Motif ID: FOSL1
Z-value: 0.984
Transcription factors associated with FOSL1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOSL1 | ENSG00000175592.4 | FOSL1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSL1 | hg19_v2_chr11_-_65667884_65667895 | 0.69 | 4.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.0 | GO:0018242 | protein O-linked glycosylation via serine(GO:0018242) |
| 0.3 | 0.8 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.3 | 2.3 | GO:1902748 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.2 | 1.0 | GO:0021812 | neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) |
| 0.2 | 0.7 | GO:2000724 | nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724) |
| 0.2 | 0.6 | GO:0002372 | myeloid dendritic cell cytokine production(GO:0002372) |
| 0.2 | 0.8 | GO:0001878 | response to yeast(GO:0001878) hepatic immune response(GO:0002384) response to prolactin(GO:1990637) |
| 0.2 | 2.1 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.2 | 1.3 | GO:1903281 | protein transport into plasma membrane raft(GO:0044861) positive regulation of calcium:sodium antiporter activity(GO:1903281) positive regulation of potassium ion import(GO:1903288) |
| 0.2 | 0.9 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.2 | 1.5 | GO:0072513 | positive regulation of secondary heart field cardioblast proliferation(GO:0072513) |
| 0.1 | 0.4 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.1 | 4.3 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.5 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 0.5 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.1 | 0.8 | GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.1 | 0.9 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.1 | 0.3 | GO:0098972 | dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972) |
| 0.1 | 0.6 | GO:0070384 | Harderian gland development(GO:0070384) |
| 0.1 | 0.5 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.1 | 0.7 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.1 | 0.8 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.4 | GO:0021966 | corticospinal neuron axon guidance(GO:0021966) |
| 0.1 | 1.5 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.1 | 0.3 | GO:0060981 | cell migration involved in coronary angiogenesis(GO:0060981) |
| 0.1 | 1.0 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 0.3 | GO:0006218 | uridine catabolic process(GO:0006218) |
| 0.1 | 0.7 | GO:1902998 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.1 | 0.6 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 0.2 | GO:0031959 | mineralocorticoid receptor signaling pathway(GO:0031959) |
| 0.1 | 0.5 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.1 | 1.6 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 0.7 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.1 | 0.4 | GO:0098886 | modification of dendritic spine(GO:0098886) |
| 0.1 | 0.5 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.1 | 1.0 | GO:0002191 | cap-dependent translational initiation(GO:0002191) |
| 0.1 | 1.3 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.1 | 0.6 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.1 | 1.7 | GO:0061436 | establishment of skin barrier(GO:0061436) |
| 0.1 | 0.2 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.1 | 0.9 | GO:0044351 | macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385) |
| 0.1 | 0.3 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.1 | 0.4 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.1 | 1.5 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 0.3 | GO:0018243 | protein O-linked glycosylation via threonine(GO:0018243) |
| 0.1 | 0.2 | GO:1990535 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535) |
| 0.1 | 0.8 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.1 | 0.3 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.0 | 0.5 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.0 | 0.4 | GO:0043932 | ossification involved in bone remodeling(GO:0043932) |
| 0.0 | 0.1 | GO:1904404 | cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404) |
| 0.0 | 0.2 | GO:0006480 | N-terminal protein amino acid methylation(GO:0006480) |
| 0.0 | 1.2 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.0 | 0.3 | GO:0023021 | termination of signal transduction(GO:0023021) |
| 0.0 | 0.2 | GO:2001045 | negative regulation of integrin-mediated signaling pathway(GO:2001045) |
| 0.0 | 0.9 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.0 | 0.0 | GO:0001767 | establishment of lymphocyte polarity(GO:0001767) |
| 0.0 | 0.1 | GO:0035750 | protein localization to myelin sheath abaxonal region(GO:0035750) |
| 0.0 | 0.6 | GO:0061635 | regulation of protein complex stability(GO:0061635) |
| 0.0 | 1.0 | GO:0071985 | multivesicular body sorting pathway(GO:0071985) |
| 0.0 | 0.2 | GO:0039506 | modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148) |
| 0.0 | 0.2 | GO:0044028 | DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) |
| 0.0 | 1.2 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 0.4 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.1 | GO:2000174 | regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176) |
| 0.0 | 0.1 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.0 | 0.9 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.0 | 0.1 | GO:0005986 | sucrose biosynthetic process(GO:0005986) |
| 0.0 | 0.4 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.0 | 1.2 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.3 | GO:0061734 | parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734) |
| 0.0 | 0.1 | GO:1903515 | calcium ion transport from cytosol to endoplasmic reticulum(GO:1903515) |
| 0.0 | 0.2 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.0 | 0.5 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.0 | 0.4 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.2 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.0 | 0.5 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.4 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.2 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.0 | 0.3 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.0 | 0.1 | GO:0030421 | defecation(GO:0030421) |
| 0.0 | 0.4 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.0 | 1.4 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.1 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.0 | 0.4 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.0 | 0.1 | GO:0036324 | vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) |
| 0.0 | 0.2 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
| 0.0 | 0.3 | GO:0008090 | retrograde axonal transport(GO:0008090) |
| 0.0 | 0.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 0.0 | 0.3 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.0 | 0.3 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.3 | GO:0001765 | membrane raft assembly(GO:0001765) |
| 0.0 | 0.4 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 0.3 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 0.0 | 0.5 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.0 | 0.1 | GO:1900042 | positive regulation of interleukin-2 secretion(GO:1900042) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) |
| 0.0 | 0.0 | GO:0033037 | polysaccharide localization(GO:0033037) |
| 0.0 | 0.2 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.4 | GO:0007250 | activation of NF-kappaB-inducing kinase activity(GO:0007250) |
| 0.0 | 0.2 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.1 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 0.0 | 0.6 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 0.4 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 0.1 | GO:0034447 | very-low-density lipoprotein particle clearance(GO:0034447) |
| 0.0 | 0.1 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.0 | 0.1 | GO:0070278 | extracellular matrix constituent secretion(GO:0070278) |
| 0.0 | 0.2 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.0 | 0.3 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 0.0 | GO:0071431 | tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 1.0 | GO:0043303 | mast cell activation involved in immune response(GO:0002279) mast cell degranulation(GO:0043303) |
| 0.0 | 0.0 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.0 | 0.9 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.0 | 0.6 | GO:0044380 | protein localization to cytoskeleton(GO:0044380) |
| 0.0 | 0.1 | GO:1900245 | positive regulation of MDA-5 signaling pathway(GO:1900245) |
| 0.0 | 0.7 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway(GO:0002756) |
| 0.0 | 0.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.5 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.6 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.0 | 0.1 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.0 | 0.1 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0043257 | laminin-8 complex(GO:0043257) |
| 0.2 | 2.4 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 0.8 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.2 | 0.6 | GO:0044753 | amphisome(GO:0044753) |
| 0.2 | 0.5 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
| 0.1 | 0.4 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.1 | 0.4 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 0.1 | 0.4 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.1 | 0.9 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.8 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 2.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 2.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 1.1 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.1 | 0.4 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.1 | 0.6 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.1 | 3.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.7 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 1.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 1.2 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.0 | 0.6 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.0 | 1.0 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.4 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 1.6 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 1.0 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.0 | 0.7 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.1 | GO:0097489 | multivesicular body, internal vesicle(GO:0097487) multivesicular body, internal vesicle lumen(GO:0097489) |
| 0.0 | 2.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.0 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 4.8 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 0.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 1.6 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 0.5 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.3 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 0.3 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.2 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 0.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.0 | GO:0002947 | tumor necrosis factor receptor superfamily complex(GO:0002947) |
| 0.0 | 1.0 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.5 | GO:0031306 | intrinsic component of mitochondrial outer membrane(GO:0031306) |
| 0.0 | 0.3 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.0 | 0.1 | GO:0031209 | SCAR complex(GO:0031209) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.5 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 0.3 | 0.6 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 0.7 | GO:0017082 | mineralocorticoid receptor activity(GO:0017082) |
| 0.2 | 0.6 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.2 | 1.6 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 0.8 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.2 | 1.3 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.2 | 0.5 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.1 | 2.1 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 1.0 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 2.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.3 | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) |
| 0.1 | 0.7 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 0.3 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.1 | 0.4 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.1 | 0.4 | GO:0086062 | voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062) |
| 0.1 | 1.6 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.1 | 0.4 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 0.8 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.8 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 0.4 | GO:1990450 | linear polyubiquitin binding(GO:1990450) |
| 0.1 | 0.3 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.1 | 0.3 | GO:0005019 | platelet-derived growth factor beta-receptor activity(GO:0005019) |
| 0.1 | 1.3 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 0.4 | GO:0050119 | N-acetylglucosamine deacetylase activity(GO:0050119) |
| 0.1 | 1.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0061663 | NEDD8 ligase activity(GO:0061663) |
| 0.0 | 0.2 | GO:0071885 | N-terminal protein N-methyltransferase activity(GO:0071885) |
| 0.0 | 0.1 | GO:0015439 | heme-transporting ATPase activity(GO:0015439) |
| 0.0 | 1.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.2 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.0 | 0.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.0 | 1.2 | GO:0031005 | filamin binding(GO:0031005) |
| 0.0 | 0.4 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 0.2 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 0.9 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.2 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.0 | 2.3 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 3.0 | GO:0030145 | manganese ion binding(GO:0030145) |
| 0.0 | 0.1 | GO:0015432 | bile acid-exporting ATPase activity(GO:0015432) |
| 0.0 | 0.7 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 0.1 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.0 | 0.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.0 | 1.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 0.1 | GO:0086039 | lutropin-choriogonadotropic hormone receptor binding(GO:0031775) calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential(GO:0086039) |
| 0.0 | 0.2 | GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199) |
| 0.0 | 0.9 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.6 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.4 | GO:0036122 | BMP binding(GO:0036122) |
| 0.0 | 0.1 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.0 | 0.5 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.0 | 0.6 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.0 | 0.1 | GO:0004530 | deoxyribonuclease I activity(GO:0004530) |
| 0.0 | 0.1 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.0 | 0.4 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.2 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 0.2 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.0 | 0.1 | GO:1990175 | EH domain binding(GO:1990175) |
| 0.0 | 0.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 1.3 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 0.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 0.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.0 | 0.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.2 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.0 | 0.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.3 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.0 | 0.1 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.0 | 0.5 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 0.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 0.4 | GO:1901682 | sulfur compound transmembrane transporter activity(GO:1901682) |
| 0.0 | 0.3 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.1 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 0.3 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.3 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.0 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.0 | 0.1 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.2 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.1 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.1 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 5.0 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 0.2 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.1 | 1.3 | PID_THROMBIN_PAR4_PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.9 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 1.2 | PID_TCR_JNK_PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.5 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.2 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 2.4 | PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 1.4 | PID_IL1_PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.4 | PID_P38_GAMMA_DELTA_PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.4 | PID_ECADHERIN_KERATINOCYTE_PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 0.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.8 | PID_PI3K_PLC_TRK_PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.5 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.6 | PID_RETINOIC_ACID_PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.7 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.5 | PID_TRAIL_PATHWAY | TRAIL signaling pathway |
| 0.0 | 1.0 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.4 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.1 | 0.9 | REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.1 | 1.1 | REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.1 | 1.2 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.9 | REACTOME_IL_6_SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 1.9 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.0 | REACTOME_MTORC1_MEDIATED_SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 3.8 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 4.7 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.4 | REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 0.4 | REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 0.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 1.4 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.3 | REACTOME_PYRIMIDINE_CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 1.2 | REACTOME_IL1_SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 0.8 | REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 0.3 | REACTOME_PROLACTIN_RECEPTOR_SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 1.0 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.3 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.3 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.0 | 0.7 | REACTOME_ERK_MAPK_TARGETS | Genes involved in ERK/MAPK targets |
| 0.0 | 0.2 | REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 0.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
