Motif ID: AAGGUGC

Z-value: 0.150


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a-5p MIMAT0000072
hsa-miR-18b-5p MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_61521495 0.190 ENST00000335670.6
 RORA
RAR-related orphan receptor A
chr1_+_117452669 0.180 ENST00000393203.2
 PTGFRN
prostaglandin F2 receptor inhibitor
chr4_+_183164574 0.114 ENST00000511685.1
 TENM3
teneurin transmembrane protein 3
chr4_-_186877502 0.093 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
 SORBS2


sorbin and SH3 domain containing 2


chr2_+_85198216 0.054 ENST00000456682.1
ENST00000409785.4
 KCMF1

potassium channel modulatory factor 1

chr8_+_142402089 0.053 ENST00000521578.1
ENST00000520105.1
ENST00000523147.1
 PTP4A3


protein tyrosine phosphatase type IVA, member 3


chr16_+_77822427 0.053 ENST00000302536.2
 VAT1L
vesicle amine transport 1-like
chr5_-_43313574 0.051 ENST00000325110.6
ENST00000433297.2
 HMGCS1

3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)

chr16_-_85722530 0.050 ENST00000253462.3
 GINS2
GINS complex subunit 2 (Psf2 homolog)
chr6_+_138188551 0.044 ENST00000237289.4
ENST00000433680.1
 TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr12_+_4382917 0.042 ENST00000261254.3
 CCND2
cyclin D2
chr15_-_56209306 0.039 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
 NEDD4


neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase


chr12_+_50690489 0.038 ENST00000598429.1
 AC140061.12
Uncharacterized protein
chr21_+_38071430 0.037 ENST00000290399.6
 SIM2
single-minded family bHLH transcription factor 2
chr3_-_123603137 0.037 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
 MYLK



myosin light chain kinase



chr3_-_113465065 0.035 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
 NAA50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr3_-_114790179 0.034 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr15_+_73344791 0.030 ENST00000261908.6
 NEO1
neogenin 1
chr4_-_185395672 0.030 ENST00000393593.3
 IRF2
interferon regulatory factor 2
chr3_+_42695176 0.029 ENST00000232974.6
ENST00000457842.3
 ZBTB47

zinc finger and BTB domain containing 47

chr6_-_111136513 0.029 ENST00000368911.3
 CDK19
cyclin-dependent kinase 19
chr7_-_111846435 0.028 ENST00000437633.1
ENST00000428084.1
 DOCK4

dedicator of cytokinesis 4

chr2_+_45168875 0.028 ENST00000260653.3
 SIX3
SIX homeobox 3
chr21_-_18985158 0.027 ENST00000339775.6
 BTG3
BTG family, member 3
chr7_-_100287071 0.026 ENST00000275732.5
 GIGYF1
GRB10 interacting GYF protein 1
chr11_-_72853091 0.025 ENST00000311172.7
ENST00000409314.1
 FCHSD2

FCH and double SH3 domains 2

chr17_+_40834580 0.024 ENST00000264638.4
 CNTNAP1
contactin associated protein 1
chr9_-_99180597 0.024 ENST00000375256.4
 ZNF367
zinc finger protein 367
chr12_+_5019061 0.023 ENST00000382545.3
 KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
chr13_-_77601282 0.021 ENST00000355619.5
 FBXL3
F-box and leucine-rich repeat protein 3
chr5_+_56111361 0.021 ENST00000399503.3
 MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr5_-_142065612 0.021 ENST00000360966.5
ENST00000411960.1
 FGF1

fibroblast growth factor 1 (acidic)

chr6_-_86352642 0.020 ENST00000355238.6
 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_-_51425902 0.019 ENST00000396153.2
 FAF1
Fas (TNFRSF6) associated factor 1
chr3_+_37903432 0.018 ENST00000443503.2
 CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr12_+_49212514 0.016 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
 CACNB3


calcium channel, voltage-dependent, beta 3 subunit


chr19_+_13229126 0.016 ENST00000292431.4
 NACC1
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
chr1_-_20812690 0.015 ENST00000375078.3
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr1_+_201617450 0.013 ENST00000295624.6
ENST00000367297.4
ENST00000367300.3
 NAV1


neuron navigator 1


chr12_+_104458235 0.013 ENST00000229330.4
 HCFC2
host cell factor C2
chr11_-_79151695 0.012 ENST00000278550.7
 TENM4
teneurin transmembrane protein 4
chr12_+_12764773 0.012 ENST00000228865.2
 CREBL2
cAMP responsive element binding protein-like 2
chr17_-_62340581 0.012 ENST00000258991.3
ENST00000583738.1
ENST00000584379.1
 TEX2


testis expressed 2


chr17_-_40306934 0.012 ENST00000550406.1
ENST00000547517.1
ENST00000393860.3
ENST00000346213.4
ENST00000592574.1
 RAB5C



CTD-2132N18.3
RAB5C, member RAS oncogene family



Uncharacterized protein
chr2_-_163695128 0.011 ENST00000332142.5
 KCNH7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr10_-_81205373 0.011 ENST00000372336.3
 ZCCHC24
zinc finger, CCHC domain containing 24
chr4_-_157892498 0.011 ENST00000502773.1
 PDGFC
platelet derived growth factor C
chr9_+_96338860 0.010 ENST00000375376.4
 PHF2
PHD finger protein 2
chr6_-_132272504 0.010 ENST00000367976.3
 CTGF
connective tissue growth factor
chr6_-_107436473 0.010 ENST00000369042.1
 BEND3
BEN domain containing 3
chr6_+_134274322 0.010 ENST00000367871.1
ENST00000237264.4
 TBPL1

TBP-like 1

chr3_+_141205852 0.010 ENST00000286364.3
ENST00000452898.1
 RASA2

RAS p21 protein activator 2

chr21_-_36260980 0.009 ENST00000344691.4
ENST00000358356.5
 RUNX1

runt-related transcription factor 1

chr5_-_59189545 0.009 ENST00000340635.6
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_56360550 0.009 ENST00000266970.4
 CDK2
cyclin-dependent kinase 2
chr6_-_99873145 0.009 ENST00000369239.5
ENST00000438806.1
 PNISR

PNN-interacting serine/arginine-rich protein

chr9_-_123639600 0.009 ENST00000373896.3
 PHF19
PHD finger protein 19
chr1_+_40862501 0.008 ENST00000539317.1
 SMAP2
small ArfGAP2
chr1_+_84543734 0.008 ENST00000370689.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr15_-_90294523 0.008 ENST00000300057.4
 MESP1
mesoderm posterior 1 homolog (mouse)
chr3_+_152017181 0.008 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
 MBNL1



muscleblind-like splicing regulator 1



chr12_-_117319236 0.008 ENST00000257572.5
 HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr6_+_112408768 0.008 ENST00000368656.2
ENST00000604268.1
 FAM229B

family with sequence similarity 229, member B

chr10_-_71930222 0.008 ENST00000458634.2
ENST00000373239.2
ENST00000373242.2
ENST00000373241.4
 SAR1A



SAR1 homolog A (S. cerevisiae)



chr2_-_9143786 0.008 ENST00000462696.1
ENST00000305997.3
 MBOAT2

membrane bound O-acyltransferase domain containing 2

chr20_+_43595115 0.007 ENST00000372806.3
ENST00000396731.4
ENST00000372801.1
ENST00000499879.2
 STK4



serine/threonine kinase 4



chr10_-_50323543 0.007 ENST00000332853.4
ENST00000298454.3
 VSTM4

V-set and transmembrane domain containing 4

chr22_+_40573921 0.007 ENST00000454349.2
ENST00000335727.9
 TNRC6B

trinucleotide repeat containing 6B

chr9_+_116638562 0.007 ENST00000374126.5
ENST00000288466.7
 ZNF618

zinc finger protein 618

chr6_+_122720681 0.007 ENST00000368455.4
ENST00000452194.1
 HSF2

heat shock transcription factor 2

chr3_+_43328004 0.006 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
 SNRK



SNF related kinase



chr5_+_78532003 0.006 ENST00000396137.4
 JMY
junction mediating and regulatory protein, p53 cofactor
chr11_-_108464321 0.006 ENST00000265843.4
 EXPH5
exophilin 5
chr1_-_55680762 0.006 ENST00000407756.1
ENST00000294383.6
 USP24

ubiquitin specific peptidase 24

chr1_+_38259540 0.005 ENST00000397631.3
 MANEAL
mannosidase, endo-alpha-like
chr3_-_33481835 0.005 ENST00000283629.3
 UBP1
upstream binding protein 1 (LBP-1a)
chr7_+_90225796 0.005 ENST00000380050.3
 CDK14
cyclin-dependent kinase 14
chrX_-_24045303 0.005 ENST00000328046.8
 KLHL15
kelch-like family member 15
chr4_+_55524085 0.005 ENST00000412167.2
ENST00000288135.5
 KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr6_-_11232891 0.005 ENST00000379433.5
ENST00000379446.5
 NEDD9

neural precursor cell expressed, developmentally down-regulated 9

chr9_+_91003271 0.005 ENST00000375859.3
ENST00000541629.1
 SPIN1

spindlin 1

chr10_-_119806085 0.005 ENST00000355624.3
 RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr22_-_30642728 0.005 ENST00000403987.3
 LIF
leukemia inhibitory factor
chr17_+_68165657 0.005 ENST00000243457.3
 KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr12_+_109535373 0.004 ENST00000242576.2
 UNG
uracil-DNA glycosylase
chr6_+_152011628 0.004 ENST00000404742.1
ENST00000440973.1
 ESR1

estrogen receptor 1

chr16_+_30960375 0.004 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
 ORAI3


ORAI calcium release-activated calcium modulator 3


chr18_+_20513782 0.004 ENST00000399722.2
ENST00000399725.2
ENST00000399721.2
ENST00000583594.1
 RBBP8



retinoblastoma binding protein 8



chr12_+_94542459 0.004 ENST00000258526.4
 PLXNC1
plexin C1
chr11_+_108093839 0.004 ENST00000452508.2
 ATM
ataxia telangiectasia mutated
chr10_-_98273668 0.004 ENST00000357947.3
 TLL2
tolloid-like 2
chr9_-_127952032 0.004 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
 PPP6C


protein phosphatase 6, catalytic subunit


chr9_+_125703282 0.004 ENST00000373647.4
ENST00000402311.1
 RABGAP1

RAB GTPase activating protein 1

chr7_+_129074266 0.004 ENST00000249344.2
ENST00000435494.2
 STRIP2

striatin interacting protein 2

chr11_-_130184555 0.003 ENST00000525842.1
 ZBTB44
zinc finger and BTB domain containing 44
chr19_+_48949030 0.003 ENST00000253237.5
 GRWD1
glutamate-rich WD repeat containing 1
chr5_-_73937244 0.003 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
 ENC1


ectodermal-neural cortex 1 (with BTB domain)


chr1_+_26737253 0.003 ENST00000326279.6
 LIN28A
lin-28 homolog A (C. elegans)
chr1_-_57889687 0.003 ENST00000371236.2
ENST00000371230.1
 DAB1

Dab, reelin signal transducer, homolog 1 (Drosophila)

chr18_-_45456930 0.002 ENST00000262160.6
ENST00000587269.1
 SMAD2

SMAD family member 2

chrX_+_108780062 0.002 ENST00000372106.1
 NXT2
nuclear transport factor 2-like export factor 2
chr10_+_72575643 0.002 ENST00000373202.3
 SGPL1
sphingosine-1-phosphate lyase 1
chr10_+_102295616 0.002 ENST00000299163.6
 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr17_-_7382834 0.002 ENST00000380599.4
 ZBTB4
zinc finger and BTB domain containing 4
chr12_+_54943134 0.002 ENST00000243052.3
 PDE1B
phosphodiesterase 1B, calmodulin-dependent
chr12_-_102874416 0.001 ENST00000392904.1
ENST00000337514.6
 IGF1

insulin-like growth factor 1 (somatomedin C)

chr5_-_139422654 0.001 ENST00000289409.4
ENST00000358522.3
ENST00000378238.4
ENST00000289422.7
ENST00000361474.1
ENST00000545385.1
ENST00000394770.1
ENST00000541337.1
 NRG2







neuregulin 2







chr10_+_102222798 0.001 ENST00000343737.5
 WNT8B
wingless-type MMTV integration site family, member 8B
chr14_+_52456327 0.001 ENST00000556760.1
 C14orf166
chromosome 14 open reading frame 166
chr12_+_19592602 0.001 ENST00000398864.3
ENST00000266508.9
 AEBP2

AE binding protein 2

chr5_-_78809950 0.001 ENST00000334082.6
 HOMER1
homer homolog 1 (Drosophila)
chr19_-_46000251 0.001 ENST00000590526.1
ENST00000344680.4
ENST00000245923.4
 RTN2


reticulon 2


chr9_+_140513438 0.001 ENST00000462484.1
ENST00000334856.6
ENST00000460843.1
 EHMT1


euchromatic histone-lysine N-methyltransferase 1


chrX_-_19905703 0.001 ENST00000397821.3
 SH3KBP1
SH3-domain kinase binding protein 1
chr20_+_56884752 0.001 ENST00000244040.3
 RAB22A
RAB22A, member RAS oncogene family
chr19_+_3572925 0.001 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
 HMG20B



high mobility group 20B



chr12_-_44200052 0.001 ENST00000548315.1
ENST00000552521.1
ENST00000546662.1
ENST00000548403.1
ENST00000546506.1
 TWF1




twinfilin actin-binding protein 1




chr8_+_65492756 0.001 ENST00000321870.1
 BHLHE22
basic helix-loop-helix family, member e22
chr1_+_167190066 0.001 ENST00000367866.2
ENST00000429375.2
ENST00000452019.1
ENST00000420254.3
ENST00000541643.3
 POU2F1




POU class 2 homeobox 1




chr4_+_154125565 0.000 ENST00000338700.5
 TRIM2
tripartite motif containing 2
chr20_+_277737 0.000 ENST00000382352.3
 ZCCHC3
zinc finger, CCHC domain containing 3
chrX_+_150565653 0.000 ENST00000330374.6
 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.0 GO:0070429 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of CD40 signaling pathway(GO:2000349)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 GO:0000811 GINS complex(GO:0000811)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)