Motif ID: EPAS1_BCL3

Z-value: 0.768

Transcription factors associated with EPAS1_BCL3:

Gene SymbolEntrez IDGene Name
BCL3 ENSG00000069399.8 BCL3
EPAS1 ENSG00000116016.9 EPAS1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EPAS1hg19_v2_chr2_+_46524537_465245530.761.6e-02Click!
BCL3hg19_v2_chr19_+_45251804_452518400.225.7e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of EPAS1_BCL3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_33701707 1.654 ENST00000425210.1
ENST00000444784.1
ENST00000423159.1
RASGRP3


RAS guanyl releasing protein 3 (calcium and DAG-regulated)


chrX_+_1387693 1.487 ENST00000381529.3
ENST00000432318.2
ENST00000361536.3
ENST00000501036.2
ENST00000381524.3
ENST00000412290.1
CSF2RA





colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)





chrX_+_1387721 1.385 ENST00000419094.1
ENST00000381509.3
ENST00000494969.2
ENST00000355805.2
ENST00000355432.3
CSF2RA




colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)




chr12_-_86230315 1.354 ENST00000361228.3
RASSF9
Ras association (RalGDS/AF-6) domain family (N-terminal) member 9
chr2_+_102686820 1.267 ENST00000409929.1
ENST00000424272.1
IL1R1

interleukin 1 receptor, type I

chr7_+_114055052 1.205 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2







forkhead box P2







chr2_-_170219037 1.187 ENST00000443831.1
LRP2
low density lipoprotein receptor-related protein 2
chr1_+_110453608 1.118 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chrX_+_9880412 1.004 ENST00000418909.2
SHROOM2
shroom family member 2
chr1_+_110453462 0.991 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr1_+_110453203 0.982 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1


colony stimulating factor 1 (macrophage)


chr14_+_71108460 0.974 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr1_+_110453514 0.954 ENST00000369802.3
ENST00000420111.2
CSF1

colony stimulating factor 1 (macrophage)

chrX_+_9880590 0.923 ENST00000452575.1
SHROOM2
shroom family member 2
chr12_+_52643077 0.851 ENST00000553310.2
ENST00000544024.1
KRT86

keratin 86

chr14_+_91709103 0.822 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr1_-_177133818 0.798 ENST00000424564.2
ENST00000361833.2
ASTN1

astrotactin 1

chr11_-_70507867 0.764 ENST00000412252.1
ENST00000409161.1
ENST00000409530.1
SHANK2


SH3 and multiple ankyrin repeat domains 2


chr17_+_73750699 0.761 ENST00000584939.1
ITGB4
integrin, beta 4
chr17_+_72427477 0.732 ENST00000342648.5
ENST00000481232.1
GPRC5C

G protein-coupled receptor, family C, group 5, member C

chr14_-_54420133 0.728 ENST00000559501.1
ENST00000558984.1
BMP4

bone morphogenetic protein 4

chr19_-_43383850 0.700 ENST00000436291.2
ENST00000595124.1
ENST00000244296.2
PSG1


pregnancy specific beta-1-glycoprotein 1


chr5_+_122424816 0.690 ENST00000407847.4
PRDM6
PR domain containing 6
chr1_+_110453109 0.686 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr2_+_14772810 0.675 ENST00000295092.2
ENST00000331243.4
FAM84A

family with sequence similarity 84, member A

chr5_+_32711419 0.671 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr3_+_187957646 0.654 ENST00000457242.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr20_+_10199468 0.624 ENST00000254976.2
ENST00000304886.2
SNAP25

synaptosomal-associated protein, 25kDa

chr8_-_110620284 0.621 ENST00000529690.1
SYBU
syntabulin (syntaxin-interacting)
chr11_-_70507901 0.607 ENST00000449833.2
ENST00000357171.3
ENST00000449116.2
SHANK2


SH3 and multiple ankyrin repeat domains 2


chr19_-_43383819 0.594 ENST00000312439.6
ENST00000403380.3
PSG1

pregnancy specific beta-1-glycoprotein 1

chr12_-_71533055 0.588 ENST00000552128.1
TSPAN8
tetraspanin 8
chr3_-_38691119 0.575 ENST00000333535.4
ENST00000413689.1
ENST00000443581.1
ENST00000425664.1
ENST00000451551.2
SCN5A




sodium channel, voltage-gated, type V, alpha subunit




chr1_-_44497024 0.573 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr10_-_61469837 0.573 ENST00000395348.3
SLC16A9
solute carrier family 16, member 9
chr19_-_43382142 0.565 ENST00000597058.1
PSG1
pregnancy specific beta-1-glycoprotein 1
chr12_-_10007448 0.560 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr4_-_105416039 0.544 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr12_-_66317967 0.520 ENST00000601398.1
AC090673.2
Uncharacterized protein
chr4_-_168155577 0.509 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3





sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3





chr4_+_86748898 0.504 ENST00000509300.1
ARHGAP24
Rho GTPase activating protein 24
chr20_+_9049682 0.500 ENST00000334005.3
ENST00000378473.3
PLCB4

phospholipase C, beta 4

chr14_-_91710852 0.495 ENST00000535815.1
ENST00000529102.1
GPR68

G protein-coupled receptor 68

chr11_+_102188224 0.494 ENST00000263464.3
BIRC3
baculoviral IAP repeat containing 3
chr20_+_43343476 0.478 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr12_+_52668394 0.474 ENST00000423955.2
KRT86
keratin 86
chr19_-_43709817 0.468 ENST00000433626.2
ENST00000405312.3
PSG4

pregnancy specific beta-1-glycoprotein 4

chr19_-_43383789 0.467 ENST00000595356.1
PSG1
pregnancy specific beta-1-glycoprotein 1
chr6_+_126070726 0.451 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr19_-_43269809 0.449 ENST00000406636.3
ENST00000404209.4
ENST00000306511.4
PSG8


pregnancy specific beta-1-glycoprotein 8


chr20_+_43343517 0.445 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr4_-_168155417 0.445 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3


sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3


chr5_+_52285144 0.437 ENST00000296585.5
ITGA2
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
chr6_+_153019069 0.433 ENST00000532295.1
MYCT1
myc target 1
chr1_-_44497118 0.428 ENST00000537678.1
ENST00000466926.1
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr19_-_43709772 0.417 ENST00000596907.1
ENST00000451895.1
PSG4

pregnancy specific beta-1-glycoprotein 4

chr10_+_72432559 0.416 ENST00000373208.1
ENST00000373207.1
ADAMTS14

ADAM metallopeptidase with thrombospondin type 1 motif, 14

chr6_-_24646249 0.414 ENST00000430948.2
ENST00000537886.1
ENST00000535378.1
ENST00000378214.3
KIAA0319



KIAA0319



chr17_+_72428218 0.412 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_-_152955213 0.409 ENST00000427385.1
CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr7_-_132261253 0.404 ENST00000321063.4
PLXNA4
plexin A4
chr4_-_168155730 0.403 ENST00000502330.1
ENST00000357154.3
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr6_+_153019023 0.400 ENST00000367245.5
ENST00000529453.1
MYCT1

myc target 1

chr20_+_43343886 0.400 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr4_+_86749045 0.397 ENST00000514229.1
ARHGAP24
Rho GTPase activating protein 24
chr2_+_102618428 0.396 ENST00000457817.1
IL1R2
interleukin 1 receptor, type II
chr7_+_87257854 0.390 ENST00000394654.3
RUNDC3B
RUN domain containing 3B
chr2_+_27719697 0.386 ENST00000264717.2
ENST00000424318.2
GCKR

glucokinase (hexokinase 4) regulator

chr19_-_43709703 0.383 ENST00000599391.1
ENST00000244295.9
PSG4

pregnancy specific beta-1-glycoprotein 4

chr22_-_29075853 0.377 ENST00000397906.2
TTC28
tetratricopeptide repeat domain 28
chr2_-_27341966 0.377 ENST00000402394.1
ENST00000402550.1
ENST00000260595.5
CGREF1


cell growth regulator with EF-hand domain 1


chr11_+_34664014 0.376 ENST00000527935.1
EHF
ets homologous factor
chr11_-_32457075 0.374 ENST00000448076.3
WT1
Wilms tumor 1
chr4_-_168155700 0.367 ENST00000357545.4
ENST00000512648.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr20_-_34025999 0.366 ENST00000374369.3
GDF5
growth differentiation factor 5
chr18_-_21242833 0.364 ENST00000586087.1
ENST00000592179.1
ANKRD29

ankyrin repeat domain 29

chr12_+_5541267 0.359 ENST00000423158.3
NTF3
neurotrophin 3
chr11_-_32457176 0.356 ENST00000332351.3
WT1
Wilms tumor 1
chr17_-_191188 0.353 ENST00000575634.1
RPH3AL
rabphilin 3A-like (without C2 domains)
chr7_+_95401851 0.353 ENST00000447467.2
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chr1_+_31971828 0.351 ENST00000418618.1
RP11-439L8.3
RP11-439L8.3
chr20_+_10199566 0.347 ENST00000430336.1
SNAP25
synaptosomal-associated protein, 25kDa
chr2_-_145277882 0.344 ENST00000465070.1
ENST00000444559.1
ZEB2

zinc finger E-box binding homeobox 2

chr11_+_134225909 0.334 ENST00000533324.1
GLB1L2
galactosidase, beta 1-like 2
chr19_+_7660716 0.331 ENST00000160298.4
ENST00000446248.2
CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chrX_+_105937068 0.331 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr19_-_43773589 0.331 ENST00000291752.5
ENST00000244293.7
ENST00000596730.1
ENST00000593948.1
ENST00000270077.3
ENST00000443718.3
ENST00000418820.2
PSG9






pregnancy specific beta-1-glycoprotein 9






chr10_+_105314881 0.330 ENST00000437579.1
NEURL
neuralized E3 ubiquitin protein ligase 1
chr11_+_102188272 0.327 ENST00000532808.1
BIRC3
baculoviral IAP repeat containing 3
chr3_+_134514093 0.326 ENST00000398015.3
EPHB1
EPH receptor B1
chr3_+_173113898 0.321 ENST00000423427.1
NLGN1
neuroligin 1
chr2_+_233243233 0.320 ENST00000392027.2
ALPP
alkaline phosphatase, placental
chr4_+_75230853 0.319 ENST00000244869.2
EREG
epiregulin
chr22_+_35776828 0.318 ENST00000216117.8
HMOX1
heme oxygenase (decycling) 1
chr7_+_95401877 0.318 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
DYNC1I1





dynein, cytoplasmic 1, intermediate chain 1





chr5_+_52776228 0.317 ENST00000256759.3
FST
follistatin
chr7_+_121513374 0.316 ENST00000449182.1
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr3_+_185080908 0.315 ENST00000265026.3
MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr17_+_73717516 0.311 ENST00000200181.3
ENST00000339591.3
ITGB4

integrin, beta 4

chr22_-_37823468 0.310 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr2_+_210444142 0.309 ENST00000360351.4
ENST00000361559.4
MAP2

microtubule-associated protein 2

chr10_+_24528108 0.309 ENST00000438429.1
KIAA1217
KIAA1217
chr2_-_238499337 0.308 ENST00000411462.1
ENST00000409822.1
RAB17

RAB17, member RAS oncogene family

chr17_+_71161140 0.299 ENST00000357585.2
SSTR2
somatostatin receptor 2
chr6_+_97372645 0.298 ENST00000536676.1
ENST00000544166.1
KLHL32

kelch-like family member 32

chr3_-_167813672 0.294 ENST00000470487.1
GOLIM4
golgi integral membrane protein 4
chr18_+_32402321 0.291 ENST00000587723.1
DTNA
dystrobrevin, alpha
chr2_-_145278475 0.289 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr19_+_36195429 0.288 ENST00000392197.2
ZBTB32
zinc finger and BTB domain containing 32
chr7_+_29519662 0.287 ENST00000424025.2
ENST00000439711.2
ENST00000421775.2
CHN2


chimerin 2


chr5_+_421030 0.287 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr9_-_139637355 0.287 ENST00000474369.1
ENST00000497771.1
ENST00000527229.1
LCN10


lipocalin 10


chr7_+_87257701 0.286 ENST00000338056.3
ENST00000493037.1
RUNDC3B

RUN domain containing 3B

chr16_-_68269971 0.286 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr12_-_96184913 0.285 ENST00000538383.1
NTN4
netrin 4
chr4_-_152329987 0.285 ENST00000508847.1
RP11-610P16.1
RP11-610P16.1
chr7_-_107642348 0.281 ENST00000393561.1
LAMB1
laminin, beta 1
chr18_+_32290218 0.280 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
DTNA


dystrobrevin, alpha


chrX_+_148793714 0.280 ENST00000355220.5
MAGEA11
melanoma antigen family A, 11
chrX_+_105936982 0.279 ENST00000418562.1
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr19_-_43708378 0.277 ENST00000599746.1
PSG4
pregnancy specific beta-1-glycoprotein 4
chr10_+_52751010 0.274 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chr16_+_57662419 0.273 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
GPR56






G protein-coupled receptor 56






chr7_+_29519486 0.272 ENST00000409041.4
CHN2
chimerin 2
chr5_+_133477868 0.270 ENST00000517855.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr11_-_27722021 0.270 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
BDNF


brain-derived neurotrophic factor


chr10_-_30348439 0.266 ENST00000375377.1
KIAA1462
KIAA1462
chr12_-_24103954 0.265 ENST00000441133.2
ENST00000545921.1
SOX5

SRY (sex determining region Y)-box 5

chr17_+_72428266 0.265 ENST00000582473.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr6_+_36646435 0.258 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
CDKN1A


cyclin-dependent kinase inhibitor 1A (p21, Cip1)


chr1_-_44482979 0.256 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr12_-_24102576 0.253 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
SOX5



SRY (sex determining region Y)-box 5



chr6_-_24645956 0.251 ENST00000543707.1
KIAA0319
KIAA0319
chr14_-_81902516 0.250 ENST00000554710.1
STON2
stonin 2
chr7_-_132261223 0.249 ENST00000423507.2
PLXNA4
plexin A4
chr2_+_7005959 0.249 ENST00000442639.1
RSAD2
radical S-adenosyl methionine domain containing 2
chr2_-_214016314 0.247 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chr8_-_33455268 0.247 ENST00000522982.1
DUSP26
dual specificity phosphatase 26 (putative)
chr5_-_146889619 0.246 ENST00000343218.5
DPYSL3
dihydropyrimidinase-like 3
chr3_-_168865522 0.245 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr8_-_61193947 0.243 ENST00000317995.4
CA8
carbonic anhydrase VIII
chr1_+_56880606 0.242 ENST00000451914.1
RP4-710M16.2
RP4-710M16.2
chr17_+_4618734 0.241 ENST00000571206.1
ARRB2
arrestin, beta 2
chr8_-_27462822 0.237 ENST00000522098.1
CLU
clusterin
chr5_+_52776449 0.236 ENST00000396947.3
FST
follistatin
chr16_+_811073 0.235 ENST00000382862.3
ENST00000563651.1
MSLN

mesothelin

chr3_+_14444063 0.230 ENST00000454876.2
ENST00000360861.3
ENST00000416216.2
SLC6A6


solute carrier family 6 (neurotransmitter transporter), member 6


chr1_+_82266053 0.228 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2






latrophilin 2






chr4_-_48082192 0.225 ENST00000507351.1
TXK
TXK tyrosine kinase
chr15_+_41245160 0.224 ENST00000444189.2
ENST00000446533.3
CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr19_+_40503013 0.223 ENST00000595225.1
ZNF546
zinc finger protein 546
chr3_-_183735731 0.223 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr9_+_2622085 0.220 ENST00000382099.2
VLDLR
very low density lipoprotein receptor
chr5_-_87980753 0.219 ENST00000511014.2
LINC00461
long intergenic non-protein coding RNA 461
chr3_+_186743261 0.219 ENST00000423451.1
ENST00000446170.1
ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr11_-_32456891 0.218 ENST00000452863.3
WT1
Wilms tumor 1
chr19_+_56915668 0.218 ENST00000333201.9
ENST00000391778.3
ZNF583

zinc finger protein 583

chr5_-_96143602 0.218 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
ERAP1



endoplasmic reticulum aminopeptidase 1



chr7_+_73442457 0.218 ENST00000438880.1
ENST00000414324.1
ENST00000380562.4
ELN


elastin


chr7_-_100493482 0.211 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE



acetylcholinesterase (Yt blood group)



chr18_+_21464737 0.211 ENST00000586751.1
LAMA3
laminin, alpha 3
chr2_+_210444298 0.211 ENST00000445941.1
MAP2
microtubule-associated protein 2
chr4_-_89152474 0.210 ENST00000515655.1
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr9_+_2621950 0.208 ENST00000382096.1
VLDLR
very low density lipoprotein receptor
chr9_-_39288092 0.207 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3



contactin associated protein-like 3



chr8_-_18541603 0.204 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr6_-_53530474 0.204 ENST00000370905.3
KLHL31
kelch-like family member 31
chr4_-_121993673 0.203 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor
chr5_-_88178964 0.203 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C



myocyte enhancer factor 2C



chr17_-_29641084 0.202 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr17_-_29641104 0.202 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chrX_+_52112158 0.201 ENST00000286049.2
XAGE2B
X antigen family, member 2B
chr2_-_170219079 0.200 ENST00000263816.3
LRP2
low density lipoprotein receptor-related protein 2
chr19_+_38085768 0.200 ENST00000316433.4
ENST00000590588.1
ENST00000586134.1
ENST00000586792.1
ZNF540



zinc finger protein 540



chr19_+_36195467 0.199 ENST00000426659.2
ZBTB32
zinc finger and BTB domain containing 32
chr2_-_233792837 0.198 ENST00000373552.4
ENST00000409079.1
NGEF

neuronal guanine nucleotide exchange factor

chr5_+_133477905 0.198 ENST00000517799.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr15_+_92396920 0.197 ENST00000318445.6
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr5_+_32710736 0.195 ENST00000415685.2
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_+_27561104 0.194 ENST00000361771.3
WDTC1
WD and tetratricopeptide repeats 1
chr12_+_56415100 0.193 ENST00000547791.1
IKZF4
IKAROS family zinc finger 4 (Eos)
chr18_-_21242774 0.193 ENST00000322980.9
ANKRD29
ankyrin repeat domain 29
chr19_-_43690642 0.192 ENST00000407356.1
ENST00000407568.1
ENST00000404580.1
ENST00000599812.1
PSG5



pregnancy specific beta-1-glycoprotein 5



chr16_-_70719925 0.192 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr2_-_152955537 0.191 ENST00000201943.5
ENST00000539935.1
CACNB4

calcium channel, voltage-dependent, beta 4 subunit

chr2_+_7017796 0.191 ENST00000382040.3
RSAD2
radical S-adenosyl methionine domain containing 2
chr9_+_95736758 0.190 ENST00000337352.6
FGD3
FYVE, RhoGEF and PH domain containing 3
chr2_-_145277569 0.189 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr2_-_145277640 0.188 ENST00000539609.3
ZEB2
zinc finger E-box binding homeobox 2
chr6_+_97372596 0.187 ENST00000369261.4
KLHL32
kelch-like family member 32
chr7_-_95064264 0.186 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
PON2


paraoxonase 2


chr5_-_169407744 0.185 ENST00000377365.3
FAM196B
family with sequence similarity 196, member B
chr1_+_6845384 0.184 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr6_-_166401527 0.184 ENST00000455853.1
ENST00000584911.1
LINC00473

long intergenic non-protein coding RNA 473

chr1_+_27669719 0.184 ENST00000473280.1
SYTL1
synaptotagmin-like 1
chr2_+_30454390 0.183 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH


limb bud and heart development


chr1_+_27561007 0.183 ENST00000319394.3
WDTC1
WD and tetratricopeptide repeats 1
chr17_+_18601299 0.182 ENST00000572555.1
ENST00000395902.3
ENST00000449552.2
TRIM16L


tripartite motif containing 16-like


chr10_+_60272814 0.182 ENST00000373886.3
BICC1
bicaudal C homolog 1 (Drosophila)
chr1_+_46640750 0.182 ENST00000372003.1
TSPAN1
tetraspanin 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.7 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.6 1.9 GO:0008057 eye pigment granule organization(GO:0008057)
0.4 1.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.4 1.2 GO:0098582 innate vocalization behavior(GO:0098582)
0.2 0.9 GO:0072299 visceral serous pericardium development(GO:0061032) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.2 0.7 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.2 1.3 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 0.7 GO:1990926 short-term synaptic potentiation(GO:1990926)
0.2 0.5 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621)
0.1 0.4 GO:0033341 regulation of collagen binding(GO:0033341)
0.1 0.7 GO:1905072 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 0.6 GO:0099545 trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.6 GO:0002415 immune response in mucosal-associated lymphoid tissue(GO:0002386) immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.5 GO:0034395 heme oxidation(GO:0006788) negative regulation of mast cell cytokine production(GO:0032764) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1 1.0 GO:1902748 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373) positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.7 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.3 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 0.4 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.1 1.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.2 GO:0046415 urate metabolic process(GO:0046415)
0.1 1.0 GO:1904378 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 0.3 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.1 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.1 0.6 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.1 0.5 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.1 0.5 GO:0034436 glycoprotein transport(GO:0034436)
0.1 0.3 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 0.1 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.1 1.1 GO:0035878 nail development(GO:0035878)
0.1 0.2 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.1 0.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 0.8 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.8 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.1 0.9 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.5 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.1 0.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.4 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.2 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.2 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.1 0.1 GO:0014855 striated muscle cell proliferation(GO:0014855) cardiac muscle cell proliferation(GO:0060038)
0.1 0.7 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.1 GO:0034443 negative regulation of lipoprotein oxidation(GO:0034443)
0.0 0.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.2 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.2 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.5 GO:0060591 chondroblast differentiation(GO:0060591)
0.0 0.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.3 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.3 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0070839 divalent metal ion export(GO:0070839)
0.0 0.3 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.0 0.4 GO:1902866 regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:1903028 positive regulation of opsonization(GO:1903028)
0.0 0.3 GO:0097327 response to antineoplastic agent(GO:0097327)
0.0 0.4 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.0 GO:0051952 gamma-aminobutyric acid secretion(GO:0014051) amine transport(GO:0015837) regulation of amine transport(GO:0051952)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0007506 gonadal mesoderm development(GO:0007506)
0.0 0.5 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.0 0.1 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 0.6 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.1 GO:0033242 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 1.1 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.2 GO:2000035 positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035)
0.0 0.3 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.2 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.0 0.2 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.2 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 1.4 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.3 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.1 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725) eosinophil fate commitment(GO:0035854)
0.0 0.4 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.2 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.2 GO:0043542 endothelial cell migration(GO:0043542)
0.0 0.1 GO:0002767 immune response-inhibiting cell surface receptor signaling pathway(GO:0002767)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.3 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.5 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0003404 optic vesicle morphogenesis(GO:0003404) optic cup structural organization(GO:0003409)
0.0 0.3 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0035669 TRAM-dependent toll-like receptor signaling pathway(GO:0035668) TRAM-dependent toll-like receptor 4 signaling pathway(GO:0035669)
0.0 0.1 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.1 GO:2000669 negative regulation of dendritic cell apoptotic process(GO:2000669)
0.0 0.1 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.2 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 0.1 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 0.2 GO:2000344 positive regulation of acrosome reaction(GO:2000344)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.3 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.2 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.4 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.0 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0 0.0 GO:0035989 tendon development(GO:0035989)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:0072675 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.0 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.1 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.0 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.2 GO:0089718 amino acid import across plasma membrane(GO:0089718)
0.0 0.1 GO:0001575 globoside metabolic process(GO:0001575)
0.0 0.1 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.2 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.1 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.0 0.3 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0 0.0 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.2 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.0 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.0 GO:0034553 respiratory chain complex II assembly(GO:0034552) mitochondrial respiratory chain complex II assembly(GO:0034553) mitochondrial respiratory chain complex II biogenesis(GO:0097032)
0.0 0.0 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.1 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.0 0.0 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.0 GO:0046022 positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.0 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.0 0.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.1 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494)
0.0 0.0 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.0 0.1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0 0.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.1 GO:0032095 regulation of response to food(GO:0032095)
0.0 0.0 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 1.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.1 1.4 GO:0005883 neurofilament(GO:0005883)
0.1 0.4 GO:0072534 perineuronal net(GO:0072534)
0.1 0.3 GO:0043257 laminin-8 complex(GO:0043257)
0.1 0.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.4 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.1 0.7 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.8 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.3 GO:0000811 GINS complex(GO:0000811)
0.1 1.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.1 0.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.7 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.3 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.1 1.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 0.2 GO:0001534 radial spoke(GO:0001534)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.5 GO:0005610 laminin-5 complex(GO:0005610)
0.0 1.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.6 GO:0097433 dense body(GO:0097433)
0.0 0.9 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.3 GO:0071953 elastic fiber(GO:0071953)
0.0 0.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.0 0.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.0 GO:0009986 cell surface(GO:0009986)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 1.3 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 0.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 2.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 0.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.3 GO:0032433 filopodium tip(GO:0032433)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.0 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.7 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.4 1.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 1.5 GO:0042954 lipoprotein transporter activity(GO:0042954)
0.2 0.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 1.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.2 1.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 0.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1 0.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.1 1.4 GO:0038132 neuregulin binding(GO:0038132)
0.1 0.3 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.3 GO:0032440 2-alkenal reductase [NAD(P)] activity(GO:0032440)
0.1 0.7 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.1 0.4 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.1 0.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.2 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.1 0.4 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1 0.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.1 0.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 0.3 GO:0035501 MH1 domain binding(GO:0035501)
0.1 0.4 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.3 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.1 0.2 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.1 0.2 GO:0070698 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) type I activin receptor binding(GO:0070698)
0.1 0.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 2.0 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.5 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.2 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 1.1 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.4 GO:0042835 BRE binding(GO:0042835)
0.1 0.2 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 0.4 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 0.7 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0016826 N-sulfoglucosamine sulfohydrolase activity(GO:0016250) hydrolase activity, acting on acid sulfur-nitrogen bonds(GO:0016826)
0.0 0.1 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.0 0.1 GO:0052856 NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857)
0.0 0.8 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.2 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.0 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 0.1 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.0 0.1 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0036122 BMP binding(GO:0036122)
0.0 0.2 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.3 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 1.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.6 GO:0048185 activin binding(GO:0048185)
0.0 0.1 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.4 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.3 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 0.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0005329 dopamine transmembrane transporter activity(GO:0005329)
0.0 0.1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.1 GO:0032089 NACHT domain binding(GO:0032089)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.8 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.1 GO:0005220 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
0.0 0.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 0.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 1.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.0 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.3 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0019981 interleukin-6 receptor activity(GO:0004915) leukemia inhibitory factor receptor activity(GO:0004923) interleukin-6 binding(GO:0019981)
0.0 0.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.1 GO:0004977 melanocortin receptor activity(GO:0004977)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.0 GO:0030109 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.0 0.2 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.0 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.0 GO:0004948 calcitonin receptor activity(GO:0004948)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0 3.6 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.2 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.9 GO:0050681 androgen receptor binding(GO:0050681)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.3 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.3 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.0 1.2 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.3 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 2.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.1 REACTOME_STEROID_HORMONES Genes involved in Steroid hormones
0.0 0.8 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.7 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.0 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.0 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.7 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 2.0 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 0.4 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.8 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors