Motif ID: IRF3
Z-value: 1.492
Transcription factors associated with IRF3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF3 | ENSG00000126456.11 | IRF3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF3 | hg19_v2_chr19_-_50168962_50169062 | 0.94 | 2.0e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 3.8 | GO:0002731 | negative regulation of dendritic cell cytokine production(GO:0002731) |
| 0.7 | 3.9 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.6 | 2.3 | GO:0034343 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.5 | 1.4 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.4 | 5.7 | GO:0035457 | cellular response to interferon-alpha(GO:0035457) |
| 0.4 | 3.4 | GO:1902748 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.4 | 4.1 | GO:0018377 | protein myristoylation(GO:0018377) |
| 0.4 | 3.7 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.4 | 1.5 | GO:0045918 | negative regulation of cytolysis(GO:0045918) |
| 0.3 | 3.5 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.3 | 0.9 | GO:2001190 | natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.2 | 1.8 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.2 | 0.6 | GO:0021538 | epithalamus development(GO:0021538) habenula development(GO:0021986) general adaptation syndrome(GO:0051866) |
| 0.2 | 2.8 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.2 | 0.7 | GO:1905123 | regulation of endosome organization(GO:1904978) regulation of glucosylceramidase activity(GO:1905123) |
| 0.2 | 0.6 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.1 | 0.4 | GO:1990641 | response to iron ion starvation(GO:1990641) |
| 0.1 | 0.5 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.1 | 0.3 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.1 | 1.0 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.1 | 0.5 | GO:0019427 | acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542) |
| 0.1 | 0.3 | GO:0060940 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 0.1 | 0.8 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.1 | 1.9 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.1 | 2.4 | GO:0019835 | cytolysis(GO:0019835) |
| 0.1 | 0.5 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.1 | 3.2 | GO:1904031 | positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.1 | 0.4 | GO:0035881 | amacrine cell differentiation(GO:0035881) |
| 0.0 | 1.3 | GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) |
| 0.0 | 0.1 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.0 | 0.5 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.0 | 0.9 | GO:0071474 | cellular hyperosmotic response(GO:0071474) |
| 0.0 | 0.2 | GO:0052551 | response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565) |
| 0.0 | 1.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.0 | 0.1 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) |
| 0.0 | 0.2 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.3 | GO:0034378 | chylomicron assembly(GO:0034378) |
| 0.0 | 0.3 | GO:2000795 | negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.0 | 0.4 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.0 | 0.4 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.0 | 0.6 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.0 | 0.2 | GO:2000510 | positive regulation of dendritic cell chemotaxis(GO:2000510) |
| 0.0 | 0.5 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 1.9 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.3 | GO:0019368 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.0 | 0.5 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 0.0 | 0.3 | GO:0031848 | protection from non-homologous end joining at telomere(GO:0031848) |
| 0.0 | 0.4 | GO:1902187 | negative regulation of viral release from host cell(GO:1902187) |
| 0.0 | 0.2 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.0 | 0.2 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 0.8 | GO:0061014 | positive regulation of mRNA catabolic process(GO:0061014) |
| 0.0 | 0.2 | GO:0035973 | aggrephagy(GO:0035973) |
| 0.0 | 0.8 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.0 | 0.3 | GO:0006054 | N-acetylneuraminate metabolic process(GO:0006054) |
| 0.0 | 0.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0020005 | symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679) |
| 0.2 | 1.4 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
| 0.1 | 1.0 | GO:0097169 | AIM2 inflammasome complex(GO:0097169) |
| 0.1 | 0.2 | GO:0031906 | late endosome lumen(GO:0031906) |
| 0.1 | 0.5 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 2.4 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 0.8 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.1 | 0.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 0.4 | GO:1990357 | terminal web(GO:1990357) |
| 0.0 | 0.2 | GO:0097635 | extrinsic component of autophagosome membrane(GO:0097635) |
| 0.0 | 0.5 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.0 | 3.5 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.8 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 3.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.3 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.1 | GO:0032044 | DSIF complex(GO:0032044) |
| 0.0 | 2.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.2 | GO:0070419 | nonhomologous end joining complex(GO:0070419) |
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.0 | GO:0005712 | chiasma(GO:0005712) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
| 0.5 | 1.5 | GO:0048248 | CXCR3 chemokine receptor binding(GO:0048248) |
| 0.5 | 1.4 | GO:0033754 | indoleamine 2,3-dioxygenase activity(GO:0033754) |
| 0.2 | 1.4 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.2 | 0.8 | GO:0005151 | interleukin-1, Type II receptor binding(GO:0005151) |
| 0.2 | 2.1 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 0.2 | 2.2 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 3.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.9 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 1.4 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.1 | 0.7 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.1 | 0.9 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.4 | GO:0022865 | transmembrane electron transfer carrier(GO:0022865) |
| 0.1 | 0.3 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.1 | 1.9 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.1 | 0.5 | GO:0003987 | acetate-CoA ligase activity(GO:0003987) |
| 0.1 | 0.5 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.1 | 0.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 3.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.0 | 6.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 1.8 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0016979 | lipoate-protein ligase activity(GO:0016979) |
| 0.0 | 0.8 | GO:0022848 | acetylcholine-gated cation channel activity(GO:0022848) |
| 0.0 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.3 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.0 | 1.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.5 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.0 | 0.2 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.0 | 0.2 | GO:0035312 | 5'-3' exodeoxyribonuclease activity(GO:0035312) |
| 0.0 | 0.1 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 2.4 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 0.1 | GO:0000702 | oxidized base lesion DNA N-glycosylase activity(GO:0000702) |
| 0.0 | 0.2 | GO:0003831 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) |
| 0.0 | 0.4 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.0 | 0.2 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.0 | 0.1 | GO:0031752 | D5 dopamine receptor binding(GO:0031752) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 1.5 | PID_CXCR3_PATHWAY | CXCR3-mediated signaling events |
| 0.0 | 3.2 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.8 | PID_ERBB2_ERBB3_PATHWAY | ErbB2/ErbB3 signaling events |
| 0.0 | 0.1 | PID_S1P_S1P4_PATHWAY | S1P4 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.9 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.1 | 10.2 | REACTOME_INTERFERON_ALPHA_BETA_SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.5 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.4 | REACTOME_TRYPTOPHAN_CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.1 | 1.8 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 0.8 | REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS | Genes involved in Presynaptic nicotinic acetylcholine receptors |
| 0.0 | 1.9 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 3.8 | REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.0 | 0.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.9 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 2.1 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.4 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.3 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.3 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
