Motif ID: E2F3

Z-value: 0.445


Transcription factors associated with E2F3:

Gene SymbolEntrez IDGene Name
E2F3 ENSG00000112242.10 E2F3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2F3hg19_v2_chr6_+_20403997_204040340.255.2e-01Click!


Activity profile for motif E2F3.

activity profile for motif E2F3


Sorted Z-values histogram for motif E2F3

Sorted Z-values for motif E2F3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_+_89642120 0.344 ENST00000268720.5
ENST00000319518.8
CPNE7

copine VII

chr11_-_17035943 0.288 ENST00000355661.3
ENST00000532079.1
ENST00000448080.2
ENST00000531066.1
PLEKHA7



pleckstrin homology domain containing, family A member 7



chr1_-_161008697 0.216 ENST00000318289.10
ENST00000368023.3
ENST00000368024.1
ENST00000423014.2
TSTD1



thiosulfate sulfurtransferase (rhodanese)-like domain containing 1



chr5_+_143550396 0.209 ENST00000512467.1
KCTD16
potassium channel tetramerization domain containing 16
chr2_-_70780770 0.208 ENST00000444975.1
ENST00000445399.1
ENST00000418333.2
TGFA


transforming growth factor, alpha


chr19_+_50979753 0.191 ENST00000597426.1
ENST00000334976.6
ENST00000376918.3
ENST00000598585.1
EMC10



ER membrane protein complex subunit 10



chr13_+_95364963 0.181 ENST00000438290.2
SOX21-AS1
SOX21 antisense RNA 1 (head to head)
chr2_-_70781087 0.161 ENST00000394241.3
ENST00000295400.6
TGFA

transforming growth factor, alpha

chr7_-_95025661 0.160 ENST00000542556.1
ENST00000265627.5
ENST00000427422.1
ENST00000451904.1
PON1
PON3


paraoxonase 1
paraoxonase 3


chr4_-_110736505 0.155 ENST00000609440.1
RP11-602N24.3
RP11-602N24.3
chr1_+_110453462 0.152 ENST00000488198.1
CSF1
colony stimulating factor 1 (macrophage)
chr8_+_21881636 0.152 ENST00000520125.1
ENST00000521157.1
ENST00000397940.1
ENST00000522813.1
NPM2



nucleophosmin/nucleoplasmin 2



chr15_-_75017711 0.150 ENST00000567032.1
ENST00000564596.1
ENST00000566503.1
ENST00000395049.4
ENST00000395048.2
ENST00000379727.3
CYP1A1





cytochrome P450, family 1, subfamily A, polypeptide 1





chr16_-_31214051 0.147 ENST00000350605.4
PYCARD
PYD and CARD domain containing
chr2_+_113403434 0.145 ENST00000272542.3
SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr2_-_70780572 0.145 ENST00000450929.1
TGFA
transforming growth factor, alpha
chr21_+_36041688 0.142 ENST00000360731.3
ENST00000349499.2
CLIC6

chloride intracellular channel 6

chr4_-_10458982 0.141 ENST00000326756.3
ZNF518B
zinc finger protein 518B
chr7_+_95401877 0.135 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
DYNC1I1





dynein, cytoplasmic 1, intermediate chain 1





chr2_+_85981008 0.130 ENST00000306279.3
ATOH8
atonal homolog 8 (Drosophila)
chr5_-_49737184 0.129 ENST00000508934.1
ENST00000303221.5
EMB

embigin

chr2_+_112656048 0.127 ENST00000295408.4
MERTK
c-mer proto-oncogene tyrosine kinase
chr14_-_47120956 0.126 ENST00000298283.3
RPL10L
ribosomal protein L10-like
chr7_-_16460863 0.123 ENST00000407010.2
ENST00000399310.3
ISPD

isoprenoid synthase domain containing

chr5_+_149340282 0.122 ENST00000286298.4
SLC26A2
solute carrier family 26 (anion exchanger), member 2
chr7_-_93204033 0.116 ENST00000359558.2
ENST00000360249.4
ENST00000426151.1
CALCR


calcitonin receptor


chr14_-_34420259 0.116 ENST00000250457.3
ENST00000547327.2
EGLN3

egl-9 family hypoxia-inducible factor 3

chr8_+_32406179 0.115 ENST00000405005.3
NRG1
neuregulin 1
chrX_+_51928002 0.114 ENST00000375626.3
MAGED4
melanoma antigen family D, 4
chr2_+_181845298 0.114 ENST00000410062.4
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr7_-_124405681 0.113 ENST00000303921.2
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
chr6_-_34524093 0.112 ENST00000544425.1
SPDEF
SAM pointed domain containing ETS transcription factor
chr6_-_34524049 0.111 ENST00000374037.3
SPDEF
SAM pointed domain containing ETS transcription factor
chr1_+_110453109 0.111 ENST00000525659.1
CSF1
colony stimulating factor 1 (macrophage)
chr16_+_67465016 0.108 ENST00000326152.5
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2
chr1_-_6321035 0.104 ENST00000377893.2
GPR153
G protein-coupled receptor 153
chr2_+_112656176 0.104 ENST00000421804.2
ENST00000409780.1
MERTK

c-mer proto-oncogene tyrosine kinase

chr3_+_49941420 0.104 ENST00000419183.1
CTD-2330K9.3
Uncharacterized protein
chr14_+_102027688 0.103 ENST00000510508.4
ENST00000359323.3
DIO3

deiodinase, iodothyronine, type III

chr17_+_4692230 0.102 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr12_+_6419877 0.101 ENST00000536531.1
PLEKHG6
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
chr7_-_50860565 0.100 ENST00000403097.1
GRB10
growth factor receptor-bound protein 10
chr9_-_39288092 0.099 ENST00000323947.7
ENST00000297668.6
ENST00000377656.2
ENST00000377659.1
CNTNAP3



contactin associated protein-like 3



chr7_-_95225768 0.098 ENST00000005178.5
PDK4
pyruvate dehydrogenase kinase, isozyme 4
chr19_+_35773242 0.096 ENST00000222304.3
HAMP
hepcidin antimicrobial peptide
chr11_-_68611721 0.096 ENST00000561996.1
CPT1A
carnitine palmitoyltransferase 1A (liver)
chr1_-_1182102 0.095 ENST00000330388.2
FAM132A
family with sequence similarity 132, member A
chr11_+_118401899 0.095 ENST00000528373.1
ENST00000544878.1
ENST00000354284.4
ENST00000533137.1
ENST00000532762.1
ENST00000526973.1
ENST00000354064.7
ENST00000533102.1
ENST00000313236.5
ENST00000527267.1
ENST00000524725.1
ENST00000533689.1
TMEM25











transmembrane protein 25











chr9_-_140115775 0.095 ENST00000391553.1
ENST00000392827.1
RNF208

ring finger protein 208

chr2_+_42275153 0.095 ENST00000294964.5
PKDCC
protein kinase domain containing, cytoplasmic
chr10_-_14880002 0.094 ENST00000465530.1
CDNF
cerebral dopamine neurotrophic factor
chr2_+_65215604 0.093 ENST00000531327.1
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr4_+_89299994 0.093 ENST00000264346.7
HERC6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr5_-_99870932 0.092 ENST00000504833.1
CTD-2001C12.1
CTD-2001C12.1
chr17_+_48712206 0.091 ENST00000427699.1
ENST00000285238.8
ABCC3

ATP-binding cassette, sub-family C (CFTR/MRP), member 3

chr1_+_3569072 0.091 ENST00000378295.4
ENST00000604074.1
TP73

tumor protein p73

chr1_+_948803 0.090 ENST00000379389.4
ISG15
ISG15 ubiquitin-like modifier
chr3_+_75721428 0.090 ENST00000463183.1
LINC00960
long intergenic non-protein coding RNA 960
chr2_+_201171372 0.089 ENST00000409140.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr1_+_3569129 0.088 ENST00000354437.4
ENST00000357733.3
ENST00000346387.4
TP73


tumor protein p73


chr18_+_59992527 0.088 ENST00000586569.1
TNFRSF11A
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
chr5_-_90610200 0.088 ENST00000511918.1
ENST00000513626.1
ENST00000607854.1
LUCAT1

RP11-213H15.4
lung cancer associated transcript 1 (non-protein coding)

RP11-213H15.4
chr2_+_30454390 0.088 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH


limb bud and heart development


chr19_-_18717627 0.087 ENST00000392386.3
CRLF1
cytokine receptor-like factor 1
chr5_+_178450753 0.086 ENST00000444149.2
ENST00000519896.1
ENST00000522442.1
ZNF879


zinc finger protein 879


chr18_+_19749386 0.086 ENST00000269216.3
GATA6
GATA binding protein 6
chr4_+_89299885 0.086 ENST00000380265.5
ENST00000273960.3
HERC6

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

chr3_+_167453026 0.085 ENST00000472941.1
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr9_-_99381660 0.085 ENST00000375240.3
ENST00000463569.1
CDC14B

cell division cycle 14B

chr19_-_58446721 0.085 ENST00000396147.1
ENST00000595569.1
ENST00000599852.1
ENST00000425570.3
ENST00000601593.1
ZNF418




zinc finger protein 418




chr14_+_52781079 0.084 ENST00000245457.5
PTGER2
prostaglandin E receptor 2 (subtype EP2), 53kDa
chr12_+_71833756 0.084 ENST00000536515.1
ENST00000540815.2
LGR5

leucine-rich repeat containing G protein-coupled receptor 5

chr1_+_110453203 0.084 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
CSF1


colony stimulating factor 1 (macrophage)


chr3_-_169487617 0.084 ENST00000330368.2
ACTRT3
actin-related protein T3
chr8_+_69242957 0.084 ENST00000518698.1
ENST00000539993.1
C8orf34

chromosome 8 open reading frame 34

chr9_+_139846708 0.083 ENST00000371633.3
LCN12
lipocalin 12
chr2_+_233497931 0.083 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr1_+_110453514 0.082 ENST00000369802.3
ENST00000420111.2
CSF1

colony stimulating factor 1 (macrophage)

chr2_+_201171577 0.081 ENST00000409397.2
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr11_-_17410869 0.080 ENST00000528731.1
KCNJ11
potassium inwardly-rectifying channel, subfamily J, member 11
chr2_+_202899310 0.080 ENST00000286201.1
FZD7
frizzled family receptor 7
chr2_-_178129853 0.079 ENST00000397062.3
NFE2L2
nuclear factor, erythroid 2-like 2
chr1_+_110453608 0.079 ENST00000369801.1
CSF1
colony stimulating factor 1 (macrophage)
chr4_+_37455536 0.078 ENST00000381980.4
ENST00000508175.1
C4orf19

chromosome 4 open reading frame 19

chr5_-_1112141 0.077 ENST00000264930.5
SLC12A7
solute carrier family 12 (potassium/chloride transporter), member 7
chr2_-_197036289 0.077 ENST00000263955.4
STK17B
serine/threonine kinase 17b
chr15_+_81071684 0.077 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
KIAA1199


KIAA1199


chr21_-_45660840 0.077 ENST00000400377.3
ICOSLG
inducible T-cell co-stimulator ligand
chr2_+_181845843 0.077 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr7_-_130418888 0.076 ENST00000310992.4
KLF14
Kruppel-like factor 14
chr4_-_55991752 0.076 ENST00000263923.4
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase)
chr7_-_73184588 0.076 ENST00000395145.2
CLDN3
claudin 3
chr10_+_4868460 0.075 ENST00000532248.1
ENST00000345253.5
ENST00000334019.4
AKR1E2


aldo-keto reductase family 1, member E2


chr20_-_10654639 0.075 ENST00000254958.5
JAG1
jagged 1
chr2_-_211090162 0.075 ENST00000233710.3
ACADL
acyl-CoA dehydrogenase, long chain
chr2_+_179345173 0.073 ENST00000234453.5
PLEKHA3
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3
chr16_+_56691606 0.073 ENST00000334350.6
MT1F
metallothionein 1F
chr4_-_89080362 0.073 ENST00000503830.1
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2
chr17_-_67323385 0.072 ENST00000588665.1
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr9_-_123476612 0.072 ENST00000426959.1
MEGF9
multiple EGF-like-domains 9
chr15_-_80695917 0.071 ENST00000559008.1
RP11-210M15.2
Uncharacterized protein
chr8_-_17941575 0.071 ENST00000417108.2
ASAH1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
chr4_-_36245561 0.070 ENST00000506189.1
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr21_+_46825032 0.070 ENST00000400337.2
COL18A1
collagen, type XVIII, alpha 1
chr19_+_50706866 0.069 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14




myosin, heavy chain 14, non-muscle




chrX_-_153718953 0.069 ENST00000369649.4
ENST00000393586.1
SLC10A3

solute carrier family 10, member 3

chr1_-_11107280 0.069 ENST00000400897.3
ENST00000400898.3
MASP2

mannan-binding lectin serine peptidase 2

chr3_-_185542817 0.068 ENST00000382199.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr1_-_32801825 0.068 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr10_+_5238793 0.068 ENST00000263126.1
AKR1C4
aldo-keto reductase family 1, member C4
chr5_-_160365601 0.068 ENST00000518580.1
ENST00000518301.1
RP11-109J4.1

RP11-109J4.1

chr1_+_10093188 0.068 ENST00000377153.1
UBE4B
ubiquitination factor E4B
chrX_-_153707246 0.068 ENST00000407062.1
LAGE3
L antigen family, member 3
chrX_-_153718988 0.067 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
SLC10A3


solute carrier family 10, member 3


chr5_-_100238918 0.067 ENST00000451528.2
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr2_-_178129551 0.067 ENST00000430047.1
NFE2L2
nuclear factor, erythroid 2-like 2
chr4_-_84255935 0.067 ENST00000513463.1
HPSE
heparanase
chr2_-_111334400 0.066 ENST00000455695.1
RGPD6
RANBP2-like and GRIP domain containing 6
chrX_-_153775047 0.066 ENST00000433845.1
ENST00000439227.1
G6PD

glucose-6-phosphate dehydrogenase

chr4_-_101111615 0.066 ENST00000273990.2
DDIT4L
DNA-damage-inducible transcript 4-like
chr8_-_30585294 0.066 ENST00000546342.1
ENST00000541648.1
ENST00000537535.1
GSR


glutathione reductase


chr8_-_29208183 0.066 ENST00000240100.2
DUSP4
dual specificity phosphatase 4
chrX_-_153285395 0.065 ENST00000369980.3
IRAK1
interleukin-1 receptor-associated kinase 1
chr2_+_102758751 0.065 ENST00000442590.1
IL1R1
interleukin 1 receptor, type I
chr3_-_171528227 0.065 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
PLD1



phospholipase D1, phosphatidylcholine-specific



chr1_+_10459433 0.065 ENST00000465632.1
ENST00000460189.1
PGD

phosphogluconate dehydrogenase

chr4_+_38869298 0.065 ENST00000510213.1
ENST00000515037.1
FAM114A1

family with sequence similarity 114, member A1

chr20_-_634000 0.065 ENST00000381962.3
SRXN1
sulfiredoxin 1
chr7_+_23719749 0.064 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A



family with sequence similarity 221, member A



chr1_-_211752073 0.064 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr1_+_26644441 0.064 ENST00000374213.2
CD52
CD52 molecule
chr8_-_681165 0.064 ENST00000522706.1
ENST00000262109.7
ERICH1

glutamate-rich 1

chr5_-_43397184 0.063 ENST00000513525.1
CCL28
chemokine (C-C motif) ligand 28
chr8_-_6735451 0.063 ENST00000297439.3
DEFB1
defensin, beta 1
chr8_-_27472198 0.063 ENST00000519472.1
ENST00000523589.1
ENST00000522413.1
ENST00000523396.1
ENST00000560366.1
CLU




clusterin




chr11_+_130184888 0.063 ENST00000602376.1
ENST00000532116.3
ENST00000602310.1
RP11-121M22.1


RP11-121M22.1


chr8_-_30585439 0.063 ENST00000221130.5
GSR
glutathione reductase
chr22_-_51066521 0.062 ENST00000395621.3
ENST00000395619.3
ENST00000356098.5
ENST00000216124.5
ENST00000453344.2
ENST00000547307.1
ENST00000547805.1
ARSA






arylsulfatase A






chr4_+_155548101 0.062 ENST00000502525.1
LRAT
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr2_-_242842587 0.062 ENST00000404031.1
AC131097.4
Protein LOC285095
chr2_+_24232918 0.062 ENST00000406420.3
ENST00000338315.4
MFSD2B

major facilitator superfamily domain containing 2B

chr5_+_135170331 0.062 ENST00000425402.1
ENST00000274513.5
ENST00000420621.1
ENST00000433282.2
ENST00000412661.2
SLC25A48




solute carrier family 25, member 48




chr11_-_1785139 0.061 ENST00000236671.2
CTSD
cathepsin D
chr11_+_48002076 0.061 ENST00000418331.2
ENST00000440289.2
PTPRJ

protein tyrosine phosphatase, receptor type, J

chr2_+_241375069 0.061 ENST00000264039.2
GPC1
glypican 1
chr7_-_135433460 0.061 ENST00000415751.1
FAM180A
family with sequence similarity 180, member A
chr22_-_36013368 0.061 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
MB



myoglobin



chr21_-_28217721 0.061 ENST00000284984.3
ADAMTS1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr11_+_48002279 0.061 ENST00000534219.1
ENST00000527952.1
PTPRJ

protein tyrosine phosphatase, receptor type, J

chr20_-_23030296 0.060 ENST00000377103.2
THBD
thrombomodulin
chr1_-_154458520 0.060 ENST00000486773.1
SHE
Src homology 2 domain containing E
chr5_-_143550159 0.060 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5



Yip1 domain family, member 5



chr2_+_201171268 0.060 ENST00000423749.1
ENST00000428692.1
ENST00000457757.1
ENST00000453663.1
SPATS2L



spermatogenesis associated, serine-rich 2-like



chr8_-_30585217 0.060 ENST00000520888.1
ENST00000414019.1
GSR

glutathione reductase

chr20_+_19738300 0.060 ENST00000432334.1
RP1-122P22.2
RP1-122P22.2
chr5_+_23507264 0.060 ENST00000502755.1
PRDM9
PR domain containing 9
chr2_-_203103281 0.059 ENST00000392244.3
ENST00000409181.1
ENST00000409712.1
ENST00000409498.2
ENST00000409368.1
ENST00000392245.1
ENST00000392246.2
SUMO1






small ubiquitin-like modifier 1






chr7_+_1609765 0.059 ENST00000437964.1
ENST00000533935.1
ENST00000532358.1
ENST00000524978.1
PSMG3-AS1



PSMG3 antisense RNA 1 (head to head)



chrX_-_153775426 0.059 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr19_+_17905919 0.059 ENST00000318683.6
ENST00000600777.1
ENST00000595387.1
B3GNT3


UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3


chr4_-_168155700 0.059 ENST00000357545.4
ENST00000512648.1
SPOCK3

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

chr5_-_99870890 0.059 ENST00000499025.1
CTD-2001C12.1
CTD-2001C12.1
chr20_-_17662878 0.059 ENST00000377813.1
ENST00000377807.2
ENST00000360807.4
ENST00000398782.2
RRBP1



ribosome binding protein 1



chr12_+_104609550 0.058 ENST00000525566.1
ENST00000429002.2
TXNRD1

thioredoxin reductase 1

chr10_-_25305011 0.058 ENST00000331161.4
ENST00000376363.1
ENKUR

enkurin, TRPC channel interacting protein

chr2_-_203103185 0.058 ENST00000409205.1
SUMO1
small ubiquitin-like modifier 1
chr4_-_18023350 0.057 ENST00000539056.1
ENST00000382226.5
ENST00000326877.4
LCORL


ligand dependent nuclear receptor corepressor-like


chr1_+_108918421 0.057 ENST00000444143.2
ENST00000294652.8
NBPF6

neuroblastoma breakpoint family, member 6

chr9_+_91605778 0.057 ENST00000375851.2
ENST00000375850.3
ENST00000334490.5
C9orf47


chromosome 9 open reading frame 47


chrX_-_11129229 0.057 ENST00000608176.1
ENST00000433747.2
ENST00000608576.1
ENST00000608916.1
RP11-120D5.1



RP11-120D5.1



chrX_+_153626571 0.057 ENST00000424325.2
RPL10
ribosomal protein L10
chr11_+_74811578 0.057 ENST00000531713.1
SLCO2B1
solute carrier organic anion transporter family, member 2B1
chr13_-_54706954 0.057 ENST00000606706.1
ENST00000607494.1
ENST00000427299.2
ENST00000423442.2
ENST00000451744.1
LINC00458




long intergenic non-protein coding RNA 458




chr2_+_181845074 0.057 ENST00000602959.1
ENST00000602479.1
ENST00000392415.2
ENST00000602291.1
UBE2E3



ubiquitin-conjugating enzyme E2E 3



chr19_-_50979981 0.056 ENST00000595790.1
ENST00000600100.1
FAM71E1

family with sequence similarity 71, member E1

chr7_-_86974785 0.056 ENST00000432193.1
ENST00000421293.1
ENST00000542586.1
ENST00000359941.5
ENST00000416560.1
TP53TG1




TP53 target 1 (non-protein coding)




chr17_+_63133587 0.056 ENST00000449996.3
ENST00000262406.9
RGS9

regulator of G-protein signaling 9

chr19_+_708910 0.056 ENST00000264560.7
PALM
paralemmin
chr1_+_10092890 0.056 ENST00000253251.8
ENST00000377157.3
UBE4B

ubiquitination factor E4B

chr2_+_102759199 0.055 ENST00000409288.1
ENST00000410023.1
IL1R1

interleukin 1 receptor, type I

chr5_-_156569850 0.055 ENST00000524219.1
HAVCR2
hepatitis A virus cellular receptor 2
chr4_+_57396766 0.055 ENST00000512175.2
THEGL
theg spermatid protein-like
chr7_+_1609694 0.055 ENST00000437621.2
ENST00000457484.2
PSMG3-AS1

PSMG3 antisense RNA 1 (head to head)

chr17_-_5015129 0.054 ENST00000575898.1
ENST00000416429.2
ZNF232

zinc finger protein 232

chr8_+_42396936 0.054 ENST00000416469.2
SMIM19
small integral membrane protein 19
chr16_+_48657337 0.054 ENST00000568150.1
ENST00000564212.1
RP11-42I10.1

RP11-42I10.1

chrX_+_153170455 0.054 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
AVPR2


arginine vasopressin receptor 2


chr3_-_185542761 0.054 ENST00000457616.2
ENST00000346192.3
IGF2BP2

insulin-like growth factor 2 mRNA binding protein 2

chrX_-_15511438 0.053 ENST00000380420.5
PIR
pirin (iron-binding nuclear protein)
chr1_-_15850676 0.053 ENST00000440484.1
ENST00000333868.5
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr4_+_38869410 0.053 ENST00000358869.2
FAM114A1
family with sequence similarity 114, member A1
chr19_+_35168633 0.053 ENST00000505365.2
ZNF302
zinc finger protein 302
chr6_+_34759837 0.052 ENST00000192788.5
ENST00000452449.2
UHRF1BP1

UHRF1 binding protein 1

chr1_-_9262678 0.052 ENST00000437157.2
RP3-510D11.1
RP3-510D11.1
chr11_+_102217936 0.052 ENST00000532832.1
ENST00000530675.1
ENST00000533742.1
ENST00000227758.2
ENST00000532672.1
ENST00000531259.1
ENST00000527465.1
BIRC2






baculoviral IAP repeat containing 2






chr4_+_39460689 0.052 ENST00000381846.1
LIAS
lipoic acid synthetase
chr4_+_6910966 0.051 ENST00000444368.1
TBC1D14
TBC1 domain family, member 14
chr1_-_15850839 0.051 ENST00000348549.5
ENST00000546424.1
CASP9

caspase 9, apoptosis-related cysteine peptidase

chr1_-_6479963 0.051 ENST00000377836.4
ENST00000487437.1
ENST00000489730.1
ENST00000377834.4
HES2



hes family bHLH transcription factor 2



chr19_+_16435625 0.051 ENST00000248071.5
ENST00000592003.1
KLF2

Kruppel-like factor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1902228 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.0 0.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894) cellular alkene metabolic process(GO:0043449)
0.0 0.2 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0002586 regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0 0.0 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.1 GO:1990641 response to iron ion starvation(GO:1990641)
0.0 0.2 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.0 0.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.1 GO:0071812 circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.1 GO:0050787 enzyme active site formation(GO:0018307) neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) detoxification of mercury ion(GO:0050787) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.3 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.5 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0 0.1 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.0 0.1 GO:0002856 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
0.0 0.1 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.0 0.0 GO:0042984 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0 0.1 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.0 0.1 GO:1901896 positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.0 GO:0072194 kidney smooth muscle tissue development(GO:0072194)
0.0 0.1 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.1 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0 0.2 GO:0097350 neutrophil clearance(GO:0097350)
0.0 0.1 GO:1903788 mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0 0.1 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.1 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.1 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.1 GO:0060356 leucine import(GO:0060356)
0.0 0.2 GO:0050428 purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:1903778 protein localization to vacuolar membrane(GO:1903778)
0.0 0.1 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.0 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.0 0.1 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.0 GO:2001226 negative regulation of chloride transport(GO:2001226)
0.0 0.1 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.0 GO:0048320 axial mesoderm formation(GO:0048320) negative regulation of chorionic trophoblast cell proliferation(GO:1901383)
0.0 0.0 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.1 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.0 0.1 GO:2000035 positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035)
0.0 0.0 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.0 0.0 GO:0007506 gonadal mesoderm development(GO:0007506)
0.0 0.1 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 0.0 GO:0016539 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0 0.0 GO:0052151 positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation of apoptotic process by virus(GO:0060139)
0.0 0.1 GO:0015811 L-cystine transport(GO:0015811)
0.0 0.1 GO:1904995 negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0 0.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 0.1 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.0 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.2 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.1 GO:0030311 poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.1 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.1 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.0 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.0 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.0 0.0 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0 0.0 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 0.1 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.1 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.0 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.3 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.0 GO:0003338 metanephros morphogenesis(GO:0003338)
0.0 0.0 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.2 GO:0000229 cytoplasmic chromosome(GO:0000229)
0.0 0.1 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 0.1 GO:0043293 apoptosome(GO:0043293)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.1 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 0.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:1990742 microvesicle(GO:1990742)
0.0 0.1 GO:0043260 laminin-11 complex(GO:0043260)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.0 GO:0030689 Noc complex(GO:0030689)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.0 GO:0005581 collagen trimer(GO:0005581)
0.0 0.0 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.3 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0016938 kinesin I complex(GO:0016938)
0.0 0.0 GO:0070701 mucus layer(GO:0070701)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.0 GO:0031933 telomeric heterochromatin(GO:0031933)
0.0 0.0 GO:0097489 multivesicular body, internal vesicle lumen(GO:0097489)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.2 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0032090 Pyrin domain binding(GO:0032090)
0.0 0.1 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.0 0.2 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.1 GO:0097643 amylin receptor activity(GO:0097643)
0.0 0.1 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.1 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.0 0.2 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.1 GO:0015432 bile acid-exporting ATPase activity(GO:0015432)
0.0 0.1 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.0 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0050571 1,5-anhydro-D-fructose reductase activity(GO:0050571)
0.0 0.1 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.1 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.1 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 0.2 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0061769 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.0 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0001855 complement component C4b binding(GO:0001855)
0.0 0.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.1 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.1 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 0.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.1 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.1 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.0 0.2 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 0.0 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.0 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.0 GO:0038131 neuregulin receptor activity(GO:0038131)
0.0 0.0 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.1 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.0 GO:0005365 myo-inositol transmembrane transporter activity(GO:0005365)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.0 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors(GO:0016614)
0.0 0.1 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.0 0.0 GO:0015439 heme-transporting ATPase activity(GO:0015439)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0 0.0 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.1 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.0 0.0 GO:0016005 phospholipase A2 activator activity(GO:0016005)
0.0 0.0 GO:0004096 catalase activity(GO:0004096)
0.0 0.0 GO:0050135 NAD+ nucleosidase activity(GO:0003953) NAD(P)+ nucleosidase activity(GO:0050135)
0.0 0.0 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.0 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 0.0 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.0 GO:0003955 NAD(P)H dehydrogenase (quinone) activity(GO:0003955) 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025)
0.0 0.0 GO:0015616 DNA translocase activity(GO:0015616)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.0 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators