Motif ID: DDIT3

Z-value: 0.349


Transcription factors associated with DDIT3:

Gene SymbolEntrez IDGene Name
DDIT3 ENSG00000175197.6 DDIT3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_57914304-0.751.9e-02Click!


Activity profile for motif DDIT3.

activity profile for motif DDIT3


Sorted Z-values histogram for motif DDIT3

Sorted Z-values for motif DDIT3



Network of associatons between targets according to the STRING database.



First level regulatory network of DDIT3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_54281407 0.596 ENST00000381403.4
ESM1
endothelial cell-specific molecule 1
chr3_-_9595480 0.362 ENST00000287585.6
LHFPL4
lipoma HMGIC fusion partner-like 4
chrX_+_16188506 0.353 ENST00000329538.5
MAGEB17
melanoma antigen family B, 17
chr17_+_4336955 0.308 ENST00000355530.2
SPNS3
spinster homolog 3 (Drosophila)
chr11_-_33913708 0.287 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr17_+_4337199 0.275 ENST00000333476.2
SPNS3
spinster homolog 3 (Drosophila)
chrX_-_133792480 0.261 ENST00000359237.4
PLAC1
placenta-specific 1
chr15_+_59730348 0.232 ENST00000288228.5
ENST00000559628.1
ENST00000557914.1
ENST00000560474.1
FAM81A



family with sequence similarity 81, member A



chr19_-_35992780 0.215 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
DMKN


dermokine


chr17_-_77967433 0.146 ENST00000571872.1
TBC1D16
TBC1 domain family, member 16
chr1_-_152196669 0.116 ENST00000368801.2
HRNR
hornerin
chr17_-_47925379 0.116 ENST00000352793.2
ENST00000334568.4
ENST00000398154.1
ENST00000436235.1
ENST00000326219.5
TAC4




tachykinin 4 (hemokinin)




chr15_-_83837983 0.110 ENST00000562702.1
HDGFRP3
Hepatoma-derived growth factor-related protein 3
chr3_+_157154578 0.108 ENST00000295927.3
PTX3
pentraxin 3, long
chr19_-_49258606 0.107 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr13_-_45915221 0.102 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
TPT1




tumor protein, translationally-controlled 1




chr6_-_86353510 0.101 ENST00000444272.1
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr17_+_56316054 0.091 ENST00000581008.1
LPO
lactoperoxidase
chr22_+_31518938 0.090 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J






inositol polyphosphate-5-phosphatase J






chr2_+_63816087 0.090 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1



malate dehydrogenase 1, NAD (soluble)



chr2_+_63816295 0.089 ENST00000539945.1
ENST00000544381.1
MDH1

malate dehydrogenase 1, NAD (soluble)

chr2_-_63815860 0.089 ENST00000272321.7
ENST00000431065.1
WDPCP

WD repeat containing planar cell polarity effector

chr7_+_18329712 0.088 ENST00000433709.2
HDAC9
histone deacetylase 9
chr19_-_6604094 0.088 ENST00000597430.2
CD70
CD70 molecule
chr2_+_63816269 0.088 ENST00000432309.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr4_-_119274121 0.087 ENST00000296498.3
PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr2_+_63816126 0.086 ENST00000454035.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr2_-_208030647 0.086 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_-_161277210 0.084 ENST00000491222.2
MPZ
myelin protein zero
chr12_+_106994905 0.082 ENST00000357881.4
RFX4
regulatory factor X, 4 (influences HLA class II expression)
chrX_-_138724677 0.081 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2


MCF.2 cell line derived transforming sequence


chr1_-_20250110 0.078 ENST00000375116.3
PLA2G2E
phospholipase A2, group IIE
chr21_-_46334186 0.074 ENST00000522931.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_-_216300784 0.073 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1













fibronectin 1













chr20_+_24929866 0.072 ENST00000480798.1
ENST00000376835.2
CST7

cystatin F (leukocystatin)

chr12_-_12491608 0.072 ENST00000545735.1
MANSC1
MANSC domain containing 1
chr2_-_208030295 0.072 ENST00000458272.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr17_+_4855053 0.072 ENST00000518175.1
ENO3
enolase 3 (beta, muscle)
chr2_+_75185619 0.070 ENST00000483063.1
POLE4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr12_-_122017542 0.069 ENST00000446152.2
KDM2B
lysine (K)-specific demethylase 2B
chr17_-_34257771 0.068 ENST00000394529.3
ENST00000293273.6
RDM1

RAD52 motif 1

chr3_+_136676707 0.067 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr17_-_2117600 0.062 ENST00000572369.1
SMG6
SMG6 nonsense mediated mRNA decay factor
chr6_+_151187074 0.062 ENST00000367308.4
MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr3_+_44840679 0.060 ENST00000425755.1
KIF15
kinesin family member 15
chr10_+_86004802 0.060 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
RGR


retinal G protein coupled receptor


chr2_-_208030886 0.058 ENST00000426163.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr9_+_110045537 0.056 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr13_-_24007815 0.052 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_+_38017264 0.051 ENST00000436654.1
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr17_-_34257731 0.051 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
RDM1



RAD52 motif 1



chr14_+_21387491 0.049 ENST00000258817.2
RP11-84C10.2
RP11-84C10.2
chr20_-_60294804 0.046 ENST00000317652.1
RP11-429E11.3
Uncharacterized protein
chr3_-_45883558 0.046 ENST00000445698.1
ENST00000296135.6
LZTFL1

leucine zipper transcription factor-like 1

chr9_+_110045418 0.046 ENST00000419616.1
RAD23B
RAD23 homolog B (S. cerevisiae)
chr6_+_80341000 0.045 ENST00000369838.4
SH3BGRL2
SH3 domain binding glutamic acid-rich protein like 2
chr11_-_8816375 0.043 ENST00000530580.1
ST5
suppression of tumorigenicity 5
chrX_-_138724994 0.043 ENST00000536274.1
MCF2
MCF.2 cell line derived transforming sequence
chr7_+_18536090 0.043 ENST00000441986.1
HDAC9
histone deacetylase 9
chr11_-_8739383 0.042 ENST00000531060.1
ST5
suppression of tumorigenicity 5
chr15_+_85923797 0.042 ENST00000559362.1
AKAP13
A kinase (PRKA) anchor protein 13
chr17_+_56315936 0.042 ENST00000543544.1
LPO
lactoperoxidase
chr2_+_216410921 0.042 ENST00000417485.2
AC012668.2
AC012668.2
chr1_+_174844645 0.041 ENST00000486220.1
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_10315741 0.041 ENST00000256190.8
SBF2
SET binding factor 2
chr17_+_56315787 0.040 ENST00000262290.4
ENST00000421678.2
LPO

lactoperoxidase

chr12_-_95774672 0.037 ENST00000549961.1
RP11-167N24.6
Uncharacterized protein
chr7_+_90338547 0.037 ENST00000446790.1
CDK14
cyclin-dependent kinase 14
chr11_+_4608021 0.036 ENST00000312614.4
OR52I2
olfactory receptor, family 52, subfamily I, member 2
chr5_+_72143988 0.034 ENST00000506351.2
TNPO1
transportin 1
chr3_+_136676851 0.034 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr15_-_64126084 0.033 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
HERC1




HECT and RLD domain containing E3 ubiquitin protein ligase family member 1




chr10_-_103874692 0.033 ENST00000361198.5
LDB1
LIM domain binding 1
chr11_-_8739566 0.033 ENST00000533020.1
ST5
suppression of tumorigenicity 5
chr15_+_85923856 0.032 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13



A kinase (PRKA) anchor protein 13



chr17_+_7477040 0.032 ENST00000581384.1
ENST00000577929.1
EIF4A1

eukaryotic translation initiation factor 4A1

chr22_-_30901637 0.030 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
SEC14L4



SEC14-like 4 (S. cerevisiae)



chr14_+_102276132 0.030 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
PPP2R5C


protein phosphatase 2, regulatory subunit B', gamma


chrX_+_149867681 0.030 ENST00000438018.1
ENST00000436701.1
MTMR1

myotubularin related protein 1

chr1_-_114447412 0.029 ENST00000369567.1
ENST00000369566.3
AP4B1

adaptor-related protein complex 4, beta 1 subunit

chr11_+_20044096 0.028 ENST00000533917.1
NAV2
neuron navigator 2
chr12_-_25102252 0.027 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr10_+_60028818 0.027 ENST00000333926.5
CISD1
CDGSH iron sulfur domain 1
chr1_-_114447683 0.027 ENST00000256658.4
ENST00000369564.1
AP4B1

adaptor-related protein complex 4, beta 1 subunit

chr3_-_148939598 0.027 ENST00000455472.3
CP
ceruloplasmin (ferroxidase)
chr19_+_10736183 0.026 ENST00000590857.1
ENST00000588688.1
ENST00000586078.1
SLC44A2


solute carrier family 44 (choline transporter), member 2


chr8_+_118147498 0.026 ENST00000519688.1
ENST00000456015.2
SLC30A8

solute carrier family 30 (zinc transporter), member 8

chr13_+_24844979 0.026 ENST00000454083.1
SPATA13
spermatogenesis associated 13
chr1_+_114447763 0.026 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chrX_-_100129128 0.026 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
NOX1


NADPH oxidase 1


chr3_+_130569429 0.025 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1



ATPase, Ca++ transporting, type 2C, member 1



chr10_+_102756800 0.025 ENST00000370223.3
LZTS2
leucine zipper, putative tumor suppressor 2
chr11_+_34073195 0.024 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr12_-_25101920 0.023 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr11_+_34073269 0.021 ENST00000389645.3
CAPRIN1
cell cycle associated protein 1
chr3_+_12392971 0.020 ENST00000287820.6
PPARG
peroxisome proliferator-activated receptor gamma
chr7_-_44530479 0.020 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr2_-_183106641 0.019 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_-_93029865 0.019 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_+_68872954 0.018 ENST00000394342.2
PROKR1
prokineticin receptor 1
chr14_+_64565442 0.017 ENST00000553308.1
SYNE2
spectrin repeat containing, nuclear envelope 2
chr12_+_101962128 0.017 ENST00000550514.1
MYBPC1
myosin binding protein C, slow type
chr14_-_92413727 0.015 ENST00000267620.10
FBLN5
fibulin 5
chr1_+_154229547 0.014 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr1_-_44820880 0.014 ENST00000372257.2
ENST00000457571.1
ENST00000452396.1
ERI3


ERI1 exoribonuclease family member 3


chr7_-_138363824 0.014 ENST00000419765.3
SVOPL
SVOP-like
chr12_-_53074182 0.012 ENST00000252244.3
KRT1
keratin 1
chr22_+_17956618 0.012 ENST00000262608.8
CECR2
cat eye syndrome chromosome region, candidate 2
chr4_+_111397216 0.012 ENST00000265162.5
ENPEP
glutamyl aminopeptidase (aminopeptidase A)
chr17_+_30594823 0.011 ENST00000536287.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr1_+_40840320 0.011 ENST00000372708.1
SMAP2
small ArfGAP2
chr12_+_57857475 0.010 ENST00000528467.1
GLI1
GLI family zinc finger 1
chr1_-_112032284 0.010 ENST00000414219.1
ADORA3
adenosine A3 receptor
chr12_+_50144381 0.010 ENST00000552370.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr7_-_99006443 0.009 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr17_-_77813186 0.009 ENST00000448310.1
ENST00000269397.4
CBX4

chromobox homolog 4

chr20_+_54987305 0.008 ENST00000371336.3
ENST00000434344.1
CASS4

Cas scaffolding protein family member 4

chr14_-_92413353 0.008 ENST00000556154.1
FBLN5
fibulin 5
chr20_+_57766075 0.007 ENST00000371030.2
ZNF831
zinc finger protein 831
chr5_+_145583107 0.007 ENST00000506502.1
RBM27
RNA binding motif protein 27
chr20_+_54987168 0.007 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr4_+_141178440 0.007 ENST00000394205.3
SCOC
short coiled-coil protein
chr20_+_5987890 0.006 ENST00000378868.4
CRLS1
cardiolipin synthase 1
chr19_+_12917364 0.006 ENST00000221486.4
RNASEH2A
ribonuclease H2, subunit A
chr4_+_157997273 0.006 ENST00000541722.1
ENST00000512619.1
GLRB

glycine receptor, beta

chr1_+_90308981 0.005 ENST00000527156.1
LRRC8D
leucine rich repeat containing 8 family, member D
chr14_-_74226961 0.005 ENST00000286523.5
ENST00000435371.1
ELMSAN1

ELM2 and Myb/SANT-like domain containing 1

chr7_+_44040488 0.004 ENST00000258704.3
SPDYE1
speedy/RINGO cell cycle regulator family member E1
chr3_+_15643476 0.003 ENST00000436193.1
ENST00000383778.4
BTD

biotinidase

chr4_+_157997209 0.003 ENST00000264428.4
GLRB
glycine receptor, beta
chrX_+_9431324 0.002 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X





transducin (beta)-like 1X-linked





chr6_-_48036363 0.002 ENST00000543600.1
ENST00000398738.2
ENST00000339488.4
PTCHD4


patched domain containing 4


chr5_-_178017355 0.002 ENST00000390654.3
COL23A1
collagen, type XXIII, alpha 1
chr14_+_32798462 0.002 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_111770294 0.002 ENST00000474304.2
CHI3L2
chitinase 3-like 2
chr9_-_95055956 0.002 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS



isoleucyl-tRNA synthetase



chr11_+_47279504 0.001 ENST00000441012.2
ENST00000437276.1
ENST00000436029.1
ENST00000467728.1
ENST00000405853.3
NR1H3




nuclear receptor subfamily 1, group H, member 3




chr5_+_145583156 0.001 ENST00000265271.5
RBM27
RNA binding motif protein 27
chr10_-_17659357 0.001 ENST00000326961.6
ENST00000361271.3
PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 0.2 GO:0018969 thiocyanate metabolic process(GO:0018969)
0.1 0.3 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.6 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.1 GO:0001878 response to yeast(GO:0001878)
0.0 0.1 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.0 0.1 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878)
0.0 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0 0.0 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.0 0.1 GO:1900169 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.0 0.1 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0000333 telomerase catalytic core complex(GO:0000333)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 0.6 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 0.4 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)
0.1 0.2 GO:0036393 thiocyanate peroxidase activity(GO:0036393)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)