Motif ID: BBX

Z-value: 0.287


Transcription factors associated with BBX:

Gene SymbolEntrez IDGene Name
BBX ENSG00000114439.14 BBX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107318157_107318172-0.791.2e-02Click!


Activity profile for motif BBX.

activity profile for motif BBX


Sorted Z-values histogram for motif BBX

Sorted Z-values for motif BBX



Network of associatons between targets according to the STRING database.



First level regulatory network of BBX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_7921090 0.362 ENST00000378789.3
 HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chrX_+_140677562 0.181 ENST00000370518.3
 SPANXA2
SPANX family, member A2
chrX_-_140786896 0.173 ENST00000370515.3
 SPANXD
SPANX family, member D
chr4_-_186682716 0.165 ENST00000445343.1
 SORBS2
sorbin and SH3 domain containing 2
chr4_-_186696425 0.154 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2


sorbin and SH3 domain containing 2


chr3_+_111260980 0.154 ENST00000438817.2
 CD96
CD96 molecule
chr4_-_186696561 0.148 ENST00000445115.1
ENST00000451701.1
ENST00000457247.1
ENST00000435480.1
ENST00000425679.1
ENST00000457934.1
 SORBS2





sorbin and SH3 domain containing 2





chr15_+_54901540 0.136 ENST00000539562.2
 UNC13C
unc-13 homolog C (C. elegans)
chr4_-_186733363 0.130 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
 SORBS2


sorbin and SH3 domain containing 2


chr13_+_77522632 0.129 ENST00000377462.1
 IRG1
immunoresponsive 1 homolog (mouse)
chr12_-_10601963 0.128 ENST00000543893.1
 KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr4_-_186697044 0.128 ENST00000437304.2
 SORBS2
sorbin and SH3 domain containing 2
chr4_-_186696515 0.127 ENST00000456596.1
ENST00000414724.1
 SORBS2

sorbin and SH3 domain containing 2

chr15_+_54305101 0.124 ENST00000260323.11
ENST00000545554.1
ENST00000537900.1
 UNC13C


unc-13 homolog C (C. elegans)


chr4_-_186696636 0.111 ENST00000444771.1
 SORBS2
sorbin and SH3 domain containing 2
chr12_-_21487829 0.095 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
 SLCO1A2




solute carrier organic anion transporter family, member 1A2




chrX_-_153141783 0.094 ENST00000458029.1
 L1CAM
L1 cell adhesion molecule
chr12_+_50690489 0.088 ENST00000598429.1
 AC140061.12
Uncharacterized protein
chr3_+_140981456 0.086 ENST00000504264.1
 ACPL2
acid phosphatase-like 2
chr6_+_106534192 0.080 ENST00000369091.2
ENST00000369096.4
 PRDM1

PR domain containing 1, with ZNF domain

chr17_-_16256718 0.080 ENST00000476243.1
ENST00000299736.4
 CENPV

centromere protein V

chr11_+_18154059 0.074 ENST00000531264.1
 MRGPRX3
MAS-related GPR, member X3
chr10_-_4285923 0.071 ENST00000418372.1
ENST00000608792.1
 LINC00702

long intergenic non-protein coding RNA 702

chr18_-_56985873 0.071 ENST00000299721.3
 CPLX4
complexin 4
chr4_-_186734275 0.071 ENST00000456060.1
 SORBS2
sorbin and SH3 domain containing 2
chr6_-_133084580 0.063 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
 VNN2


vanin 2


chr13_+_33160553 0.063 ENST00000315596.10
 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_+_151358048 0.062 ENST00000450635.1
 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr6_-_88001706 0.062 ENST00000369576.2
 GJB7
gap junction protein, beta 7, 25kDa
chr5_+_140514782 0.061 ENST00000231134.5
 PCDHB5
protocadherin beta 5
chr3_+_111260954 0.060 ENST00000283285.5
 CD96
CD96 molecule
chr10_-_4285835 0.057 ENST00000454470.1
 LINC00702
long intergenic non-protein coding RNA 702
chr11_-_18956556 0.056 ENST00000302797.3
 MRGPRX1
MAS-related GPR, member X1
chr3_+_111260856 0.056 ENST00000352690.4
 CD96
CD96 molecule
chr6_+_72922505 0.055 ENST00000401910.3
 RIMS1
regulating synaptic membrane exocytosis 1
chr6_+_72922590 0.055 ENST00000523963.1
 RIMS1
regulating synaptic membrane exocytosis 1
chr14_+_67656110 0.055 ENST00000524532.1
ENST00000530728.1
 FAM71D

family with sequence similarity 71, member D

chr1_+_109265033 0.052 ENST00000445274.1
 FNDC7
fibronectin type III domain containing 7
chr18_+_29769978 0.052 ENST00000269202.6
ENST00000581447.1
 MEP1B

meprin A, beta

chr1_-_206785789 0.051 ENST00000437518.1
ENST00000367114.3
 EIF2D

eukaryotic translation initiation factor 2D

chrX_-_119077695 0.048 ENST00000371410.3
 NKAP
NFKB activating protein
chr12_-_11339543 0.047 ENST00000334266.1
 TAS2R42
taste receptor, type 2, member 42
chr12_+_4382917 0.047 ENST00000261254.3
 CCND2
cyclin D2
chr20_-_56286479 0.046 ENST00000265626.4
 PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_-_133380731 0.045 ENST00000260810.5
 TOPBP1
topoisomerase (DNA) II binding protein 1
chr2_+_63816295 0.045 ENST00000539945.1
ENST00000544381.1
 MDH1

malate dehydrogenase 1, NAD (soluble)

chr14_-_81425828 0.044 ENST00000555529.1
ENST00000556042.1
ENST00000556981.1
 CEP128


centrosomal protein 128kDa


chr8_-_116673894 0.043 ENST00000395713.2
 TRPS1
trichorhinophalangeal syndrome I
chr2_+_78143006 0.041 ENST00000443419.1
 AC073628.1
AC073628.1
chr17_+_4853442 0.040 ENST00000522301.1
 ENO3
enolase 3 (beta, muscle)
chr4_+_129349188 0.038 ENST00000511497.1
 RP11-420A23.1
RP11-420A23.1
chr2_-_62081254 0.036 ENST00000405894.3
 FAM161A
family with sequence similarity 161, member A
chr15_+_65823092 0.036 ENST00000566074.1
 PTPLAD1
protein tyrosine phosphatase-like A domain containing 1
chr16_+_53483983 0.036 ENST00000544545.1
 RBL2
retinoblastoma-like 2 (p130)
chr4_-_70080449 0.035 ENST00000446444.1
 UGT2B11
UDP glucuronosyltransferase 2 family, polypeptide B11
chr2_-_62081148 0.035 ENST00000404929.1
 FAM161A
family with sequence similarity 161, member A
chr6_-_161085291 0.034 ENST00000316300.5
 LPA
lipoprotein, Lp(a)
chr12_-_100656134 0.032 ENST00000548313.1
 DEPDC4
DEP domain containing 4
chr3_+_148583043 0.032 ENST00000296046.3
 CPA3
carboxypeptidase A3 (mast cell)
chr12_-_4754356 0.031 ENST00000540967.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr12_-_4754318 0.030 ENST00000536414.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr1_+_55464600 0.030 ENST00000371265.4
 BSND
Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr7_-_130080977 0.029 ENST00000223208.5
 CEP41
centrosomal protein 41kDa
chr6_-_133084564 0.029 ENST00000532012.1
 VNN2
vanin 2
chr22_+_44319619 0.028 ENST00000216180.3
 PNPLA3
patatin-like phospholipase domain containing 3
chr4_-_159644507 0.028 ENST00000307720.3
 PPID
peptidylprolyl isomerase D
chr6_-_150067696 0.027 ENST00000340413.2
ENST00000367403.3
 NUP43

nucleoporin 43kDa

chr4_+_187813673 0.027 ENST00000606881.1
 RP11-11N5.3
RP11-11N5.3
chr6_+_54173227 0.027 ENST00000259782.4
ENST00000370864.3
 TINAG

tubulointerstitial nephritis antigen

chr17_-_17184605 0.026 ENST00000268717.5
 COPS3
COP9 signalosome subunit 3
chr3_+_122399444 0.026 ENST00000474629.2
 PARP14
poly (ADP-ribose) polymerase family, member 14
chr2_+_13677795 0.026 ENST00000434509.1
 AC092635.1
AC092635.1
chr6_+_29424958 0.026 ENST00000377136.1
ENST00000377133.1
 OR2H1

olfactory receptor, family 2, subfamily H, member 1

chr19_+_49109990 0.026 ENST00000321762.1
 SPACA4
sperm acrosome associated 4
chr17_-_17184546 0.025 ENST00000417352.1
 COPS3
COP9 signalosome subunit 3
chr7_+_5085452 0.024 ENST00000353796.3
ENST00000396912.1
ENST00000396904.2
 RBAK

RBAK-RBAKDN
RB-associated KRAB zinc finger

RBAK-RBAKDN readthrough
chr17_+_44803922 0.022 ENST00000465370.1
 NSF
N-ethylmaleimide-sensitive factor
chr9_-_95166976 0.022 ENST00000447356.1
 OGN
osteoglycin
chr3_-_112218205 0.022 ENST00000383680.4
 BTLA
B and T lymphocyte associated
chr1_+_192286122 0.022 ENST00000417209.2
 RGS21
regulator of G-protein signaling 21
chr2_+_110656005 0.022 ENST00000437679.2
 LIMS3
LIM and senescent cell antigen-like domains 3
chr13_+_50570019 0.021 ENST00000442421.1
 TRIM13
tripartite motif containing 13
chr3_+_127770455 0.021 ENST00000464451.1
 SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr12_+_96196875 0.020 ENST00000553095.1
 RP11-536G4.1
Uncharacterized protein
chr11_+_61717279 0.020 ENST00000378043.4
 BEST1
bestrophin 1
chr16_-_58768177 0.020 ENST00000434819.2
ENST00000245206.5
 GOT2

glutamic-oxaloacetic transaminase 2, mitochondrial

chr2_-_158182322 0.020 ENST00000420719.2
ENST00000409216.1
 ERMN

ermin, ERM-like protein

chr1_-_198509804 0.019 ENST00000489986.1
ENST00000367382.1
 ATP6V1G3

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3

chr7_+_135611542 0.019 ENST00000416501.1
 AC015987.2
AC015987.2
chr1_+_212475148 0.019 ENST00000537030.3
 PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr4_-_104021009 0.018 ENST00000509245.1
ENST00000296424.4
 BDH2

3-hydroxybutyrate dehydrogenase, type 2

chr4_-_104020968 0.017 ENST00000504285.1
 BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr2_+_102927962 0.017 ENST00000233954.1
ENST00000393393.3
ENST00000410040.1
 IL1RL1

IL18R1
interleukin 1 receptor-like 1

interleukin 18 receptor 1
chr13_+_28494130 0.016 ENST00000381033.4
 PDX1
pancreatic and duodenal homeobox 1
chr9_-_5833027 0.016 ENST00000339450.5
 ERMP1
endoplasmic reticulum metallopeptidase 1
chr14_-_21624222 0.015 ENST00000304418.3
 OR5AU1
olfactory receptor, family 5, subfamily AU, member 1
chr4_+_108910870 0.015 ENST00000403312.1
ENST00000603302.1
ENST00000309522.3
 HADH


hydroxyacyl-CoA dehydrogenase


chr18_-_56985776 0.014 ENST00000587244.1
 CPLX4
complexin 4
chr3_+_138067666 0.014 ENST00000475711.1
ENST00000464896.1
 MRAS

muscle RAS oncogene homolog

chr1_+_110577229 0.014 ENST00000369795.3
ENST00000369794.2
 STRIP1

striatin interacting protein 1

chr17_+_40950900 0.014 ENST00000588527.1
 CNTD1
cyclin N-terminal domain containing 1
chr3_+_51851612 0.013 ENST00000456080.1
 IQCF3
IQ motif containing F3
chr3_+_130569429 0.013 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
 ATP2C1



ATPase, Ca++ transporting, type 2C, member 1



chr18_-_13915530 0.013 ENST00000327606.3
 MC2R
melanocortin 2 receptor (adrenocorticotropic hormone)
chr1_+_229440129 0.013 ENST00000366688.3
 SPHAR
S-phase response (cyclin related)
chr1_+_52082751 0.013 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
 OSBPL9



oxysterol binding protein-like 9



chr5_+_180794269 0.013 ENST00000456475.1
 OR4F3
olfactory receptor, family 4, subfamily F, member 3
chr21_+_19617140 0.013 ENST00000299295.2
ENST00000338326.3
 CHODL

chondrolectin

chr17_+_66255310 0.013 ENST00000448504.2
 ARSG
arylsulfatase G
chr14_+_38264418 0.012 ENST00000267368.7
ENST00000382320.3
 TTC6

tetratricopeptide repeat domain 6

chr22_+_32871224 0.011 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
 FBXO7


F-box protein 7


chr16_+_57139933 0.011 ENST00000566259.1
 CPNE2
copine II
chr2_+_228735763 0.011 ENST00000373666.2
 DAW1
dynein assembly factor with WDR repeat domains 1
chr4_+_114066764 0.011 ENST00000511380.1
 ANK2
ankyrin 2, neuronal
chr17_-_59668550 0.010 ENST00000521764.1
 NACA2
nascent polypeptide-associated complex alpha subunit 2
chr12_-_49581152 0.010 ENST00000550811.1
 TUBA1A
tubulin, alpha 1a
chr15_+_49715293 0.010 ENST00000267843.4
ENST00000560270.1
 FGF7

fibroblast growth factor 7

chr11_-_14541872 0.010 ENST00000419365.2
ENST00000530457.1
ENST00000532256.1
ENST00000533068.1
 PSMA1



proteasome (prosome, macropain) subunit, alpha type, 1



chr11_+_61717336 0.009 ENST00000378042.3
 BEST1
bestrophin 1
chr11_+_118443098 0.009 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
 ARCN1



archain 1



chr3_+_177534653 0.009 ENST00000436078.1
 RP11-91K9.1
RP11-91K9.1
chr5_+_140810132 0.008 ENST00000252085.3
 PCDHGA12
protocadherin gamma subfamily A, 12
chr14_+_57671888 0.007 ENST00000391612.1
 AL391152.1
AL391152.1
chr6_-_138060103 0.007 ENST00000411615.1
ENST00000419220.1
 RP11-356I2.1

RP11-356I2.1

chr3_-_47950745 0.007 ENST00000429422.1
 MAP4
microtubule-associated protein 4
chr12_-_4754339 0.006 ENST00000228850.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr5_+_179135246 0.005 ENST00000508787.1
 CANX
calnexin
chr5_-_78809950 0.004 ENST00000334082.6
 HOMER1
homer homolog 1 (Drosophila)
chr1_-_36948879 0.004 ENST00000373106.1
ENST00000373104.1
ENST00000373103.1
 CSF3R


colony stimulating factor 3 receptor (granulocyte)


chr1_-_216978709 0.004 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chr14_+_75230011 0.004 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
 YLPM1


YLP motif containing 1


chr18_-_21017817 0.004 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241





transmembrane protein 241





chrX_-_19817869 0.003 ENST00000379698.4
 SH3KBP1
SH3-domain kinase binding protein 1
chr6_-_107235378 0.003 ENST00000606430.1
 RP1-60O19.1
RP1-60O19.1
chr12_-_8765446 0.003 ENST00000537228.1
ENST00000229335.6
 AICDA

activation-induced cytidine deaminase

chr5_+_161494521 0.002 ENST00000356592.3
 GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr3_-_112218378 0.002 ENST00000334529.5
 BTLA
B and T lymphocyte associated
chr19_+_7828035 0.002 ENST00000327325.5
ENST00000394122.2
ENST00000248228.4
ENST00000334806.5
ENST00000359059.5
ENST00000357361.2
ENST00000596363.1
ENST00000595751.1
ENST00000596707.1
ENST00000597522.1
ENST00000595496.1
 CLEC4M










C-type lectin domain family 4, member M










chr7_-_38969150 0.001 ENST00000418457.2
 VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr7_+_128349106 0.001 ENST00000485070.1
 FAM71F1
family with sequence similarity 71, member F1
chr8_-_108510224 0.001 ENST00000517746.1
ENST00000297450.3
 ANGPT1

angiopoietin 1

chr13_+_76413852 0.000 ENST00000533809.2
 LMO7
LIM domain 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0002728 negative regulation of natural killer cell cytokine production(GO:0002728)
0.1 0.4 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.1 GO:1990654 sebum secreting cell proliferation(GO:1990654)
0.0 0.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 1.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0044305 calyx of Held(GO:0044305)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 1.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.0 GO:0047860 diiodophenylpyruvate reductase activity(GO:0047860)