Motif ID: IRX3

Z-value: 0.457


Transcription factors associated with IRX3:

Gene SymbolEntrez IDGene Name
IRX3 ENSG00000177508.11 IRX3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
IRX3hg19_v2_chr16_-_54320675_54320715-0.818.0e-03Click!


Activity profile for motif IRX3.

activity profile for motif IRX3


Sorted Z-values histogram for motif IRX3

Sorted Z-values for motif IRX3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_233527443 0.783 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr1_+_220863187 0.599 ENST00000294889.5
C1orf115
chromosome 1 open reading frame 115
chr2_-_136875712 0.496 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr4_-_75695366 0.488 ENST00000512743.1
BTC
betacellulin
chr19_-_22379753 0.454 ENST00000397121.2
ZNF676
zinc finger protein 676
chr1_+_171060018 0.438 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3




flavin containing monooxygenase 3




chr12_-_10007448 0.417 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr5_+_140566 0.413 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr1_+_207070775 0.388 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24


interleukin 24


chr19_-_44388116 0.382 ENST00000587539.1
ZNF404
zinc finger protein 404
chr6_+_116782527 0.379 ENST00000368606.3
ENST00000368605.1
FAM26F

family with sequence similarity 26, member F

chr6_-_47009996 0.378 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr3_-_169487617 0.371 ENST00000330368.2
ACTRT3
actin-related protein T3
chr2_+_33661382 0.366 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr10_-_61122220 0.348 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C






family with sequence similarity 13, member C






chr5_+_32788945 0.346 ENST00000326958.1
AC026703.1
AC026703.1
chr12_+_71833550 0.346 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr7_+_139529040 0.346 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr15_+_81225699 0.343 ENST00000560027.1
KIAA1199
KIAA1199
chr7_+_139528952 0.338 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr20_+_10199468 0.334 ENST00000254976.2
ENST00000304886.2
SNAP25

synaptosomal-associated protein, 25kDa

chr10_+_60272814 0.333 ENST00000373886.3
BICC1
bicaudal C homolog 1 (Drosophila)
chr1_+_31883048 0.329 ENST00000536859.1
SERINC2
serine incorporator 2
chr4_+_75480629 0.329 ENST00000380846.3
AREGB
amphiregulin B
chr17_-_29641104 0.321 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr6_+_71104588 0.316 ENST00000418403.1
RP11-462G2.1
RP11-462G2.1
chr17_-_29641084 0.304 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr2_-_202483867 0.301 ENST00000439802.1
ENST00000286195.3
ENST00000439140.1
ENST00000450242.1
ALS2CR11



amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11



chr3_+_173116225 0.293 ENST00000457714.1
NLGN1
neuroligin 1
chr16_+_19421803 0.285 ENST00000541464.1
TMC5
transmembrane channel-like 5
chr2_-_16804320 0.270 ENST00000355549.2
FAM49A
family with sequence similarity 49, member A
chr10_+_5090940 0.254 ENST00000602997.1
AKR1C3
aldo-keto reductase family 1, member C3
chr20_+_10199566 0.253 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chrX_-_55291163 0.251 ENST00000519203.1
ENST00000374951.1
PAGE3

P antigen family, member 3 (prostate associated)

chr12_-_10978957 0.250 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr2_-_228579305 0.245 ENST00000456524.1
SLC19A3
solute carrier family 19 (thiamine transporter), member 3
chr17_+_25958174 0.244 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
LGALS9



lectin, galactoside-binding, soluble, 9



chr4_+_71091786 0.243 ENST00000317987.5
FDCSP
follicular dendritic cell secreted protein
chr2_-_145275109 0.242 ENST00000431672.2
ZEB2
zinc finger E-box binding homeobox 2
chr3_-_93747425 0.239 ENST00000315099.2
STX19
syntaxin 19
chr19_-_43708378 0.238 ENST00000599746.1
PSG4
pregnancy specific beta-1-glycoprotein 4
chr7_-_92777606 0.230 ENST00000437805.1
ENST00000446959.1
ENST00000439952.1
ENST00000414791.1
ENST00000446033.1
ENST00000411955.1
ENST00000318238.4
SAMD9L






sterile alpha motif domain containing 9-like






chr8_-_125577940 0.230 ENST00000519168.1
ENST00000395508.2
MTSS1

metastasis suppressor 1

chr11_-_104905840 0.230 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1










caspase 1, apoptosis-related cysteine peptidase










chr19_-_14911023 0.229 ENST00000248073.2
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr19_+_36203830 0.223 ENST00000262630.3
ZBTB32
zinc finger and BTB domain containing 32
chr4_+_75310851 0.220 ENST00000395748.3
ENST00000264487.2
AREG

amphiregulin

chr1_-_31902614 0.219 ENST00000596131.1
AC114494.1
HCG1787699; Uncharacterized protein
chr1_+_196788887 0.215 ENST00000367421.3
ENST00000320493.5
ENST00000367424.4
CFHR2
CFHR1

complement factor H-related 2
complement factor H-related 1

chr19_+_12305824 0.212 ENST00000415793.1
ENST00000440004.1
ENST00000426044.1
CTD-2666L21.1


CTD-2666L21.1


chr8_-_17555164 0.212 ENST00000297488.6
MTUS1
microtubule associated tumor suppressor 1
chr3_-_185270342 0.211 ENST00000424591.2
LIPH
lipase, member H
chr2_+_182850551 0.206 ENST00000452904.1
ENST00000409137.3
ENST00000280295.3
PPP1R1C


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr2_-_211090162 0.206 ENST00000233710.3
ACADL
acyl-CoA dehydrogenase, long chain
chr2_-_190446738 0.206 ENST00000427419.1
ENST00000455320.1
SLC40A1

solute carrier family 40 (iron-regulated transporter), member 1

chr6_+_123038689 0.198 ENST00000354275.2
ENST00000368446.1
PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

chr3_+_173302222 0.195 ENST00000361589.4
NLGN1
neuroligin 1
chr8_-_19459993 0.194 ENST00000454498.2
ENST00000520003.1
CSGALNACT1

chondroitin sulfate N-acetylgalactosaminyltransferase 1

chr7_+_139529085 0.185 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr6_-_32920794 0.183 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA


XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha


Uncharacterized protein
chr11_-_74408739 0.183 ENST00000529912.1
CHRDL2
chordin-like 2
chr4_-_76957214 0.181 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr3_-_185270383 0.181 ENST00000296252.4
LIPH
lipase, member H
chr10_+_91092241 0.178 ENST00000371811.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr5_-_115890554 0.177 ENST00000509665.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr3_+_171844762 0.176 ENST00000443501.1
FNDC3B
fibronectin type III domain containing 3B
chr2_+_182850743 0.176 ENST00000409702.1
PPP1R1C
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_-_233877912 0.173 ENST00000264051.3
NGEF
neuronal guanine nucleotide exchange factor
chrX_-_15402498 0.173 ENST00000297904.3
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr5_-_75919217 0.171 ENST00000504899.1
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr12_-_52800139 0.171 ENST00000257974.2
KRT82
keratin 82
chr11_+_121461097 0.169 ENST00000527934.1
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr14_-_92247032 0.167 ENST00000556661.1
ENST00000553676.1
ENST00000554560.1
CATSPERB


catsper channel auxiliary subunit beta


chr11_-_104480019 0.167 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1


RP11-886D15.1


chr4_-_42154895 0.165 ENST00000502486.1
ENST00000504360.1
BEND4

BEN domain containing 4

chrX_-_15683147 0.164 ENST00000380342.3
TMEM27
transmembrane protein 27
chr1_+_160709055 0.163 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7



SLAM family member 7



chr18_+_21529811 0.162 ENST00000588004.1
LAMA3
laminin, alpha 3
chr5_-_146833803 0.156 ENST00000512722.1
DPYSL3
dihydropyrimidinase-like 3
chr5_-_75919253 0.154 ENST00000296641.4
F2RL2
coagulation factor II (thrombin) receptor-like 2
chr1_+_160709076 0.153 ENST00000359331.4
ENST00000495334.1
SLAMF7

SLAM family member 7

chr1_-_8763278 0.151 ENST00000468247.1
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr4_+_147145709 0.150 ENST00000504313.1
RP11-6L6.2
Uncharacterized protein
chr6_-_75828774 0.150 ENST00000493109.2
COL12A1
collagen, type XII, alpha 1
chr5_+_140571902 0.148 ENST00000239446.4
PCDHB10
protocadherin beta 10
chr17_+_18601299 0.147 ENST00000572555.1
ENST00000395902.3
ENST00000449552.2
TRIM16L


tripartite motif containing 16-like


chr3_-_178969403 0.146 ENST00000314235.5
ENST00000392685.2
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr5_+_59783540 0.145 ENST00000515734.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr1_+_160709029 0.145 ENST00000444090.2
ENST00000441662.2
SLAMF7

SLAM family member 7

chr6_-_32634425 0.144 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
HLA-DQB1



major histocompatibility complex, class II, DQ beta 1



chr19_+_12305895 0.144 ENST00000451691.2
CTD-2666L21.1
CTD-2666L21.1
chr3_-_183543301 0.142 ENST00000318631.3
ENST00000431348.1
MAP6D1

MAP6 domain containing 1

chr11_-_104972158 0.141 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1



CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase



caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr12_+_11187087 0.140 ENST00000601123.1
AC018630.1
Uncharacterized protein
chr10_-_127371675 0.140 ENST00000532135.1
ENST00000526819.1
ENST00000368821.3
TEX36


testis expressed 36


chr6_-_18122843 0.138 ENST00000340650.3
NHLRC1
NHL repeat containing E3 ubiquitin protein ligase 1
chr12_-_11214893 0.136 ENST00000533467.1
TAS2R46
taste receptor, type 2, member 46
chr18_+_32173276 0.133 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA








dystrobrevin, alpha








chr11_-_58378759 0.132 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr19_-_56343353 0.131 ENST00000592953.1
ENST00000589093.1
NLRP11

NLR family, pyrin domain containing 11

chr12_-_11287243 0.130 ENST00000539585.1
TAS2R30
taste receptor, type 2, member 30
chr1_-_16302608 0.130 ENST00000375743.4
ENST00000375733.2
ZBTB17

zinc finger and BTB domain containing 17

chr5_+_36608280 0.129 ENST00000513646.1
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_57396766 0.129 ENST00000512175.2
THEGL
theg spermatid protein-like
chr5_-_115872124 0.128 ENST00000515009.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr17_-_29648761 0.128 ENST00000247270.3
ENST00000462804.2
EVI2A

ecotropic viral integration site 2A

chr12_-_13256571 0.127 ENST00000545401.1
ENST00000432710.2
ENST00000351606.6
GSG1


germ cell associated 1


chr1_-_89591749 0.125 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr12_+_93115281 0.125 ENST00000549856.1
PLEKHG7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr1_-_16302565 0.124 ENST00000537142.1
ENST00000448462.2
ZBTB17

zinc finger and BTB domain containing 17

chr14_+_96722152 0.123 ENST00000216629.6
BDKRB1
bradykinin receptor B1
chr2_+_169658928 0.123 ENST00000317647.7
ENST00000445023.2
NOSTRIN

nitric oxide synthase trafficking

chr1_-_198509804 0.123 ENST00000489986.1
ENST00000367382.1
ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr11_+_57365150 0.122 ENST00000457869.1
ENST00000340687.6
ENST00000378323.4
ENST00000378324.2
ENST00000403558.1
SERPING1




serpin peptidase inhibitor, clade G (C1 inhibitor), member 1




chr15_+_41057818 0.122 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr15_+_26360970 0.121 ENST00000556159.1
ENST00000557523.1
LINC00929

long intergenic non-protein coding RNA 929

chr12_+_10365082 0.121 ENST00000545859.1
GABARAPL1
GABA(A) receptor-associated protein like 1
chr22_-_36556821 0.120 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3


apolipoprotein L, 3


chr3_+_46395219 0.120 ENST00000445132.2
ENST00000292301.4
CCR2

chemokine (C-C motif) receptor 2

chr16_+_33204156 0.119 ENST00000398667.4
TP53TG3C
TP53 target 3C
chr1_+_26644441 0.119 ENST00000374213.2
CD52
CD52 molecule
chr10_+_52094298 0.118 ENST00000595931.1
AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr9_+_26746951 0.116 ENST00000523363.1
RP11-18A15.1
RP11-18A15.1
chr11_+_86085778 0.116 ENST00000354755.1
ENST00000278487.3
ENST00000531271.1
ENST00000445632.2
CCDC81



coiled-coil domain containing 81



chr3_-_187455680 0.115 ENST00000438077.1
BCL6
B-cell CLL/lymphoma 6
chr3_+_14058794 0.114 ENST00000424053.1
ENST00000528067.1
ENST00000429201.1
TPRXL


tetra-peptide repeat homeobox-like


chr2_+_102624977 0.114 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chr8_+_58890917 0.113 ENST00000522992.1
RP11-1112C15.1
RP11-1112C15.1
chr2_+_143635222 0.113 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU


kynureninase


chr12_+_10365404 0.113 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABARAPL1





GABA(A) receptor-associated protein like 1





chr1_-_53608249 0.112 ENST00000371494.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr17_-_30470154 0.111 ENST00000398832.2
AC090616.2
Uncharacterized protein
chr2_+_231090471 0.111 ENST00000373645.3
SP140
SP140 nuclear body protein
chr7_-_6388389 0.111 ENST00000578372.1
FAM220A
family with sequence similarity 220, member A
chr5_-_115872142 0.109 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr5_+_55147205 0.108 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA



interleukin 31 receptor A



chr3_+_180586536 0.107 ENST00000465551.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr3_-_180707306 0.107 ENST00000479269.1
DNAJC19
DnaJ (Hsp40) homolog, subfamily C, member 19
chr2_+_133874577 0.107 ENST00000596384.1
AC011755.1
HCG2006742; Protein LOC100996685
chr3_-_176915215 0.107 ENST00000457928.2
ENST00000422442.1
TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr8_+_22225041 0.105 ENST00000289952.5
ENST00000524285.1
SLC39A14

solute carrier family 39 (zinc transporter), member 14

chr2_-_196933536 0.105 ENST00000312428.6
ENST00000410072.1
DNAH7

dynein, axonemal, heavy chain 7

chr3_+_169539710 0.104 ENST00000340806.6
LRRIQ4
leucine-rich repeats and IQ motif containing 4
chr7_-_122339162 0.104 ENST00000340112.2
RNF133
ring finger protein 133
chr4_+_41361616 0.104 ENST00000513024.1
LIMCH1
LIM and calponin homology domains 1
chr14_-_106453155 0.103 ENST00000390594.2
IGHV1-2
immunoglobulin heavy variable 1-2
chr12_-_58329819 0.103 ENST00000551421.1
RP11-620J15.3
RP11-620J15.3
chr21_+_42733870 0.103 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2


myxovirus (influenza virus) resistance 2 (mouse)


chr3_+_69928256 0.100 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr2_-_145275211 0.099 ENST00000462355.1
ZEB2
zinc finger E-box binding homeobox 2
chr4_-_84035905 0.099 ENST00000311507.4
PLAC8
placenta-specific 8
chr10_-_90712520 0.098 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr2_+_38177575 0.098 ENST00000407257.1
ENST00000417700.2
ENST00000234195.3
ENST00000442857.1
RMDN2



regulator of microtubule dynamics 2



chr14_+_39944025 0.097 ENST00000554328.1
ENST00000556620.1
ENST00000557197.1
RP11-111A21.1


RP11-111A21.1


chr11_-_36619771 0.096 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2


recombination activating gene 2


chr5_+_118668846 0.096 ENST00000513374.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr12_+_56114189 0.096 ENST00000548082.1
RDH5
retinol dehydrogenase 5 (11-cis/9-cis)
chr1_-_201438282 0.094 ENST00000367311.3
ENST00000367309.1
PHLDA3

pleckstrin homology-like domain, family A, member 3

chr6_-_24799117 0.093 ENST00000565469.1
RP3-369A17.5
chromosome 6 open reading frame 229
chr11_+_827248 0.093 ENST00000527089.1
ENST00000530183.1
EFCAB4A

EF-hand calcium binding domain 4A

chr7_-_151330218 0.093 ENST00000476632.1
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr12_+_21679220 0.092 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr6_+_10528560 0.092 ENST00000379597.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_+_2912363 0.091 ENST00000544366.1
FKBP4
FK506 binding protein 4, 59kDa
chr1_+_207262881 0.089 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr19_+_38779778 0.088 ENST00000590738.1
ENST00000587519.2
ENST00000591889.1
SPINT2
CTB-102L5.4

serine peptidase inhibitor, Kunitz type, 2
CTB-102L5.4

chr17_-_38978847 0.088 ENST00000269576.5
KRT10
keratin 10
chr12_+_56114151 0.086 ENST00000547072.1
ENST00000552930.1
ENST00000257895.5
RDH5


retinol dehydrogenase 5 (11-cis/9-cis)


chr14_+_62453803 0.086 ENST00000446982.2
SYT16
synaptotagmin XVI
chr5_+_169758393 0.086 ENST00000521471.1
ENST00000518357.1
ENST00000436248.3
CTB-114C7.3


CTB-114C7.3


chr3_-_124606502 0.086 ENST00000483168.1
ITGB5
integrin, beta 5
chr19_-_38183201 0.085 ENST00000590008.1
ENST00000358582.4
ZNF781

zinc finger protein 781

chr2_-_238333919 0.085 ENST00000409162.1
AC112721.1
Uncharacterized protein
chr1_-_10003372 0.085 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC


leucine zipper and CTNNBIP1 domain containing


chr11_-_87908600 0.085 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38


RAB38, member RAS oncogene family


chr6_-_31628512 0.085 ENST00000375911.1
C6orf47
chromosome 6 open reading frame 47
chr18_-_21166841 0.085 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr12_+_5541267 0.085 ENST00000423158.3
NTF3
neurotrophin 3
chr1_+_10509971 0.083 ENST00000320498.4
CORT
cortistatin
chr14_+_96722539 0.082 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr7_-_101212244 0.082 ENST00000451953.1
ENST00000434537.1
ENST00000437900.1
LINC01007


long intergenic non-protein coding RNA 1007


chr2_+_111562758 0.082 ENST00000433706.1
ACOXL
acyl-CoA oxidase-like
chr6_-_154677866 0.081 ENST00000367220.4
IPCEF1
interaction protein for cytohesin exchange factors 1
chr10_-_14614122 0.081 ENST00000378465.3
ENST00000452706.2
ENST00000378458.2
FAM107B


family with sequence similarity 107, member B


chr12_+_21207503 0.081 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chrX_-_120066151 0.080 ENST00000419982.2
ENST00000416816.1
CT47A12

cancer/testis antigen family 47, member A12

chr2_+_191208196 0.080 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1



inositol polyphosphate-1-phosphatase



chr9_-_4679419 0.080 ENST00000609131.1
ENST00000607997.1
RP11-6J24.6

RP11-6J24.6

chr4_-_22444733 0.080 ENST00000508133.1
GPR125
G protein-coupled receptor 125
chr12_-_10573149 0.079 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
KLRC3


killer cell lectin-like receptor subfamily C, member 3


chr3_+_185080908 0.078 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr6_-_154677900 0.077 ENST00000265198.4
ENST00000520261.1
IPCEF1

interaction protein for cytohesin exchange factors 1

chr12_+_75874460 0.077 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr7_-_130597935 0.076 ENST00000447307.1
ENST00000418546.1
MIR29B1

microRNA 29a

chr6_+_42584847 0.076 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr3_-_46068969 0.076 ENST00000542109.1
ENST00000395946.2
XCR1

chemokine (C motif) receptor 1

chr8_+_30496078 0.075 ENST00000517349.1
SMIM18
small integral membrane protein 18
chr11_+_114166536 0.075 ENST00000299964.3
NNMT
nicotinamide N-methyltransferase
chr13_+_24846799 0.075 ENST00000488060.1
SPATA13
spermatogenesis associated 13
chr17_-_15522826 0.074 ENST00000395906.3
CDRT1
CMT1A duplicated region transcript 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 0.5 GO:0098942 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) circadian sleep/wake cycle, wakefulness(GO:0042746) cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.1 0.4 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 0.3 GO:0006714 sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224)
0.1 0.2 GO:2001190 natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.2 GO:0006579 amino-acid betaine catabolic process(GO:0006579) carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.1 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.1 0.2 GO:1905246 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.1 0.5 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1 0.3 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 0.3 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.1 0.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.2 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) divalent metal ion export(GO:0070839)
0.0 0.2 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.6 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.1 GO:1902567 astrocyte chemotaxis(GO:0035700) negative regulation of eosinophil activation(GO:1902567) positive regulation of T cell extravasation(GO:2000409) positive regulation of CD8-positive, alpha-beta T cell extravasation(GO:2000451) regulation of astrocyte chemotaxis(GO:2000458) regulation of hematopoietic stem cell migration(GO:2000471) positive regulation of hematopoietic stem cell migration(GO:2000473)
0.0 0.3 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 0.1 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0 0.1 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.4 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.0 0.2 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0 0.2 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.1 GO:2000502 negative regulation of natural killer cell chemotaxis(GO:2000502)
0.0 0.1 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.2 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0051957 positive regulation of amino acid transport(GO:0051957)
0.0 0.1 GO:0002586 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.0 0.5 GO:0035810 positive regulation of urine volume(GO:0035810)
0.0 0.2 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.0 0.0 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.2 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.1 GO:0090131 mesenchyme migration(GO:0090131)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.0 GO:0035608 protein deglutamylation(GO:0035608)
0.0 0.2 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.2 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.0 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.0 0.5 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.1 GO:0070269 pyroptosis(GO:0070269)
0.0 0.1 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.3 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.0 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.0 0.0 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)
0.0 0.0 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0 0.1 GO:0070779 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.0 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.0 0.0 GO:1901569 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
0.0 0.2 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.2 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.0 GO:1902722 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) positive regulation of prolactin secretion(GO:1902722)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 0.4 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.1 GO:0005595 collagen type XII trimer(GO:0005595)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.4 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.1 GO:0034684 integrin alphav-beta5 complex(GO:0034684)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.2 GO:0036128 CatSper complex(GO:0036128)
0.0 0.5 GO:0032433 filopodium tip(GO:0032433)
0.0 0.1 GO:0031905 early endosome lumen(GO:0031905)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.2 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.0 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)
0.0 0.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.3 GO:0045550 geranylgeranyl reductase activity(GO:0045550) prostaglandin-F synthase activity(GO:0047017)
0.1 0.2 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.1 0.2 GO:0004947 bradykinin receptor activity(GO:0004947)
0.1 0.3 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.1 0.2 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.5 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0 0.3 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0097677 STAT family protein binding(GO:0097677)
0.0 0.2 GO:0005534 galactose binding(GO:0005534)
0.0 0.2 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.0 0.3 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.2 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.3 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 0.1 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.0 0.1 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 0.0 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.3 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 0.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0010348 lithium:proton antiporter activity(GO:0010348)
0.0 0.1 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.2 GO:0030957 Tat protein binding(GO:0030957)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.0 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.0 GO:0050051 leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.1 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.5 PID_S1P_S1P3_PATHWAY S1P3 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.4 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle