Motif ID: ATF4

Z-value: 0.274


Transcription factors associated with ATF4:

Gene SymbolEntrez IDGene Name
ATF4 ENSG00000128272.10 ATF4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.521.5e-01Click!


Activity profile for motif ATF4.

activity profile for motif ATF4


Sorted Z-values histogram for motif ATF4

Sorted Z-values for motif ATF4



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_87812735 0.404 ENST00000570159.1
 RP4-536B24.4
RP4-536B24.4
chr19_-_51192661 0.349 ENST00000391813.1
 SHANK1
SH3 and multiple ankyrin repeat domains 1
chr10_+_102106829 0.258 ENST00000370355.2
 SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chrX_-_133792480 0.231 ENST00000359237.4
 PLAC1
placenta-specific 1
chr11_-_33913708 0.198 ENST00000257818.2
 LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_+_93963590 0.181 ENST00000340600.2
 SOCS2
suppressor of cytokine signaling 2
chr17_+_1665345 0.173 ENST00000576406.1
ENST00000571149.1
 SERPINF1

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

chr17_+_56316054 0.136 ENST00000581008.1
 LPO
lactoperoxidase
chr5_+_174151536 0.128 ENST00000239243.6
ENST00000507785.1
 MSX2

msh homeobox 2

chr22_+_42229100 0.121 ENST00000361204.4
 SREBF2
sterol regulatory element binding transcription factor 2
chr10_-_113943447 0.089 ENST00000369425.1
ENST00000348367.4
ENST00000423155.1
 GPAM


glycerol-3-phosphate acyltransferase, mitochondrial


chr3_-_99595037 0.088 ENST00000383694.2
 FILIP1L
filamin A interacting protein 1-like
chr11_-_128737259 0.087 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
 KCNJ1


potassium inwardly-rectifying channel, subfamily J, member 1


chr7_-_48068671 0.087 ENST00000297325.4
 SUN3
Sad1 and UNC84 domain containing 3
chr3_-_99594948 0.087 ENST00000471562.1
ENST00000495625.2
 FILIP1L

filamin A interacting protein 1-like

chr1_-_20250110 0.086 ENST00000375116.3
 PLA2G2E
phospholipase A2, group IIE
chr11_+_58938903 0.085 ENST00000532982.1
 DTX4
deltex homolog 4 (Drosophila)
chr10_-_14880002 0.084 ENST00000465530.1
 CDNF
cerebral dopamine neurotrophic factor
chr7_-_48068699 0.080 ENST00000412142.1
ENST00000395572.2
 SUN3

Sad1 and UNC84 domain containing 3

chr6_+_151187615 0.078 ENST00000441122.1
ENST00000423867.1
 MTHFD1L

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

chr17_+_56315787 0.078 ENST00000262290.4
ENST00000421678.2
 LPO

lactoperoxidase

chr17_+_56315936 0.075 ENST00000543544.1
 LPO
lactoperoxidase
chr3_+_11314099 0.074 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
 ATG7



autophagy related 7



chr6_+_151187074 0.073 ENST00000367308.4
 MTHFD1L
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
chr7_-_48068643 0.067 ENST00000453192.2
 SUN3
Sad1 and UNC84 domain containing 3
chr2_-_98280383 0.064 ENST00000289228.5
 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr11_-_128737163 0.062 ENST00000324003.3
ENST00000392665.2
 KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

chr9_+_36169380 0.057 ENST00000335119.2
 CCIN
calicin
chr17_+_1665306 0.056 ENST00000571360.1
 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_-_38412683 0.054 ENST00000373024.3
ENST00000373023.2
 INPP5B

inositol polyphosphate-5-phosphatase, 75kDa

chr17_-_77967433 0.054 ENST00000571872.1
 TBC1D16
TBC1 domain family, member 16
chr17_-_79895097 0.054 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
 PYCR1




pyrroline-5-carboxylate reductase 1




chr3_+_11313995 0.053 ENST00000451513.1
ENST00000435760.1
ENST00000451830.1
 ATG7


autophagy related 7


chr8_-_116681686 0.051 ENST00000519815.1
 TRPS1
trichorhinophalangeal syndrome I
chr17_-_79895154 0.050 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
 PYCR1



pyrroline-5-carboxylate reductase 1



chr19_-_49258606 0.050 ENST00000310160.3
 FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr1_+_162601774 0.050 ENST00000415555.1
 DDR2
discoidin domain receptor tyrosine kinase 2
chr5_+_33441053 0.048 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
 TARS


threonyl-tRNA synthetase


chr5_+_33440802 0.048 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
 TARS


threonyl-tRNA synthetase


chr2_-_216300784 0.047 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr3_-_3152031 0.047 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
 IL5RA



interleukin 5 receptor, alpha



chr15_+_40886439 0.047 ENST00000532056.1
ENST00000399668.2
 CASC5

cancer susceptibility candidate 5

chr17_-_46703826 0.045 ENST00000550387.1
ENST00000311177.5
 HOXB9

homeobox B9

chrX_-_71792477 0.045 ENST00000421523.1
ENST00000415409.1
ENST00000373559.4
ENST00000373556.3
ENST00000373560.2
ENST00000373583.1
ENST00000429103.2
ENST00000373571.1
ENST00000373554.1
 HDAC8








histone deacetylase 8








chr12_+_106994905 0.045 ENST00000357881.4
 RFX4
regulatory factor X, 4 (influences HLA class II expression)
chr11_+_93754513 0.044 ENST00000315765.9
 HEPHL1
hephaestin-like 1
chr14_+_24563262 0.043 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
 PCK2




phosphoenolpyruvate carboxykinase 2 (mitochondrial)




chr15_+_40886199 0.043 ENST00000346991.5
ENST00000528975.1
ENST00000527044.1
 CASC5


cancer susceptibility candidate 5


chr17_+_1665253 0.043 ENST00000254722.4
 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr10_+_14880157 0.042 ENST00000378372.3
 HSPA14
heat shock 70kDa protein 14
chr11_-_77185094 0.040 ENST00000278568.4
ENST00000356341.3
 PAK1

p21 protein (Cdc42/Rac)-activated kinase 1

chr14_+_24563510 0.039 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
 PCK2


phosphoenolpyruvate carboxykinase 2 (mitochondrial)


chr12_-_92539614 0.039 ENST00000256015.3
 BTG1
B-cell translocation gene 1, anti-proliferative
chr6_+_73076432 0.039 ENST00000414192.2
 RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_14880364 0.037 ENST00000441647.1
 HSPA14
heat shock 70kDa protein 14
chr3_+_11314072 0.036 ENST00000444619.1
 ATG7
autophagy related 7
chr1_+_228353495 0.036 ENST00000366711.3
 IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chrX_+_24072833 0.035 ENST00000253039.4
 EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr3_+_148415571 0.035 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
 AGTR1




angiotensin II receptor, type 1




chr19_-_51014345 0.035 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
 JOSD2


Josephin domain containing 2


chrX_-_68385274 0.035 ENST00000374584.3
ENST00000590146.1
 PJA1

praja ring finger 1, E3 ubiquitin protein ligase

chr10_+_50507181 0.035 ENST00000323868.4
 C10orf71
chromosome 10 open reading frame 71
chr14_-_23292596 0.034 ENST00000554741.1
 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chrX_-_68385354 0.034 ENST00000361478.1
 PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr8_-_116680833 0.033 ENST00000220888.5
 TRPS1
trichorhinophalangeal syndrome I
chr5_+_44809027 0.032 ENST00000507110.1
 MRPS30
mitochondrial ribosomal protein S30
chr17_-_76836963 0.031 ENST00000312010.6
 USP36
ubiquitin specific peptidase 36
chr12_-_10324716 0.031 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1



oxidized low density lipoprotein (lectin-like) receptor 1



chr19_-_51014588 0.030 ENST00000598418.1
 JOSD2
Josephin domain containing 2
chr14_-_23762777 0.029 ENST00000431326.2
 HOMEZ
homeobox and leucine zipper encoding
chr19_-_51014460 0.029 ENST00000595669.1
 JOSD2
Josephin domain containing 2
chrX_+_24073048 0.029 ENST00000423068.1
 EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr1_+_52521928 0.029 ENST00000489308.2
 BTF3L4
basic transcription factor 3-like 4
chr17_+_73089382 0.029 ENST00000538213.2
ENST00000584118.1
 SLC16A5

solute carrier family 16 (monocarboxylate transporter), member 5

chr9_+_100745615 0.027 ENST00000339399.4
 ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_52521797 0.027 ENST00000313334.8
 BTF3L4
basic transcription factor 3-like 4
chr2_-_46769694 0.026 ENST00000522587.1
 ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr12_-_12674032 0.025 ENST00000298573.4
 DUSP16
dual specificity phosphatase 16
chr12_+_50135588 0.025 ENST00000423828.1
ENST00000550445.1
 TMBIM6

transmembrane BAX inhibitor motif containing 6

chr17_-_76836729 0.024 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
 USP36




ubiquitin specific peptidase 36




chr1_-_52521831 0.024 ENST00000371626.4
 TXNDC12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr10_+_50507232 0.023 ENST00000374144.3
 C10orf71
chromosome 10 open reading frame 71
chr3_-_33686925 0.022 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
 CLASP2


cytoplasmic linker associated protein 2


chr1_+_162602244 0.020 ENST00000367922.3
ENST00000367921.3
 DDR2

discoidin domain receptor tyrosine kinase 2

chr3_-_33686743 0.020 ENST00000333778.6
ENST00000539981.1
 CLASP2

cytoplasmic linker associated protein 2

chr1_-_207143802 0.019 ENST00000324852.4
ENST00000400962.3
 FCAMR

Fc receptor, IgA, IgM, high affinity

chr12_+_57623477 0.019 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
 SHMT2


serine hydroxymethyltransferase 2 (mitochondrial)


chr21_-_44495964 0.017 ENST00000398168.1
ENST00000398165.3
 CBS

cystathionine-beta-synthase

chr3_-_48130707 0.017 ENST00000360240.6
ENST00000383737.4
 MAP4

microtubule-associated protein 4

chr21_-_44495919 0.016 ENST00000398158.1
 CBS
cystathionine-beta-synthase
chr1_-_204380919 0.016 ENST00000367188.4
 PPP1R15B
protein phosphatase 1, regulatory subunit 15B
chr22_-_29457832 0.016 ENST00000216071.4
 C22orf31
chromosome 22 open reading frame 31
chr9_-_34665983 0.016 ENST00000416454.1
ENST00000544078.2
ENST00000421828.2
ENST00000423809.1
 RP11-195F19.5



HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015



chr1_-_216978709 0.015 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chr12_-_25102252 0.015 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chrX_-_33357558 0.015 ENST00000288447.4
 DMD
dystrophin
chr7_-_93633658 0.014 ENST00000433727.1
 BET1
Bet1 golgi vesicular membrane trafficking protein
chr12_-_46662772 0.014 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
 SLC38A1


solute carrier family 38, member 1


chr12_+_57623869 0.012 ENST00000414700.3
ENST00000557703.1
 SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr12_+_57623907 0.011 ENST00000553529.1
ENST00000554310.1
 SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

chr7_+_48211048 0.010 ENST00000435803.1
 ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr5_+_179105615 0.010 ENST00000514383.1
 CANX
calnexin
chr10_+_63661053 0.010 ENST00000279873.7
 ARID5B
AT rich interactive domain 5B (MRF1-like)
chr17_-_77813186 0.009 ENST00000448310.1
ENST00000269397.4
 CBX4

chromobox homolog 4

chr12_-_117318788 0.009 ENST00000550505.1
 HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr15_+_89181974 0.009 ENST00000306072.5
 ISG20
interferon stimulated exonuclease gene 20kDa
chr12_+_57624059 0.008 ENST00000557427.1
 SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_-_25101920 0.008 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr12_+_57624085 0.007 ENST00000553474.1
 SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chrX_+_77359671 0.007 ENST00000373316.4
 PGK1
phosphoglycerate kinase 1
chr7_-_138386097 0.006 ENST00000421622.1
 SVOPL
SVOP-like
chr12_+_57624119 0.006 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
 SHMT2



serine hydroxymethyltransferase 2 (mitochondrial)



chr3_-_48130314 0.006 ENST00000439356.1
ENST00000395734.3
ENST00000426837.2
 MAP4


microtubule-associated protein 4


chr8_-_38008783 0.005 ENST00000276449.4
 STAR
steroidogenic acute regulatory protein
chrX_+_77359726 0.005 ENST00000442431.1
 PGK1
phosphoglycerate kinase 1
chr11_-_57092381 0.005 ENST00000358252.3
 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr15_+_89182156 0.005 ENST00000379224.5
 ISG20
interferon stimulated exonuclease gene 20kDa
chr7_-_93633684 0.004 ENST00000222547.3
ENST00000425626.1
 BET1

Bet1 golgi vesicular membrane trafficking protein

chrX_+_9431324 0.004 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked





chr5_+_167956121 0.003 ENST00000338333.4
 FBLL1
fibrillarin-like 1
chr12_-_46662888 0.003 ENST00000546893.1
 SLC38A1
solute carrier family 38, member 1
chr7_-_99006443 0.002 ENST00000350498.3
 PDAP1
PDGFA associated protein 1
chr9_-_95055956 0.002 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
 IARS



isoleucyl-tRNA synthetase



chr1_-_167883353 0.001 ENST00000545172.1
 ADCY10
adenylate cyclase 10 (soluble)
chr14_-_92413727 0.000 ENST00000267620.10
 FBLN5
fibulin 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0050894 determination of affect(GO:0050894)
0.1 0.3 GO:0018969 thiocyanate metabolic process(GO:0018969)
0.1 0.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.2 GO:0016237 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521)
0.0 0.2 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.1 GO:0051795 positive regulation of catagen(GO:0051795)
0.0 0.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.2 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.0 GO:1904235 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.0 0.0 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.0 0.0 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.1 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.0 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.1 GO:0006116 NADH oxidation(GO:0006116)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031877 somatostatin receptor binding(GO:0031877)
0.1 0.3 GO:0036393 thiocyanate peroxidase activity(GO:0036393)
0.1 0.2 GO:0019779 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.0 0.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.3 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.0 GO:0004914 interleukin-5 receptor activity(GO:0004914)