Motif ID: HOXB13

Z-value: 0.257


Transcription factors associated with HOXB13:

Gene SymbolEntrez IDGene Name
HOXB13 ENSG00000159184.7 HOXB13

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB13hg19_v2_chr17_-_46806540_468065580.723.0e-02Click!


Activity profile for motif HOXB13.

activity profile for motif HOXB13


Sorted Z-values histogram for motif HOXB13

Sorted Z-values for motif HOXB13



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_52715179 0.319 ENST00000293670.3
 KRT83
keratin 83
chr15_-_88247083 0.219 ENST00000560439.1
 RP11-648K4.2
RP11-648K4.2
chr9_+_125133315 0.185 ENST00000223423.4
ENST00000362012.2
 PTGS1

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

chr6_+_122793058 0.162 ENST00000392491.2
 PKIB
protein kinase (cAMP-dependent, catalytic) inhibitor beta
chr11_+_118401706 0.157 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
 TMEM25


transmembrane protein 25


chr6_-_27782548 0.135 ENST00000333151.3
 HIST1H2AJ
histone cluster 1, H2aj
chr19_+_35634146 0.118 ENST00000586063.1
ENST00000270310.2
ENST00000588265.1
 FXYD7


FXYD domain containing ion transport regulator 7


chr2_-_69180083 0.114 ENST00000328895.4
 GKN2
gastrokine 2
chr16_-_80926457 0.111 ENST00000563626.1
ENST00000562231.1
 RP11-314O13.1

RP11-314O13.1

chr9_+_125132803 0.107 ENST00000540753.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr17_-_46806540 0.086 ENST00000290295.7
 HOXB13
homeobox B13
chr8_+_86376081 0.076 ENST00000285379.5
 CA2
carbonic anhydrase II
chr7_-_50860565 0.074 ENST00000403097.1
 GRB10
growth factor receptor-bound protein 10
chr1_-_178838404 0.069 ENST00000444255.1
 ANGPTL1
angiopoietin-like 1
chr3_-_150690786 0.068 ENST00000327047.1
 CLRN1
clarin 1
chr3_+_89156674 0.065 ENST00000336596.2
 EPHA3
EPH receptor A3
chr9_-_104198042 0.061 ENST00000374855.4
 ALDOB
aldolase B, fructose-bisphosphate
chr2_-_69180012 0.057 ENST00000481498.1
 GKN2
gastrokine 2
chr9_-_14180778 0.055 ENST00000380924.1
ENST00000543693.1
 NFIB

nuclear factor I/B

chr2_-_175629164 0.054 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
 CHRNA1


cholinergic receptor, nicotinic, alpha 1 (muscle)


chr4_+_95972822 0.051 ENST00000509540.1
ENST00000440890.2
 BMPR1B

bone morphogenetic protein receptor, type IB

chr1_+_23037323 0.051 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
 EPHB2



EPH receptor B2



chr2_-_205099700 0.050 ENST00000419860.1
 AC009498.1
AC009498.1
chr9_+_125133467 0.045 ENST00000426608.1
 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_175629135 0.044 ENST00000409542.1
ENST00000409219.1
 CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr5_-_159766528 0.039 ENST00000505287.2
 CCNJL
cyclin J-like
chr11_-_102714534 0.037 ENST00000299855.5
 MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_-_149783914 0.037 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
 HIST2H2BF


histone cluster 2, H2bf


chr1_-_155880672 0.035 ENST00000609492.1
ENST00000368322.3
 RIT1

Ras-like without CAAX 1

chr18_+_3252265 0.035 ENST00000580887.1
ENST00000536605.1
 MYL12A

myosin, light chain 12A, regulatory, non-sarcomeric

chr22_-_38240412 0.034 ENST00000215941.4
 ANKRD54
ankyrin repeat domain 54
chr11_+_47279155 0.031 ENST00000444396.1
ENST00000457932.1
ENST00000412937.1
 NR1H3


nuclear receptor subfamily 1, group H, member 3


chr18_+_3252206 0.030 ENST00000578562.2
 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr14_-_50583271 0.027 ENST00000395860.2
ENST00000395859.2
 VCPKMT

valosin containing protein lysine (K) methyltransferase

chr22_-_38240316 0.027 ENST00000411961.2
ENST00000434930.1
 ANKRD54

ankyrin repeat domain 54

chr14_-_51027838 0.026 ENST00000555216.1
 MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr8_+_97597148 0.024 ENST00000521590.1
 SDC2
syndecan 2
chr2_-_176046391 0.023 ENST00000392541.3
ENST00000409194.1
 ATP5G3

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

chr8_-_114449112 0.021 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
 CSMD3


CUB and Sushi multiple domains 3


chr5_-_140053152 0.020 ENST00000542735.1
 DND1
DND microRNA-mediated repression inhibitor 1
chr7_-_11871815 0.020 ENST00000423059.4
 THSD7A
thrombospondin, type I, domain containing 7A
chr5_-_126409159 0.018 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
 C5orf63



chromosome 5 open reading frame 63



chr1_-_12679171 0.017 ENST00000606790.1
 RP11-474O21.5
RP11-474O21.5
chr12_+_80838126 0.016 ENST00000266688.5
 PTPRQ
protein tyrosine phosphatase, receptor type, Q
chr5_-_145214848 0.016 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
 PRELID2



PRELI domain containing 2



chr1_-_45956800 0.015 ENST00000538496.1
 TESK2
testis-specific kinase 2
chr1_-_45956822 0.015 ENST00000372086.3
ENST00000341771.6
 TESK2

testis-specific kinase 2

chr4_-_164534657 0.015 ENST00000339875.5
 MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr11_+_63606373 0.014 ENST00000402010.2
ENST00000315032.8
ENST00000377809.4
ENST00000413835.2
ENST00000377810.3
 MARK2




MAP/microtubule affinity-regulating kinase 2




chr1_-_45956868 0.013 ENST00000451835.2
 TESK2
testis-specific kinase 2
chr15_+_66994561 0.012 ENST00000288840.5
 SMAD6
SMAD family member 6
chr10_-_13350447 0.012 ENST00000429930.1
 AL138764.1
Uncharacterized protein
chr13_-_45768841 0.011 ENST00000379108.1
 KCTD4
potassium channel tetramerization domain containing 4
chr5_-_145214893 0.011 ENST00000394450.2
 PRELID2
PRELI domain containing 2
chr6_-_43021612 0.010 ENST00000535468.1
 CUL7
cullin 7
chr1_-_36863481 0.010 ENST00000315732.2
 LSM10
LSM10, U7 small nuclear RNA associated
chr6_-_116833500 0.008 ENST00000356128.4
 TRAPPC3L
trafficking protein particle complex 3-like
chr7_+_132937820 0.005 ENST00000393161.2
ENST00000253861.4
 EXOC4

exocyst complex component 4

chr14_+_76776957 0.005 ENST00000512784.1
 ESRRB
estrogen-related receptor beta
chr12_+_8309630 0.003 ENST00000396570.3
 ZNF705A
zinc finger protein 705A
chr3_+_89156799 0.002 ENST00000452448.2
ENST00000494014.1
 EPHA3

EPH receptor A3

chr2_-_51259229 0.002 ENST00000405472.3
 NRXN1
neurexin 1
chr2_-_51259292 0.002 ENST00000401669.2
 NRXN1
neurexin 1
chr3_-_123710199 0.002 ENST00000184183.4
 ROPN1
rhophilin associated tail protein 1
chr4_+_110749143 0.001 ENST00000317735.4
 RRH
retinal pigment epithelium-derived rhodopsin homolog
chr12_-_16430619 0.001 ENST00000344941.3
 SLC15A5
solute carrier family 15, member 5
chr19_+_56154913 0.001 ENST00000270451.5
ENST00000588537.1
 ZNF581

zinc finger protein 581

chr3_-_195310802 0.000 ENST00000421243.1
ENST00000453131.1
 APOD

apolipoprotein D


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032849 positive regulation of cellular pH reduction(GO:0032849) dipeptide transport(GO:0042938)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0051389 inactivation of MAPKK activity(GO:0051389)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)