Motif ID: HBP1
Z-value: 1.014
Transcription factors associated with HBP1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HBP1 | ENSG00000105856.9 | HBP1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HBP1 | hg19_v2_chr7_+_106809406_106809460 | -0.85 | 3.5e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0001798 | positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894) |
| 0.4 | 1.3 | GO:0014016 | neuroblast differentiation(GO:0014016) |
| 0.1 | 0.4 | GO:0046356 | acetyl-CoA catabolic process(GO:0046356) |
| 0.1 | 2.4 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 2.3 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.1 | 0.7 | GO:0021993 | initiation of neural tube closure(GO:0021993) |
| 0.1 | 0.5 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.1 | 0.3 | GO:0090294 | nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250) |
| 0.1 | 4.5 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.5 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) |
| 0.1 | 0.3 | GO:1901076 | positive regulation of engulfment of apoptotic cell(GO:1901076) |
| 0.1 | 0.5 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.1 | 0.6 | GO:0070164 | negative regulation of adiponectin secretion(GO:0070164) |
| 0.1 | 0.2 | GO:0051685 | maintenance of ER location(GO:0051685) |
| 0.1 | 0.4 | GO:2001184 | positive regulation of interleukin-12 secretion(GO:2001184) |
| 0.1 | 0.3 | GO:0031508 | pericentric heterochromatin assembly(GO:0031508) |
| 0.1 | 0.3 | GO:0002215 | defense response to nematode(GO:0002215) |
| 0.1 | 0.2 | GO:0040040 | thermosensory behavior(GO:0040040) |
| 0.1 | 0.5 | GO:0035166 | post-embryonic hemopoiesis(GO:0035166) |
| 0.1 | 0.4 | GO:0002729 | positive regulation of natural killer cell cytokine production(GO:0002729) |
| 0.1 | 0.4 | GO:1903976 | negative regulation of glial cell migration(GO:1903976) |
| 0.1 | 0.4 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.0 | 0.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 0.4 | GO:0006526 | arginine biosynthetic process(GO:0006526) |
| 0.0 | 0.1 | GO:0031106 | septin ring assembly(GO:0000921) septin ring organization(GO:0031106) |
| 0.0 | 1.5 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.0 | 0.2 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.0 | 0.2 | GO:0045209 | MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209) |
| 0.0 | 0.2 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
| 0.0 | 1.7 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 0.0 | 0.1 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.0 | 0.2 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.0 | 0.1 | GO:0021775 | smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776) |
| 0.0 | 0.1 | GO:1905166 | negative regulation of protein catabolic process in the vacuole(GO:1904351) negative regulation of lysosomal protein catabolic process(GO:1905166) |
| 0.0 | 0.5 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.1 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) |
| 0.0 | 0.2 | GO:0030950 | establishment or maintenance of actin cytoskeleton polarity(GO:0030950) |
| 0.0 | 0.6 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) |
| 0.0 | 0.3 | GO:0032494 | response to peptidoglycan(GO:0032494) |
| 0.0 | 0.2 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.0 | 0.1 | GO:0045226 | hyaluranon cable assembly(GO:0036118) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.0 | 0.1 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.1 | GO:0010446 | response to alkaline pH(GO:0010446) |
| 0.0 | 0.2 | GO:1900262 | regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264) |
| 0.0 | 0.1 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.0 | 0.1 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.0 | 0.2 | GO:0048864 | stem cell development(GO:0048864) |
| 0.0 | 0.6 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.0 | 0.2 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.0 | 0.2 | GO:0030916 | otic vesicle formation(GO:0030916) |
| 0.0 | 0.2 | GO:0001955 | blood vessel maturation(GO:0001955) |
| 0.0 | 0.2 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.0 | 0.1 | GO:0051177 | meiotic sister chromatid cohesion(GO:0051177) |
| 0.0 | 0.1 | GO:0044778 | meiotic DNA integrity checkpoint(GO:0044778) |
| 0.0 | 0.1 | GO:0098535 | de novo centriole assembly(GO:0098535) |
| 0.0 | 0.1 | GO:0003025 | regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) |
| 0.0 | 0.1 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.0 | 0.1 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.0 | 0.1 | GO:1904637 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.0 | 0.1 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.0 | 0.6 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.0 | 0.1 | GO:1902775 | mitochondrial large ribosomal subunit assembly(GO:1902775) |
| 0.0 | 0.2 | GO:0010886 | positive regulation of cholesterol storage(GO:0010886) |
| 0.0 | 0.2 | GO:0016926 | protein desumoylation(GO:0016926) |
| 0.0 | 0.0 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.0 | 0.0 | GO:0015747 | urate transport(GO:0015747) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.3 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.1 | 1.3 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.4 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.0 | 0.1 | GO:0000438 | core TFIIH complex portion of holo TFIIH complex(GO:0000438) |
| 0.0 | 0.3 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.3 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.1 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.0 | 0.2 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.2 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 0.2 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.0 | 0.1 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.1 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.0 | 0.1 | GO:0031166 | integral component of vacuolar membrane(GO:0031166) |
| 0.0 | 0.3 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.2 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.0 | 1.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.2 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.1 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 0.1 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 0.5 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 3.9 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.2 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 0.2 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.0 | 0.1 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.0 | 0.1 | GO:0030681 | multimeric ribonuclease P complex(GO:0030681) |
| 0.0 | 0.2 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.7 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.3 | 1.3 | GO:0033265 | acetylcholinesterase activity(GO:0003990) choline binding(GO:0033265) |
| 0.3 | 2.4 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 0.4 | GO:0003986 | acetyl-CoA hydrolase activity(GO:0003986) |
| 0.1 | 2.3 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.1 | 0.3 | GO:1902122 | chenodeoxycholic acid binding(GO:1902122) |
| 0.1 | 0.3 | GO:0004487 | methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) |
| 0.1 | 1.5 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.1 | 4.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.5 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.1 | 0.4 | GO:0051800 | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800) |
| 0.1 | 1.3 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 0.5 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.1 | 0.2 | GO:0031728 | CCR3 chemokine receptor binding(GO:0031728) |
| 0.1 | 0.3 | GO:0034188 | apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.0 | 0.4 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 0.1 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.0 | 0.7 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.3 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 0.2 | GO:0046899 | nucleoside triphosphate adenylate kinase activity(GO:0046899) |
| 0.0 | 0.2 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.0 | 0.4 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.0 | 0.1 | GO:0051765 | inositol tetrakisphosphate kinase activity(GO:0051765) |
| 0.0 | 0.1 | GO:0071633 | dihydroceramidase activity(GO:0071633) |
| 0.0 | 0.1 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.0 | 0.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.0 | 0.1 | GO:0016428 | tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) |
| 0.0 | 0.6 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 0.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.0 | 0.2 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 0.6 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 0.1 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.0 | 0.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.1 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
| 0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.1 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.0 | 0.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.2 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.0 | 0.6 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.0 | 0.1 | GO:0000386 | second spliceosomal transesterification activity(GO:0000386) |
| 0.0 | 0.1 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.0 | 0.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.1 | GO:0004905 | type I interferon receptor activity(GO:0004905) |
| 0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.0 | 0.1 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.0 | 0.1 | GO:0008889 | glycerophosphodiester phosphodiesterase activity(GO:0008889) |
| 0.0 | 0.1 | GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947) |
| 0.0 | 0.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.1 | GO:0050815 | phosphoserine binding(GO:0050815) |
| 0.0 | 0.1 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.0 | 0.1 | GO:0099580 | ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580) |
| 0.0 | 0.2 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.6 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.5 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 1.5 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
| 0.1 | 1.4 | REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 1.3 | REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.1 | 1.7 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.1 | 1.1 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.5 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
| 0.0 | 0.5 | REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 0.3 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.4 | REACTOME_DSCAM_INTERACTIONS | Genes involved in DSCAM interactions |
| 0.0 | 0.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.5 | REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 0.4 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.2 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 0.7 | REACTOME_STRIATED_MUSCLE_CONTRACTION | Genes involved in Striated Muscle Contraction |
