Motif ID: DLX5

Z-value: 0.231


Transcription factors associated with DLX5:

Gene SymbolEntrez IDGene Name
DLX5 ENSG00000105880.4 DLX5



Activity profile for motif DLX5.

activity profile for motif DLX5


Sorted Z-values histogram for motif DLX5

Sorted Z-values for motif DLX5



Network of associatons between targets according to the STRING database.



First level regulatory network of DLX5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_52695617 0.301 ENST00000293525.5
 KRT86
keratin 86
chr6_+_123038689 0.183 ENST00000354275.2
ENST00000368446.1
 PKIB

protein kinase (cAMP-dependent, catalytic) inhibitor beta

chr8_+_32579271 0.146 ENST00000518084.1
 NRG1
neuregulin 1
chr8_+_32579341 0.134 ENST00000519240.1
ENST00000539990.1
 NRG1

neuregulin 1

chr8_+_32579321 0.133 ENST00000522402.1
 NRG1
neuregulin 1
chr8_+_92261516 0.123 ENST00000276609.3
ENST00000309536.2
 SLC26A7

solute carrier family 26 (anion exchanger), member 7

chr3_-_180397256 0.118 ENST00000442201.2
 CCDC39
coiled-coil domain containing 39
chr4_+_66536248 0.117 ENST00000514260.1
ENST00000507117.1
 RP11-807H7.1

RP11-807H7.1

chr4_+_77356248 0.095 ENST00000296043.6
 SHROOM3
shroom family member 3
chr10_-_56561022 0.093 ENST00000373965.2
ENST00000414778.1
ENST00000395438.1
ENST00000409834.1
ENST00000395445.1
ENST00000395446.1
ENST00000395442.1
ENST00000395440.1
ENST00000395432.2
ENST00000361849.3
ENST00000395433.1
ENST00000320301.6
ENST00000395430.1
ENST00000437009.1
 PCDH15













protocadherin-related 15













chr16_+_58010339 0.089 ENST00000290871.5
ENST00000441824.2
 TEPP

testis, prostate and placenta expressed

chr3_-_186288097 0.085 ENST00000446782.1
 TBCCD1
TBCC domain containing 1
chr3_-_105587879 0.073 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr4_-_105416039 0.072 ENST00000394767.2
 CXXC4
CXXC finger protein 4
chr6_-_27860956 0.069 ENST00000359611.2
 HIST1H2AM
histone cluster 1, H2am
chr7_+_100770328 0.066 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr3_+_186288454 0.065 ENST00000265028.3
 DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11
chr8_-_22526597 0.062 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
 BIN3



bridging integrator 3



chr7_-_14029283 0.062 ENST00000433547.1
ENST00000405192.2
 ETV1

ets variant 1

chr3_-_105588231 0.061 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr1_-_21620877 0.061 ENST00000527991.1
 ECE1
endothelin converting enzyme 1
chr4_-_66536196 0.059 ENST00000511294.1
 EPHA5
EPH receptor A5
chr16_+_24621546 0.057 ENST00000566108.1
 CTD-2540M10.1
CTD-2540M10.1
chr7_-_14028488 0.055 ENST00000405358.4
 ETV1
ets variant 1
chr11_+_115498761 0.055 ENST00000424313.2
 AP000997.1
AP000997.1
chr6_+_27861190 0.053 ENST00000303806.4
 HIST1H2BO
histone cluster 1, H2bo
chr9_+_116225999 0.050 ENST00000317613.6
 RGS3
regulator of G-protein signaling 3
chr14_-_24711806 0.050 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
 TINF2



TERF1 (TRF1)-interacting nuclear factor 2



chr17_+_28268623 0.049 ENST00000394835.3
ENST00000320856.5
ENST00000394832.2
ENST00000378738.3
 EFCAB5



EF-hand calcium binding domain 5



chr14_-_24711865 0.048 ENST00000399423.4
ENST00000267415.7
 TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr14_-_24711764 0.046 ENST00000557921.1
ENST00000558476.1
 TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr17_+_42264556 0.044 ENST00000319511.6
ENST00000589785.1
ENST00000592825.1
ENST00000589184.1
 TMUB2



transmembrane and ubiquitin-like domain containing 2



chr19_+_36239576 0.042 ENST00000587751.1
 LIN37
lin-37 homolog (C. elegans)
chr2_+_95963052 0.041 ENST00000295225.5
 KCNIP3
Kv channel interacting protein 3, calsenilin
chr4_-_66536057 0.040 ENST00000273854.3
 EPHA5
EPH receptor A5
chr4_-_39979576 0.039 ENST00000303538.8
ENST00000503396.1
 PDS5A

PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)

chr14_-_24711470 0.039 ENST00000559969.1
 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_102709441 0.039 ENST00000434103.1
 MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr11_+_118398178 0.038 ENST00000302783.4
ENST00000539546.1
 TTC36

tetratricopeptide repeat domain 36

chrX_+_100224676 0.037 ENST00000450049.2
 ARL13A
ADP-ribosylation factor-like 13A
chr11_+_818902 0.034 ENST00000336615.4
 PNPLA2
patatin-like phospholipase domain containing 2
chr10_-_56560939 0.033 ENST00000373955.1
 PCDH15
protocadherin-related 15
chr5_+_110559312 0.030 ENST00000508074.1
 CAMK4
calcium/calmodulin-dependent protein kinase IV
chr5_+_173930676 0.029 ENST00000504512.1
 RP11-267A15.1
RP11-267A15.1
chr1_-_28969517 0.028 ENST00000263974.4
ENST00000373824.4
 TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr12_-_53171128 0.026 ENST00000332411.2
 KRT76
keratin 76
chr11_+_76092353 0.026 ENST00000530460.1
ENST00000321844.4
 RP11-111M22.2

Homo sapiens putative uncharacterized protein FLJ37770-like (LOC100506127), mRNA.

chr6_-_33160231 0.025 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
 COL11A2









collagen, type XI, alpha 2









chr2_+_196313239 0.024 ENST00000413290.1
 AC064834.1
AC064834.1
chr17_+_43238438 0.023 ENST00000593138.1
ENST00000586681.1
 HEXIM2

hexamethylene bis-acetamide inducible 2

chr5_-_42811986 0.022 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
 SEPP1


selenoprotein P, plasma, 1


chr5_+_173930710 0.019 ENST00000511707.1
 RP11-267A15.1
RP11-267A15.1
chr12_+_7456880 0.019 ENST00000399422.4
 ACSM4
acyl-CoA synthetase medium-chain family member 4
chr12_-_10978957 0.018 ENST00000240619.2
 TAS2R10
taste receptor, type 2, member 10
chr1_+_160160346 0.016 ENST00000368078.3
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chrX_-_16887963 0.016 ENST00000380084.4
 RBBP7
retinoblastoma binding protein 7
chr2_-_172290482 0.014 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
 METTL8


methyltransferase like 8


chr12_+_64798826 0.014 ENST00000540203.1
 XPOT
exportin, tRNA
chr7_+_97736197 0.014 ENST00000297293.5
 LMTK2
lemur tyrosine kinase 2
chr2_-_183387283 0.014 ENST00000435564.1
 PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr1_+_160160283 0.013 ENST00000368079.3
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr12_-_50616382 0.013 ENST00000552783.1
 LIMA1
LIM domain and actin binding 1
chr1_+_54569968 0.012 ENST00000391366.1
 AL161915.1
Uncharacterized protein
chr2_-_220117867 0.012 ENST00000456818.1
ENST00000447205.1
 TUBA4A

tubulin, alpha 4a

chr15_+_38296918 0.010 ENST00000557883.2
 RP11-1008C21.1
RP11-1008C21.1
chr1_-_198906528 0.010 ENST00000432296.1
 MIR181A1HG
MIR181A1 host gene (non-protein coding)
chr4_-_89442940 0.010 ENST00000527353.1
 PIGY
phosphatidylinositol glycan anchor biosynthesis, class Y
chr5_+_142286887 0.010 ENST00000451259.1
 ARHGAP26
Rho GTPase activating protein 26
chr2_-_183387064 0.009 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
 PDE1A



phosphodiesterase 1A, calmodulin-dependent



chr4_+_175839517 0.009 ENST00000502940.1
ENST00000502305.1
 ADAM29

ADAM metallopeptidase domain 29

chr3_+_186560476 0.009 ENST00000320741.2
ENST00000444204.2
 ADIPOQ

adiponectin, C1Q and collagen domain containing

chr1_-_23670752 0.009 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
 HNRNPR




heterogeneous nuclear ribonucleoprotein R




chr12_+_7013897 0.009 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr2_-_44550441 0.008 ENST00000420756.1
ENST00000444696.1
 PREPL

prolyl endopeptidase-like

chr1_-_23670817 0.008 ENST00000478691.1
 HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr3_+_186560462 0.008 ENST00000412955.2
 ADIPOQ
adiponectin, C1Q and collagen domain containing
chr1_-_23670813 0.008 ENST00000374612.1
 HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr6_-_33256664 0.007 ENST00000444176.1
 WDR46
WD repeat domain 46
chr19_-_19302931 0.007 ENST00000444486.3
ENST00000514819.3
ENST00000162023.5
ENST00000585679.1
 MEF2BNB-MEF2B

MEF2B
MEF2BNB
MEF2BNB-MEF2B readthrough

myocyte enhancer factor 2B
MEF2B neighbor
chr5_-_42812143 0.007 ENST00000514985.1
 SEPP1
selenoprotein P, plasma, 1
chr6_-_38670897 0.007 ENST00000373365.4
 GLO1
glyoxalase I
chrX_-_73051037 0.006 ENST00000445814.1
 XIST
X inactive specific transcript (non-protein coding)
chr1_-_78444738 0.006 ENST00000436586.2
ENST00000370768.2
 FUBP1

far upstream element (FUSE) binding protein 1

chr18_-_33709268 0.005 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr2_+_30369807 0.005 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
 YPEL5


yippee-like 5 (Drosophila)


chr12_-_57039739 0.005 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
 ATP5B





ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide





chrX_+_150565653 0.004 ENST00000330374.6
 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr6_-_112194484 0.003 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
 FYN






FYN oncogene related to SRC, FGR, YES






chr1_-_78444776 0.003 ENST00000370767.1
ENST00000421641.1
 FUBP1

far upstream element (FUSE) binding protein 1

chr7_-_99717463 0.003 ENST00000437822.2
 TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr2_+_105050794 0.003 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
 AC013402.2


long intergenic non-protein coding RNA 1102


chr2_-_220118631 0.002 ENST00000248437.4
 TUBA4A
tubulin, alpha 4a
chr17_-_37009882 0.002 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
 RPL23




ribosomal protein L23




chr10_+_99205959 0.002 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
 ZDHHC16



zinc finger, DHHC-type containing 16



chr12_+_7014064 0.001 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr19_+_4007644 0.001 ENST00000262971.2
 PIAS4
protein inhibitor of activated STAT, 4
chr10_+_99205894 0.001 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
 ZDHHC16



zinc finger, DHHC-type containing 16



chr14_+_32798462 0.001 ENST00000280979.4
 AKAP6
A kinase (PRKA) anchor protein 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.2 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.0 0.1 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 0.1 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.1 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0010816 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.0 0.0 GO:0002372 myeloid dendritic cell cytokine production(GO:0002372)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.1 GO:0031302 intrinsic component of endosome membrane(GO:0031302)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling