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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: HAND1

Z-value: 0.375

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr1_+_207262578	0.694	ENST00000243611.5 ENST00000367076.3	C4BPB	complement component 4 binding protein, beta
chr1_+_207262627	0.622	ENST00000391923.1	C4BPB	complement component 4 binding protein, beta
chr1_+_207262170	0.613	ENST00000367078.3	C4BPB	complement component 4 binding protein, beta
chr1_+_207262540	0.605	ENST00000452902.2	C4BPB	complement component 4 binding protein, beta
chr2_+_210444142	0.339	ENST00000360351.4 ENST00000361559.4	MAP2	microtubule-associated protein 2
chr1_+_28261533	0.312	ENST00000411604.1 ENST00000373888.4	SMPDL3B	sphingomyelin phosphodiesterase, acid-like 3B
chr2_-_27718052	0.295	ENST00000264703.3	FNDC4	fibronectin type III domain containing 4
chr19_+_18492973	0.291	ENST00000595973.2	GDF15	growth differentiation factor 15
chr2_+_210443993	0.272	ENST00000392193.1	MAP2	microtubule-associated protein 2
chr1_+_28261492	0.246	ENST00000373894.3	SMPDL3B	sphingomyelin phosphodiesterase, acid-like 3B
chr1_+_164528866	0.241	ENST00000420696.2	PBX1	pre-B-cell leukemia homeobox 1
chr11_+_124932955	0.230	ENST00000403796.2	SLC37A2	solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr11_+_124932986	0.220	ENST00000407458.1 ENST00000298280.5	SLC37A2	solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr9_+_35805527	0.220	ENST00000421267.1	NPR2	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr2_+_210444298	0.219	ENST00000445941.1	MAP2	microtubule-associated protein 2
chr1_+_28261621	0.209	ENST00000549094.1	SMPDL3B	sphingomyelin phosphodiesterase, acid-like 3B
chr11_+_124933191	0.205	ENST00000532000.1 ENST00000308074.4	SLC37A2	solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr5_+_36608422	0.193	ENST00000381918.3	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr17_-_40337470	0.150	ENST00000293330.1	HCRT	hypocretin (orexin) neuropeptide precursor
chr4_-_40631859	0.146	ENST00000295971.7 ENST00000319592.4	RBM47	RNA binding motif protein 47
chr15_-_33447055	0.135	ENST00000559047.1 ENST00000561249.1	FMN1	formin 1
chr17_-_39942322	0.132	ENST00000449889.1 ENST00000465293.1	JUP	junction plakoglobin
chr4_-_40632605	0.131	ENST00000514014.1	RBM47	RNA binding motif protein 47
chr2_+_204732487	0.122	ENST00000302823.3	CTLA4	cytotoxic T-lymphocyte-associated protein 4
chr2_-_231860596	0.118	ENST00000441063.1 ENST00000434094.1 ENST00000418330.1 ENST00000457803.1 ENST00000414876.1 ENST00000446741.1 ENST00000426904.1	AC105344.2	SPATA3 antisense RNA 1 (head to head)
chrX_+_49832231	0.117	ENST00000376108.3	CLCN5	chloride channel, voltage-sensitive 5
chr7_+_141490017	0.109	ENST00000247883.4	TAS2R5	taste receptor, type 2, member 5
chr4_+_41614720	0.108	ENST00000509277.1	LIMCH1	LIM and calponin homology domains 1
chr14_+_74083548	0.107	ENST00000381139.1	ACOT6	acyl-CoA thioesterase 6
chr20_-_1165117	0.106	ENST00000381894.3	TMEM74B	transmembrane protein 74B
chr20_+_3713314	0.104	ENST00000254963.2 ENST00000542646.1 ENST00000399701.1	HSPA12B	heat shock 70kD protein 12B
chr14_+_96722152	0.102	ENST00000216629.6	BDKRB1	bradykinin receptor B1
chr4_+_41614909	0.102	ENST00000509454.1 ENST00000396595.3 ENST00000381753.4	LIMCH1	LIM and calponin homology domains 1
chr4_-_40632757	0.090	ENST00000511902.1 ENST00000505220.1	RBM47	RNA binding motif protein 47
chr12_-_110271178	0.089	ENST00000261740.2 ENST00000392719.2 ENST00000346520.2	TRPV4	transient receptor potential cation channel, subfamily V, member 4
chr5_+_36608280	0.085	ENST00000513646.1	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr16_-_28621353	0.074	ENST00000567512.1	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr16_-_28621298	0.071	ENST00000566189.1	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chrX_+_15767971	0.070	ENST00000479740.1 ENST00000454127.2	CA5B	carbonic anhydrase VB, mitochondrial
chr17_+_78193443	0.069	ENST00000577155.1	SLC26A11	solute carrier family 26 (anion exchanger), member 11
chr3_+_112051994	0.069	ENST00000473539.1 ENST00000315711.8 ENST00000383681.3	CD200	CD200 molecule
chr11_-_112131583	0.068	ENST00000338832.2	C11orf34	placenta expressed transcript 1
chr12_-_57630873	0.065	ENST00000556732.1	NDUFA4L2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr2_-_238343455	0.063	ENST00000409910.1	AC112721.2	AC112721.2
chr4_-_40632140	0.062	ENST00000514782.1	RBM47	RNA binding motif protein 47
chrX_+_149531606	0.062	ENST00000432680.2	MAMLD1	mastermind-like domain containing 1
chr6_+_124125286	0.062	ENST00000368416.1 ENST00000368417.1 ENST00000546092.1	NKAIN2	Na+/K+ transporting ATPase interacting 2
chr19_-_37701386	0.061	ENST00000527838.1 ENST00000591492.1 ENST00000532828.2	ZNF585B	zinc finger protein 585B
chr17_+_46133307	0.061	ENST00000580037.1	NFE2L1	nuclear factor, erythroid 2-like 1
chr8_+_1993173	0.060	ENST00000523438.1	MYOM2	myomesin 2
chr2_-_159237472	0.060	ENST00000409187.1	CCDC148	coiled-coil domain containing 148
chrX_+_149531524	0.059	ENST00000370401.2	MAMLD1	mastermind-like domain containing 1
chr8_+_1993152	0.056	ENST00000262113.4	MYOM2	myomesin 2
chr2_-_197791441	0.053	ENST00000409475.1 ENST00000354764.4 ENST00000374738.3	PGAP1	post-GPI attachment to proteins 1
chr20_+_34020827	0.050	ENST00000374375.1	GDF5OS	growth differentiation factor 5 opposite strand
chr6_+_44191507	0.049	ENST00000371724.1 ENST00000371713.1	SLC29A1	solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr7_-_2883928	0.046	ENST00000275364.3	GNA12	guanine nucleotide binding protein (G protein) alpha 12
chr2_-_228582709	0.046	ENST00000541617.1 ENST00000409456.2 ENST00000409287.1 ENST00000258403.3	SLC19A3	solute carrier family 19 (thiamine transporter), member 3
chr2_+_228678550	0.045	ENST00000409189.3 ENST00000358813.4	CCL20	chemokine (C-C motif) ligand 20
chr7_-_91794590	0.043	ENST00000430130.2 ENST00000454089.2	LRRD1	leucine-rich repeats and death domain containing 1
chr22_-_24093267	0.042	ENST00000341976.3	ZNF70	zinc finger protein 70
chr7_-_116963334	0.042	ENST00000265441.3	WNT2	wingless-type MMTV integration site family member 2
chr20_+_3767547	0.040	ENST00000344256.6 ENST00000379598.5	CDC25B	cell division cycle 25B
chr2_-_128784846	0.039	ENST00000259235.3 ENST00000357702.5 ENST00000424298.1	SAP130	Sin3A-associated protein, 130kDa
chr14_-_93673353	0.038	ENST00000556566.1 ENST00000306954.4	C14orf142	chromosome 14 open reading frame 142
chr14_+_96722539	0.038	ENST00000553356.1	BDKRB1	bradykinin receptor B1
chr17_-_72619869	0.037	ENST00000392619.1 ENST00000426295.2	CD300E	CD300e molecule
chr11_-_112131312	0.036	ENST00000527122.1	C11orf34	placenta expressed transcript 1
chr10_-_99393242	0.035	ENST00000370635.3 ENST00000478953.1 ENST00000335628.3	MORN4	MORN repeat containing 4
chr17_-_36358166	0.034	ENST00000537432.1	TBC1D3	TBC1 domain family, member 3
chr17_-_34890037	0.033	ENST00000589404.1	MYO19	myosin XIX
chr5_-_41870621	0.032	ENST00000196371.5	OXCT1	3-oxoacid CoA transferase 1
chr2_+_204732666	0.032	ENST00000295854.6 ENST00000472206.1	CTLA4	cytotoxic T-lymphocyte-associated protein 4
chr11_+_111410998	0.031	ENST00000533999.1	LAYN	layilin
chr5_+_167913450	0.030	ENST00000231572.3 ENST00000538719.1	RARS	arginyl-tRNA synthetase
chr11_-_19223523	0.029	ENST00000265968.3	CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr12_+_67663056	0.029	ENST00000545606.1	CAND1	cullin-associated and neddylation-dissociated 1
chr12_+_27619743	0.028	ENST00000298876.4 ENST00000416383.1	SMCO2	single-pass membrane protein with coiled-coil domains 2
chr7_+_96634850	0.028	ENST00000518156.2	DLX6	distal-less homeobox 6
chr2_+_201997676	0.028	ENST00000462763.1 ENST00000479953.2	CFLAR	CASP8 and FADD-like apoptosis regulator
chr17_-_45908875	0.028	ENST00000351111.2 ENST00000414011.1	MRPL10	mitochondrial ribosomal protein L10
chr16_-_28608424	0.027	ENST00000335715.4	SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr1_+_11249398	0.026	ENST00000376819.3	ANGPTL7	angiopoietin-like 7
chr5_+_143584814	0.025	ENST00000507359.3	KCTD16	potassium channel tetramerization domain containing 16
chr10_-_99393208	0.025	ENST00000307450.6	MORN4	MORN repeat containing 4
chr16_+_56969284	0.024	ENST00000568358.1	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr9_-_25678856	0.024	ENST00000358022.3	TUSC1	tumor suppressor candidate 1
chr6_-_112194484	0.024	ENST00000518295.1 ENST00000484067.2 ENST00000229470.5 ENST00000356013.2 ENST00000368678.4 ENST00000523238.1 ENST00000354650.3	FYN	FYN oncogene related to SRC, FGR, YES
chr9_-_123555655	0.023	ENST00000340778.5 ENST00000453291.1 ENST00000608872.1	FBXW2	F-box and WD repeat domain containing 2
chr7_-_116963095	0.023	ENST00000491214.1	WNT2	wingless-type MMTV integration site family member 2
chrX_+_70364667	0.023	ENST00000536169.1 ENST00000395855.2 ENST00000374051.3 ENST00000358741.3	NLGN3	neuroligin 3
chr11_-_62476694	0.022	ENST00000524862.1	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr2_+_201997492	0.021	ENST00000494258.1	CFLAR	CASP8 and FADD-like apoptosis regulator
chr11_+_101785727	0.020	ENST00000263468.8	KIAA1377	KIAA1377
chr20_+_1115821	0.019	ENST00000435720.1	PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr20_+_816695	0.019	ENST00000246100.3	FAM110A	family with sequence similarity 110, member A
chr17_+_45908974	0.018	ENST00000269025.4	LRRC46	leucine rich repeat containing 46
chr19_-_55866061	0.018	ENST00000588572.2 ENST00000593184.1 ENST00000589467.1	COX6B2	cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr2_+_201997595	0.017	ENST00000470178.2	CFLAR	CASP8 and FADD-like apoptosis regulator
chr19_+_47421933	0.017	ENST00000404338.3	ARHGAP35	Rho GTPase activating protein 35
chrX_-_133930285	0.017	ENST00000486347.1 ENST00000343004.5	FAM122B	family with sequence similarity 122B
chr17_-_61781750	0.016	ENST00000582026.1	STRADA	STE20-related kinase adaptor alpha
chr17_+_66624280	0.015	ENST00000585484.1	RP11-118B18.1	RP11-118B18.1
chr3_-_43147431	0.014	ENST00000441964.1	POMGNT2	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
chr16_-_70729496	0.014	ENST00000567648.1	VAC14	Vac14 homolog (S. cerevisiae)
chr11_+_111411384	0.014	ENST00000375615.3 ENST00000525126.1 ENST00000436913.2 ENST00000533265.1	LAYN	layilin
chr6_+_35996859	0.014	ENST00000472333.1	MAPK14	mitogen-activated protein kinase 14
chr3_-_43147549	0.013	ENST00000344697.2	POMGNT2	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
chr15_-_31393910	0.012	ENST00000397795.2 ENST00000256552.6 ENST00000559179.1	TRPM1	transient receptor potential cation channel, subfamily M, member 1
chr9_-_35828576	0.011	ENST00000377984.2 ENST00000423537.2 ENST00000472182.1	FAM221B	family with sequence similarity 221, member B
chr5_-_150467221	0.011	ENST00000522226.1	TNIP1	TNFAIP3 interacting protein 1
chr15_+_45028753	0.011	ENST00000338264.4	TRIM69	tripartite motif containing 69
chr11_+_67171548	0.010	ENST00000542590.1	TBC1D10C	TBC1 domain family, member 10C
chr11_+_67171391	0.010	ENST00000312390.5	TBC1D10C	TBC1 domain family, member 10C
chr11_-_63330842	0.009	ENST00000255695.1	HRASLS2	HRAS-like suppressor 2
chr14_+_24422795	0.008	ENST00000313250.5 ENST00000558263.1 ENST00000543741.2 ENST00000421831.1 ENST00000397073.2 ENST00000308178.8 ENST00000382761.3 ENST00000397075.3 ENST00000397074.3 ENST00000559632.1 ENST00000558581.1	DHRS4	dehydrogenase/reductase (SDR family) member 4
chr11_+_67171358	0.008	ENST00000526387.1	TBC1D10C	TBC1 domain family, member 10C
chr16_-_31146961	0.008	ENST00000567531.1	PRSS8	protease, serine, 8
chr19_-_13044494	0.008	ENST00000593021.1 ENST00000587981.1 ENST00000423140.2 ENST00000314606.4	FARSA	phenylalanyl-tRNA synthetase, alpha subunit
chr16_-_28621312	0.008	ENST00000314752.7	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr11_-_62477313	0.007	ENST00000464544.1 ENST00000530009.1	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr5_-_150466692	0.006	ENST00000315050.7 ENST00000523338.1 ENST00000522100.1	TNIP1	TNFAIP3 interacting protein 1
chr12_-_25801478	0.006	ENST00000540106.1 ENST00000445693.1 ENST00000545543.1 ENST00000542224.1	IFLTD1	intermediate filament tail domain containing 1
chr16_-_28608364	0.006	ENST00000533150.1	SULT1A2	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr19_+_507299	0.006	ENST00000359315.5	TPGS1	tubulin polyglutamylase complex subunit 1
chr9_-_115095229	0.006	ENST00000210227.4	PTBP3	polypyrimidine tract binding protein 3
chr14_-_21624222	0.005	ENST00000304418.3	OR5AU1	olfactory receptor, family 5, subfamily AU, member 1
chr10_+_99344071	0.005	ENST00000370647.4 ENST00000370646.4	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1
chr7_-_150754935	0.005	ENST00000297518.4	CDK5	cyclin-dependent kinase 5
chr10_+_103113840	0.004	ENST00000393441.4 ENST00000408038.2	BTRC	beta-transducin repeat containing E3 ubiquitin protein ligase
chr11_-_102496063	0.003	ENST00000260228.2	MMP20	matrix metallopeptidase 20
chr7_-_141957847	0.003	ENST00000552471.1 ENST00000547058.2	PRSS58	protease, serine, 58
chr6_-_53013620	0.001	ENST00000259803.7	GCM1	glial cells missing homolog 1 (Drosophila)
chr4_-_25161996	0.001	ENST00000513285.1 ENST00000382103.2	SEPSECS	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr21_-_16125773	0.000	ENST00000454128.2	AF127936.3	AF127936.3

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.5	GO:0045959	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.1	0.7	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	0.8	GO:0006685	sphingomyelin catabolic process(GO:0006685)
0.0	0.2	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.4	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.2	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.2	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.1	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338) positive regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000340)
0.0	0.3	GO:0070779	gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.1	GO:0071603	endothelial cell-cell adhesion(GO:0071603)
0.0	0.0	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0	0.1	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.3	GO:1901741	positive regulation of myoblast fusion(GO:1901741)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	0.1	GO:0071665	gamma-catenin-TCF7L2 complex(GO:0071665)
0.0	2.5	GO:0044217	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	0.8	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0004947	bradykinin receptor activity(GO:0004947)
0.0	0.1	GO:0005199	structural constituent of cell wall(GO:0005199)
0.0	0.1	GO:0015275	stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.0	0.3	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.0	0.2	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.2	GO:0047894	flavonol 3-sulfotransferase activity(GO:0047894)
0.0	0.8	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.0	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.0	0.0	GO:0015403	thiamine uptake transmembrane transporter activity(GO:0015403)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.5	PID_HNF3A_PATHWAY	FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	REACTOME_REGULATION_OF_COMPLEMENT_CASCADE	Genes involved in Regulation of Complement cascade

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