Motif ID: E2F4

Z-value: 0.638


Transcription factors associated with E2F4:

Gene SymbolEntrez IDGene Name
E2F4 ENSG00000205250.4 E2F4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F4hg19_v2_chr16_+_67226019_67226127-0.971.6e-05Click!


Activity profile for motif E2F4.

activity profile for motif E2F4


Sorted Z-values histogram for motif E2F4

Sorted Z-values for motif E2F4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_149682447 1.035 ENST00000328668.7
ARSI
arylsulfatase family, member I
chr18_-_45935663 0.880 ENST00000589194.1
ENST00000591279.1
ENST00000590855.1
ENST00000587107.1
ENST00000588970.1
ENST00000586525.1
ENST00000592387.1
ENST00000590800.1
ZBTB7C







zinc finger and BTB domain containing 7C







chrX_-_51812268 0.798 ENST00000486010.1
ENST00000497164.1
ENST00000360134.6
ENST00000485287.1
ENST00000335504.5
ENST00000431659.1
MAGED4B





melanoma antigen family D, 4B





chr9_+_504674 0.756 ENST00000382297.2
KANK1
KN motif and ankyrin repeat domains 1
chr2_-_166650700 0.685 ENST00000422973.1
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr1_+_60280458 0.676 ENST00000455990.1
ENST00000371208.3
HOOK1

hook microtubule-tethering protein 1

chr2_+_154728426 0.675 ENST00000392825.3
ENST00000434213.1
GALNT13

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)

chr6_+_19837592 0.659 ENST00000378700.3
ID4
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
chr14_-_54420133 0.631 ENST00000559501.1
ENST00000558984.1
BMP4

bone morphogenetic protein 4

chrX_+_105066524 0.604 ENST00000243300.9
ENST00000428173.2
NRK

Nik related kinase

chrX_+_51928002 0.582 ENST00000375626.3
MAGED4
melanoma antigen family D, 4
chrX_+_51927919 0.531 ENST00000416960.1
MAGED4
melanoma antigen family D, 4
chr6_-_27100529 0.489 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ


histone cluster 1, H2bj


chr1_-_44497024 0.479 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9


solute carrier family 6 (neurotransmitter transporter, glycine), member 9


chr6_-_19804973 0.463 ENST00000457670.1
ENST00000607810.1
ENST00000606628.1
RP4-625H18.2


RP4-625H18.2


chr1_-_44497118 0.462 ENST00000537678.1
ENST00000466926.1
SLC6A9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr3_+_180630444 0.454 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
FXR1



fragile X mental retardation, autosomal homolog 1



chrX_+_105066554 0.451 ENST00000536164.1
NRK
Nik related kinase
chr8_-_41754231 0.437 ENST00000265709.8
ANK1
ankyrin 1, erythrocytic
chr2_-_136875712 0.431 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chrX_-_110039038 0.427 ENST00000372042.1
ENST00000482160.1
ENST00000444321.2
ENST00000218054.4
CHRDL1



chordin-like 1



chrX_-_110039286 0.412 ENST00000434224.1
CHRDL1
chordin-like 1
chr4_-_73434498 0.397 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chrX_-_110038990 0.394 ENST00000372045.1
ENST00000394797.4
CHRDL1

chordin-like 1

chr6_+_31865552 0.367 ENST00000469372.1
ENST00000497706.1
C2

complement component 2

chr21_-_45660840 0.365 ENST00000400377.3
ICOSLG
inducible T-cell co-stimulator ligand
chr11_-_61734599 0.344 ENST00000532601.1
FTH1
ferritin, heavy polypeptide 1
chr6_-_27782548 0.331 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr9_-_114557207 0.329 ENST00000374287.3
ENST00000374283.5
C9orf84

chromosome 9 open reading frame 84

chr6_+_27114861 0.328 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chrX_+_21392529 0.315 ENST00000425654.2
ENST00000543067.1
CNKSR2

connector enhancer of kinase suppressor of Ras 2

chr6_-_27114577 0.302 ENST00000356950.1
ENST00000396891.4
HIST1H2BK

histone cluster 1, H2bk

chr4_+_88928777 0.301 ENST00000237596.2
PKD2
polycystic kidney disease 2 (autosomal dominant)
chr11_-_61735103 0.298 ENST00000529191.1
ENST00000529631.1
ENST00000530019.1
ENST00000529548.1
ENST00000273550.7
FTH1




ferritin, heavy polypeptide 1




chr2_+_102803433 0.297 ENST00000264257.2
ENST00000441515.2
IL1RL2

interleukin 1 receptor-like 2

chr5_-_127873659 0.297 ENST00000262464.4
FBN2
fibrillin 2
chr6_+_45389893 0.289 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chrX_+_109245863 0.283 ENST00000372072.3
TMEM164
transmembrane protein 164
chr1_+_10093188 0.277 ENST00000377153.1
UBE4B
ubiquitination factor E4B
chr2_+_157292859 0.276 ENST00000438166.2
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr1_+_10092890 0.273 ENST00000253251.8
ENST00000377157.3
UBE4B

ubiquitination factor E4B

chr8_-_38325219 0.273 ENST00000533668.1
ENST00000413133.2
ENST00000397108.4
ENST00000526742.1
ENST00000525001.1
ENST00000425967.3
ENST00000529552.1
ENST00000397113.2
FGFR1







fibroblast growth factor receptor 1







chr8_-_60031762 0.271 ENST00000361421.1
TOX
thymocyte selection-associated high mobility group box
chr1_-_10003372 0.268 ENST00000377223.1
ENST00000541052.1
ENST00000377213.1
LZIC


leucine zipper and CTNNBIP1 domain containing


chr3_+_180630090 0.264 ENST00000357559.4
ENST00000305586.7
FXR1

fragile X mental retardation, autosomal homolog 1

chr5_+_109025067 0.263 ENST00000261483.4
MAN2A1
mannosidase, alpha, class 2A, member 1
chr6_+_27775899 0.262 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr2_-_204400013 0.261 ENST00000374489.2
ENST00000374488.2
ENST00000308091.4
ENST00000453034.1
ENST00000420371.1
RAPH1




Ras association (RalGDS/AF-6) and pleckstrin homology domains 1




chr7_+_73703728 0.256 ENST00000361545.5
ENST00000223398.6
CLIP2

CAP-GLY domain containing linker protein 2

chr3_-_169899504 0.255 ENST00000474275.1
ENST00000484931.1
ENST00000494943.1
ENST00000497658.1
ENST00000465896.1
ENST00000475729.1
ENST00000495893.2
ENST00000481639.1
ENST00000467570.1
ENST00000466189.1
PHC3









polyhomeotic homolog 3 (Drosophila)









chr10_+_60936347 0.253 ENST00000373880.4
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr8_-_29120604 0.244 ENST00000521515.1
KIF13B
kinesin family member 13B
chrX_+_21392553 0.242 ENST00000279451.4
CNKSR2
connector enhancer of kinase suppressor of Ras 2
chr10_+_122216316 0.240 ENST00000398250.1
ENST00000439221.1
ENST00000398248.1
PPAPDC1A


phosphatidic acid phosphatase type 2 domain containing 1A


chr9_-_110251836 0.235 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr19_+_49468558 0.225 ENST00000331825.6
FTL
ferritin, light polypeptide
chr17_-_34890759 0.225 ENST00000431794.3
MYO19
myosin XIX
chr14_+_53019993 0.221 ENST00000542169.2
ENST00000555622.1
GPR137C

G protein-coupled receptor 137C

chr2_-_204399976 0.220 ENST00000457812.1
RAPH1
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
chr3_+_179280668 0.214 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A



actin-like 6A



chr9_+_35732312 0.213 ENST00000353704.2
CREB3
cAMP responsive element binding protein 3
chr8_+_42128861 0.213 ENST00000518983.1
IKBKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
chr11_+_62623621 0.212 ENST00000535296.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr11_+_62623544 0.208 ENST00000377890.2
ENST00000377891.2
ENST00000377889.2
SLC3A2


solute carrier family 3 (amino acid transporter heavy chain), member 2


chr1_-_935491 0.208 ENST00000304952.6
HES4
hes family bHLH transcription factor 4
chr14_+_53019822 0.203 ENST00000321662.6
GPR137C
G protein-coupled receptor 137C
chr8_+_42128812 0.200 ENST00000520810.1
ENST00000416505.2
ENST00000519735.1
ENST00000520835.1
ENST00000379708.3
IKBKB




inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta




chr19_+_48673949 0.200 ENST00000328759.7
C19orf68
chromosome 19 open reading frame 68
chr1_-_8939265 0.195 ENST00000489867.1
ENO1
enolase 1, (alpha)
chr17_+_34890807 0.194 ENST00000429467.2
ENST00000592983.1
PIGW

phosphatidylinositol glycan anchor biosynthesis, class W

chr1_+_10490779 0.192 ENST00000477755.1
APITD1
apoptosis-inducing, TAF9-like domain 1
chr11_+_62623512 0.187 ENST00000377892.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr4_-_2264015 0.186 ENST00000337190.2
MXD4
MAX dimerization protein 4
chr18_+_77623668 0.185 ENST00000316249.3
KCNG2
potassium voltage-gated channel, subfamily G, member 2
chr9_-_38424443 0.181 ENST00000377694.1
IGFBPL1
insulin-like growth factor binding protein-like 1
chr2_+_231902193 0.178 ENST00000373640.4
C2orf72
chromosome 2 open reading frame 72
chr10_+_60936921 0.177 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr21_-_45660723 0.177 ENST00000344330.4
ENST00000407780.3
ENST00000400379.3
ICOSLG


inducible T-cell co-stimulator ligand


chr16_-_89268070 0.176 ENST00000562855.2
SLC22A31
solute carrier family 22, member 31
chr2_+_157292933 0.173 ENST00000540309.1
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chrX_+_109246285 0.172 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
TMEM164


transmembrane protein 164


chr4_+_1714548 0.172 ENST00000605571.1
RP11-572O17.1
RP11-572O17.1
chrX_+_14891522 0.170 ENST00000380492.3
ENST00000482354.1
MOSPD2

motile sperm domain containing 2

chrX_-_15511438 0.167 ENST00000380420.5
PIR
pirin (iron-binding nuclear protein)
chr6_+_45390222 0.164 ENST00000359524.5
RUNX2
runt-related transcription factor 2
chr8_+_17104401 0.163 ENST00000324815.3
ENST00000518038.1
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr8_+_17104539 0.162 ENST00000521829.1
ENST00000521005.1
VPS37A

vacuolar protein sorting 37 homolog A (S. cerevisiae)

chr1_+_6845384 0.160 ENST00000303635.7
CAMTA1
calmodulin binding transcription activator 1
chr5_+_141348721 0.159 ENST00000507163.1
ENST00000394519.1
RNF14

ring finger protein 14

chr6_-_139695757 0.158 ENST00000367651.2
CITED2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr4_+_166794383 0.158 ENST00000061240.2
ENST00000507499.1
TLL1

tolloid-like 1

chr1_+_6845497 0.157 ENST00000473578.1
ENST00000557126.1
CAMTA1

calmodulin binding transcription activator 1

chr1_-_935519 0.156 ENST00000428771.2
HES4
hes family bHLH transcription factor 4
chr5_+_141348640 0.153 ENST00000540015.1
ENST00000506938.1
ENST00000394514.2
ENST00000512565.1
ENST00000394515.3
RNF14




ring finger protein 14




chr5_+_141348598 0.152 ENST00000394520.2
ENST00000347642.3
RNF14

ring finger protein 14

chr9_+_131314859 0.149 ENST00000358161.5
ENST00000372731.4
ENST00000372739.3
SPTAN1


spectrin, alpha, non-erythrocytic 1


chr3_+_32280159 0.147 ENST00000458535.2
ENST00000307526.3
CMTM8

CKLF-like MARVEL transmembrane domain containing 8

chr2_+_204192942 0.145 ENST00000295851.5
ENST00000261017.5
ABI2

abl-interactor 2

chr16_+_28834531 0.145 ENST00000570200.1
ATXN2L
ataxin 2-like
chr1_-_935361 0.143 ENST00000484667.2
HES4
hes family bHLH transcription factor 4
chr6_+_97372596 0.142 ENST00000369261.4
KLHL32
kelch-like family member 32
chr6_+_43739697 0.141 ENST00000230480.6
VEGFA
vascular endothelial growth factor A
chr1_-_236030216 0.140 ENST00000389794.3
ENST00000389793.2
LYST

lysosomal trafficking regulator

chr17_+_38444115 0.139 ENST00000580824.1
ENST00000577249.1
CDC6

cell division cycle 6

chr6_-_44225231 0.139 ENST00000538577.1
ENST00000537814.1
ENST00000393810.1
ENST00000393812.3
SLC35B2



solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2



chr7_-_152373216 0.138 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr1_+_11333245 0.136 ENST00000376810.5
UBIAD1
UbiA prenyltransferase domain containing 1
chr17_+_73106035 0.132 ENST00000581078.1
ENST00000582136.1
ENST00000245543.1
ARMC7


armadillo repeat containing 7


chr14_-_23526739 0.132 ENST00000397359.3
ENST00000487137.2
CDH24

cadherin 24, type 2

chrX_+_53449839 0.131 ENST00000457095.1
RIBC1
RIB43A domain with coiled-coils 1
chr6_+_83073952 0.128 ENST00000543496.1
TPBG
trophoblast glycoprotein
chr3_-_124774802 0.125 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr9_+_1050331 0.124 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2


doublesex and mab-3 related transcription factor 2


chr1_+_11333546 0.123 ENST00000376804.2
UBIAD1
UbiA prenyltransferase domain containing 1
chr1_-_41950342 0.121 ENST00000372587.4
EDN2
endothelin 2
chr20_+_2082494 0.119 ENST00000246032.3
STK35
serine/threonine kinase 35
chr14_-_74960030 0.119 ENST00000553490.1
ENST00000557510.1
NPC2

Niemann-Pick disease, type C2

chr6_+_53659746 0.117 ENST00000370888.1
LRRC1
leucine rich repeat containing 1
chr6_-_57086200 0.116 ENST00000468148.1
RAB23
RAB23, member RAS oncogene family
chr11_-_61129723 0.116 ENST00000537680.1
ENST00000426130.2
ENST00000294072.4
CYB561A3


cytochrome b561 family, member A3


chr1_-_36615065 0.114 ENST00000373166.3
ENST00000373159.1
ENST00000373162.1
TRAPPC3


trafficking protein particle complex 3


chr1_+_10490441 0.113 ENST00000309048.3
ENST00000470413.2
APITD1
APITD1-CORT
apoptosis-inducing, TAF9-like domain 1
APITD1-CORT readthrough
chr7_-_108096765 0.113 ENST00000379024.4
ENST00000351718.4
NRCAM

neuronal cell adhesion molecule

chr14_-_74959994 0.112 ENST00000238633.2
ENST00000434013.2
NPC2

Niemann-Pick disease, type C2

chr1_+_44399347 0.111 ENST00000477048.1
ENST00000471394.2
ARTN

artemin

chr4_-_18023350 0.110 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL


ligand dependent nuclear receptor corepressor-like


chr1_+_6845578 0.109 ENST00000467404.2
ENST00000439411.2
CAMTA1

calmodulin binding transcription activator 1

chr5_+_141348755 0.108 ENST00000506004.1
ENST00000507291.1
RNF14

ring finger protein 14

chr1_-_11741155 0.108 ENST00000445656.1
ENST00000376669.5
ENST00000456915.1
ENST00000376692.4
MAD2L2



MAD2 mitotic arrest deficient-like 2 (yeast)



chr5_+_118604385 0.108 ENST00000274456.6
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr11_-_34379546 0.107 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr8_+_38089198 0.107 ENST00000528358.1
ENST00000529642.1
ENST00000532222.1
ENST00000520272.2
DDHD2



DDHD domain containing 2



chr17_+_75136980 0.107 ENST00000585618.1
ENST00000413679.2
SEC14L1

SEC14-like 1 (S. cerevisiae)

chr14_-_74959978 0.107 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr1_-_36615051 0.106 ENST00000373163.1
TRAPPC3
trafficking protein particle complex 3
chr17_+_75137034 0.105 ENST00000436233.4
ENST00000443798.4
SEC14L1

SEC14-like 1 (S. cerevisiae)

chrX_-_47863348 0.105 ENST00000376943.3
ENST00000396965.1
ENST00000305127.6
ZNF182


zinc finger protein 182


chr19_-_53238260 0.104 ENST00000453741.2
ENST00000602162.1
ENST00000601643.1
ENST00000596702.1
ENST00000600943.1
ENST00000543227.1
ENST00000540744.1
ZNF611






zinc finger protein 611






chr14_-_50065882 0.104 ENST00000539688.1
AL139099.1
Full-length cDNA clone CS0DK012YO09 of HeLa cells of Homo sapiens (human); Uncharacterized protein
chr7_-_108096822 0.103 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM


neuronal cell adhesion molecule


chr8_-_67525524 0.103 ENST00000517885.1
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr1_-_145076186 0.102 ENST00000369348.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_+_58694396 0.101 ENST00000326804.4
ENST00000345813.3
ENST00000424679.2
ZNF274


zinc finger protein 274


chr8_+_38088861 0.100 ENST00000397166.2
ENST00000533100.1
DDHD2

DDHD domain containing 2

chr16_+_50775971 0.099 ENST00000311559.9
ENST00000564326.1
ENST00000566206.1
CYLD


cylindromatosis (turban tumor syndrome)


chr11_-_82612549 0.098 ENST00000528082.1
ENST00000533126.1
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr11_-_119234876 0.097 ENST00000525735.1
USP2
ubiquitin specific peptidase 2
chr12_+_112451120 0.097 ENST00000261735.3
ENST00000455836.1
ERP29

endoplasmic reticulum protein 29

chr7_-_129845313 0.096 ENST00000397622.2
TMEM209
transmembrane protein 209
chr6_-_27775694 0.096 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr16_+_50775948 0.096 ENST00000569681.1
ENST00000569418.1
ENST00000540145.1
CYLD


cylindromatosis (turban tumor syndrome)


chr12_-_57472522 0.095 ENST00000379391.3
ENST00000300128.4
TMEM194A

transmembrane protein 194A

chr4_+_39460620 0.095 ENST00000340169.2
ENST00000261434.3
LIAS

lipoic acid synthetase

chr4_+_39460689 0.094 ENST00000381846.1
LIAS
lipoic acid synthetase
chr1_+_10490127 0.094 ENST00000602787.1
ENST00000602296.1
ENST00000400900.2
APITD1

APITD1-CORT
apoptosis-inducing, TAF9-like domain 1

APITD1-CORT readthrough
chr4_+_39460659 0.093 ENST00000513731.1
LIAS
lipoic acid synthetase
chr5_+_139027877 0.093 ENST00000302517.3
CXXC5
CXXC finger protein 5
chr17_-_27044810 0.093 ENST00000395242.2
RAB34
RAB34, member RAS oncogene family
chr16_+_50776021 0.092 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
CYLD


cylindromatosis (turban tumor syndrome)


chr1_-_33283754 0.092 ENST00000373477.4
YARS
tyrosyl-tRNA synthetase
chrX_-_14891150 0.092 ENST00000452869.1
ENST00000398334.1
ENST00000324138.3
FANCB


Fanconi anemia, complementation group B


chr17_-_27044903 0.092 ENST00000395245.3
RAB34
RAB34, member RAS oncogene family
chr11_-_82612727 0.091 ENST00000531128.1
ENST00000535099.1
ENST00000527444.1
PRCP


prolylcarboxypeptidase (angiotensinase C)


chr6_+_30687978 0.091 ENST00000327892.8
ENST00000435534.1
TUBB

tubulin, beta class I

chr12_-_51477333 0.090 ENST00000228515.1
ENST00000548206.1
ENST00000546935.1
ENST00000548981.1
CSRNP2



cysteine-serine-rich nuclear protein 2



chr9_-_131709858 0.090 ENST00000372586.3
DOLK
dolichol kinase
chr8_-_67525473 0.090 ENST00000522677.3
MYBL1
v-myb avian myeloblastosis viral oncogene homolog-like 1
chr7_-_129845188 0.090 ENST00000462753.1
ENST00000471077.1
ENST00000473456.1
ENST00000336804.8
TMEM209



transmembrane protein 209



chr12_-_15942503 0.089 ENST00000281172.5
EPS8
epidermal growth factor receptor pathway substrate 8
chr9_-_35115836 0.089 ENST00000378566.1
ENST00000378554.2
ENST00000322813.5
FAM214B


family with sequence similarity 214, member B


chr14_-_93673353 0.089 ENST00000556566.1
ENST00000306954.4
C14orf142

chromosome 14 open reading frame 142

chr11_-_82612678 0.086 ENST00000534631.1
ENST00000531801.1
PRCP

prolylcarboxypeptidase (angiotensinase C)

chr3_-_183979251 0.086 ENST00000296238.3
CAMK2N2
calcium/calmodulin-dependent protein kinase II inhibitor 2
chr12_-_15942309 0.085 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8


epidermal growth factor receptor pathway substrate 8


chr2_+_43864387 0.084 ENST00000282406.4
PLEKHH2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr2_-_46844159 0.084 ENST00000474980.1
ENST00000306465.4
PIGF

phosphatidylinositol glycan anchor biosynthesis, class F

chr2_-_43453734 0.083 ENST00000282388.3
ZFP36L2
ZFP36 ring finger protein-like 2
chr8_-_101322132 0.082 ENST00000523481.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr12_+_112451222 0.081 ENST00000552052.1
ERP29
endoplasmic reticulum protein 29
chr11_+_117198801 0.081 ENST00000527609.1
ENST00000533570.1
CEP164

centrosomal protein 164kDa

chr7_-_150779995 0.080 ENST00000462940.1
ENST00000492838.1
ENST00000392818.3
ENST00000488752.1
ENST00000476627.1
TMUB1




transmembrane and ubiquitin-like domain containing 1




chr22_+_50946645 0.080 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
NCAPH2




non-SMC condensin II complex, subunit H2




chr5_+_118604439 0.080 ENST00000388882.5
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr7_-_77427676 0.080 ENST00000257663.3
TMEM60
transmembrane protein 60
chr19_-_18717627 0.078 ENST00000392386.3
CRLF1
cytokine receptor-like factor 1
chr1_+_113217345 0.077 ENST00000357443.2
MOV10
Mov10, Moloney leukemia virus 10, homolog (mouse)
chr8_-_17103951 0.077 ENST00000520178.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr14_-_64010006 0.077 ENST00000555899.1
PPP2R5E
protein phosphatase 2, regulatory subunit B', epsilon isoform
chr2_-_46844242 0.075 ENST00000281382.6
PIGF
phosphatidylinositol glycan anchor biosynthesis, class F
chr10_-_33623310 0.075 ENST00000395995.1
ENST00000374823.5
ENST00000374821.5
ENST00000374816.3
NRP1



neuropilin 1



chr8_-_119964434 0.075 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chr17_-_27044760 0.073 ENST00000395243.3
RAB34
RAB34, member RAS oncogene family
chr16_-_75467274 0.073 ENST00000566254.1
CFDP1
craniofacial development protein 1
chr3_-_185655795 0.073 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B


transformer 2 beta homolog (Drosophila)


chr19_-_4182497 0.073 ENST00000597896.1
SIRT6
sirtuin 6
chr17_+_43238438 0.072 ENST00000593138.1
ENST00000586681.1
HEXIM2

hexamethylene bis-acetamide inducible 2

chr17_-_30185971 0.071 ENST00000378634.2
COPRS
coordinator of PRMT5, differentiation stimulator
chr17_+_47653178 0.071 ENST00000328741.5
NXPH3
neurexophilin 3
chr15_-_71184724 0.071 ENST00000560604.1
THAP10
THAP domain containing 10
chr12_-_77459306 0.070 ENST00000547316.1
ENST00000416496.2
ENST00000550669.1
ENST00000322886.7
E2F7



E2F transcription factor 7




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.1 GO:0060721 spongiotrophoblast cell proliferation(GO:0060720) regulation of spongiotrophoblast cell proliferation(GO:0060721) cell proliferation involved in embryonic placenta development(GO:0060722) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)
0.3 0.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 1.2 GO:0048749 compound eye development(GO:0048749)
0.1 0.9 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.1 0.7 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 0.9 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.3 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 0.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.5 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.1 0.3 GO:0007037 vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.1 0.4 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.1 0.4 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 0.6 GO:0060356 leucine import(GO:0060356)
0.1 0.7 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.1 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.3 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.1 0.3 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.1 0.9 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.8 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.0 0.4 GO:0039663 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0 0.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.1 GO:1902559 3'-phosphoadenosine 5'-phosphosulfate transport(GO:0046963) 3'-phospho-5'-adenylyl sulfate transmembrane transport(GO:1902559)
0.0 0.3 GO:0009233 menaquinone metabolic process(GO:0009233)
0.0 0.1 GO:1990619 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) positive regulation of chondrocyte proliferation(GO:1902732) histone H3-K9 deacetylation(GO:1990619)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.3 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 0.2 GO:0042412 taurine biosynthetic process(GO:0042412)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.2 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.2 GO:0097021 lymphocyte migration into lymphoid organs(GO:0097021)
0.0 0.1 GO:1904116 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.0 0.5 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.2 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.2 GO:0035802 adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802)
0.0 0.1 GO:0060585 vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.1 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.0 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.0 0.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0019230 pathogenesis(GO:0009405) proprioception(GO:0019230)
0.0 0.2 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.4 GO:0035090 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.2 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.7 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.0 0.0 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.0 0.1 GO:1904978 regulation of endosome organization(GO:1904978)
0.0 0.0 GO:0006434 seryl-tRNA aminoacylation(GO:0006434)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:1902378 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) sensory neuron axon guidance(GO:0097374) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0 0.5 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.0 GO:0032240 negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0 0.1 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.0 0.1 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.7 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.0 0.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.5 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.1 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.0 0.3 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.0 0.0 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.0 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.1 0.7 GO:0070695 FHF complex(GO:0070695)
0.1 0.3 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458)
0.1 0.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.2 GO:0075341 host cell PML body(GO:0075341)
0.0 0.3 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.1 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 1.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.0 0.3 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.3 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.0 GO:0034676 integrin alpha6-beta4 complex(GO:0034676)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.4 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.1 0.3 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.1 0.4 GO:0008384 IkappaB kinase activity(GO:0008384)
0.1 0.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.3 GO:0043398 HLH domain binding(GO:0043398) calcium-induced calcium release activity(GO:0048763)
0.1 0.1 GO:0046969 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.1 0.3 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity(GO:0004572)
0.0 0.6 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 1.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity(GO:0046964)
0.0 0.6 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.7 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.1 GO:0031705 bombesin receptor binding(GO:0031705)
0.0 0.2 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.2 GO:0004782 sulfinoalanine decarboxylase activity(GO:0004782)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:0034736 sterol O-acyltransferase activity(GO:0004772) cholesterol O-acyltransferase activity(GO:0034736)
0.0 0.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0039552 RIG-I binding(GO:0039552)
0.0 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.3 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.0 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.0 0.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.5 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.0 GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity(GO:0004583)
0.0 0.2 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.3 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.6 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME_BINDING_AND_ENTRY_OF_HIV_VIRION Genes involved in Binding and entry of HIV virion
0.1 1.0 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.9 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 1.3 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.2 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.4 REACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.3 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 0.9 REACTOME_IRON_UPTAKE_AND_TRANSPORT Genes involved in Iron uptake and transport
0.0 1.4 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.3 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.4 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)