parathyroid hormone 1 receptor
chr15_+_90118723 0.373 ENST00000560985.1
TICRR
TOPBP1-interacting checkpoint and replication regulator
chr17_-_8534067 0.373 ENST00000360416.3
ENST00000269243.4
MYH10

myosin, heavy chain 10, non-muscle

chr15_+_90118685 0.373 ENST00000268138.7
TICRR
TOPBP1-interacting checkpoint and replication regulator
chr2_+_90458201 0.370 ENST00000603238.1
CH17-132F21.1
Uncharacterized protein
chr14_+_65171315 0.365 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr17_-_8534031 0.363 ENST00000411957.1
ENST00000396239.1
ENST00000379980.4
MYH10


myosin, heavy chain 10, non-muscle


chr7_+_140373619 0.357 ENST00000483369.1
ADCK2
aarF domain containing kinase 2
chr20_+_61867235 0.355 ENST00000342412.6
ENST00000217169.3
BIRC7

baculoviral IAP repeat containing 7

chr5_+_34656450 0.354 ENST00000514527.1
RAI14
retinoic acid induced 14
chr1_-_159832438 0.354 ENST00000368100.1
VSIG8
V-set and immunoglobulin domain containing 8
chr2_-_74779744 0.349 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr6_-_134639180 0.348 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr4_-_107957454 0.342 ENST00000285311.3
DKK2
dickkopf WNT signaling pathway inhibitor 2
chr12_-_82153087 0.337 ENST00000547623.1
ENST00000549396.1
PPFIA2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr2_-_65659762 0.331 ENST00000440972.1
SPRED2
sprouty-related, EVH1 domain containing 2
chr9_-_134151915 0.326 ENST00000372271.3
FAM78A
family with sequence similarity 78, member A
chr2_+_220495800 0.325 ENST00000413743.1
SLC4A3
solute carrier family 4 (anion exchanger), member 3
chr7_+_18329712 0.325 ENST00000433709.2
HDAC9
histone deacetylase 9
chr1_+_16083154 0.324 ENST00000375771.1
FBLIM1
filamin binding LIM protein 1
chr3_-_133614467 0.323 ENST00000469959.1
RAB6B
RAB6B, member RAS oncogene family
chr8_-_7320974 0.323 ENST00000528943.1
ENST00000359758.5
ENST00000361111.2
ENST00000398462.2
ENST00000297498.2
ENST00000317900.5
SPAG11B





sperm associated antigen 11B





chr20_-_36794902 0.323 ENST00000373403.3
TGM2
transglutaminase 2
chr17_-_2117600 0.318 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr12_-_54778444 0.312 ENST00000551771.1
ZNF385A
zinc finger protein 385A
chr12_-_54778471 0.312 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
ZNF385A


zinc finger protein 385A


chr8_+_7705398 0.311 ENST00000400125.2
ENST00000434307.2
ENST00000326558.5
ENST00000351436.4
ENST00000528033.1
SPAG11A




sperm associated antigen 11A




chr12_+_79258547 0.311 ENST00000457153.2
SYT1
synaptotagmin I
chr12_-_120907459 0.308 ENST00000229390.3
SRSF9
serine/arginine-rich splicing factor 9
chr20_-_36794938 0.308 ENST00000453095.1
TGM2
transglutaminase 2
chr9_+_126131131 0.305 ENST00000373629.2
CRB2
crumbs homolog 2 (Drosophila)
chr12_-_71148413 0.304 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
PTPRR


protein tyrosine phosphatase, receptor type, R


chr10_-_75401500 0.302 ENST00000359322.4
MYOZ1
myozenin 1
chr16_+_89168753 0.301 ENST00000544543.1
ACSF3
acyl-CoA synthetase family member 3
chrX_-_118739835 0.299 ENST00000542113.1
ENST00000304449.5
NKRF

NFKB repressing factor

chr5_+_74632993 0.297 ENST00000287936.4
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
chr5_+_74633036 0.296 ENST00000343975.5
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
chr12_-_121973974 0.296 ENST00000538379.1
ENST00000541318.1
ENST00000541511.1
KDM2B


lysine (K)-specific demethylase 2B


chr6_-_134639042 0.294 ENST00000461976.2
SGK1
serum/glucocorticoid regulated kinase 1
chr14_+_77425972 0.294 ENST00000553613.1
RP11-7F17.7
RP11-7F17.7
chr13_-_30160925 0.292 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr11_-_47400062 0.290 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr19_+_41094612 0.283 ENST00000595726.1
SHKBP1
SH3KBP1 binding protein 1
chr11_-_47399942 0.282 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr17_+_7211280 0.282 ENST00000419711.2
ENST00000571955.1
ENST00000573714.1
EIF5A


eukaryotic translation initiation factor 5A


chr12_-_71148357 0.278 ENST00000378778.1
PTPRR
protein tyrosine phosphatase, receptor type, R
chr14_+_65171099 0.277 ENST00000247226.7
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr1_+_53068020 0.270 ENST00000361314.4
GPX7
glutathione peroxidase 7
chr6_+_99282570 0.270 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr12_-_120907374 0.267 ENST00000550458.1
SRSF9
serine/arginine-rich splicing factor 9
chr17_+_1665253 0.265 ENST00000254722.4
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_+_150229554 0.263 ENST00000369111.4
CA14
carbonic anhydrase XIV
chr16_+_89168993 0.262 ENST00000538340.1
ENST00000543676.1
ACSF3

acyl-CoA synthetase family member 3

chr1_+_109792641 0.259 ENST00000271332.3
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2
chr15_+_74218787 0.258 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr3_+_159481988 0.257 ENST00000472451.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr12_+_79258444 0.257 ENST00000261205.4
SYT1
synaptotagmin I
chr3_-_99833333 0.256 ENST00000354552.3
ENST00000331335.5
ENST00000398326.2
FILIP1L


filamin A interacting protein 1-like


chr19_+_36602104 0.251 ENST00000585332.1
ENST00000262637.4
OVOL3

ovo-like zinc finger 3

chr19_+_45174994 0.251 ENST00000403660.3
CEACAM19
carcinoembryonic antigen-related cell adhesion molecule 19
chr5_-_180632293 0.245 ENST00000334421.5
TRIM7
tripartite motif containing 7
chr2_-_220435963 0.244 ENST00000373876.1
ENST00000404537.1
ENST00000603926.1
ENST00000373873.4
ENST00000289656.3
OBSL1




obscurin-like 1




chr19_+_45312347 0.243 ENST00000270233.6
ENST00000591520.1
BCAM

basal cell adhesion molecule (Lutheran blood group)

chr2_-_225266711 0.241 ENST00000389874.3
FAM124B
family with sequence similarity 124B
chr1_-_213020991 0.237 ENST00000332912.3
C1orf227
chromosome 1 open reading frame 227
chr17_+_7210852 0.236 ENST00000576930.1
EIF5A
eukaryotic translation initiation factor 5A
chr16_+_1291240 0.232 ENST00000561736.1
TPSAB1
tryptase alpha/beta 1
chr10_+_81272287 0.232 ENST00000520547.2
EIF5AL1
eukaryotic translation initiation factor 5A-like 1
chr4_-_185570590 0.232 ENST00000517513.1
ENST00000447121.2
ENST00000393588.4
ENST00000308394.4
ENST00000523916.1
CASP3




caspase 3, apoptosis-related cysteine peptidase




chr20_-_31071309 0.230 ENST00000326071.4
C20orf112
chromosome 20 open reading frame 112
chr19_+_45174724 0.229 ENST00000358777.4
CEACAM19
carcinoembryonic antigen-related cell adhesion molecule 19
chr11_+_1463728 0.225 ENST00000544817.1
BRSK2
BR serine/threonine kinase 2
chr3_-_51994694 0.223 ENST00000395014.2
PCBP4
poly(rC) binding protein 4
chr7_+_143013198 0.221 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr10_-_71906342 0.221 ENST00000287078.6
ENST00000335494.5
TYSND1

trypsin domain containing 1

chr17_+_7210921 0.219 ENST00000573542.1
EIF5A
eukaryotic translation initiation factor 5A
chr3_+_29322851 0.219 ENST00000445033.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr1_+_110036674 0.218 ENST00000393709.3
CYB561D1
cytochrome b561 family, member D1
chr1_+_86064794 0.218 ENST00000426794.1
RP11-290M5.2
RP11-290M5.2
chr18_-_53253000 0.217 ENST00000566514.1
TCF4
transcription factor 4
chr16_-_103572 0.216 ENST00000293860.5
POLR3K
polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
chr15_-_75230368 0.215 ENST00000564811.1
ENST00000562233.1
ENST00000567270.1
ENST00000568783.1
COX5A



cytochrome c oxidase subunit Va



chr2_-_225266802 0.215 ENST00000243806.2
FAM124B
family with sequence similarity 124B
chr17_+_7210898 0.214 ENST00000572815.1
EIF5A
eukaryotic translation initiation factor 5A
chr12_+_121416489 0.212 ENST00000541395.1
ENST00000544413.1
HNF1A

HNF1 homeobox A

chr17_-_16256718 0.212 ENST00000476243.1
ENST00000299736.4
CENPV

centromere protein V

chrX_+_71354000 0.211 ENST00000510661.1
ENST00000535692.1
NHSL2

NHS-like 2

chr3_-_133614597 0.211 ENST00000285208.4
ENST00000460865.3
RAB6B

RAB6B, member RAS oncogene family

chr19_-_45909585 0.211 ENST00000593226.1
ENST00000418234.2
PPP1R13L

protein phosphatase 1, regulatory subunit 13 like

chr5_+_72509751 0.209 ENST00000515556.1
ENST00000513379.1
ENST00000427584.2
RP11-60A8.1


RP11-60A8.1


chr3_+_29322933 0.209 ENST00000273139.9
ENST00000383766.2
RBMS3

RNA binding motif, single stranded interacting protein 3

chr10_+_99473455 0.207 ENST00000285605.6
MARVELD1
MARVEL domain containing 1
chr11_-_93583697 0.207 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr17_+_1633755 0.205 ENST00000545662.1
WDR81
WD repeat domain 81
chr3_-_113415441 0.205 ENST00000491165.1
ENST00000316407.4
KIAA2018

KIAA2018

chr2_+_173724771 0.202 ENST00000538974.1
ENST00000540783.1
RAPGEF4

Rap guanine nucleotide exchange factor (GEF) 4

chr17_+_17584763 0.199 ENST00000353383.1
RAI1
retinoic acid induced 1
chr11_+_61159832 0.197 ENST00000334888.5
ENST00000398979.3
TMEM216

transmembrane protein 216

chr17_+_17942594 0.197 ENST00000268719.4
GID4
GID complex subunit 4
chr17_+_8191815 0.196 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
RANGRF



RAN guanine nucleotide release factor



chr6_-_111804393 0.194 ENST00000368802.3
ENST00000368805.1
REV3L

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

chr10_+_104155450 0.193 ENST00000471698.1
ENST00000189444.6
NFKB2

nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

chr15_-_75134992 0.193 ENST00000568667.1
ULK3
unc-51 like kinase 3
chr3_-_52002194 0.193 ENST00000466412.1
PCBP4
poly(rC) binding protein 4
chr3_-_52567792 0.193 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2


5'-nucleotidase domain containing 2


chr9_-_34637718 0.191 ENST00000378892.1
ENST00000277010.4
SIGMAR1

sigma non-opioid intracellular receptor 1

chr22_-_24110063 0.190 ENST00000520222.1
ENST00000401675.3
CHCHD10

coiled-coil-helix-coiled-coil-helix domain containing 10

chr16_-_67360662 0.188 ENST00000304372.5
KCTD19
potassium channel tetramerization domain containing 19
chr6_-_130536774 0.188 ENST00000532763.1
SAMD3
sterile alpha motif domain containing 3
chr2_-_25565377 0.184 ENST00000264709.3
ENST00000406659.3
DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha

chr1_+_153600869 0.183 ENST00000292169.1
ENST00000368696.3
ENST00000436839.1
S100A1


S100 calcium binding protein A1


chr3_-_149688502 0.182 ENST00000481767.1
ENST00000475518.1
PFN2

profilin 2

chr17_-_47045949 0.182 ENST00000357424.2
GIP
gastric inhibitory polypeptide
chr16_+_3019246 0.181 ENST00000318782.8
ENST00000293978.8
PAQR4

progestin and adipoQ receptor family member IV

chr15_-_75230478 0.180 ENST00000322347.6
COX5A
cytochrome c oxidase subunit Va
chr12_+_106994905 0.180 ENST00000357881.4
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr1_-_155177677 0.180 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3


thrombospondin 3


chr11_-_47400078 0.179 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr16_+_85204882 0.178 ENST00000574293.1
CTC-786C10.1
CTC-786C10.1
chr8_+_145086574 0.178 ENST00000377470.3
ENST00000447830.2
SPATC1

spermatogenesis and centriole associated 1

chr14_-_65346555 0.175 ENST00000542895.1
ENST00000556626.1
SPTB

spectrin, beta, erythrocytic

chr16_+_67360712 0.175 ENST00000569499.2
ENST00000329956.6
ENST00000561948.1
LRRC36


leucine rich repeat containing 36


chr12_+_121416340 0.174 ENST00000257555.6
ENST00000400024.2
HNF1A

HNF1 homeobox A

chr3_-_133614421 0.174 ENST00000543906.1
RAB6B
RAB6B, member RAS oncogene family
chr6_+_72596406 0.171 ENST00000491071.2
RIMS1
regulating synaptic membrane exocytosis 1
chr13_+_28712614 0.171 ENST00000380958.3
PAN3
PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr10_-_81205373 0.170 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr1_+_110036728 0.169 ENST00000369868.3
ENST00000430195.2
CYB561D1

cytochrome b561 family, member D1

chr11_-_65374430 0.168 ENST00000532507.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr1_+_110036699 0.167 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
CYB561D1





cytochrome b561 family, member D1





chr2_-_89568263 0.167 ENST00000473726.1
IGKV1-33
immunoglobulin kappa variable 1-33
chr15_+_40763150 0.166 ENST00000306243.5
ENST00000559991.1
CHST14

carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14

chr9_-_34637806 0.166 ENST00000477726.1
SIGMAR1
sigma non-opioid intracellular receptor 1
chr7_-_127032114 0.166 ENST00000436992.1
ZNF800
zinc finger protein 800
chr12_+_118573663 0.165 ENST00000261313.2
PEBP1
phosphatidylethanolamine binding protein 1
chr3_-_61237050 0.165 ENST00000476844.1
ENST00000488467.1
ENST00000492590.1
ENST00000468189.1
FHIT



fragile histidine triad



chr19_+_10812108 0.162 ENST00000250237.5
ENST00000592254.1
QTRT1

queuine tRNA-ribosyltransferase 1

chr7_-_27702455 0.162 ENST00000265395.2
HIBADH
3-hydroxyisobutyrate dehydrogenase
chrX_+_152953505 0.161 ENST00000253122.5
SLC6A8
solute carrier family 6 (neurotransmitter transporter), member 8
chr19_+_41092680 0.158 ENST00000594298.1
ENST00000597396.1
SHKBP1

SH3KBP1 binding protein 1

chr15_+_64428529 0.157 ENST00000560861.1
SNX1
sorting nexin 1
chr9_+_131445703 0.156 ENST00000454747.1
SET
SET nuclear oncogene
chr11_-_119247004 0.156 ENST00000531070.1
USP2
ubiquitin specific peptidase 2
chr7_-_65447192 0.156 ENST00000421103.1
ENST00000345660.6
ENST00000304895.4
GUSB


glucuronidase, beta


chr10_-_77161650 0.155 ENST00000372524.4
ZNF503
zinc finger protein 503
chr1_-_203144941 0.154 ENST00000255416.4
MYBPH
myosin binding protein H
chr13_-_100624012 0.153 ENST00000267294.4
ZIC5
Zic family member 5
chr12_-_54778244 0.152 ENST00000549937.1
ZNF385A
zinc finger protein 385A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.2 0.6 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.2 0.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.2 0.9 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.1 0.6 GO:0090410 malonate catabolic process(GO:0090410)
0.1 0.4 GO:0035623 renal glucose absorption(GO:0035623)
0.1 1.2 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.1 1.0 GO:0021592 fourth ventricle development(GO:0021592)
0.1 0.6 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.1 1.6 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 1.1 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.8 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.1 0.6 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1 0.6 GO:0033490 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1 0.7 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.5 GO:0032796 uropod organization(GO:0032796)
0.1 0.3 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.1 0.4 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.1 0.6 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 2.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.8 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.7 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.3 GO:0018277 protein deamination(GO:0018277)
0.1 0.3 GO:0014028 notochord formation(GO:0014028)
0.1 0.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 1.2 GO:0097264 self proteolysis(GO:0097264)
0.1 0.2 GO:0015881 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.1 0.2 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.2 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.2 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
0.0 0.5 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.1 GO:1903216 regulation of protein processing involved in protein targeting to mitochondrion(GO:1903216) negative regulation of protein processing involved in protein targeting to mitochondrion(GO:1903217)
0.0 0.1 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.0 0.6 GO:0010666 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0 0.6 GO:0060453 regulation of gastric acid secretion(GO:0060453)
0.0 0.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.5 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.3 GO:1903826 arginine transmembrane transport(GO:1903826)
0.0 0.1 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.2 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 0.2 GO:0032484 Ral protein signal transduction(GO:0032484) regulation of Ral protein signal transduction(GO:0032485)
0.0 0.1 GO:0072287 metanephric distal tubule morphogenesis(GO:0072287)
0.0 0.1 GO:0033058 directional locomotion(GO:0033058)
0.0 0.1 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.2 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.3 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.2 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847) protein auto-ADP-ribosylation(GO:0070213)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.3 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.4 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.5 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.2 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.6 GO:0035640 exploration behavior(GO:0035640)
0.0 0.2 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0 0.1 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.2 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:1902725 negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.4 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.9 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.4 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.0 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.0 0.1 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.3 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.0 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.1 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.1 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.5 GO:0001964 startle response(GO:0001964)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0060346 bone trabecula formation(GO:0060346)
0.0 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.0 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.1 GO:0033484 nitric oxide homeostasis(GO:0033484)
0.0 0.0 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466)
0.0 0.1 GO:1990822 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.0 0.3 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.0 0.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.0 0.2 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.1 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:0002432 granuloma formation(GO:0002432)
0.0 0.1 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0097513 myosin II filament(GO:0097513)
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.5 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.6 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 1.5 GO:0043203 axon hillock(GO:0043203)
0.1 0.9 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.3 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.0 0.2 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.0 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.2 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 1.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0008623 CHRAC(GO:0008623)
0.0 1.0 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.1 GO:0002133 polycystin complex(GO:0002133)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.4 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0090409 malonyl-CoA synthetase activity(GO:0090409)
0.1 0.4 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.1 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 0.2 GO:0005055 laminin receptor activity(GO:0005055)
0.1 0.6 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.8 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.4 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 0.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.3 GO:0051373 FATZ binding(GO:0051373)
0.1 0.2 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.1 0.2 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.1 0.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0004096 catalase activity(GO:0004096)
0.0 0.5 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.6 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0004566 beta-glucuronidase activity(GO:0004566)
0.0 0.1 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0004324 ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731)
0.0 0.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.0 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.2 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0 0.2 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.6 GO:0070402 NADPH binding(GO:0070402)
0.0 0.1 GO:0016520 growth hormone-releasing hormone receptor activity(GO:0016520)
0.0 0.1 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.0 0.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.2 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.0 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.0 0.7 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 0.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.1 GO:0003880 protein C-terminal carboxyl O-methyltransferase activity(GO:0003880)
0.0 0.3 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 0.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 2.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.2 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.0 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 3.2 GO:0051015 actin filament binding(GO:0051015)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 1.0 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.6 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.7 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)