Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_VIRAL_MYOCARDITIS |
| Enrichment Score (ES) | 0.5432514 |
| Normalized Enrichment Score (NES) | 1.84517 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0029759523 |
| FWER p-Value | 0.03 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0516 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.1017 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.1445 | Yes |
| 4 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.1884 | Yes |
| 5 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.2316 | Yes |
| 6 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.2704 | Yes |
| 7 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.3112 | Yes |
| 8 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.3476 | Yes |
| 9 | LAMA2 | NA | LAMA2 Entrez, Source | laminin, alpha 2 (merosin, congenital muscular dystrophy) | 424 | 3.370 | 0.3758 | Yes |
| 10 | CD55 | NA | CD55 Entrez, Source | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 431 | 3.362 | 0.4108 | Yes |
| 11 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.4456 | Yes |
| 12 | EIF4G1 | NA | EIF4G1 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 1 | 1003 | 2.288 | 0.4382 | Yes |
| 13 | CASP9 | NA | CASP9 Entrez, Source | caspase 9, apoptosis-related cysteine peptidase | 1081 | 2.192 | 0.4569 | Yes |
| 14 | CXADR | NA | CXADR Entrez, Source | coxsackie virus and adenovirus receptor | 1099 | 2.170 | 0.4787 | Yes |
| 15 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.4997 | Yes |
| 16 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.5000 | Yes |
| 17 | SGCB | NA | SGCB Entrez, Source | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 1467 | 1.790 | 0.5185 | Yes |
| 18 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 1528 | 1.738 | 0.5334 | Yes |
| 19 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.5433 | Yes |
| 20 | ICAM1 | NA | ICAM1 Entrez, Source | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor | 1997 | 1.422 | 0.5394 | No |
| 21 | DAG1 | NA | DAG1 Entrez, Source | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 2575 | 1.146 | 0.5192 | No |
| 22 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4338 | 0.693 | 0.4281 | No |
| 23 | ABL2 | NA | ABL2 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 4501 | 0.657 | 0.4259 | No |
| 24 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 4577 | 0.642 | 0.4285 | No |
| 25 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4720 | 0.613 | 0.4270 | No |
| 26 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 4736 | 0.609 | 0.4325 | No |
| 27 | ACTG1 | NA | ACTG1 Entrez, Source | actin, gamma 1 | 4890 | 0.579 | 0.4301 | No |
| 28 | CCND1 | NA | CCND1 Entrez, Source | cyclin D1 | 4946 | 0.569 | 0.4330 | No |
| 29 | CASP8 | NA | CASP8 Entrez, Source | caspase 8, apoptosis-related cysteine peptidase | 5270 | 0.505 | 0.4202 | No |
| 30 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 5383 | 0.490 | 0.4191 | No |
| 31 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.3826 | No |
| 32 | FYN | NA | FYN Entrez, Source | FYN oncogene related to SRC, FGR, YES | 6328 | 0.393 | 0.3749 | No |
| 33 | MYH4 | NA | MYH4 Entrez, Source | myosin, heavy chain 4, skeletal muscle | 6335 | 0.392 | 0.3787 | No |
| 34 | EIF4G3 | NA | EIF4G3 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 3 | 7367 | 0.231 | 0.3236 | No |
| 35 | MYH13 | NA | MYH13 Entrez, Source | myosin, heavy chain 13, skeletal muscle | 7919 | 0.155 | 0.2944 | No |
| 36 | CAV1 | NA | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 8434 | 0.089 | 0.2666 | No |
| 37 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 8759 | 0.043 | 0.2490 | No |
| 38 | MYH7 | NA | MYH7 Entrez, Source | myosin, heavy chain 7, cardiac muscle, beta | 9742 | -0.046 | 0.1946 | No |
| 39 | ITGAL | NA | ITGAL Entrez, Source | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 9755 | -0.047 | 0.1945 | No |
| 40 | SGCD | NA | SGCD Entrez, Source | sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | 9849 | -0.058 | 0.1899 | No |
| 41 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 10403 | -0.111 | 0.1601 | No |
| 42 | MYH14 | NA | MYH14 Entrez, Source | myosin, heavy chain 14 | 10709 | -0.156 | 0.1447 | No |
| 43 | MYH1 | NA | MYH1 Entrez, Source | myosin, heavy chain 1, skeletal muscle, adult | 10820 | -0.172 | 0.1404 | No |
| 44 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 10856 | -0.177 | 0.1403 | No |
| 45 | RAC1 | NA | RAC1 Entrez, Source | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 10982 | -0.195 | 0.1354 | No |
| 46 | ABL1 | NA | ABL1 Entrez, Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 11310 | -0.241 | 0.1196 | No |
| 47 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.1198 | No |
| 48 | SGCA | NA | SGCA Entrez, Source | sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) | 11518 | -0.274 | 0.1136 | No |
| 49 | SGCG | NA | SGCG Entrez, Source | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) | 11881 | -0.326 | 0.0968 | No |
| 50 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 12489 | -0.411 | 0.0672 | No |
| 51 | MYH2 | NA | MYH2 Entrez, Source | myosin, heavy chain 2, skeletal muscle, adult | 12617 | -0.418 | 0.0645 | No |
| 52 | BID | NA | BID Entrez, Source | BH3 interacting domain death agonist | 12708 | -0.435 | 0.0641 | No |
| 53 | MYH11 | NA | MYH11 Entrez, Source | myosin, heavy chain 11, smooth muscle | 12889 | -0.450 | 0.0587 | No |
| 54 | ACTB | NA | ACTB Entrez, Source | actin, beta | 13165 | -0.481 | 0.0484 | No |
| 55 | EIF4G2 | NA | EIF4G2 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 2 | 13481 | -0.532 | 0.0364 | No |
| 56 | MYH8 | NA | MYH8 Entrez, Source | myosin, heavy chain 8, skeletal muscle, perinatal | 13605 | -0.559 | 0.0354 | No |
| 57 | MYH9 | NA | MYH9 Entrez, Source | myosin, heavy chain 9, non-muscle | 13628 | -0.563 | 0.0401 | No |
| 58 | CYCS | NA | CYCS Entrez, Source | cytochrome c, somatic | 13931 | -0.620 | 0.0297 | No |
| 59 | RAC2 | NA | RAC2 Entrez, Source | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) | 14098 | -0.658 | 0.0274 | No |
| 60 | MYH3 | NA | MYH3 Entrez, Source | myosin, heavy chain 3, skeletal muscle, embryonic | 14248 | -0.691 | 0.0263 | No |
| 61 | MYH7B | NA | MYH7B Entrez, Source | myosin, heavy chain 7B, cardiac muscle, beta | 14770 | -0.817 | 0.0058 | No |
| 62 | ITGB2 | NA | ITGB2 Entrez, Source | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | 14916 | -0.848 | 0.0066 | No |
| 63 | RAC3 | NA | RAC3 Entrez, Source | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 16175 | -1.249 | -0.0506 | No |
| 64 | MYH15 | NA | MYH15 Entrez, Source | myosin, heavy chain 15 | 16369 | -1.345 | -0.0472 | No |
| 65 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 17036 | -1.802 | -0.0655 | No |
| 66 | CASP3 | NA | CASP3 Entrez, Source | caspase 3, apoptosis-related cysteine peptidase | 17177 | -1.978 | -0.0525 | No |
| 67 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 17453 | -2.414 | -0.0426 | No |
| 68 | MYH10 | NA | MYH10 Entrez, Source | myosin, heavy chain 10, non-muscle | 17657 | -2.912 | -0.0233 | No |
| 69 | DMD | NA | DMD Entrez, Source | dystrophin (muscular dystrophy, Duchenne and Becker types) | 17848 | -3.904 | 0.0070 | No |
