Motif ID: BHLHE40

Z-value: 0.181


Transcription factors associated with BHLHE40:

Gene SymbolEntrez IDGene Name
BHLHE40 ENSG00000134107.4 BHLHE40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_5020952-0.511.6e-01Click!


Activity profile for motif BHLHE40.

activity profile for motif BHLHE40


Sorted Z-values histogram for motif BHLHE40

Sorted Z-values for motif BHLHE40



Network of associatons between targets according to the STRING database.



First level regulatory network of BHLHE40

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr9_+_706842 0.167 ENST00000382293.3
 KANK1
KN motif and ankyrin repeat domains 1
chr1_+_207070775 0.137 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
 IL24


interleukin 24


chr17_+_72428218 0.121 ENST00000392628.2
 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr11_+_34664014 0.101 ENST00000527935.1
 EHF
ets homologous factor
chr19_+_12305824 0.089 ENST00000415793.1
ENST00000440004.1
ENST00000426044.1
 CTD-2666L21.1


CTD-2666L21.1


chr1_+_43637996 0.085 ENST00000528956.1
ENST00000529956.1
 WDR65

WD repeat domain 65

chr8_+_32405728 0.084 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
 NRG1




neuregulin 1




chr8_+_32405785 0.083 ENST00000287842.3
 NRG1
neuregulin 1
chr17_+_72428266 0.079 ENST00000582473.1
 GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_-_17109579 0.064 ENST00000321560.3
 PLD6
phospholipase D family, member 6
chr19_+_12305895 0.061 ENST00000451691.2
 CTD-2666L21.1
CTD-2666L21.1
chr1_-_207095324 0.051 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
 FAIM3


Fas apoptotic inhibitory molecule 3


chr3_+_174577070 0.051 ENST00000454872.1
 NAALADL2
N-acetylated alpha-linked acidic dipeptidase-like 2
chr7_+_141463897 0.051 ENST00000247879.2
 TAS2R3
taste receptor, type 2, member 3
chr16_-_56701933 0.050 ENST00000568675.1
ENST00000569500.1
ENST00000444837.2
ENST00000379811.3
 MT1G



metallothionein 1G



chr3_-_178789220 0.047 ENST00000414084.1
 ZMAT3
zinc finger, matrin-type 3
chr6_+_31865552 0.046 ENST00000469372.1
ENST00000497706.1
 C2

complement component 2

chr7_-_107642348 0.043 ENST00000393561.1
 LAMB1
laminin, beta 1
chr4_+_47487285 0.042 ENST00000273859.3
ENST00000504445.1
 ATP10D

ATPase, class V, type 10D

chr8_-_11710979 0.038 ENST00000415599.2
 CTSB
cathepsin B
chr8_+_26240414 0.037 ENST00000380629.2
 BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr5_+_140588269 0.034 ENST00000541609.1
ENST00000239450.2
 PCDHB12

protocadherin beta 12

chrX_+_55101495 0.033 ENST00000374974.3
ENST00000374971.1
 PAGE2B

P antigen family, member 2B

chr5_+_94982435 0.032 ENST00000511684.1
ENST00000380005.4
 RFESD

Rieske (Fe-S) domain containing

chr4_-_76861392 0.031 ENST00000505594.1
 NAAA
N-acylethanolamine acid amidase
chr2_-_179343226 0.030 ENST00000434643.2
 FKBP7
FK506 binding protein 7
chr22_-_50964558 0.029 ENST00000535425.1
ENST00000439934.1
 SCO2

SCO2 cytochrome c oxidase assembly protein

chr13_-_98829501 0.028 ENST00000267291.6
 RNF113B
ring finger protein 113B
chrX_-_55187531 0.027 ENST00000489298.1
ENST00000477847.2
 FAM104B

family with sequence similarity 104, member B

chr22_-_43411106 0.027 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
 PACSIN2


protein kinase C and casein kinase substrate in neurons 2


chr8_+_58890917 0.026 ENST00000522992.1
 RP11-1112C15.1
RP11-1112C15.1
chr8_+_125985531 0.026 ENST00000319286.5
 ZNF572
zinc finger protein 572
chr2_-_190649082 0.026 ENST00000392350.3
ENST00000392349.4
 ORMDL1

ORM1-like 1 (S. cerevisiae)

chr19_-_16045619 0.024 ENST00000402119.4
 CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr4_+_41983713 0.024 ENST00000333141.5
 DCAF4L1
DDB1 and CUL4 associated factor 4-like 1
chr6_-_154677866 0.024 ENST00000367220.4
 IPCEF1
interaction protein for cytohesin exchange factors 1
chr12_-_55042140 0.024 ENST00000293371.6
ENST00000456047.2
 DCD

dermcidin

chr4_-_159094194 0.024 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
 FAM198B


family with sequence similarity 198, member B


chr19_-_16045665 0.023 ENST00000248041.8
 CYP4F11
cytochrome P450, family 4, subfamily F, polypeptide 11
chr18_+_32402321 0.023 ENST00000587723.1
 DTNA
dystrobrevin, alpha
chr1_-_26700943 0.023 ENST00000416125.1
 ZNF683
zinc finger protein 683
chr1_+_9648921 0.022 ENST00000377376.4
ENST00000340305.5
ENST00000340381.6
 TMEM201


transmembrane protein 201


chr5_-_145214848 0.021 ENST00000505416.1
ENST00000334744.4
ENST00000358004.2
ENST00000511435.1
 PRELID2



PRELI domain containing 2



chr8_+_22857048 0.021 ENST00000251822.6
 RHOBTB2
Rho-related BTB domain containing 2
chr3_-_98312548 0.021 ENST00000264193.2
 CPOX
coproporphyrinogen oxidase
chr2_-_241497390 0.020 ENST00000272972.3
ENST00000401804.1
ENST00000361678.4
ENST00000405523.3
 ANKMY1



ankyrin repeat and MYND domain containing 1



chr2_-_179343268 0.020 ENST00000424785.2
 FKBP7
FK506 binding protein 7
chr6_-_136871957 0.020 ENST00000354570.3
 MAP7
microtubule-associated protein 7
chr7_-_100493744 0.020 ENST00000428317.1
ENST00000441605.1
 ACHE

acetylcholinesterase (Yt blood group)

chr1_+_12079517 0.019 ENST00000235332.4
ENST00000436478.2
 MIIP

migration and invasion inhibitory protein

chr5_+_421030 0.019 ENST00000506456.1
 AHRR
aryl-hydrocarbon receptor repressor
chr2_-_10588630 0.019 ENST00000234111.4
 ODC1
ornithine decarboxylase 1
chr2_-_241497374 0.019 ENST00000373318.2
ENST00000406958.1
ENST00000391987.1
ENST00000373320.4
 ANKMY1



ankyrin repeat and MYND domain containing 1



chr2_+_190649107 0.019 ENST00000441310.2
ENST00000409985.1
ENST00000446877.1
ENST00000418224.3
ENST00000409823.3
ENST00000374826.4
ENST00000424766.1
ENST00000447232.2
ENST00000432292.3
 PMS1








PMS1 postmeiotic segregation increased 1 (S. cerevisiae)








chr8_-_72459885 0.018 ENST00000523987.1
 RP11-1102P16.1
Uncharacterized protein
chr19_+_7660716 0.018 ENST00000160298.4
ENST00000446248.2
 CAMSAP3

calmodulin regulated spectrin-associated protein family, member 3

chr9_+_131684027 0.018 ENST00000426694.1
 PHYHD1
phytanoyl-CoA dioxygenase domain containing 1
chr2_-_10587897 0.017 ENST00000405333.1
ENST00000443218.1
 ODC1

ornithine decarboxylase 1

chr9_-_123691047 0.016 ENST00000373887.3
 TRAF1
TNF receptor-associated factor 1
chr2_-_190649023 0.015 ENST00000409519.1
ENST00000458355.1
 ORMDL1

ORM1-like 1 (S. cerevisiae)

chr4_-_57301748 0.015 ENST00000264220.2
 PPAT
phosphoribosyl pyrophosphate amidotransferase
chr6_-_36842784 0.015 ENST00000373699.5
 PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr4_-_100009856 0.014 ENST00000296412.8
 ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr12_+_65004292 0.014 ENST00000542104.1
ENST00000336061.2
 RASSF3

Ras association (RalGDS/AF-6) domain family member 3

chr5_-_145214893 0.014 ENST00000394450.2
 PRELID2
PRELI domain containing 2
chr2_+_103236004 0.014 ENST00000233969.2
 SLC9A2
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
chr5_-_36152031 0.013 ENST00000296603.4
 LMBRD2
LMBR1 domain containing 2
chr17_+_74733744 0.013 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
 MFSD11




major facilitator superfamily domain containing 11




chr2_-_47142884 0.013 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
 MCFD2



multiple coagulation factor deficiency 2



chrX_-_128977364 0.013 ENST00000371064.3
 ZDHHC9
zinc finger, DHHC-type containing 9
chr6_+_36410762 0.012 ENST00000483557.1
ENST00000498267.1
ENST00000544295.1
ENST00000449081.2
ENST00000536244.1
ENST00000460983.1
 KCTD20





potassium channel tetramerization domain containing 20





chr17_+_36908984 0.012 ENST00000225426.4
ENST00000579088.1
 PSMB3

proteasome (prosome, macropain) subunit, beta type, 3

chr4_-_15683118 0.012 ENST00000507899.1
ENST00000510802.1
 FBXL5

F-box and leucine-rich repeat protein 5

chr2_-_47143160 0.012 ENST00000409800.1
ENST00000409218.1
 MCFD2

multiple coagulation factor deficiency 2

chr17_+_53046096 0.011 ENST00000376352.2
ENST00000299341.4
ENST00000405898.1
ENST00000434978.2
ENST00000398391.2
 STXBP4




syntaxin binding protein 4




chr5_+_121187625 0.011 ENST00000321339.1
 FTMT
ferritin mitochondrial
chr19_+_54058073 0.011 ENST00000505949.1
ENST00000513265.1
 ZNF331

zinc finger protein 331

chr6_-_154677900 0.011 ENST00000265198.4
ENST00000520261.1
 IPCEF1

interaction protein for cytohesin exchange factors 1

chr1_-_113498943 0.010 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr7_-_151574191 0.010 ENST00000287878.4
 PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr9_-_95640218 0.010 ENST00000395506.3
ENST00000375495.3
ENST00000332591.6
 ZNF484


zinc finger protein 484


chr16_+_57844549 0.010 ENST00000564282.1
 CTD-2600O9.1
uncharacterized protein LOC388282
chr17_-_61850894 0.010 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
 CCDC47


coiled-coil domain containing 47


chr22_-_37505449 0.009 ENST00000406725.1
 TMPRSS6
transmembrane protease, serine 6
chrX_+_66764375 0.009 ENST00000374690.3
 AR
androgen receptor
chr5_+_89770664 0.009 ENST00000503973.1
ENST00000399107.1
 POLR3G

polymerase (RNA) III (DNA directed) polypeptide G (32kD)

chr12_+_14369524 0.008 ENST00000538329.1
 RP11-134N1.2
RP11-134N1.2
chrX_-_16887963 0.008 ENST00000380084.4
 RBBP7
retinoblastoma binding protein 7
chr12_-_6677422 0.008 ENST00000382421.3
ENST00000545200.1
ENST00000399466.2
ENST00000536124.1
ENST00000540228.1
ENST00000542867.1
ENST00000545492.1
ENST00000322166.5
ENST00000545915.1
 NOP2








NOP2 nucleolar protein








chr22_-_38245304 0.008 ENST00000609454.1
 ANKRD54
ankyrin repeat domain 54
chr5_-_114880533 0.008 ENST00000274457.3
 FEM1C
fem-1 homolog c (C. elegans)
chr5_+_6766004 0.008 ENST00000506093.1
 RP11-332J15.3
RP11-332J15.3
chr11_+_73019282 0.007 ENST00000263674.3
 ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr5_-_137090028 0.007 ENST00000314940.4
 HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr4_+_188916918 0.007 ENST00000509524.1
ENST00000326866.4
 ZFP42

ZFP42 zinc finger protein

chr19_-_37064145 0.007 ENST00000591340.1
ENST00000334116.7
 ZNF529

zinc finger protein 529

chrX_+_54556633 0.007 ENST00000336470.4
ENST00000360845.2
 GNL3L

guanine nucleotide binding protein-like 3 (nucleolar)-like

chrX_-_128977781 0.007 ENST00000357166.6
 ZDHHC9
zinc finger, DHHC-type containing 9
chr7_-_138720763 0.007 ENST00000275766.1
 ZC3HAV1L
zinc finger CCCH-type, antiviral 1-like
chr7_-_73133959 0.006 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A



syntaxin 1A (brain)



chr4_+_57302297 0.006 ENST00000399688.3
ENST00000512576.1
 PAICS

phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

chr17_+_33307503 0.006 ENST00000378526.4
ENST00000585941.1
ENST00000262327.5
ENST00000592690.1
ENST00000585740.1
 LIG3




ligase III, DNA, ATP-dependent




chr20_-_35374456 0.006 ENST00000373803.2
ENST00000359675.2
ENST00000540765.1
ENST00000349004.1
 NDRG3



NDRG family member 3



chr15_-_35088340 0.005 ENST00000290378.4
 ACTC1
actin, alpha, cardiac muscle 1
chr22_-_50523760 0.005 ENST00000395876.2
 MLC1
megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_+_105654441 0.005 ENST00000258455.3
 MRPS9
mitochondrial ribosomal protein S9
chr20_+_23331373 0.005 ENST00000254998.2
 NXT1
NTF2-like export factor 1
chr2_-_240230890 0.005 ENST00000446876.1
 HDAC4
histone deacetylase 4
chr16_+_4897912 0.005 ENST00000545171.1
 UBN1
ubinuclein 1
chr4_+_57301896 0.004 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
 PAICS


phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase


chr17_-_8066843 0.004 ENST00000404970.3
 VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr10_-_6019455 0.003 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
 IL15RA





interleukin 15 receptor, alpha





chr14_+_77924373 0.003 ENST00000216479.3
ENST00000535854.2
ENST00000555517.1
 AHSA1


AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)


chr5_+_89770696 0.003 ENST00000504930.1
ENST00000514483.1
 POLR3G

polymerase (RNA) III (DNA directed) polypeptide G (32kD)

chrX_-_128977875 0.003 ENST00000406492.2
 ZDHHC9
zinc finger, DHHC-type containing 9
chr12_+_66217911 0.003 ENST00000403681.2
 HMGA2
high mobility group AT-hook 2
chr21_+_33784670 0.003 ENST00000300255.2
 EVA1C
eva-1 homolog C (C. elegans)
chr16_+_19729586 0.002 ENST00000564186.1
ENST00000541926.1
ENST00000433597.2
 IQCK


IQ motif containing K


chr17_-_53046058 0.002 ENST00000571584.1
ENST00000299335.3
 COX11

cytochrome c oxidase assembly homolog 11 (yeast)

chr8_-_99129384 0.002 ENST00000521560.1
ENST00000254878.3
 HRSP12

heat-responsive protein 12

chr4_+_119200215 0.002 ENST00000602573.1
 SNHG8
small nucleolar RNA host gene 8 (non-protein coding)
chr4_+_119199864 0.002 ENST00000602414.1
ENST00000602520.1
 SNHG8

small nucleolar RNA host gene 8 (non-protein coding)

chr4_+_119199904 0.002 ENST00000602483.1
ENST00000602819.1
 SNHG8

small nucleolar RNA host gene 8 (non-protein coding)

chr20_+_31755934 0.002 ENST00000354932.5
 BPIFA2
BPI fold containing family A, member 2
chr12_-_54673871 0.001 ENST00000209875.4
 CBX5
chromobox homolog 5
chrX_+_43515467 0.001 ENST00000338702.3
ENST00000542639.1
 MAOA

monoamine oxidase A

chr5_+_149737202 0.001 ENST00000451292.1
ENST00000377797.3
ENST00000445265.2
ENST00000323668.7
ENST00000439160.2
ENST00000394269.3
ENST00000427724.2
ENST00000504761.2
ENST00000513346.1
ENST00000515516.1
 TCOF1









Treacher Collins-Franceschetti syndrome 1









chr7_-_229557 0.001 ENST00000514988.1
 AC145676.2
Uncharacterized protein
chr2_+_201676908 0.001 ENST00000409226.1
ENST00000452790.2
 BZW1

basic leucine zipper and W2 domains 1

chr1_+_231376941 0.001 ENST00000436239.1
ENST00000366647.4
ENST00000366646.3
ENST00000416000.1
 GNPAT



glyceronephosphate O-acyltransferase



chr7_-_960521 0.001 ENST00000437486.1
 ADAP1
ArfGAP with dual PH domains 1
chr12_-_25101920 0.001 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr10_-_6019552 0.001 ENST00000379977.3
ENST00000397251.3
ENST00000397248.2
 IL15RA


interleukin 15 receptor, alpha


chr13_-_38172863 0.001 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
 POSTN





periostin, osteoblast specific factor





chr8_-_99129338 0.001 ENST00000520507.1
 HRSP12
heat-responsive protein 12
chr16_+_4897632 0.001 ENST00000262376.6
 UBN1
ubinuclein 1
chr19_+_56154913 0.000 ENST00000270451.5
ENST00000588537.1
 ZNF581

zinc finger protein 581

chr17_+_7982800 0.000 ENST00000399413.3
 AC129492.6
AC129492.6
chr9_+_131901710 0.000 ENST00000524946.2
 PPP2R4
protein phosphatase 2A activator, regulatory subunit 4
chr6_+_13615554 0.000 ENST00000451315.2
 NOL7
nucleolar protein 7, 27kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.0 0.2 GO:0021842 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.0 0.1 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.0 GO:0042361 menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.0 0.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0043257 laminin-8 complex(GO:0043257)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)