Motif ID: FOSB
Z-value: 0.761
Transcription factors associated with FOSB:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOSB | ENSG00000125740.9 | FOSB |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOSB | hg19_v2_chr19_+_45971246_45971265 | -0.61 | 8.0e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:2000523 | regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) |
| 0.1 | 0.4 | GO:0052314 | terpene metabolic process(GO:0042214) phytoalexin metabolic process(GO:0052314) |
| 0.1 | 2.1 | GO:0035878 | nail development(GO:0035878) |
| 0.1 | 0.9 | GO:1902748 | mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.1 | 0.4 | GO:1903028 | positive regulation of opsonization(GO:1903028) |
| 0.1 | 0.3 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.1 | 1.0 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.1 | 0.3 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) |
| 0.1 | 0.2 | GO:0002541 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) |
| 0.1 | 0.3 | GO:0043376 | regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) |
| 0.1 | 0.4 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.1 | 2.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.4 | GO:0002415 | immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415) |
| 0.1 | 0.3 | GO:0002426 | immunoglobulin production in mucosal tissue(GO:0002426) |
| 0.1 | 0.4 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.1 | 0.7 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.9 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.1 | 0.3 | GO:0050712 | negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712) |
| 0.1 | 0.5 | GO:0071603 | endothelial cell-cell adhesion(GO:0071603) |
| 0.1 | 1.1 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) |
| 0.1 | 0.2 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.1 | 0.3 | GO:1903237 | negative regulation of leukocyte tethering or rolling(GO:1903237) |
| 0.1 | 0.4 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.0 | 0.3 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.0 | 0.6 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.0 | 0.2 | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response(GO:0002528) |
| 0.0 | 0.3 | GO:0072675 | osteoclast fusion(GO:0072675) |
| 0.0 | 0.1 | GO:1902723 | negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) negative regulation of satellite cell differentiation(GO:1902725) |
| 0.0 | 0.2 | GO:0051414 | response to cortisol(GO:0051414) |
| 0.0 | 0.5 | GO:0044351 | macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385) |
| 0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
| 0.0 | 0.2 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.0 | 0.1 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.0 | 0.0 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) |
| 0.0 | 0.1 | GO:1903031 | regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033) |
| 0.0 | 0.1 | GO:0072156 | distal tubule morphogenesis(GO:0072156) |
| 0.0 | 0.4 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 0.5 | GO:0032802 | low-density lipoprotein particle receptor catabolic process(GO:0032802) |
| 0.0 | 0.2 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
| 0.0 | 0.3 | GO:0034058 | endosomal vesicle fusion(GO:0034058) |
| 0.0 | 0.4 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 0.3 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.1 | GO:0006740 | NADPH regeneration(GO:0006740) |
| 0.0 | 0.2 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.0 | 0.2 | GO:0098734 | macromolecule depalmitoylation(GO:0098734) |
| 0.0 | 0.1 | GO:1905045 | Schwann cell proliferation involved in axon regeneration(GO:0014011) negative regulation of Schwann cell migration(GO:1900148) regulation of Schwann cell proliferation involved in axon regeneration(GO:1905044) negative regulation of Schwann cell proliferation involved in axon regeneration(GO:1905045) |
| 0.0 | 0.7 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.0 | 0.1 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.0 | 0.2 | GO:0051599 | response to hydrostatic pressure(GO:0051599) |
| 0.0 | 0.4 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 1.3 | GO:0070268 | cornification(GO:0070268) |
| 0.0 | 0.1 | GO:0035897 | proteolysis in other organism(GO:0035897) |
| 0.0 | 0.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.0 | 0.0 | GO:0060734 | regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) |
| 0.0 | 0.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.5 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 1.0 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.1 | 0.5 | GO:0071665 | gamma-catenin-TCF7L2 complex(GO:0071665) |
| 0.1 | 2.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 0.7 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.3 | GO:0033263 | CORVET complex(GO:0033263) |
| 0.0 | 0.8 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.0 | 0.4 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.2 | GO:0005827 | polar microtubule(GO:0005827) |
| 0.0 | 0.1 | GO:1990796 | photoreceptor cell terminal bouton(GO:1990796) |
| 0.0 | 1.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.1 | GO:0045323 | interleukin-1 receptor complex(GO:0045323) |
| 0.0 | 0.3 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 0.0 | GO:0002947 | tumor necrosis factor receptor superfamily complex(GO:0002947) |
| 0.0 | 0.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.1 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.4 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.5 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 0.4 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 0.2 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.1 | 0.5 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.1 | 0.3 | GO:0047225 | acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0047225) |
| 0.1 | 0.4 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 0.1 | 0.3 | GO:0003955 | NAD(P)H dehydrogenase (quinone) activity(GO:0003955) |
| 0.1 | 0.3 | GO:0016716 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716) |
| 0.1 | 0.6 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
| 0.1 | 0.9 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.1 | 0.4 | GO:0034617 | tetrahydrobiopterin binding(GO:0034617) |
| 0.1 | 1.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.1 | 0.7 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.1 | 0.5 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 1.2 | GO:0042923 | neuropeptide binding(GO:0042923) |
| 0.1 | 0.3 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.0 | 0.3 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.0 | 0.6 | GO:0019957 | C-C chemokine binding(GO:0019957) |
| 0.0 | 0.1 | GO:0008746 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.0 | 0.4 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 1.0 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0003974 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.0 | 0.2 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 0.2 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.0 | 0.7 | GO:0035615 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 0.0 | 0.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.0 | 0.3 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.0 | 0.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 0.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.0 | 0.1 | GO:0008260 | 3-oxoacid CoA-transferase activity(GO:0008260) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.1 | GO:0015439 | heme-transporting ATPase activity(GO:0015439) |
| 0.0 | 0.7 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.1 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.0 | 0.2 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.0 | 0.1 | GO:1904408 | dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408) |
| 0.0 | 0.1 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.0 | 0.5 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.1 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.0 | 0.1 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.0 | 0.1 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.7 | GO:0070412 | R-SMAD binding(GO:0070412) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | PID_INTEGRIN4_PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.8 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.9 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.2 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.9 | PID_ARF6_PATHWAY | Arf6 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 1.1 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 4.7 | REACTOME_CELL_JUNCTION_ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 0.5 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_PA | Genes involved in Synthesis of PA |
| 0.0 | 0.4 | REACTOME_AMINE_DERIVED_HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.8 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.2 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.4 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
