Motif ID: HSF1

Z-value: 1.449


Transcription factors associated with HSF1:

Gene SymbolEntrez IDGene Name
HSF1 ENSG00000185122.6 HSF1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HSF1hg19_v2_chr8_+_145515263_1455152990.703.5e-02Click!


Activity profile for motif HSF1.

activity profile for motif HSF1


Sorted Z-values histogram for motif HSF1

Sorted Z-values for motif HSF1



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_+_47666275 3.713 ENST00000327753.3
ENST00000283303.2
GPR115

G protein-coupled receptor 115

chr3_+_42977846 2.880 ENST00000383748.4
KRBOX1
KRAB box domain containing 1
chr6_-_33041378 2.726 ENST00000428995.1
HLA-DPA1
major histocompatibility complex, class II, DP alpha 1
chr2_+_85981008 2.495 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr2_+_233527443 2.026 ENST00000410095.1
EFHD1
EF-hand domain family, member D1
chr9_+_470288 1.949 ENST00000382303.1
KANK1
KN motif and ankyrin repeat domains 1
chr11_+_34645791 1.773 ENST00000529527.1
ENST00000531728.1
ENST00000525253.1
EHF


ets homologous factor


chr4_-_25865159 1.746 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3



sel-1 suppressor of lin-12-like 3 (C. elegans)



chr19_-_43709817 1.745 ENST00000433626.2
ENST00000405312.3
PSG4

pregnancy specific beta-1-glycoprotein 4

chr12_+_52668394 1.713 ENST00000423955.2
KRT86
keratin 86
chr4_+_57396766 1.705 ENST00000512175.2
THEGL
theg spermatid protein-like
chr6_-_32557610 1.598 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr19_-_43709772 1.547 ENST00000596907.1
ENST00000451895.1
PSG4

pregnancy specific beta-1-glycoprotein 4

chrX_-_55515635 1.486 ENST00000500968.3
USP51
ubiquitin specific peptidase 51
chrX_-_154563889 1.448 ENST00000369449.2
ENST00000321926.4
CLIC2

chloride intracellular channel 2

chr1_+_28261533 1.351 ENST00000411604.1
ENST00000373888.4
SMPDL3B

sphingomyelin phosphodiesterase, acid-like 3B

chr17_+_72427477 1.252 ENST00000342648.5
ENST00000481232.1
GPRC5C

G protein-coupled receptor, family C, group 5, member C

chr1_+_28261492 1.235 ENST00000373894.3
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr19_-_43709703 1.177 ENST00000599391.1
ENST00000244295.9
PSG4

pregnancy specific beta-1-glycoprotein 4

chr6_-_46620522 1.152 ENST00000275016.2
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr20_-_23807358 1.139 ENST00000304725.2
CST2
cystatin SA
chr7_+_1127723 1.113 ENST00000397088.3
GPER1
G protein-coupled estrogen receptor 1
chr17_+_72426891 1.107 ENST00000392627.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr1_+_28261621 1.047 ENST00000549094.1
SMPDL3B
sphingomyelin phosphodiesterase, acid-like 3B
chr20_-_23731893 0.998 ENST00000398402.1
CST1
cystatin SN
chr6_-_32498046 0.983 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr12_+_71833756 0.982 ENST00000536515.1
ENST00000540815.2
LGR5

leucine-rich repeat containing G protein-coupled receptor 5

chr11_+_65190245 0.971 ENST00000499732.1
ENST00000501122.2
ENST00000601801.1
NEAT1


nuclear paraspeckle assembly transcript 1 (non-protein coding)


chr5_-_146889619 0.959 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr2_+_102624977 0.932 ENST00000441002.1
IL1R2
interleukin 1 receptor, type II
chr2_+_28718921 0.926 ENST00000327757.5
ENST00000422425.2
ENST00000404858.1
PLB1


phospholipase B1


chr20_-_23669590 0.922 ENST00000217423.3
CST4
cystatin S
chr8_+_8559406 0.884 ENST00000519106.1
CLDN23
claudin 23
chr20_-_23731569 0.871 ENST00000304749.2
CST1
cystatin SN
chr1_+_207070775 0.862 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24


interleukin 24


chr17_-_39928106 0.859 ENST00000540235.1
JUP
junction plakoglobin
chrX_+_49020882 0.809 ENST00000454342.1
MAGIX
MAGI family member, X-linked
chr5_+_169659950 0.777 ENST00000593851.1
C5orf58
chromosome 5 open reading frame 58
chr8_-_120605194 0.760 ENST00000522167.1
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr1_+_23695680 0.759 ENST00000454117.1
ENST00000335648.3
ENST00000518821.1
ENST00000437367.2
C1orf213



chromosome 1 open reading frame 213



chr17_-_39928501 0.750 ENST00000420370.1
JUP
junction plakoglobin
chr22_+_35776828 0.733 ENST00000216117.8
HMOX1
heme oxygenase (decycling) 1
chr12_-_47219733 0.733 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4


solute carrier family 38, member 4


chr22_+_35776354 0.732 ENST00000412893.1
HMOX1
heme oxygenase (decycling) 1
chr14_-_24809154 0.728 ENST00000216274.5
RIPK3
receptor-interacting serine-threonine kinase 3
chrX_+_148769880 0.705 ENST00000412632.2
MAGEA11
melanoma antigen family A, 11
chr11_-_104905840 0.697 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1










caspase 1, apoptosis-related cysteine peptidase










chr4_-_40632757 0.697 ENST00000511902.1
ENST00000505220.1
RBM47

RNA binding motif protein 47

chr21_+_35445827 0.682 ENST00000381151.3
ENST00000608209.1
SLC5A3
SLC5A3
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
sodium/myo-inositol cotransporter
chr3_-_179322436 0.681 ENST00000392659.2
ENST00000476781.1
MRPL47

mitochondrial ribosomal protein L47

chr14_+_71165292 0.680 ENST00000553682.1
RP6-65G23.1
RP6-65G23.1
chr3_-_179322416 0.678 ENST00000259038.2
MRPL47
mitochondrial ribosomal protein L47
chrX_+_49020121 0.676 ENST00000415364.1
ENST00000376338.3
ENST00000425285.1
MAGIX


MAGI family member, X-linked


chr1_-_183538319 0.665 ENST00000420553.1
ENST00000419402.1
NCF2

neutrophil cytosolic factor 2

chr11_-_1785139 0.653 ENST00000236671.2
CTSD
cathepsin D
chr19_-_56904799 0.652 ENST00000589895.1
ENST00000589143.1
ENST00000301310.4
ENST00000586929.1
ZNF582



zinc finger protein 582



chr1_-_204436344 0.617 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr2_-_128399706 0.611 ENST00000426981.1
LIMS2
LIM and senescent cell antigen-like domains 2
chr1_-_151345159 0.607 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
SELENBP1




selenium binding protein 1




chrX_-_73072534 0.603 ENST00000429829.1
XIST
X inactive specific transcript (non-protein coding)
chr6_+_153019069 0.603 ENST00000532295.1
MYCT1
myc target 1
chr3_+_179322573 0.602 ENST00000493866.1
ENST00000472629.1
ENST00000482604.1
NDUFB5


NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa


chrX_-_15683147 0.601 ENST00000380342.3
TMEM27
transmembrane protein 27
chrX_+_52511925 0.597 ENST00000375588.1
XAGE1C
X antigen family, member 1C
chr9_-_114545768 0.593 ENST00000318737.4
C9orf84
chromosome 9 open reading frame 84
chr3_+_179322481 0.589 ENST00000259037.3
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chrX_+_148863584 0.586 ENST00000439010.2
ENST00000298974.5
ENST00000522429.1
ENST00000519822.1
MAGEA9



melanoma antigen family A, 9



chr15_-_72490114 0.580 ENST00000309731.7
GRAMD2
GRAM domain containing 2
chr7_+_141478242 0.572 ENST00000247881.2
TAS2R4
taste receptor, type 2, member 4
chr4_-_48082192 0.569 ENST00000507351.1
TXK
TXK tyrosine kinase
chr10_+_24528108 0.561 ENST00000438429.1
KIAA1217
KIAA1217
chr6_+_153019023 0.559 ENST00000367245.5
ENST00000529453.1
MYCT1

myc target 1

chr3_-_10334585 0.557 ENST00000430179.1
ENST00000449238.2
ENST00000437422.2
ENST00000287656.7
ENST00000457360.1
ENST00000439975.2
ENST00000446937.2
GHRL






ghrelin/obestatin prepropeptide






chr9_+_19408999 0.554 ENST00000340967.2
ACER2
alkaline ceramidase 2
chr3_+_183853052 0.550 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
EIF2B5


eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa


chr4_+_166300084 0.548 ENST00000402744.4
CPE
carboxypeptidase E
chr4_+_110834033 0.545 ENST00000509793.1
ENST00000265171.5
EGF

epidermal growth factor

chr18_+_21452964 0.541 ENST00000587184.1
LAMA3
laminin, alpha 3
chrX_+_22050546 0.541 ENST00000379374.4
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr4_-_40632844 0.541 ENST00000505414.1
RBM47
RNA binding motif protein 47
chr5_+_140593509 0.538 ENST00000341948.4
PCDHB13
protocadherin beta 13
chr22_-_36556821 0.538 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
APOL3


apolipoprotein L, 3


chr18_+_21452804 0.537 ENST00000269217.6
LAMA3
laminin, alpha 3
chr19_-_55453077 0.535 ENST00000328092.5
ENST00000590030.1
NLRP7

NLR family, pyrin domain containing 7

chrX_-_52260199 0.535 ENST00000375600.1
XAGE1A
X antigen family, member 1A
chr4_-_48136217 0.533 ENST00000264316.4
TXK
TXK tyrosine kinase
chr3_-_183735731 0.529 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr2_+_217524323 0.528 ENST00000456764.1
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr11_-_58275578 0.526 ENST00000360374.2
OR5B21
olfactory receptor, family 5, subfamily B, member 21
chr7_-_100493744 0.524 ENST00000428317.1
ENST00000441605.1
ACHE

acetylcholinesterase (Yt blood group)

chr1_-_10856694 0.524 ENST00000377022.3
ENST00000344008.5
CASZ1

castor zinc finger 1

chr1_-_10003372 0.519 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC


leucine zipper and CTNNBIP1 domain containing


chr18_-_52626622 0.505 ENST00000591504.1
CCDC68
coiled-coil domain containing 68
chr20_+_43803517 0.504 ENST00000243924.3
PI3
peptidase inhibitor 3, skin-derived
chr5_-_56778635 0.503 ENST00000423391.1
ACTBL2
actin, beta-like 2
chr9_+_19408919 0.501 ENST00000380376.1
ACER2
alkaline ceramidase 2
chr6_+_46620676 0.499 ENST00000371347.5
ENST00000411689.2
SLC25A27

solute carrier family 25, member 27

chr16_+_10971037 0.497 ENST00000324288.8
ENST00000381835.5
CIITA

class II, major histocompatibility complex, transactivator

chr4_-_40632881 0.496 ENST00000511598.1
RBM47
RNA binding motif protein 47
chr5_+_421030 0.493 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr8_+_124194752 0.493 ENST00000318462.6
FAM83A
family with sequence similarity 83, member A
chr18_-_21166841 0.485 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr6_-_38607628 0.484 ENST00000498633.1
BTBD9
BTB (POZ) domain containing 9
chr19_+_8429031 0.466 ENST00000301455.2
ENST00000541807.1
ENST00000393962.2
ANGPTL4


angiopoietin-like 4


chrX_-_106243451 0.464 ENST00000355610.4
ENST00000535534.1
MORC4

MORC family CW-type zinc finger 4

chr5_+_173472607 0.458 ENST00000303177.3
ENST00000519867.1
NSG2

Neuron-specific protein family member 2

chr17_+_45401308 0.458 ENST00000331493.2
ENST00000519772.1
ENST00000517484.1
EFCAB13


EF-hand calcium binding domain 13


chr6_+_46620705 0.458 ENST00000452689.2
SLC25A27
solute carrier family 25, member 27
chr2_-_27851745 0.458 ENST00000394775.3
ENST00000522876.1
CCDC121

coiled-coil domain containing 121

chrX_-_106243294 0.453 ENST00000255495.7
MORC4
MORC family CW-type zinc finger 4
chr20_+_8112824 0.452 ENST00000378641.3
PLCB1
phospholipase C, beta 1 (phosphoinositide-specific)
chr1_-_11322551 0.451 ENST00000361445.4
MTOR
mechanistic target of rapamycin (serine/threonine kinase)
chr1_-_24469602 0.450 ENST00000270800.1
IL22RA1
interleukin 22 receptor, alpha 1
chr19_+_12203100 0.450 ENST00000596883.1
ZNF788
zinc finger family member 788
chr17_+_78193443 0.448 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr16_+_28996572 0.444 ENST00000360872.5
ENST00000566177.1
ENST00000354453.4
LAT


linker for activation of T cells


chr5_-_101632153 0.425 ENST00000310954.6
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr14_-_94421923 0.424 ENST00000555507.1
ASB2
ankyrin repeat and SOCS box containing 2
chr1_-_236030216 0.420 ENST00000389794.3
ENST00000389793.2
LYST

lysosomal trafficking regulator

chrX_-_52533139 0.408 ENST00000374959.3
XAGE1D
X antigen family, member 1D
chr1_+_1260598 0.408 ENST00000488011.1
GLTPD1
glycolipid transfer protein domain containing 1
chr6_-_41909466 0.405 ENST00000414200.2
CCND3
cyclin D3
chr13_-_26625169 0.403 ENST00000319420.3
SHISA2
shisa family member 2
chr3_-_187454281 0.399 ENST00000232014.4
BCL6
B-cell CLL/lymphoma 6
chr2_+_135011731 0.397 ENST00000281923.2
MGAT5
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr1_+_10003486 0.393 ENST00000403197.1
ENST00000377205.1
NMNAT1

nicotinamide nucleotide adenylyltransferase 1

chr19_+_12203069 0.390 ENST00000339302.4
ENST00000430298.2
ZNF788
ZNF788
Zinc finger protein 788
zinc finger family member 788
chrX_-_52546033 0.390 ENST00000375567.3
XAGE1E
X antigen family, member 1E
chrX_-_148669116 0.389 ENST00000243314.5
MAGEA9B
melanoma antigen family A, 9B
chr2_+_220143989 0.388 ENST00000336576.5
DNAJB2
DnaJ (Hsp40) homolog, subfamily B, member 2
chr5_+_178450753 0.385 ENST00000444149.2
ENST00000519896.1
ENST00000522442.1
ZNF879


zinc finger protein 879


chr3_+_186501979 0.384 ENST00000498746.1
EIF4A2
eukaryotic translation initiation factor 4A2
chr14_-_24020858 0.382 ENST00000419474.3
ZFHX2
zinc finger homeobox 2
chr17_+_38516907 0.381 ENST00000578774.1
CTD-2267D19.3
Uncharacterized protein
chr6_-_41909561 0.378 ENST00000372991.4
CCND3
cyclin D3
chr3_+_46448648 0.377 ENST00000399036.3
CCRL2
chemokine (C-C motif) receptor-like 2
chr16_+_222846 0.374 ENST00000251595.6
ENST00000397806.1
HBA2

hemoglobin, alpha 2

chr4_-_84030996 0.374 ENST00000411416.2
PLAC8
placenta-specific 8
chr3_+_42947600 0.373 ENST00000328199.6
ENST00000541208.1
ZNF662

zinc finger protein 662

chr3_+_186501336 0.373 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2


eukaryotic translation initiation factor 4A2


chr17_+_41005283 0.369 ENST00000592999.1
AOC3
amine oxidase, copper containing 3
chr6_-_41909191 0.368 ENST00000512426.1
ENST00000372987.4
CCND3

cyclin D3

chr17_-_33864772 0.363 ENST00000361112.4
SLFN12L
schlafen family member 12-like
chr6_+_10521574 0.362 ENST00000495262.1
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr17_-_39677971 0.354 ENST00000393976.2
KRT15
keratin 15
chr9_-_34372830 0.354 ENST00000379142.3
KIAA1161
KIAA1161
chr8_+_22853345 0.353 ENST00000522948.1
RHOBTB2
Rho-related BTB domain containing 2
chr3_-_183735651 0.352 ENST00000427120.2
ENST00000392579.2
ENST00000382494.2
ENST00000446941.2
ABCC5



ATP-binding cassette, sub-family C (CFTR/MRP), member 5



chr1_-_196577489 0.352 ENST00000609185.1
ENST00000451324.2
ENST00000367433.5
ENST00000367431.4
KCNT2



potassium channel, subfamily T, member 2



chr8_+_38677850 0.350 ENST00000518809.1
ENST00000520611.1
TACC1

transforming, acidic coiled-coil containing protein 1

chr5_+_118690466 0.349 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr14_-_60097524 0.348 ENST00000342503.4
RTN1
reticulon 1
chr2_-_175629135 0.347 ENST00000409542.1
ENST00000409219.1
CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr3_-_183967296 0.342 ENST00000455059.1
ENST00000445626.2
ALG3

ALG3, alpha-1,3- mannosyltransferase

chr2_-_238499131 0.338 ENST00000538644.1
RAB17
RAB17, member RAS oncogene family
chr2_-_190627481 0.337 ENST00000264151.5
ENST00000520350.1
ENST00000521630.1
ENST00000517895.1
OSGEPL1



O-sialoglycoprotein endopeptidase-like 1



chr16_+_28986134 0.330 ENST00000352260.7
SPNS1
spinster homolog 1 (Drosophila)
chr5_-_89825328 0.330 ENST00000500869.2
ENST00000315948.6
ENST00000509384.1
LYSMD3


LysM, putative peptidoglycan-binding, domain containing 3


chr3_+_188817891 0.326 ENST00000412373.1
TPRG1
tumor protein p63 regulated 1
chr1_+_8021954 0.326 ENST00000377491.1
ENST00000377488.1
PARK7

parkinson protein 7

chr11_+_28724129 0.324 ENST00000513853.1
RP11-115J23.1
RP11-115J23.1
chr8_-_29940569 0.323 ENST00000523761.1
TMEM66
transmembrane protein 66
chr17_+_78194261 0.321 ENST00000572725.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chrX_+_86772787 0.321 ENST00000373114.4
KLHL4
kelch-like family member 4
chr8_+_17104401 0.320 ENST00000324815.3
ENST00000518038.1
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr17_+_78194205 0.320 ENST00000573809.1
ENST00000361193.3
ENST00000574967.1
ENST00000576126.1
ENST00000411502.3
ENST00000546047.2
SLC26A11





solute carrier family 26 (anion exchanger), member 11





chr6_-_38607673 0.320 ENST00000481247.1
BTBD9
BTB (POZ) domain containing 9
chr12_-_130529501 0.317 ENST00000567788.1
ENST00000561864.1
RP11-474D1.3
RP11-474D1.4
RP11-474D1.3
RP11-474D1.4
chr16_-_75529273 0.316 ENST00000390664.2
CHST6
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
chr7_+_157129660 0.311 ENST00000429029.2
ENST00000262177.4
ENST00000417758.1
ENST00000452797.2
ENST00000443280.1
DNAJB6




DnaJ (Hsp40) homolog, subfamily B, member 6




chr6_+_31783291 0.311 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A


heat shock 70kDa protein 1A


chr8_+_17104539 0.311 ENST00000521829.1
ENST00000521005.1
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr17_-_78194716 0.311 ENST00000576707.1
SGSH
N-sulfoglucosamine sulfohydrolase
chrX_+_52238974 0.310 ENST00000375613.3
XAGE1B
X antigen family, member 1B
chr7_+_157129738 0.310 ENST00000437030.1
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6
chr20_+_5451845 0.309 ENST00000430097.2
RP5-828H9.1
RP5-828H9.1
chrX_-_72434628 0.309 ENST00000536638.1
ENST00000373517.3
NAP1L2

nucleosome assembly protein 1-like 2

chr16_+_28986085 0.307 ENST00000565975.1
ENST00000311008.11
ENST00000323081.8
ENST00000334536.8
SPNS1



spinster homolog 1 (Drosophila)



chr1_+_15632231 0.305 ENST00000375997.4
ENST00000524761.1
ENST00000375995.3
ENST00000401090.2
FHAD1



forkhead-associated (FHA) phosphopeptide binding domain 1



chr1_+_8021713 0.303 ENST00000338639.5
ENST00000493678.1
ENST00000377493.5
PARK7


parkinson protein 7


chr6_+_31795506 0.302 ENST00000375650.3
HSPA1B
heat shock 70kDa protein 1B
chr4_-_39529049 0.299 ENST00000501493.2
ENST00000509391.1
ENST00000507089.1
UGDH


UDP-glucose 6-dehydrogenase


chr8_-_29940464 0.297 ENST00000521265.1
ENST00000536273.1
TMEM66

transmembrane protein 66

chr2_-_151395525 0.296 ENST00000439275.1
RND3
Rho family GTPase 3
chr6_-_34216766 0.294 ENST00000481533.1
ENST00000468145.1
ENST00000413013.2
ENST00000394990.4
ENST00000335352.3
C6orf1




chromosome 6 open reading frame 1




chr8_-_29940628 0.291 ENST00000545648.1
ENST00000256255.6
TMEM66

transmembrane protein 66

chr3_+_180319918 0.287 ENST00000296015.4
ENST00000491380.1
ENST00000412756.2
ENST00000382584.4
TTC14



tetratricopeptide repeat domain 14



chr20_-_18038521 0.287 ENST00000278780.6
OVOL2
ovo-like zinc finger 2
chr2_+_220144052 0.286 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
DNAJB2


DnaJ (Hsp40) homolog, subfamily B, member 2


chrX_-_230884 0.282 ENST00000400701.3
ENST00000326153.4
GTPBP6

GTP binding protein 6 (putative)

chr14_+_39734482 0.278 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
CTAGE5



CTAGE family, member 5



chr16_+_28985542 0.277 ENST00000567771.1
ENST00000568388.1
SPNS1

spinster homolog 1 (Drosophila)

chr21_+_42733870 0.275 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
MX2


myxovirus (influenza virus) resistance 2 (mouse)


chr2_+_220144168 0.274 ENST00000392087.2
ENST00000442681.1
ENST00000439026.1
DNAJB2


DnaJ (Hsp40) homolog, subfamily B, member 2


chr4_-_39529180 0.273 ENST00000515021.1
ENST00000510490.1
ENST00000316423.6
UGDH


UDP-glucose 6-dehydrogenase


chr19_+_751122 0.272 ENST00000215582.6
MISP
mitotic spindle positioning
chr1_+_92683467 0.272 ENST00000370375.3
ENST00000370373.2
C1orf146

chromosome 1 open reading frame 146

chrX_+_15767971 0.271 ENST00000479740.1
ENST00000454127.2
CA5B

carbonic anhydrase VB, mitochondrial

chr9_-_19149276 0.270 ENST00000434144.1
PLIN2
perilipin 2
chr1_-_6260896 0.268 ENST00000497965.1
RPL22
ribosomal protein L22

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 1.9 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764)
0.4 1.1 GO:2000724 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.3 1.6 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.3 1.0 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.3 3.6 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.3 1.0 GO:1904000 positive regulation of eating behavior(GO:1904000)
0.2 0.7 GO:2000452 CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:0035698) regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation(GO:2000452)
0.2 0.9 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.2 1.2 GO:0030573 bile acid catabolic process(GO:0030573)
0.2 1.6 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 1.1 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.2 0.6 GO:0050787 enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.2 0.6 GO:1902283 negative regulation of primary amine oxidase activity(GO:1902283)
0.2 0.9 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.2 0.5 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.2 0.5 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.2 0.6 GO:0050717 regulation of interleukin-1 alpha secretion(GO:0050705) positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2 1.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.2 0.5 GO:0090427 regulation of fertilization(GO:0080154) activation of meiosis(GO:0090427)
0.1 1.7 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.4 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.5 GO:0030070 insulin processing(GO:0030070)
0.1 4.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.5 GO:0002415 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 2.3 GO:0051450 myoblast proliferation(GO:0051450)
0.1 0.5 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.4 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.1 0.3 GO:0045041 B cell cytokine production(GO:0002368) protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.7 GO:0015798 myo-inositol transport(GO:0015798)
0.1 0.3 GO:0045210 FasL biosynthetic process(GO:0045210)
0.1 0.1 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730)
0.1 0.5 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 1.4 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.1 0.3 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.2 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.1 0.8 GO:0042748 circadian sleep/wake cycle, non-REM sleep(GO:0042748)
0.1 0.2 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1 0.9 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.1 0.3 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308)
0.1 0.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.1 1.0 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 0.6 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.1 0.3 GO:0005986 sucrose biosynthetic process(GO:0005986)
0.1 0.4 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.2 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.1 0.6 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.1 0.2 GO:0002586 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.1 0.9 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.1 0.8 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.1 0.3 GO:0060214 endocardium formation(GO:0060214)
0.1 0.6 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 0.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1 0.5 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.1 0.3 GO:0003409 optic cup structural organization(GO:0003409)
0.1 0.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1 0.3 GO:2000035 regulation of stem cell division(GO:2000035)
0.1 0.6 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.0 0.2 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.5 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.9 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.0 0.1 GO:0006424 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.4 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.3 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.9 GO:0019532 oxalate transport(GO:0019532)
0.0 0.1 GO:0032570 response to progesterone(GO:0032570)
0.0 1.4 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0015881 creatine transport(GO:0015881) creatine transmembrane transport(GO:1902598)
0.0 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.3 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.9 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.1 GO:0008052 sensory organ boundary specification(GO:0008052) formation of organ boundary(GO:0010160) taste bud development(GO:0061193)
0.0 0.1 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.0 0.2 GO:1901142 insulin metabolic process(GO:1901142)
0.0 0.3 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 1.1 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 3.0 GO:0032729 positive regulation of interferon-gamma production(GO:0032729)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.1 GO:0061386 closure of optic fissure(GO:0061386)
0.0 0.2 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.4 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.9 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.2 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0006844 acyl carnitine transport(GO:0006844) acyl carnitine transmembrane transport(GO:1902616)
0.0 1.0 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.1 GO:1990619 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.0 0.1 GO:0042214 terpene metabolic process(GO:0042214)
0.0 0.1 GO:2001178 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.5 GO:0007620 copulation(GO:0007620)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.3 GO:0046631 alpha-beta T cell activation(GO:0046631)
0.0 0.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.3 GO:1904251 regulation of bile acid metabolic process(GO:1904251)
0.0 0.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.0 0.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.0 0.1 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.3 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 0.2 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:0044010 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) positive regulation of bone mineralization involved in bone maturation(GO:1900159) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.0 0.2 GO:0021543 pallium development(GO:0021543)
0.0 0.1 GO:0046668 regulation of retinal cell programmed cell death(GO:0046668)
0.0 0.1 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.0 0.2 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.2 GO:0021984 adenohypophysis development(GO:0021984)
0.0 0.5 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.2 GO:0032025 response to cobalt ion(GO:0032025)
0.0 0.2 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.7 GO:0042554 superoxide anion generation(GO:0042554)
0.0 1.9 GO:0070268 cornification(GO:0070268)
0.0 1.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0072752 cellular response to rapamycin(GO:0072752) response to rapamycin(GO:1901355)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.1 GO:0035624 receptor transactivation(GO:0035624)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.0 4.0 GO:0007565 female pregnancy(GO:0007565)
0.0 0.1 GO:0046785 microtubule polymerization(GO:0046785)
0.0 0.1 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.5 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.0 GO:0051466 positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0 1.0 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.1 GO:0044501 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0 0.6 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0 0.1 GO:0031999 negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0 0.2 GO:0050918 positive chemotaxis(GO:0050918)
0.0 0.1 GO:0002877 acute inflammatory response to non-antigenic stimulus(GO:0002525) regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877) positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:1900004 negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0 0.3 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0 0.1 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 0.2 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.0 GO:0035397 helper T cell enhancement of adaptive immune response(GO:0035397)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.2 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.0 GO:0038178 complement component C5a signaling pathway(GO:0038178)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0009615 response to virus(GO:0009615)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.1 GO:0038098 sequestering of BMP in extracellular matrix(GO:0035582) sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.1 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.1 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.2 GO:0015886 heme transport(GO:0015886)
0.0 0.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.3 5.5 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 0.5 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.1 0.7 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.1 0.5 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 1.1 GO:0005610 laminin-5 complex(GO:0005610)
0.1 0.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1 1.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.7 GO:0032010 phagolysosome(GO:0032010)
0.1 0.2 GO:0043293 apoptosome(GO:0043293)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.5 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0075341 host cell PML body(GO:0075341)
0.0 0.4 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.5 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 1.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.6 GO:0097342 ripoptosome(GO:0097342)
0.0 0.3 GO:0030061 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) mitochondrial crista(GO:0030061)
0.0 1.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.1 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.1 GO:0030849 autosome(GO:0030849)
0.0 0.2 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 2.5 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 0.6 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.4 1.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.4 1.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.4 1.1 GO:0071633 dihydroceramidase activity(GO:0071633)
0.3 3.6 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 0.7 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.2 2.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.2 0.6 GO:0031768 ghrelin receptor binding(GO:0031768)
0.2 0.9 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.2 0.9 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 0.6 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.2 0.9 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.2 0.8 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.2 0.5 GO:0001156 TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.6 GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.1 0.5 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.3 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 0.3 GO:0016826 N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826)
0.1 0.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.1 0.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 2.7 GO:0042605 peptide antigen binding(GO:0042605)
0.1 0.6 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 0.3 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.4 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.1 1.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.7 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 0.6 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.2 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.3 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 1.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.9 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.1 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.0 0.2 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.6 GO:0008430 selenium binding(GO:0008430)
0.0 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.3 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.1 GO:0005308 creatine transmembrane transporter activity(GO:0005308)
0.0 3.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.4 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.5 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 2.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.1 GO:0004947 bradykinin receptor activity(GO:0004947)
0.0 0.2 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.7 GO:0043028 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.0 0.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.2 GO:0047288 monosialoganglioside sialyltransferase activity(GO:0047288)
0.0 0.1 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.0 0.5 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.2 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.1 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.0 0.4 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 0.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.0 1.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.1 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 2.1 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 1.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.9 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.0 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.2 GO:0005549 odorant binding(GO:0005549)
0.0 0.2 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:0004878 complement component C5a receptor activity(GO:0004878)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.2 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.6 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.9 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 1.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.2 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.9 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID_IL1_PATHWAY IL1-mediated signaling events
0.0 0.9 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 3.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.4 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 1.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.6 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.9 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.0 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.0 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.5 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.6 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.2 REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.5 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.8 REACTOME_GPVI_MEDIATED_ACTIVATION_CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein