Motif ID: E4F1

Z-value: 0.295


Transcription factors associated with E4F1:

Gene SymbolEntrez IDGene Name
E4F1 ENSG00000167967.11 E4F1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273558_2273637-0.462.1e-01Click!


Activity profile for motif E4F1.

activity profile for motif E4F1


Sorted Z-values histogram for motif E4F1

Sorted Z-values for motif E4F1



Network of associatons between targets according to the STRING database.



First level regulatory network of E4F1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_222436988 0.204 ENST00000409854.1
ENST00000281821.2
ENST00000392071.4
ENST00000443796.1
 EPHA4



EPH receptor A4



chr2_-_222437049 0.194 ENST00000541600.1
 EPHA4
EPH receptor A4
chr4_+_75310851 0.190 ENST00000395748.3
ENST00000264487.2
 AREG

amphiregulin

chr4_+_75311019 0.187 ENST00000502307.1
 AREG
amphiregulin
chr3_+_184053703 0.166 ENST00000450976.1
ENST00000418281.1
ENST00000340957.5
ENST00000433578.1
 FAM131A



family with sequence similarity 131, member A



chr6_-_47445214 0.155 ENST00000604014.1
 RP11-385F7.1
RP11-385F7.1
chr20_+_33292507 0.155 ENST00000414082.1
 TP53INP2
tumor protein p53 inducible nuclear protein 2
chr5_+_122424816 0.142 ENST00000407847.4
 PRDM6
PR domain containing 6
chr4_+_47487285 0.140 ENST00000273859.3
ENST00000504445.1
 ATP10D

ATPase, class V, type 10D

chr2_+_202899310 0.133 ENST00000286201.1
 FZD7
frizzled family receptor 7
chr2_-_157189180 0.130 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
 NR4A2




nuclear receptor subfamily 4, group A, member 2




chr3_+_173113898 0.122 ENST00000423427.1
 NLGN1
neuroligin 1
chrX_-_13835461 0.118 ENST00000316715.4
ENST00000356942.5
 GPM6B

glycoprotein M6B

chr8_-_29208183 0.103 ENST00000240100.2
 DUSP4
dual specificity phosphatase 4
chr1_-_8086343 0.101 ENST00000474874.1
ENST00000469499.1
ENST00000377482.5
 ERRFI1


ERBB receptor feedback inhibitor 1


chr17_+_41476327 0.100 ENST00000320033.4
 ARL4D
ADP-ribosylation factor-like 4D
chr17_+_71161140 0.096 ENST00000357585.2
 SSTR2
somatostatin receptor 2
chr1_-_16482554 0.095 ENST00000358432.5
 EPHA2
EPH receptor A2
chrX_-_13835147 0.085 ENST00000493677.1
ENST00000355135.2
 GPM6B

glycoprotein M6B

chr1_+_180199393 0.084 ENST00000263726.2
 LHX4
LIM homeobox 4
chr6_-_34664612 0.082 ENST00000374023.3
ENST00000374026.3
 C6orf106

chromosome 6 open reading frame 106

chr8_-_95274536 0.079 ENST00000297596.2
ENST00000396194.2
 GEM

GTP binding protein overexpressed in skeletal muscle

chr17_-_4643161 0.079 ENST00000574412.1
 CXCL16
chemokine (C-X-C motif) ligand 16
chrX_+_153672468 0.075 ENST00000393600.3
 FAM50A
family with sequence similarity 50, member A
chr6_+_28048753 0.074 ENST00000377325.1
 ZNF165
zinc finger protein 165
chr20_-_5591626 0.073 ENST00000379019.4
 GPCPD1
glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)
chr10_-_50970382 0.069 ENST00000419399.1
ENST00000432695.1
 OGDHL

oxoglutarate dehydrogenase-like

chr1_+_26496362 0.060 ENST00000374266.5
ENST00000270812.5
 ZNF593

zinc finger protein 593

chr6_-_31774714 0.060 ENST00000375661.5
 LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chrX_+_153237740 0.059 ENST00000369982.4
 TMEM187
transmembrane protein 187
chr5_+_138210919 0.058 ENST00000522013.1
ENST00000520260.1
ENST00000523298.1
ENST00000520865.1
ENST00000519634.1
ENST00000517533.1
ENST00000523685.1
ENST00000519768.1
ENST00000517656.1
ENST00000521683.1
ENST00000521640.1
ENST00000519116.1
 CTNNA1











catenin (cadherin-associated protein), alpha 1, 102kDa











chr3_+_185304059 0.056 ENST00000427465.2
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr17_-_4643114 0.056 ENST00000293778.6
 CXCL16
chemokine (C-X-C motif) ligand 16
chr7_-_36406750 0.054 ENST00000453212.1
ENST00000415803.2
ENST00000440378.1
ENST00000431396.1
ENST00000317020.6
ENST00000436884.1
 KIAA0895





KIAA0895





chr3_+_185303962 0.052 ENST00000296257.5
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr9_-_99381660 0.051 ENST00000375240.3
ENST00000463569.1
 CDC14B

cell division cycle 14B

chr5_-_138210977 0.048 ENST00000274711.6
ENST00000521094.2
 LRRTM2

leucine rich repeat transmembrane neuronal 2

chr9_-_99382065 0.045 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
 CDC14B


cell division cycle 14B


chr7_+_30174574 0.045 ENST00000409688.1
 C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr10_-_50970322 0.045 ENST00000374103.4
 OGDHL
oxoglutarate dehydrogenase-like
chr2_-_75426826 0.045 ENST00000305249.5
 TACR1
tachykinin receptor 1
chr9_-_131644202 0.044 ENST00000320665.6
ENST00000436267.2
 CCBL1

cysteine conjugate-beta lyase, cytoplasmic

chr1_-_151254362 0.044 ENST00000447795.2
 RP11-126K1.2
Uncharacterized protein
chr14_+_94492674 0.043 ENST00000203664.5
ENST00000553723.1
 OTUB2

OTU domain, ubiquitin aldehyde binding 2

chr9_-_131644306 0.043 ENST00000302586.3
 CCBL1
cysteine conjugate-beta lyase, cytoplasmic
chr6_+_26204825 0.041 ENST00000360441.4
 HIST1H4E
histone cluster 1, H4e
chr20_+_58179582 0.041 ENST00000371015.1
ENST00000395639.4
 PHACTR3

phosphatase and actin regulator 3

chr2_-_128145498 0.040 ENST00000409179.2
 MAP3K2
mitogen-activated protein kinase kinase kinase 2
chr7_+_30174668 0.037 ENST00000415604.1
 C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr7_-_129592471 0.034 ENST00000473814.2
ENST00000490974.1
 UBE2H

ubiquitin-conjugating enzyme E2H

chr10_-_64576105 0.032 ENST00000242480.3
ENST00000411732.1
 EGR2

early growth response 2

chr11_-_8680383 0.030 ENST00000299550.6
 TRIM66
tripartite motif containing 66
chr7_-_129592700 0.030 ENST00000472396.1
ENST00000355621.3
 UBE2H

ubiquitin-conjugating enzyme E2H

chr6_+_33176265 0.029 ENST00000374656.4
 RING1
ring finger protein 1
chr7_+_30174426 0.029 ENST00000324453.8
 C7orf41
maturin, neural progenitor differentiation regulator homolog (Xenopus)
chr14_-_39901618 0.029 ENST00000554932.1
ENST00000298097.7
 FBXO33

F-box protein 33

chr4_-_54930790 0.028 ENST00000263921.3
 CHIC2
cysteine-rich hydrophobic domain 2
chr11_+_3819049 0.027 ENST00000396986.2
ENST00000300730.6
ENST00000532535.1
ENST00000396993.4
ENST00000396991.2
ENST00000532523.1
ENST00000459679.1
ENST00000464261.1
ENST00000464906.2
ENST00000464441.1
 PGAP2









post-GPI attachment to proteins 2









chr4_-_76598326 0.027 ENST00000503660.1
 G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr1_+_8378140 0.027 ENST00000377479.2
 SLC45A1
solute carrier family 45, member 1
chr4_-_76598544 0.026 ENST00000515457.1
ENST00000357854.3
 G3BP2

GTPase activating protein (SH3 domain) binding protein 2

chr9_+_131644781 0.025 ENST00000259324.5
 LRRC8A
leucine rich repeat containing 8 family, member A
chr6_+_64282447 0.025 ENST00000370650.2
ENST00000578299.1
 PTP4A1

protein tyrosine phosphatase type IVA, member 1

chrX_-_73834449 0.025 ENST00000332687.6
ENST00000349225.2
 RLIM

ring finger protein, LIM domain interacting

chr8_-_94928861 0.025 ENST00000607097.1
 MIR378D2
microRNA 378d-2
chr6_-_27440460 0.025 ENST00000377419.1
 ZNF184
zinc finger protein 184
chr1_+_110527308 0.025 ENST00000369799.5
 AHCYL1
adenosylhomocysteinase-like 1
chr1_+_9599540 0.024 ENST00000302692.6
 SLC25A33
solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr6_-_29595779 0.024 ENST00000355973.3
ENST00000377012.4
 GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

chr5_+_133707252 0.022 ENST00000506787.1
ENST00000507277.1
 UBE2B

ubiquitin-conjugating enzyme E2B

chr9_+_131644398 0.021 ENST00000372599.3
 LRRC8A
leucine rich repeat containing 8 family, member A
chr9_+_131644388 0.021 ENST00000372600.4
 LRRC8A
leucine rich repeat containing 8 family, member A
chr6_+_47445467 0.020 ENST00000359314.5
 CD2AP
CD2-associated protein
chr5_-_95297534 0.019 ENST00000513343.1
ENST00000431061.2
 ELL2

elongation factor, RNA polymerase II, 2

chr6_-_27440837 0.019 ENST00000211936.6
 ZNF184
zinc finger protein 184
chr5_+_133706865 0.019 ENST00000265339.2
 UBE2B
ubiquitin-conjugating enzyme E2B
chr11_+_111410998 0.018 ENST00000533999.1
 LAYN
layilin
chr20_+_33146510 0.018 ENST00000397709.1
 MAP1LC3A
microtubule-associated protein 1 light chain 3 alpha
chr19_+_13858593 0.018 ENST00000221554.8
 CCDC130
coiled-coil domain containing 130
chr2_-_220408260 0.017 ENST00000373891.2
 CHPF
chondroitin polymerizing factor
chr12_-_107168696 0.017 ENST00000551505.1
 RP11-144F15.1
Uncharacterized protein
chr19_+_13858701 0.016 ENST00000586666.1
 CCDC130
coiled-coil domain containing 130
chr5_-_133706695 0.016 ENST00000521755.1
ENST00000523054.1
ENST00000435240.2
ENST00000609654.1
ENST00000536186.1
ENST00000609383.1
 CDKL3





cyclin-dependent kinase-like 3





chr11_+_111411384 0.016 ENST00000375615.3
ENST00000525126.1
ENST00000436913.2
ENST00000533265.1
 LAYN



layilin



chr4_-_111558135 0.015 ENST00000394598.2
ENST00000394595.3
 PITX2

paired-like homeodomain 2

chr1_-_212208842 0.015 ENST00000366992.3
ENST00000366993.3
ENST00000440600.2
ENST00000366994.3
 INTS7



integrator complex subunit 7



chr17_-_80231300 0.015 ENST00000398519.5
ENST00000580446.1
 CSNK1D

casein kinase 1, delta

chr6_+_15249128 0.014 ENST00000397311.3
 JARID2
jumonji, AT rich interactive domain 2
chr1_-_70820357 0.013 ENST00000370944.4
ENST00000262346.6
 ANKRD13C

ankyrin repeat domain 13C

chr8_-_66754172 0.013 ENST00000401827.3
 PDE7A
phosphodiesterase 7A
chr3_-_185655795 0.013 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
 TRA2B


transformer 2 beta homolog (Drosophila)


chr17_+_39845134 0.012 ENST00000591776.1
ENST00000469257.1
 EIF1

eukaryotic translation initiation factor 1

chrX_-_153236819 0.012 ENST00000354233.3
 HCFC1
host cell factor C1 (VP16-accessory protein)
chr2_-_220408430 0.012 ENST00000243776.6
 CHPF
chondroitin polymerizing factor
chr17_-_80231557 0.011 ENST00000392334.2
ENST00000314028.6
 CSNK1D

casein kinase 1, delta

chr1_+_212208919 0.010 ENST00000366991.4
ENST00000542077.1
 DTL

denticleless E3 ubiquitin protein ligase homolog (Drosophila)

chr6_+_64281906 0.010 ENST00000370651.3
 PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr16_-_27561209 0.009 ENST00000356183.4
ENST00000561623.1
 GTF3C1

general transcription factor IIIC, polypeptide 1, alpha 220kDa

chr6_+_30029008 0.008 ENST00000332435.5
ENST00000376782.2
ENST00000359374.4
ENST00000376785.2
 ZNRD1



zinc ribbon domain containing 1



chr1_+_39456895 0.008 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
 AKIRIN1


akirin 1


chr20_-_44420507 0.008 ENST00000243938.4
 WFDC3
WAP four-disulfide core domain 3
chr19_-_46088068 0.007 ENST00000263275.4
ENST00000323060.3
 OPA3

optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

chr1_+_109289279 0.006 ENST00000370008.3
 STXBP3
syntaxin binding protein 3
chr11_+_12695944 0.006 ENST00000361905.4
 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr19_+_45349432 0.006 ENST00000252485.4
 PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B)
chr19_+_52693259 0.006 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
 PPP2R1A



protein phosphatase 2, regulatory subunit A, alpha



chr3_-_101395936 0.006 ENST00000461821.1
 ZBTB11
zinc finger and BTB domain containing 11
chr11_+_12696102 0.006 ENST00000527636.1
ENST00000527376.1
 TEAD1

TEA domain family member 1 (SV40 transcriptional enhancer factor)

chr19_-_59066327 0.005 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
 CHMP2A


charged multivesicular body protein 2A


chr1_-_32110467 0.005 ENST00000440872.2
ENST00000373703.4
 PEF1

penta-EF-hand domain containing 1

chr6_-_30523865 0.004 ENST00000433809.1
 GNL1
guanine nucleotide binding protein-like 1
chr19_-_59066452 0.004 ENST00000312547.2
 CHMP2A
charged multivesicular body protein 2A
chr5_-_95297678 0.004 ENST00000237853.4
 ELL2
elongation factor, RNA polymerase II, 2
chr22_+_18121356 0.004 ENST00000317582.5
ENST00000543133.1
ENST00000538149.1
ENST00000337612.5
ENST00000493680.1
 BCL2L13




BCL2-like 13 (apoptosis facilitator)




chrX_-_83757399 0.003 ENST00000373177.2
ENST00000297977.5
ENST00000506585.2
ENST00000449553.2
 HDX



highly divergent homeobox



chr14_-_23388338 0.003 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
 RBM23














RNA binding motif protein 23














chr4_-_104119488 0.003 ENST00000514974.1
 CENPE
centromere protein E, 312kDa
chr4_+_1873100 0.003 ENST00000508803.1
 WHSC1
Wolf-Hirschhorn syndrome candidate 1
chrX_-_153237258 0.003 ENST00000310441.7
 HCFC1
host cell factor C1 (VP16-accessory protein)
chr16_+_68057179 0.003 ENST00000567100.1
ENST00000432752.1
ENST00000569289.1
ENST00000564781.1
 DUS2



dihydrouridine synthase 2



chr5_+_68513622 0.002 ENST00000512880.1
ENST00000602380.1
 MRPS36

mitochondrial ribosomal protein S36

chr16_+_68057153 0.002 ENST00000358896.6
ENST00000568099.2
 DUS2

dihydrouridine synthase 2

chr11_-_33183048 0.002 ENST00000438862.2
 CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr3_+_150126101 0.001 ENST00000361875.3
ENST00000361136.2
 TSC22D2

TSC22 domain family, member 2

chr17_+_685513 0.001 ENST00000304478.4
 RNMTL1
RNA methyltransferase like 1
chr2_-_240964716 0.000 ENST00000404554.1
ENST00000407129.3
ENST00000307300.4
ENST00000443626.1
ENST00000252711.2
 NDUFA10




NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa




chr22_+_18121562 0.000 ENST00000355028.3
 BCL2L13
BCL2-like 13 (apoptosis facilitator)
chr4_-_104119528 0.000 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE


centromere protein E, 312kDa



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986) general adaptation syndrome(GO:0051866)
0.0 0.4 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 0.1 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.1 GO:0098942 regulation of circadian sleep/wake cycle, wakefulness(GO:0010840) positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) circadian sleep/wake cycle, wakefulness(GO:0042746) cytoskeletal matrix organization at active zone(GO:0048789) neurexin clustering involved in presynaptic membrane assembly(GO:0097115) retrograde trans-synaptic signaling by trans-synaptic protein complex(GO:0098942)
0.0 0.1 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.0 0.1 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.2 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.0 GO:0021571 rhombomere 5 development(GO:0021571)
0.0 0.0 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0044295 axonal growth cone(GO:0044295)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.1 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.1 GO:0031177 phosphopantetheine binding(GO:0031177)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)