Motif ID: FOXO3_FOXD2

Z-value: 0.359

Transcription factors associated with FOXO3_FOXD2:

Gene SymbolEntrez IDGene Name
FOXD2 ENSG00000186564.5 FOXD2
FOXO3 ENSG00000118689.10 FOXO3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
FOXO3hg19_v2_chr6_+_108881012_108881038-0.891.3e-03Click!
FOXD2hg19_v2_chr1_+_47901689_47901689-0.826.2e-03Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of FOXO3_FOXD2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_71551652 1.507 ENST00000546561.1
TSPAN8
tetraspanin 8
chr12_-_71551868 0.811 ENST00000247829.3
TSPAN8
tetraspanin 8
chr17_+_72426891 0.792 ENST00000392627.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr14_-_54418598 0.733 ENST00000609748.1
ENST00000558961.1
BMP4

bone morphogenetic protein 4

chr8_+_31497271 0.729 ENST00000520407.1
NRG1
neuregulin 1
chr7_-_121944491 0.643 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
FEZF1


FEZ family zinc finger 1


chr17_+_72427477 0.610 ENST00000342648.5
ENST00000481232.1
GPRC5C

G protein-coupled receptor, family C, group 5, member C

chr7_-_95225768 0.556 ENST00000005178.5
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr2_+_33661382 0.526 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_+_34643600 0.508 ENST00000530286.1
ENST00000533754.1
EHF

ets homologous factor

chr2_-_207078086 0.491 ENST00000442134.1
GPR1
G protein-coupled receptor 1
chr7_+_114055052 0.452 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2







forkhead box P2







chr9_+_118916082 0.443 ENST00000328252.3
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr19_-_58609570 0.388 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
ZSCAN18





zinc finger and SCAN domain containing 18





chrX_+_105936982 0.386 ENST00000418562.1
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr6_+_125540951 0.376 ENST00000524679.1
TPD52L1
tumor protein D52-like 1
chr8_+_31496809 0.373 ENST00000518104.1
ENST00000519301.1
NRG1

neuregulin 1

chr8_-_29208183 0.364 ENST00000240100.2
DUSP4
dual specificity phosphatase 4
chr10_+_75668916 0.309 ENST00000481390.1
PLAU
plasminogen activator, urokinase
chr4_+_165675197 0.305 ENST00000515485.1
RP11-294O2.2
RP11-294O2.2
chr1_+_104159999 0.280 ENST00000414303.2
ENST00000423678.1
AMY2A

amylase, alpha 2A (pancreatic)

chr2_-_69180083 0.279 ENST00000328895.4
GKN2
gastrokine 2
chr2_-_207078154 0.278 ENST00000447845.1
GPR1
G protein-coupled receptor 1
chrX_+_9880412 0.278 ENST00000418909.2
SHROOM2
shroom family member 2
chr7_-_142511084 0.275 ENST00000417977.2
TRBV30
T cell receptor beta variable 30 (gene/pseudogene)
chr17_-_29641104 0.273 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr17_-_29641084 0.272 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr13_-_67802549 0.269 ENST00000328454.5
ENST00000377865.2
PCDH9

protocadherin 9

chr4_+_86396321 0.266 ENST00000503995.1
ARHGAP24
Rho GTPase activating protein 24
chr11_+_34654011 0.259 ENST00000531794.1
EHF
ets homologous factor
chr5_+_169064245 0.254 ENST00000256935.8
DOCK2
dedicator of cytokinesis 2
chr7_-_16844611 0.249 ENST00000401412.1
ENST00000419304.2
AGR2

anterior gradient 2

chrX_+_9880590 0.238 ENST00000452575.1
SHROOM2
shroom family member 2
chr2_-_136875712 0.237 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr8_+_24151553 0.236 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
ADAM28


ADAM metallopeptidase domain 28


chr12_-_52761262 0.234 ENST00000257901.3
KRT85
keratin 85
chr3_+_178865887 0.222 ENST00000477735.1
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr2_-_145188137 0.220 ENST00000440875.1
ZEB2
zinc finger E-box binding homeobox 2
chr22_-_28490123 0.219 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr5_-_115872124 0.217 ENST00000515009.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr4_-_168155169 0.215 ENST00000534949.1
ENST00000535728.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr18_+_3449330 0.215 ENST00000549253.1
TGIF1
TGFB-induced factor homeobox 1
chr7_+_139528952 0.215 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1



thromboxane A synthase 1 (platelet)



chr12_-_52779433 0.205 ENST00000257951.3
KRT84
keratin 84
chr9_+_113431059 0.204 ENST00000416899.2
MUSK
muscle, skeletal, receptor tyrosine kinase
chr1_-_207095324 0.202 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
FAIM3


Fas apoptotic inhibitory molecule 3


chr7_+_139529040 0.198 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
TBXAS1


thromboxane A synthase 1 (platelet)


chr20_+_10199468 0.198 ENST00000254976.2
ENST00000304886.2
SNAP25

synaptosomal-associated protein, 25kDa

chr3_+_46449049 0.195 ENST00000357392.4
ENST00000400880.3
ENST00000433848.1
CCRL2


chemokine (C-C motif) receptor-like 2


chr5_-_38557561 0.193 ENST00000511561.1
LIFR
leukemia inhibitory factor receptor alpha
chr6_-_32083106 0.191 ENST00000442721.1
TNXB
tenascin XB
chr9_-_119162885 0.191 ENST00000445861.2
PAPPA-AS1
PAPPA antisense RNA 1
chr12_+_106696581 0.190 ENST00000547153.1
ENST00000299045.3
ENST00000546625.1
ENST00000553098.1
TCP11L2



t-complex 11, testis-specific-like 2



chr20_-_50179368 0.190 ENST00000609943.1
ENST00000609507.1
NFATC2

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

chr3_-_185826855 0.181 ENST00000306376.5
ETV5
ets variant 5
chr6_-_56707943 0.180 ENST00000370769.4
ENST00000421834.2
ENST00000312431.6
ENST00000361203.3
ENST00000523817.1
DST




dystonin




chr6_-_42016385 0.179 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
CCND3





cyclin D3





chr3_+_172468749 0.179 ENST00000366254.2
ENST00000415665.1
ENST00000438041.1
ECT2


epithelial cell transforming sequence 2 oncogene


chr3_+_172468472 0.178 ENST00000232458.5
ENST00000392692.3
ECT2

epithelial cell transforming sequence 2 oncogene

chr2_+_33701707 0.174 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3


RAS guanyl releasing protein 3 (calcium and DAG-regulated)


chr1_+_104104379 0.173 ENST00000435302.1
AMY2B
amylase, alpha 2B (pancreatic)
chr8_+_26150628 0.172 ENST00000523925.1
ENST00000315985.7
PPP2R2A

protein phosphatase 2, regulatory subunit B, alpha

chr8_-_28243934 0.172 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395


zinc finger protein 395


chr4_-_139163491 0.170 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr4_+_86396265 0.170 ENST00000395184.1
ARHGAP24
Rho GTPase activating protein 24
chr7_-_16840820 0.170 ENST00000450569.1
AGR2
anterior gradient 2
chr3_-_185826718 0.168 ENST00000413301.1
ENST00000421809.1
ETV5

ets variant 5

chr7_-_81635106 0.168 ENST00000443883.1
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1
chr1_-_207095212 0.166 ENST00000420007.2
FAIM3
Fas apoptotic inhibitory molecule 3
chr3_+_69928256 0.165 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr3_+_178866199 0.165 ENST00000263967.3
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
chr3_+_172468505 0.165 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2




epithelial cell transforming sequence 2 oncogene




chr2_-_69180012 0.164 ENST00000481498.1
GKN2
gastrokine 2
chr2_-_145275828 0.163 ENST00000392861.2
ENST00000409211.1
ZEB2

zinc finger E-box binding homeobox 2

chr4_-_105416039 0.163 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr10_-_61122220 0.162 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C






family with sequence similarity 13, member C






chr17_+_67410832 0.161 ENST00000590474.1
MAP2K6
mitogen-activated protein kinase kinase 6
chr5_+_32788945 0.161 ENST00000326958.1
AC026703.1
AC026703.1
chr2_-_198175495 0.159 ENST00000409153.1
ENST00000409919.1
ENST00000539527.1
ANKRD44


ankyrin repeat domain 44


chr8_+_92261516 0.159 ENST00000276609.3
ENST00000309536.2
SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr6_-_152623231 0.158 ENST00000540663.1
ENST00000537033.1
SYNE1

spectrin repeat containing, nuclear envelope 1

chr7_+_73242490 0.155 ENST00000431918.1
CLDN4
claudin 4
chr17_-_39150385 0.155 ENST00000391586.1
KRTAP3-3
keratin associated protein 3-3
chr5_+_140602904 0.155 ENST00000515856.2
ENST00000239449.4
PCDHB14

protocadherin beta 14

chr7_-_115670792 0.155 ENST00000265440.7
ENST00000393485.1
TFEC

transcription factor EC

chr10_-_13570533 0.153 ENST00000396900.2
ENST00000396898.2
BEND7

BEN domain containing 7

chr14_+_71165292 0.152 ENST00000553682.1
RP6-65G23.1
RP6-65G23.1
chrX_-_74145273 0.152 ENST00000055682.6
KIAA2022
KIAA2022
chr5_+_133451254 0.152 ENST00000517851.1
ENST00000521639.1
ENST00000522375.1
ENST00000378560.4
ENST00000432532.2
ENST00000520958.1
ENST00000518915.1
ENST00000395023.1
TCF7







transcription factor 7 (T-cell specific, HMG-box)







chr1_-_60392452 0.150 ENST00000371204.3
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2
chr2_+_197577841 0.148 ENST00000409270.1
CCDC150
coiled-coil domain containing 150
chr14_+_56584414 0.146 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr17_-_38721711 0.146 ENST00000578085.1
ENST00000246657.2
CCR7

chemokine (C-C motif) receptor 7

chr3_+_69985734 0.145 ENST00000314557.6
ENST00000394351.3
MITF

microphthalmia-associated transcription factor

chr3_+_69811858 0.144 ENST00000433517.1
MITF
microphthalmia-associated transcription factor
chr4_+_165675269 0.144 ENST00000507311.1
RP11-294O2.2
RP11-294O2.2
chr18_-_2982869 0.143 ENST00000584915.1
LPIN2
lipin 2
chr1_-_111743285 0.143 ENST00000357640.4
DENND2D
DENN/MADD domain containing 2D
chr20_-_22559211 0.142 ENST00000564492.1
LINC00261
long intergenic non-protein coding RNA 261
chr3_+_138153451 0.142 ENST00000389567.4
ENST00000289135.4
ESYT3

extended synaptotagmin-like protein 3

chr6_-_56716686 0.142 ENST00000520645.1
DST
dystonin
chr8_-_33455268 0.142 ENST00000522982.1
DUSP26
dual specificity phosphatase 26 (putative)
chr9_+_140125385 0.142 ENST00000361134.2
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr5_-_142782862 0.142 ENST00000415690.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr9_+_140125209 0.141 ENST00000538474.1
SLC34A3
solute carrier family 34 (type II sodium/phosphate contransporter), member 3
chr2_-_145275228 0.140 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2



zinc finger E-box binding homeobox 2



chr10_+_24738355 0.138 ENST00000307544.6
KIAA1217
KIAA1217
chr22_+_21128167 0.137 ENST00000215727.5
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr7_-_14028488 0.136 ENST00000405358.4
ETV1
ets variant 1
chr3_+_69985792 0.135 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr8_+_24151620 0.135 ENST00000437154.2
ADAM28
ADAM metallopeptidase domain 28
chr5_-_146833485 0.133 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr18_+_3449695 0.132 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr3_-_178865747 0.128 ENST00000435560.1
RP11-360P21.2
RP11-360P21.2
chr2_+_33701286 0.127 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_39942940 0.127 ENST00000310706.5
ENST00000393931.3
ENST00000424457.1
ENST00000591690.1
JUP



junction plakoglobin



chr20_+_10199566 0.126 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chrX_+_106163626 0.125 ENST00000336803.1
CLDN2
claudin 2
chrX_-_10851762 0.124 ENST00000380785.1
ENST00000380787.1
MID1

midline 1 (Opitz/BBB syndrome)

chr6_-_46922659 0.121 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr10_-_92681033 0.121 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_+_86525299 0.121 ENST00000512201.1
ARHGAP24
Rho GTPase activating protein 24
chr10_+_80008505 0.118 ENST00000434974.1
ENST00000423770.1
ENST00000432742.1
LINC00856


long intergenic non-protein coding RNA 856


chr1_-_12677714 0.117 ENST00000376223.2
DHRS3
dehydrogenase/reductase (SDR family) member 3
chr6_+_32121908 0.115 ENST00000375143.2
ENST00000424499.1
PPT2

palmitoyl-protein thioesterase 2

chr3_+_181429704 0.114 ENST00000431565.2
ENST00000325404.1
SOX2

SRY (sex determining region Y)-box 2

chr6_+_101847105 0.114 ENST00000369137.3
ENST00000318991.6
GRIK2

glutamate receptor, ionotropic, kainate 2

chr3_+_187930491 0.113 ENST00000443217.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_+_140579162 0.112 ENST00000536699.1
ENST00000354757.3
PCDHB11

protocadherin beta 11

chr1_+_26503894 0.111 ENST00000361530.6
ENST00000374253.5
CNKSR1

connector enhancer of kinase suppressor of Ras 1

chr5_+_133859996 0.108 ENST00000512386.1
PHF15
jade family PHD finger 2
chr6_+_32121789 0.108 ENST00000437001.2
ENST00000375137.2
PPT2

palmitoyl-protein thioesterase 2

chr14_+_23067146 0.108 ENST00000428304.2
ABHD4
abhydrolase domain containing 4
chr5_-_115872142 0.107 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr16_+_4421841 0.107 ENST00000304735.3
VASN
vasorin
chr5_-_88180342 0.107 ENST00000502983.1
MEF2C
myocyte enhancer factor 2C
chr14_+_23067166 0.106 ENST00000216327.6
ENST00000542041.1
ABHD4

abhydrolase domain containing 4

chr7_+_139529085 0.105 ENST00000539806.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr6_+_26020672 0.104 ENST00000357647.3
HIST1H3A
histone cluster 1, H3a
chrX_-_48693955 0.103 ENST00000218230.5
PCSK1N
proprotein convertase subtilisin/kexin type 1 inhibitor
chr5_-_142783175 0.102 ENST00000231509.3
ENST00000394464.2
NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

chr11_-_85397167 0.102 ENST00000316398.3
CCDC89
coiled-coil domain containing 89
chr14_+_51026926 0.102 ENST00000557735.1
ATL1
atlastin GTPase 1
chr2_+_113875466 0.101 ENST00000361779.3
ENST00000259206.5
ENST00000354115.2
IL1RN


interleukin 1 receptor antagonist


chr19_+_859654 0.101 ENST00000592860.1
CFD
complement factor D (adipsin)
chrX_-_15402498 0.100 ENST00000297904.3
FIGF
c-fos induced growth factor (vascular endothelial growth factor D)
chr3_-_168865522 0.099 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr19_+_859425 0.098 ENST00000327726.6
CFD
complement factor D (adipsin)
chr4_+_187148556 0.098 ENST00000264690.6
ENST00000446598.2
ENST00000414291.1
ENST00000513864.1
KLKB1



kallikrein B, plasma (Fletcher factor) 1



chr4_+_147145709 0.097 ENST00000504313.1
RP11-6L6.2
Uncharacterized protein
chr5_+_137673200 0.097 ENST00000434981.2
FAM53C
family with sequence similarity 53, member C
chr5_-_131132658 0.096 ENST00000511848.1
ENST00000510461.1
ENST00000514667.1
FNIP1

CTC-432M15.3
folliculin interacting protein 1

Folliculin-interacting protein 1
chr2_+_177053307 0.096 ENST00000331462.4
HOXD1
homeobox D1
chr2_+_175260451 0.096 ENST00000458563.1
ENST00000409673.3
ENST00000272732.6
ENST00000435964.1
SCRN3



secernin 3



chr5_-_139937895 0.095 ENST00000336283.6
SRA1
steroid receptor RNA activator 1
chr21_-_43735446 0.094 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr18_-_35145689 0.094 ENST00000591287.1
ENST00000601019.1
ENST00000601392.1
CELF4


CUGBP, Elav-like family member 4


chr2_+_189157536 0.093 ENST00000409580.1
ENST00000409637.3
GULP1

GULP, engulfment adaptor PTB domain containing 1

chr1_-_12679171 0.093 ENST00000606790.1
RP11-474O21.5
RP11-474O21.5
chr3_-_48956818 0.092 ENST00000408959.2
ARIH2OS
ariadne homolog 2 opposite strand
chr12_+_13349711 0.092 ENST00000538364.1
ENST00000396301.3
EMP1

epithelial membrane protein 1

chr2_-_233877912 0.092 ENST00000264051.3
NGEF
neuronal guanine nucleotide exchange factor
chr7_-_130598059 0.091 ENST00000432045.2
MIR29B1
microRNA 29a
chr7_+_1127723 0.091 ENST00000397088.3
GPER1
G protein-coupled estrogen receptor 1
chr10_+_24755416 0.091 ENST00000396446.1
ENST00000396445.1
ENST00000376451.2
KIAA1217


KIAA1217


chr12_-_52585765 0.091 ENST00000313234.5
ENST00000394815.2
KRT80

keratin 80

chr14_-_73493825 0.091 ENST00000318876.5
ENST00000556143.1
ZFYVE1

zinc finger, FYVE domain containing 1

chr8_+_87111059 0.091 ENST00000285393.3
ATP6V0D2
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
chr9_-_39288092 0.090 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3



contactin associated protein-like 3



chr8_-_27469383 0.090 ENST00000519742.1
CLU
clusterin
chr2_+_189157498 0.090 ENST00000359135.3
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr12_+_13349650 0.089 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
EMP1



epithelial membrane protein 1



chr7_-_122339162 0.089 ENST00000340112.2
RNF133
ring finger protein 133
chr2_-_157198860 0.089 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr22_+_40342819 0.088 ENST00000407075.3
GRAP2
GRB2-related adaptor protein 2
chr4_-_40632605 0.088 ENST00000514014.1
RBM47
RNA binding motif protein 47
chr8_+_99956662 0.088 ENST00000523368.1
ENST00000297565.4
ENST00000435298.2
OSR2


odd-skipped related transciption factor 2


chr10_+_123922941 0.088 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_143635222 0.087 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU


kynureninase


chr2_+_149402989 0.087 ENST00000397424.2
EPC2
enhancer of polycomb homolog 2 (Drosophila)
chr10_+_123923105 0.087 ENST00000368999.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_175260514 0.086 ENST00000424069.1
ENST00000427038.1
SCRN3

secernin 3

chr4_+_90032651 0.086 ENST00000603357.1
RP11-84C13.1
RP11-84C13.1
chrX_-_106146547 0.086 ENST00000276173.4
ENST00000411805.1
RIPPLY1

ripply transcriptional repressor 1

chr2_+_111878483 0.085 ENST00000308659.8
ENST00000357757.2
ENST00000393253.2
ENST00000337565.5
ENST00000393256.3
BCL2L11




BCL2-like 11 (apoptosis facilitator)




chr7_-_115670804 0.085 ENST00000320239.7
TFEC
transcription factor EC
chr18_-_35145593 0.085 ENST00000334919.5
ENST00000591282.1
ENST00000588597.1
CELF4


CUGBP, Elav-like family member 4


chr2_+_143635067 0.085 ENST00000264170.4
KYNU
kynureninase
chr6_+_97372645 0.084 ENST00000536676.1
ENST00000544166.1
KLHL32

kelch-like family member 32

chr11_-_27723158 0.083 ENST00000395980.2
BDNF
brain-derived neurotrophic factor
chr7_-_115608304 0.083 ENST00000457268.1
TFEC
transcription factor EC
chr16_-_65106110 0.083 ENST00000562882.1
ENST00000567934.1
CDH11

cadherin 11, type 2, OB-cadherin (osteoblast)

chr8_+_22132810 0.082 ENST00000356766.6
PIWIL2
piwi-like RNA-mediated gene silencing 2
chr3_+_187930429 0.082 ENST00000420410.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr4_+_108745711 0.082 ENST00000394684.4
SGMS2
sphingomyelin synthase 2
chr11_-_66336060 0.081 ENST00000310325.5
CTSF
cathepsin F
chr1_-_151826173 0.080 ENST00000368817.5
THEM5
thioesterase superfamily member 5
chr1_-_153514241 0.080 ENST00000368718.1
ENST00000359215.1
S100A5

S100 calcium binding protein A5

chr4_+_71588372 0.079 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr3_+_98216448 0.079 ENST00000427338.1
OR5K2
olfactory receptor, family 5, subfamily K, member 2

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0008057 eye pigment granule organization(GO:0008057)
0.2 0.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.5 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.7 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 1.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.4 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.1 0.3 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.1 0.3 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.3 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.4 GO:0060480 lung goblet cell differentiation(GO:0060480) positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.1 0.5 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.2 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 0.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.0 0.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0 0.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.0 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.1 GO:2000724 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.0 0.3 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986) general adaptation syndrome(GO:0051866)
0.0 0.1 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139) apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0 0.6 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.0 0.2 GO:0048861 oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.4 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.5 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.2 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
0.0 0.1 GO:1902362 melanocyte apoptotic process(GO:1902362)
0.0 0.2 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.3 GO:0031580 membrane raft polarization(GO:0001766) establishment of T cell polarity(GO:0001768) membrane raft distribution(GO:0031580)
0.0 2.2 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 0.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.3 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0 0.2 GO:0086048 membrane depolarization during bundle of His cell action potential(GO:0086048)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.1 GO:0045081 negative regulation of interleukin-10 biosynthetic process(GO:0045081)
0.0 0.2 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.1 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0036023 limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0 0.2 GO:0021781 glial cell fate commitment(GO:0021781)
0.0 0.3 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 0.1 GO:0044179 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.0 0.1 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.2 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.1 GO:0072143 mesangial cell differentiation(GO:0072007) glomerular mesangial cell differentiation(GO:0072008) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.0 0.1 GO:0045014 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.0 0.0 GO:0060351 growth plate cartilage development(GO:0003417) cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.0 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.1 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725)
0.0 0.2 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.0 GO:0032489 regulation of Cdc42 protein signal transduction(GO:0032489)
0.0 0.0 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.0 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.0 0.1 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.0 0.1 GO:0006210 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0 0.1 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.2 GO:0035878 nail development(GO:0035878)
0.0 0.0 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.0 GO:1904404 cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0 0.2 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.0 0.0 GO:2000697 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560) positive regulation of type B pancreatic cell development(GO:2000078)
0.0 0.0 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.3 GO:0030900 forebrain development(GO:0030900)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.2 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.0 GO:0019087 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.0 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.3 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.0 0.1 GO:1990923 PET complex(GO:1990923)
0.0 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 0.1 GO:0097444 spine apparatus(GO:0097444)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.1 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.8 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363) discoidal high-density lipoprotein particle(GO:0034365)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.5 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.1 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.1 1.1 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.5 GO:0004556 alpha-amylase activity(GO:0004556)
0.1 0.2 GO:0086057 voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057)
0.1 0.2 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.3 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.8 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.3 GO:0042835 BRE binding(GO:0042835)
0.0 0.1 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.0 0.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0051499 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 0.3 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0051373 FATZ binding(GO:0051373)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.0 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.0 0.0 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.0 0.0 GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.0 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.0 GO:0061663 NEDD8 ligase activity(GO:0061663)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.0 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.1 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.2 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.3 GO:0051427 nuclear hormone receptor binding(GO:0035257) hormone receptor binding(GO:0051427)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.4 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.1 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.5 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.4 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.2 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism