Motif ID: HOXA2_HOXB1

Z-value: 0.443

Transcription factors associated with HOXA2_HOXB1:

Gene SymbolEntrez IDGene Name
HOXA2 ENSG00000105996.5 HOXA2
HOXB1 ENSG00000120094.6 HOXB1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXB1hg19_v2_chr17_-_46608272_466083850.732.6e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of HOXA2_HOXB1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_+_39975544 0.587 ENST00000544340.1
FKBP10
FK506 binding protein 10, 65 kDa
chr17_+_39975455 0.578 ENST00000455106.1
FKBP10
FK506 binding protein 10, 65 kDa
chr6_+_151561506 0.478 ENST00000253332.1
AKAP12
A kinase (PRKA) anchor protein 12
chr17_-_46623441 0.473 ENST00000330070.4
HOXB2
homeobox B2
chr6_+_151561085 0.470 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr17_+_37824217 0.433 ENST00000394246.1
PNMT
phenylethanolamine N-methyltransferase
chr17_+_37824411 0.371 ENST00000269582.2
PNMT
phenylethanolamine N-methyltransferase
chr17_+_37824700 0.349 ENST00000581428.1
PNMT
phenylethanolamine N-methyltransferase
chr17_-_46608272 0.313 ENST00000577092.1
ENST00000239174.6
HOXB1

homeobox B1

chr5_+_167181917 0.239 ENST00000519204.1
TENM2
teneurin transmembrane protein 2
chr11_-_126870655 0.195 ENST00000525144.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr12_+_57610562 0.185 ENST00000349394.5
NXPH4
neurexophilin 4
chr1_-_205391178 0.166 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1



LEM domain containing 1



chr6_+_155334780 0.164 ENST00000538270.1
ENST00000535231.1
TIAM2

T-cell lymphoma invasion and metastasis 2

chr16_+_15596123 0.154 ENST00000452191.2
C16orf45
chromosome 16 open reading frame 45
chr2_-_190044480 0.150 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr18_-_53070913 0.148 ENST00000568186.1
ENST00000564228.1
TCF4

transcription factor 4

chr12_-_15038779 0.148 ENST00000228938.5
ENST00000539261.1
MGP

matrix Gla protein

chr12_+_101988627 0.137 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
MYBPC1








myosin binding protein C, slow type








chr1_+_243419306 0.126 ENST00000355875.4
ENST00000391846.1
ENST00000366541.3
ENST00000343783.6
SDCCAG8



serologically defined colon cancer antigen 8



chr5_-_10761206 0.125 ENST00000432074.2
ENST00000230895.6
DAP

death-associated protein

chr12_+_101988774 0.118 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
MYBPC1





myosin binding protein C, slow type





chr10_+_102891048 0.111 ENST00000467928.2
TLX1
T-cell leukemia homeobox 1
chr3_+_159481988 0.111 ENST00000472451.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr11_-_126870683 0.100 ENST00000525704.2
KIRREL3
kin of IRRE like 3 (Drosophila)
chr3_+_189507432 0.095 ENST00000354600.5
TP63
tumor protein p63
chr10_-_79397202 0.087 ENST00000372437.1
ENST00000372408.2
ENST00000372403.4
KCNMA1


potassium large conductance calcium-activated channel, subfamily M, alpha member 1


chr3_+_189507523 0.082 ENST00000437221.1
ENST00000392463.2
ENST00000392461.3
ENST00000449992.1
ENST00000456148.1
TP63




tumor protein p63




chr15_+_81591757 0.080 ENST00000558332.1
IL16
interleukin 16
chr10_-_98945677 0.080 ENST00000266058.4
ENST00000371041.3
SLIT1

slit homolog 1 (Drosophila)

chr10_-_98945264 0.076 ENST00000314867.5
SLIT1
slit homolog 1 (Drosophila)
chr12_+_21168630 0.074 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr15_-_93616340 0.072 ENST00000557420.1
ENST00000542321.2
RGMA

repulsive guidance molecule family member a

chr7_-_143956815 0.072 ENST00000493325.1
OR2A7
olfactory receptor, family 2, subfamily A, member 7
chr11_-_128712362 0.070 ENST00000392664.2
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1
chr6_+_32006042 0.068 ENST00000418967.2
CYP21A2
cytochrome P450, family 21, subfamily A, polypeptide 2
chr19_-_49944806 0.067 ENST00000221485.3
SLC17A7
solute carrier family 17 (vesicular glutamate transporter), member 7
chrX_+_95939711 0.066 ENST00000373049.4
ENST00000324765.8
DIAPH2

diaphanous-related formin 2

chr7_+_86273218 0.065 ENST00000361669.2
GRM3
glutamate receptor, metabotropic 3
chr12_-_49393092 0.065 ENST00000421952.2
DDN
dendrin
chr3_+_150264555 0.064 ENST00000406576.3
ENST00000482093.1
ENST00000273435.5
EIF2A


eukaryotic translation initiation factor 2A, 65kDa


chr10_-_79397316 0.064 ENST00000372421.5
ENST00000457953.1
KCNMA1

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

chr9_+_44867571 0.060 ENST00000377548.2
RP11-160N1.10
RP11-160N1.10
chrX_+_95939638 0.060 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2


diaphanous-related formin 2


chr15_-_64673630 0.059 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101


KIAA0101


chr3_+_150264458 0.058 ENST00000487799.1
ENST00000460851.1
EIF2A

eukaryotic translation initiation factor 2A, 65kDa

chr11_-_93583697 0.056 ENST00000409977.1
VSTM5
V-set and transmembrane domain containing 5
chr3_-_156877997 0.055 ENST00000295926.3
CCNL1
cyclin L1
chr7_+_39017504 0.055 ENST00000403058.1
POU6F2
POU class 6 homeobox 2
chr10_-_65028938 0.054 ENST00000402544.1
JMJD1C
jumonji domain containing 1C
chr17_-_1588101 0.054 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
PRPF8


pre-mRNA processing factor 8


chr15_-_64673665 0.054 ENST00000300035.4
KIAA0101
KIAA0101
chr5_+_162864575 0.052 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1






cyclin G1






chr6_-_159065741 0.051 ENST00000367085.3
ENST00000367089.3
DYNLT1

dynein, light chain, Tctex-type 1

chr15_-_74501360 0.050 ENST00000323940.5
STRA6
stimulated by retinoic acid 6
chr10_-_65028817 0.050 ENST00000542921.1
JMJD1C
jumonji domain containing 1C
chr12_+_57390745 0.049 ENST00000600202.1
HBCBP
HBcAg-binding protein; Uncharacterized protein
chr6_+_32006159 0.049 ENST00000478281.1
ENST00000471671.1
ENST00000435122.2
CYP21A2


cytochrome P450, family 21, subfamily A, polypeptide 2


chrX_-_45629661 0.049 ENST00000602507.1
ENST00000602461.1
RP6-99M1.2

RP6-99M1.2

chr8_-_67874805 0.049 ENST00000563496.1
TCF24
transcription factor 24
chr12_-_86650045 0.049 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr15_-_93616892 0.047 ENST00000556658.1
ENST00000538818.1
ENST00000425933.2
RGMA


repulsive guidance molecule family member a


chr9_+_132099158 0.047 ENST00000444125.1
RP11-65J3.1
RP11-65J3.1
chr6_-_113754604 0.047 ENST00000421737.1
RP1-124C6.1
RP1-124C6.1
chr8_-_101730061 0.046 ENST00000519100.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr8_+_77316233 0.045 ENST00000603284.1
ENST00000603837.1
RP11-706J10.2
RP11-706J10.3
RP11-706J10.2
long intergenic non-protein coding RNA 1109
chr16_+_66429358 0.044 ENST00000539168.1
CDH5
cadherin 5, type 2 (vascular endothelium)
chr6_-_6225026 0.042 ENST00000445223.1
F13A1
coagulation factor XIII, A1 polypeptide
chr4_-_90756769 0.041 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
SNCA


synuclein, alpha (non A4 component of amyloid precursor)


chr2_+_26624775 0.040 ENST00000288710.2
DRC1
dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chr12_-_58135903 0.039 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr10_-_79397479 0.038 ENST00000404771.3
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr9_+_125562370 0.037 ENST00000277309.2
OR1K1
olfactory receptor, family 1, subfamily K, member 1
chr6_-_112575838 0.037 ENST00000455073.1
LAMA4
laminin, alpha 4
chr12_+_10658489 0.036 ENST00000538173.1
EIF2S3L
Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr13_+_52586517 0.036 ENST00000523764.1
ENST00000521508.1
ALG11

ALG11, alpha-1,2-mannosyltransferase

chr17_-_57229155 0.033 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr3_+_191046810 0.033 ENST00000392455.3
ENST00000392456.3
CCDC50

coiled-coil domain containing 50

chr9_+_44868935 0.031 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr21_+_19617140 0.031 ENST00000299295.2
ENST00000338326.3
CHODL

chondrolectin

chr10_-_102890883 0.029 ENST00000445873.1
TLX1NB
TLX1 neighbor
chr15_-_74501310 0.028 ENST00000423167.2
ENST00000432245.2
STRA6

stimulated by retinoic acid 6

chr4_-_90757364 0.028 ENST00000508895.1
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr9_-_36276966 0.028 ENST00000543356.2
ENST00000396594.3
GNE

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr7_+_20370746 0.028 ENST00000222573.4
ITGB8
integrin, beta 8
chr2_+_36923830 0.028 ENST00000379242.3
ENST00000389975.3
VIT

vitrin

chr2_+_36923901 0.027 ENST00000457137.2
VIT
vitrin
chr1_+_68150744 0.027 ENST00000370986.4
ENST00000370985.3
GADD45A

growth arrest and DNA-damage-inducible, alpha

chr19_+_35849723 0.027 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr12_-_88423164 0.027 ENST00000298699.2
ENST00000550553.1
C12orf50

chromosome 12 open reading frame 50

chr14_-_21516590 0.026 ENST00000555026.1
NDRG2
NDRG family member 2
chr2_-_45236540 0.025 ENST00000303077.6
SIX2
SIX homeobox 2
chr2_-_49381572 0.025 ENST00000454032.1
ENST00000304421.4
FSHR

follicle stimulating hormone receptor

chr7_-_100881109 0.024 ENST00000308344.5
CLDN15
claudin 15
chr17_+_21729593 0.024 ENST00000581769.1
ENST00000584755.1
UBBP4

ubiquitin B pseudogene 4

chr7_-_100881041 0.024 ENST00000412417.1
ENST00000414035.1
CLDN15

claudin 15

chr1_-_108507631 0.023 ENST00000527011.1
ENST00000370056.4
VAV3

vav 3 guanine nucleotide exchange factor

chr5_-_179045199 0.023 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_+_178062855 0.022 ENST00000448150.3
RASAL2
RAS protein activator like 2
chr2_-_242089677 0.022 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr17_-_37353950 0.022 ENST00000394310.3
ENST00000394303.3
ENST00000344140.5
CACNB1


calcium channel, voltage-dependent, beta 1 subunit


chr3_+_189507460 0.022 ENST00000434928.1
TP63
tumor protein p63
chr15_+_75335604 0.022 ENST00000563393.1
PPCDC
phosphopantothenoylcysteine decarboxylase
chr10_-_100995540 0.021 ENST00000370546.1
ENST00000404542.1
HPSE2

heparanase 2

chr3_+_112929850 0.021 ENST00000464546.1
BOC
BOC cell adhesion associated, oncogene regulated
chr12_-_86650154 0.021 ENST00000552435.2
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr4_-_113437328 0.020 ENST00000313341.3
NEUROG2
neurogenin 2
chr1_+_52082751 0.019 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
OSBPL9



oxysterol binding protein-like 9



chr14_+_68189190 0.018 ENST00000539142.1
RDH12
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
chr3_-_150264272 0.017 ENST00000491660.1
ENST00000487153.1
ENST00000239944.2
SERP1


stress-associated endoplasmic reticulum protein 1


chr10_-_100995603 0.016 ENST00000370552.3
ENST00000370549.1
HPSE2

heparanase 2

chr2_+_36923933 0.016 ENST00000497382.1
ENST00000404084.1
ENST00000379241.3
ENST00000401530.1
VIT



vitrin



chr7_-_86595190 0.016 ENST00000398276.2
ENST00000416314.1
ENST00000425689.1
KIAA1324L


KIAA1324-like


chr2_-_49381646 0.016 ENST00000346173.3
ENST00000406846.2
FSHR

follicle stimulating hormone receptor

chr1_+_67390578 0.015 ENST00000371018.3
ENST00000355977.6
ENST00000357692.2
ENST00000401041.1
ENST00000371016.1
ENST00000371014.1
ENST00000371012.2
MIER1






mesoderm induction early response 1, transcriptional regulator






chr8_-_38008783 0.015 ENST00000276449.4
STAR
steroidogenic acute regulatory protein
chr16_+_85645007 0.014 ENST00000405402.2
GSE1
Gse1 coiled-coil protein
chr6_+_73331520 0.014 ENST00000342056.2
ENST00000355194.4
KCNQ5

potassium voltage-gated channel, KQT-like subfamily, member 5

chr6_+_33388013 0.014 ENST00000449372.2
SYNGAP1
synaptic Ras GTPase activating protein 1
chr9_+_140135665 0.013 ENST00000340384.4
TUBB4B
tubulin, beta 4B class IVb
chr6_+_33387830 0.012 ENST00000293748.5
SYNGAP1
synaptic Ras GTPase activating protein 1
chr6_+_29426230 0.012 ENST00000442615.1
OR2H1
olfactory receptor, family 2, subfamily H, member 1
chr11_+_68228186 0.012 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
PPP6R3












protein phosphatase 6, regulatory subunit 3












chr9_-_101471479 0.011 ENST00000259455.2
GABBR2
gamma-aminobutyric acid (GABA) B receptor, 2
chr12_-_118490217 0.011 ENST00000542304.1
WSB2
WD repeat and SOCS box containing 2
chr19_-_45735138 0.011 ENST00000252482.3
EXOC3L2
exocyst complex component 3-like 2
chr2_-_200322723 0.011 ENST00000417098.1
SATB2
SATB homeobox 2
chr10_-_98945515 0.010 ENST00000371070.4
SLIT1
slit homolog 1 (Drosophila)
chr21_-_43430440 0.010 ENST00000398505.3
ENST00000310826.5
ENST00000449949.1
ENST00000398499.1
ENST00000398497.2
ENST00000398511.3
ZBTB21





zinc finger and BTB domain containing 21





chr12_+_7282795 0.009 ENST00000266546.6
CLSTN3
calsyntenin 3
chr19_+_13051206 0.009 ENST00000586760.1
CALR
calreticulin
chr16_+_7560114 0.009 ENST00000570626.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr13_-_36050819 0.008 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr10_-_105615164 0.008 ENST00000355946.2
ENST00000369774.4
SH3PXD2A

SH3 and PX domains 2A

chr12_+_21679220 0.008 ENST00000256969.2
C12orf39
chromosome 12 open reading frame 39
chr2_+_242089833 0.006 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7



protein phosphatase 1, regulatory subunit 7



chr12_-_28124903 0.006 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
PTHLH


parathyroid hormone-like hormone


chr12_-_86650077 0.006 ENST00000552808.2
ENST00000547225.1
MGAT4C

mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)

chr13_+_36050881 0.006 ENST00000537702.1
NBEA
neurobeachin
chr18_+_18943554 0.006 ENST00000580732.2
GREB1L
growth regulation by estrogen in breast cancer-like
chr5_-_145895753 0.006 ENST00000311104.2
GPR151
G protein-coupled receptor 151
chr10_-_46342921 0.005 ENST00000448048.2
AGAP4
ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
chr20_+_21284416 0.005 ENST00000539513.1
XRN2
5'-3' exoribonuclease 2
chr17_+_58755184 0.005 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
BCAS3


breast carcinoma amplified sequence 3


chr6_-_64029879 0.004 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
LGSN


lengsin, lens protein with glutamine synthetase domain


chr2_-_200323414 0.004 ENST00000443023.1
SATB2
SATB homeobox 2
chr6_+_33387868 0.004 ENST00000418600.2
SYNGAP1
synaptic Ras GTPase activating protein 1
chr6_-_112575758 0.003 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4



laminin, alpha 4



chrX_-_110655391 0.003 ENST00000356915.2
ENST00000356220.3
DCX

doublecortin

chr20_+_30467600 0.003 ENST00000375934.4
ENST00000375922.4
TTLL9

tubulin tyrosine ligase-like family, member 9

chr12_-_28125638 0.003 ENST00000545234.1
PTHLH
parathyroid hormone-like hormone
chr9_-_127269661 0.001 ENST00000373588.4
NR5A1
nuclear receptor subfamily 5, group A, member 1
chr16_-_11617444 0.001 ENST00000598234.1
CTD-3088G3.8
Protein LOC388210

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
0.3 1.2 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.1 0.8 GO:0021546 rhombomere development(GO:0021546)
0.1 0.3 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.1 0.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.1 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.2 GO:0007499 ectoderm and mesoderm interaction(GO:0007499) female genitalia morphogenesis(GO:0048807)
0.0 0.2 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.0 0.1 GO:0042137 sequestering of neurotransmitter(GO:0042137)
0.0 0.2 GO:1903976 negative regulation of glial cell migration(GO:1903976)
0.0 0.1 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.0 0.2 GO:0034465 response to carbon monoxide(GO:0034465)
0.0 0.1 GO:0061143 alveolar primary septum development(GO:0061143)
0.0 0.0 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.0 0.3 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0007402 ganglion mother cell fate determination(GO:0007402)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.9 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.1 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.0 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.3 GO:0031432 titin binding(GO:0031432)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones