Motif ID: EGR1_EGR4

Z-value: 0.606

Transcription factors associated with EGR1_EGR4:

Gene SymbolEntrez IDGene Name
EGR1 ENSG00000120738.7 EGR1
EGR4 ENSG00000135625.6 EGR4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
EGR4hg19_v2_chr2_-_73520667_73520833-0.836.0e-03Click!
EGR1hg19_v2_chr5_+_137801160_1378011790.627.5e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1_EGR4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_38691119 1.676 ENST00000333535.4
ENST00000413689.1
ENST00000443581.1
ENST00000425664.1
ENST00000451551.2
SCN5A




sodium channel, voltage-gated, type V, alpha subunit




chr7_-_100493482 1.044 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE



acetylcholinesterase (Yt blood group)



chr11_+_134201768 1.003 ENST00000535456.2
ENST00000339772.7
GLB1L2

galactosidase, beta 1-like 2

chr17_+_72428218 0.920 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr4_-_25864581 0.916 ENST00000399878.3
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr11_+_134201911 0.881 ENST00000389881.3
GLB1L2
galactosidase, beta 1-like 2
chr2_-_27718052 0.792 ENST00000264703.3
FNDC4
fibronectin type III domain containing 4
chr1_-_9189144 0.631 ENST00000414642.2
GPR157
G protein-coupled receptor 157
chr9_-_130742792 0.617 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr17_+_72428266 0.580 ENST00000582473.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr8_+_32405728 0.565 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1




neuregulin 1




chr3_+_134514093 0.554 ENST00000398015.3
EPHB1
EPH receptor B1
chr2_+_30454390 0.543 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH


limb bud and heart development


chr3_-_169487617 0.508 ENST00000330368.2
ACTRT3
actin-related protein T3
chr5_+_150404904 0.503 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr7_-_100493744 0.501 ENST00000428317.1
ENST00000441605.1
ACHE

acetylcholinesterase (Yt blood group)

chr15_-_75017711 0.466 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1





cytochrome P450, family 1, subfamily A, polypeptide 1





chr6_+_31865552 0.446 ENST00000469372.1
ENST00000497706.1
C2

complement component 2

chr7_-_130418888 0.443 ENST00000310992.4
KLF14
Kruppel-like factor 14
chr4_-_36246060 0.436 ENST00000303965.4
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_184056614 0.431 ENST00000453072.1
FAM131A
family with sequence similarity 131, member A
chrX_-_51812268 0.403 ENST00000486010.1
ENST00000497164.1
ENST00000360134.6
ENST00000485287.1
ENST00000335504.5
ENST00000431659.1
MAGED4B





melanoma antigen family D, 4B





chr18_-_45935663 0.398 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
ZBTB7C







zinc finger and BTB domain containing 7C







chrX_+_16964794 0.392 ENST00000357277.3
REPS2
RALBP1 associated Eps domain containing 2
chr1_-_9189229 0.387 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr20_+_36531544 0.379 ENST00000448944.1
VSTM2L
V-set and transmembrane domain containing 2 like
chr5_-_88179017 0.379 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C



myocyte enhancer factor 2C



chr2_-_98612379 0.377 ENST00000425805.2
TMEM131
transmembrane protein 131
chr4_-_819901 0.376 ENST00000304062.6
CPLX1
complexin 1
chr4_+_30721968 0.366 ENST00000361762.2
PCDH7
protocadherin 7
chr5_-_88178964 0.360 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C



myocyte enhancer factor 2C



chr5_-_88179302 0.355 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr9_+_96928516 0.354 ENST00000602703.1
RP11-2B6.3
RP11-2B6.3
chr18_+_3449821 0.354 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1


TGFB-induced factor homeobox 1


chr2_+_14772810 0.347 ENST00000295092.2
ENST00000331243.4
FAM84A

family with sequence similarity 84, member A

chr2_-_128145498 0.344 ENST00000409179.2
MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr20_+_36531499 0.341 ENST00000373458.3
ENST00000373461.4
ENST00000373459.4
VSTM2L


V-set and transmembrane domain containing 2 like


chr3_-_185542761 0.338 ENST00000457616.2
ENST00000346192.3
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chr3_+_75721428 0.336 ENST00000463183.1
LINC00960
long intergenic non-protein coding RNA 960
chr3_-_185542817 0.335 ENST00000382199.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr9_-_101017900 0.331 ENST00000375066.5
TBC1D2
TBC1 domain family, member 2
chr3_+_50192833 0.326 ENST00000426511.1
SEMA3F
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr4_-_36245561 0.325 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_15004165 0.322 ENST00000538197.1
ENST00000541112.1
ENST00000442003.2
CPEB2


cytoplasmic polyadenylation element binding protein 2


chr3_+_184279566 0.321 ENST00000330394.2
EPHB3
EPH receptor B3
chr2_-_98612350 0.319 ENST00000186436.5
TMEM131
transmembrane protein 131
chr18_+_3449695 0.317 ENST00000343820.5
TGIF1
TGFB-induced factor homeobox 1
chr8_-_110704014 0.317 ENST00000529190.1
ENST00000422135.1
ENST00000419099.1
SYBU


syntabulin (syntaxin-interacting)


chr19_+_45844032 0.316 ENST00000589837.1
KLC3
kinesin light chain 3
chr6_+_43739697 0.313 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr4_+_150999418 0.310 ENST00000296550.7
DCLK2
doublecortin-like kinase 2
chr7_+_94537542 0.310 ENST00000433881.1
PPP1R9A
protein phosphatase 1, regulatory subunit 9A
chr8_+_32406137 0.306 ENST00000521670.1
NRG1
neuregulin 1
chr4_+_38869410 0.305 ENST00000358869.2
FAM114A1
family with sequence similarity 114, member A1
chr7_-_44365020 0.303 ENST00000395747.2
ENST00000347193.4
ENST00000346990.4
ENST00000258682.6
ENST00000353625.4
ENST00000421607.1
ENST00000424197.1
ENST00000502837.2
ENST00000350811.3
ENST00000395749.2
CAMK2B









calcium/calmodulin-dependent protein kinase II beta









chr5_+_133450365 0.300 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
TCF7




transcription factor 7 (T-cell specific, HMG-box)




chr8_-_57233103 0.298 ENST00000303749.3
ENST00000522671.1
SDR16C5

short chain dehydrogenase/reductase family 16C, member 5

chrX_+_16964985 0.296 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr7_-_103629963 0.295 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
RELN


reelin


chr19_+_16435625 0.293 ENST00000248071.5
ENST00000592003.1
KLF2

Kruppel-like factor 2

chr1_+_170633047 0.292 ENST00000239461.6
ENST00000497230.2
PRRX1

paired related homeobox 1

chr4_-_819880 0.291 ENST00000505203.1
CPLX1
complexin 1
chr8_+_32406179 0.288 ENST00000405005.3
NRG1
neuregulin 1
chr1_+_23695680 0.287 ENST00000454117.1
ENST00000335648.3
ENST00000518821.1
ENST00000437367.2
C1orf213



chromosome 1 open reading frame 213



chr15_+_41136369 0.287 ENST00000563656.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr10_-_43762329 0.284 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chrX_+_55478538 0.284 ENST00000342972.1
MAGEH1
melanoma antigen family H, 1
chr1_+_6845384 0.284 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr8_-_110703819 0.280 ENST00000532779.1
ENST00000534578.1
SYBU

syntabulin (syntaxin-interacting)

chr2_+_46524537 0.274 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr8_+_61822605 0.271 ENST00000526936.1
AC022182.1
AC022182.1
chr11_-_64612041 0.271 ENST00000342711.5
CDC42BPG
CDC42 binding protein kinase gamma (DMPK-like)
chr1_+_6845578 0.266 ENST00000467404.2
ENST00000439411.2
CAMTA1

calmodulin binding transcription activator 1

chr8_+_32405785 0.264 ENST00000287842.3
NRG1
neuregulin 1
chrX_+_49126294 0.264 ENST00000466508.1
ENST00000438316.1
ENST00000055335.6
ENST00000495799.1
PPP1R3F



protein phosphatase 1, regulatory subunit 3F



chr17_+_6900201 0.263 ENST00000480801.1
ALOX12
arachidonate 12-lipoxygenase
chr5_-_142784101 0.263 ENST00000503201.1
ENST00000502892.1
NR3C1

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

chr1_+_6845497 0.262 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr12_-_53625958 0.262 ENST00000327550.3
ENST00000546717.1
ENST00000425354.2
ENST00000394426.1
RARG



retinoic acid receptor, gamma



chrX_+_51927919 0.261 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr12_+_70760056 0.258 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr6_+_19837592 0.255 ENST00000378700.3
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr7_+_95401851 0.254 ENST00000447467.2
DYNC1I1
dynein, cytoplasmic 1, intermediate chain 1
chrX_-_48814278 0.254 ENST00000455452.1
OTUD5
OTU domain containing 5
chr1_-_153518270 0.251 ENST00000354332.4
ENST00000368716.4
S100A4

S100 calcium binding protein A4

chr15_+_41136216 0.251 ENST00000562057.1
ENST00000344051.4
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr1_+_11714914 0.248 ENST00000425796.1
ENST00000376770.1
ENST00000376768.1
ENST00000251547.5
ENST00000376760.1
ENST00000376762.4
FBXO44





F-box protein 44





chr1_-_177133818 0.247 ENST00000424564.2
ENST00000361833.2
ASTN1

astrotactin 1

chr3_-_180707466 0.247 ENST00000491873.1
ENST00000486355.1
ENST00000382564.2
DNAJC19


DnaJ (Hsp40) homolog, subfamily C, member 19


chr11_-_110583451 0.243 ENST00000260283.4
ENST00000528829.1
ARHGAP20

Rho GTPase activating protein 20

chr7_+_95401877 0.243 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
DYNC1I1





dynein, cytoplasmic 1, intermediate chain 1





chr20_-_22565101 0.240 ENST00000419308.2
FOXA2
forkhead box A2
chr4_+_38869298 0.239 ENST00000510213.1
ENST00000515037.1
FAM114A1

family with sequence similarity 114, member A1

chr9_+_19230433 0.239 ENST00000434457.2
ENST00000602925.1
DENND4C

DENN/MADD domain containing 4C

chr1_-_23694794 0.234 ENST00000374608.3
ZNF436
zinc finger protein 436
chrX_+_117957741 0.234 ENST00000310164.2
ZCCHC12
zinc finger, CCHC domain containing 12
chr19_-_50979981 0.233 ENST00000595790.1
ENST00000600100.1
FAM71E1

family with sequence similarity 71, member E1

chr2_+_121493717 0.232 ENST00000418323.1
GLI2
GLI family zinc finger 2
chr4_-_168155730 0.228 ENST00000502330.1
ENST00000357154.3
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr9_-_86153218 0.227 ENST00000304195.3
ENST00000376438.1
FRMD3

FERM domain containing 3

chr1_-_6321035 0.226 ENST00000377893.2
GPR153
G protein-coupled receptor 153
chr4_+_108745711 0.223 ENST00000394684.4
SGMS2
sphingomyelin synthase 2
chr10_+_134000404 0.222 ENST00000338492.4
ENST00000368629.1
DPYSL4

dihydropyrimidinase-like 4

chr16_+_810728 0.221 ENST00000563941.1
ENST00000545450.2
ENST00000566549.1
MSLN


mesothelin


chr7_+_94023873 0.217 ENST00000297268.6
COL1A2
collagen, type I, alpha 2
chr6_+_122931366 0.216 ENST00000368452.2
ENST00000368448.1
ENST00000392490.1
PKIB


protein kinase (cAMP-dependent, catalytic) inhibitor beta


chr17_-_6459802 0.216 ENST00000262483.8
PITPNM3
PITPNM family member 3
chr6_-_19804973 0.215 ENST00000457670.1
ENST00000607810.1
ENST00000606628.1
RP4-625H18.2


RP4-625H18.2


chr1_+_46640750 0.215 ENST00000372003.1
TSPAN1
tetraspanin 1
chr4_-_82393052 0.214 ENST00000335927.7
ENST00000504863.1
ENST00000264400.2
RASGEF1B


RasGEF domain family, member 1B


chr2_-_129076151 0.213 ENST00000259241.6
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr8_+_26149274 0.212 ENST00000522535.1
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr11_-_32452357 0.203 ENST00000379079.2
ENST00000530998.1
WT1

Wilms tumor 1

chr3_-_124774802 0.203 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr2_-_214016314 0.202 ENST00000434687.1
ENST00000374319.4
IKZF2

IKAROS family zinc finger 2 (Helios)

chr10_+_60272814 0.201 ENST00000373886.3
BICC1
bicaudal C homolog 1 (Drosophila)
chr17_-_6459768 0.201 ENST00000421306.3
PITPNM3
PITPNM family member 3
chr10_+_124221036 0.199 ENST00000368984.3
HTRA1
HtrA serine peptidase 1
chr2_+_191208601 0.198 ENST00000413239.1
ENST00000431594.1
ENST00000444194.1
INPP1


inositol polyphosphate-1-phosphatase


chr14_-_105635090 0.197 ENST00000331782.3
ENST00000347004.2
JAG2

jagged 2

chr5_+_421030 0.197 ENST00000506456.1
AHRR
aryl-hydrocarbon receptor repressor
chr21_-_45660723 0.195 ENST00000344330.4
ENST00000407780.3
ENST00000400379.3
ICOSLG


inducible T-cell co-stimulator ligand


chr3_+_170075436 0.192 ENST00000476188.1
ENST00000259119.4
ENST00000426052.2
SKIL


SKI-like oncogene


chr14_+_91709103 0.192 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chrX_-_48814810 0.191 ENST00000376488.3
ENST00000396743.3
ENST00000156084.4
OTUD5


OTU domain containing 5


chr2_+_191208196 0.190 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
INPP1



inositol polyphosphate-1-phosphatase



chr4_-_57976544 0.189 ENST00000295666.4
ENST00000537922.1
IGFBP7

insulin-like growth factor binding protein 7

chr5_+_133562095 0.188 ENST00000602919.1
CTD-2410N18.3
CTD-2410N18.3
chr11_-_32456891 0.188 ENST00000452863.3
WT1
Wilms tumor 1
chr1_+_65886244 0.187 ENST00000344610.8
LEPR
leptin receptor
chr15_+_41136586 0.185 ENST00000431806.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr12_-_58145889 0.182 ENST00000547853.1
CDK4
cyclin-dependent kinase 4
chr5_-_101632153 0.182 ENST00000310954.6
SLCO4C1
solute carrier organic anion transporter family, member 4C1
chr2_+_191208656 0.182 ENST00000458647.1
INPP1
inositol polyphosphate-1-phosphatase
chr12_-_57634475 0.181 ENST00000393825.1
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr4_+_88928777 0.180 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr19_+_54412517 0.177 ENST00000391767.1
CACNG7
calcium channel, voltage-dependent, gamma subunit 7
chr13_-_20735178 0.174 ENST00000241125.3
GJA3
gap junction protein, alpha 3, 46kDa
chr8_-_75233563 0.174 ENST00000342232.4
JPH1
junctophilin 1
chr9_+_2621950 0.173 ENST00000382096.1
VLDLR
very low density lipoprotein receptor
chr20_+_42543504 0.173 ENST00000341197.4
TOX2
TOX high mobility group box family member 2
chr9_+_2622085 0.173 ENST00000382099.2
VLDLR
very low density lipoprotein receptor
chr2_+_103236004 0.173 ENST00000233969.2
SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr2_+_121103706 0.173 ENST00000295228.3
INHBB
inhibin, beta B
chr16_-_68269971 0.172 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chrX_+_9880412 0.172 ENST00000418909.2
SHROOM2
shroom family member 2
chr15_+_41136734 0.171 ENST00000568580.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr4_-_168155577 0.171 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3





sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3





chr5_+_94982435 0.170 ENST00000511684.1
ENST00000380005.4
RFESD

Rieske (Fe-S) domain containing

chr1_-_15850676 0.169 ENST00000440484.1
ENST00000333868.5
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr19_+_37096194 0.167 ENST00000460670.1
ENST00000292928.2
ENST00000439428.1
ZNF382


zinc finger protein 382


chr2_-_148778323 0.167 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
ORC4



origin recognition complex, subunit 4



chr12_-_100378392 0.165 ENST00000549866.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_+_241375069 0.165 ENST00000264039.2
GPC1
glypican 1
chr19_-_36870087 0.164 ENST00000270001.7
ZFP14
ZFP14 zinc finger protein
chrX_-_53350522 0.164 ENST00000396435.3
ENST00000375368.5
IQSEC2

IQ motif and Sec7 domain 2

chr5_-_142784003 0.162 ENST00000416954.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chrX_+_21392529 0.161 ENST00000425654.2
ENST00000543067.1
CNKSR2

connector enhancer of kinase suppressor of Ras 2

chr5_+_109025067 0.161 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr5_-_142783694 0.159 ENST00000394466.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr15_+_92396920 0.159 ENST00000318445.6
SLCO3A1
solute carrier organic anion transporter family, member 3A1
chr15_-_93199069 0.159 ENST00000327355.5
FAM174B
family with sequence similarity 174, member B
chr1_-_16302608 0.159 ENST00000375743.4
ENST00000375733.2
ZBTB17

zinc finger and BTB domain containing 17

chr3_-_171177852 0.159 ENST00000284483.8
ENST00000475336.1
ENST00000357327.5
ENST00000460047.1
ENST00000488470.1
ENST00000470834.1
TNIK





TRAF2 and NCK interacting kinase





chr1_+_9648921 0.156 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
TMEM201


transmembrane protein 201


chr21_+_37529055 0.155 ENST00000270190.4
DOPEY2
dopey family member 2
chr3_-_88108212 0.155 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr12_-_111126910 0.153 ENST00000242607.8
HVCN1
hydrogen voltage-gated channel 1
chr6_+_126070726 0.153 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr19_-_14201776 0.152 ENST00000269724.5
SAMD1
sterile alpha motif domain containing 1
chr4_-_11431188 0.152 ENST00000510712.1
HS3ST1
heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr17_-_39780634 0.152 ENST00000577817.2
KRT17
keratin 17
chr22_-_38484922 0.151 ENST00000428572.1
BAIAP2L2
BAI1-associated protein 2-like 2
chr11_-_64512803 0.151 ENST00000377489.1
ENST00000354024.3
RASGRP2

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

chr3_+_171758344 0.150 ENST00000336824.4
ENST00000423424.1
FNDC3B

fibronectin type III domain containing 3B

chr3_-_171178157 0.150 ENST00000465393.1
ENST00000436636.2
ENST00000369326.5
ENST00000538048.1
ENST00000341852.6
TNIK




TRAF2 and NCK interacting kinase




chr20_+_43343886 0.149 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr15_+_32322709 0.147 ENST00000455693.2
CHRNA7
cholinergic receptor, nicotinic, alpha 7 (neuronal)
chr16_+_28834303 0.146 ENST00000340394.8
ENST00000325215.6
ENST00000395547.2
ENST00000336783.4
ENST00000382686.4
ENST00000564304.1
ATXN2L





ataxin 2-like





chr20_-_17539456 0.146 ENST00000544874.1
ENST00000377868.2
BFSP1

beaded filament structural protein 1, filensin

chr10_+_52833883 0.145 ENST00000373980.4
PRKG1
protein kinase, cGMP-dependent, type I
chr3_-_180707306 0.144 ENST00000479269.1
DNAJC19
DnaJ (Hsp40) homolog, subfamily C, member 19
chr1_+_65886326 0.143 ENST00000371059.3
ENST00000371060.3
ENST00000349533.6
ENST00000406510.3
LEPR



leptin receptor



chr3_+_50712672 0.141 ENST00000266037.9
DOCK3
dedicator of cytokinesis 3
chr1_-_16302565 0.141 ENST00000537142.1
ENST00000448462.2
ZBTB17

zinc finger and BTB domain containing 17

chrX_+_37545012 0.141 ENST00000378616.3
XK
X-linked Kx blood group (McLeod syndrome)
chr2_+_219433588 0.141 ENST00000295701.5
RQCD1
RCD1 required for cell differentiation1 homolog (S. pombe)
chr11_+_64685026 0.141 ENST00000526559.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chrX_+_9880590 0.141 ENST00000452575.1
SHROOM2
shroom family member 2
chr3_+_183873240 0.140 ENST00000431765.1
DVL3
dishevelled segment polarity protein 3
chr1_+_10459111 0.139 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD



phosphogluconate dehydrogenase



chr9_-_101017862 0.139 ENST00000375064.1
ENST00000342112.5
TBC1D2

TBC1 domain family, member 2

chr2_-_158732340 0.139 ENST00000539637.1
ENST00000413751.1
ENST00000434821.1
ENST00000424669.1
ACVR1



activin A receptor, type I



chr17_+_75137034 0.138 ENST00000436233.4
ENST00000443798.4
SEC14L1

SEC14-like 1 (S. cerevisiae)

chr12_+_57482877 0.137 ENST00000342556.6
ENST00000357680.4
NAB2

NGFI-A binding protein 2 (EGR1 binding protein 2)

chr4_+_57371509 0.137 ENST00000360096.2
ARL9
ADP-ribosylation factor-like 9
chr15_+_32322685 0.137 ENST00000454250.3
ENST00000306901.3
CHRNA7

cholinergic receptor, nicotinic, alpha 7 (neuronal)

chr4_-_109541610 0.136 ENST00000510212.1
RPL34-AS1
RPL34 antisense RNA 1 (head to head)
chr3_+_183873098 0.136 ENST00000313143.3
DVL3
dishevelled segment polarity protein 3
chrX_+_23925918 0.135 ENST00000379211.3
CXorf58
chromosome X open reading frame 58

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.2 1.7 GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization(GO:0060372)
0.2 0.6 GO:0021631 optic nerve morphogenesis(GO:0021631) inactivation of MAPKK activity(GO:0051389)
0.2 0.5 GO:0043449 cellular alkene metabolic process(GO:0043449)
0.2 1.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.2 1.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.1 0.2 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.3 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1 0.3 GO:0008057 eye pigment granule organization(GO:0008057)
0.1 0.3 GO:0097476 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.1 0.4 GO:0072299 visceral serous pericardium development(GO:0061032) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1 0.5 GO:2000035 positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035)
0.1 0.2 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.1 0.4 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.3 GO:1900248 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.3 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.1 0.2 GO:0060948 cardiac vascular smooth muscle cell development(GO:0060948)
0.1 0.4 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.1 0.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 0.1 GO:0003274 endocardial cushion fusion(GO:0003274)
0.1 0.2 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.2 GO:0097187 dentinogenesis(GO:0097187)
0.1 0.3 GO:2001301 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.1 0.2 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.5 GO:0034436 glycoprotein transport(GO:0034436)
0.1 0.2 GO:2001113 negative regulation of hepatocyte growth factor receptor signaling pathway(GO:1902203) regulation of cellular response to hepatocyte growth factor stimulus(GO:2001112) negative regulation of cellular response to hepatocyte growth factor stimulus(GO:2001113)
0.1 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.2 GO:1903410 lysine import(GO:0034226) L-lysine import(GO:0061461) L-lysine import into cell(GO:1903410)
0.1 0.2 GO:0045014 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.1 0.4 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.2 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1 0.2 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.2 GO:0098972 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1 0.8 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.1 0.6 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.3 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
0.0 0.1 GO:0033319 UDP-D-xylose metabolic process(GO:0033319) UDP-D-xylose biosynthetic process(GO:0033320)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.6 GO:0036486 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.0 0.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.0 0.4 GO:0033210 leptin-mediated signaling pathway(GO:0033210)
0.0 0.4 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.0 0.2 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.2 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.0 0.3 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.2 GO:0070426 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.0 0.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.6 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 0.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.3 GO:0050893 sensory processing(GO:0050893)
0.0 0.1 GO:0019521 aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521)
0.0 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0 0.1 GO:0021793 chemorepulsion of branchiomotor axon(GO:0021793)
0.0 0.1 GO:0061364 apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035358)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0060585 artery smooth muscle contraction(GO:0014824) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0045210 FasL biosynthetic process(GO:0045210)
0.0 0.2 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0060730 regulation of intestinal epithelial structure maintenance(GO:0060730)
0.0 0.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 0.2 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0051414 response to cortisol(GO:0051414)
0.0 0.1 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.0 0.1 GO:1900168 glial cell-derived neurotrophic factor secretion(GO:0044467) regulation of glial cell-derived neurotrophic factor secretion(GO:1900166) positive regulation of glial cell-derived neurotrophic factor secretion(GO:1900168)
0.0 0.1 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.1 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:1904717 excitatory chemical synaptic transmission(GO:0098976) regulation of AMPA glutamate receptor clustering(GO:1904717) positive regulation of AMPA glutamate receptor clustering(GO:1904719)
0.0 0.1 GO:0097069 cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387)
0.0 0.3 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.0 0.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479) negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.0 0.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.0 0.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:1905075 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905007) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0 0.4 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.5 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.3 GO:0051823 regulation of synapse structural plasticity(GO:0051823)
0.0 0.1 GO:1905123 regulation of endosome organization(GO:1904978) regulation of glucosylceramidase activity(GO:1905123)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 0.4 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.0 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.0 0.2 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.1 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.1 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.0 0.0 GO:0060300 regulation of cytokine activity(GO:0060300)
0.0 0.2 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.4 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
0.0 0.1 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.0 0.1 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.2 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.1 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.3 GO:0043589 skin morphogenesis(GO:0043589)
0.0 0.1 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.2 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.3 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0 0.1 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.0 GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734)
0.0 0.0 GO:0003220 left ventricular cardiac muscle tissue morphogenesis(GO:0003220)
0.0 0.1 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.0 0.3 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0 0.1 GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0 0.1 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 0.1 GO:0015798 myo-inositol transport(GO:0015798)
0.0 0.1 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.0 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.0 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0 0.1 GO:1903615 regulation of protein tyrosine phosphatase activity(GO:1903613) positive regulation of protein tyrosine phosphatase activity(GO:1903615)
0.0 0.1 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 0.1 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.0 0.2 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.2 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.0 GO:0021586 pons maturation(GO:0021586) superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.0 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.2 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.1 GO:0035865 cellular response to potassium ion(GO:0035865)
0.0 0.1 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0 0.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.1 GO:0015862 uridine transport(GO:0015862)
0.0 0.0 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 0.1 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.1 GO:1990034 calcium ion export from cell(GO:1990034)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.0 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.0 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.0 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.0 0.1 GO:0032252 secretory granule localization(GO:0032252)
0.0 0.1 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0 0.2 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.2 GO:0070262 mitotic nuclear envelope reassembly(GO:0007084) peptidyl-serine dephosphorylation(GO:0070262)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 0.2 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.3 GO:0043293 apoptosome(GO:0043293)
0.0 0.2 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.0 0.2 GO:0034753 nuclear aryl hydrocarbon receptor complex(GO:0034753)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.3 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.0 0.5 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.0 0.2 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.5 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.5 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.0 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0044292 dendrite terminus(GO:0044292) dendritic growth cone(GO:0044294)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.0 GO:0070701 mucus layer(GO:0070701)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.4 1.5 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.1 1.9 GO:0004565 beta-galactosidase activity(GO:0004565)
0.1 1.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.6 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.1 0.5 GO:0034189 very-low-density lipoprotein particle binding(GO:0034189)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.5 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.1 0.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.6 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 0.3 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165) hepoxilin-epoxide hydrolase activity(GO:0047977)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 0.2 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.1 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0048040 UDP-glucuronate decarboxylase activity(GO:0048040)
0.0 0.4 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.6 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.2 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0005289 high-affinity basic amino acid transmembrane transporter activity(GO:0005287) high-affinity arginine transmembrane transporter activity(GO:0005289) high-affinity lysine transmembrane transporter activity(GO:0005292)
0.0 0.1 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.0 0.1 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.0 0.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0047291 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 0.4 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.1 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.0 1.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.1 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.0 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.1 GO:0052827 inositol pentakisphosphate phosphatase activity(GO:0052827)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.0 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0031859 platelet activating factor receptor binding(GO:0031859)
0.0 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.1 GO:0042835 BRE binding(GO:0042835)
0.0 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.6 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.0 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0034711 inhibin binding(GO:0034711) BMP receptor activity(GO:0098821)
0.0 0.0 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.3 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.1 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.0 GO:0045131 pre-mRNA branch point binding(GO:0045131)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.0 GO:1990259 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.3 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.2 GO:0048156 tau protein binding(GO:0048156)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.1 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.5 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 0.7 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.5 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.3 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.3 REACTOME_HIGHLY_CALCIUM_PERMEABLE_POSTSYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 0.6 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 0.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.2 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.3 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 0.4 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects