Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION |
| Enrichment Score (ES) | -0.35344237 |
| Normalized Enrichment Score (NES) | -1.2135047 |
| Nominal p-value | 0.15659341 |
| FDR q-value | 0.47284693 |
| FWER p-Value | 1.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | MCCC1 | NA | MCCC1 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) | 661 | 2.808 | 0.0404 | No |
| 2 | EHHADH | NA | EHHADH Entrez, Source | enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase | 1038 | 2.247 | 0.0813 | No |
| 3 | ALDH3A2 | NA | ALDH3A2 Entrez, Source | aldehyde dehydrogenase 3 family, member A2 | 3064 | 0.971 | -0.0049 | No |
| 4 | HIBCH | NA | HIBCH Entrez, Source | 3-hydroxyisobutyryl-Coenzyme A hydrolase | 3200 | 0.940 | 0.0135 | No |
| 5 | ALDH2 | NA | ALDH2 Entrez, Source | aldehyde dehydrogenase 2 family (mitochondrial) | 3635 | 0.839 | 0.0124 | No |
| 6 | MUT | NA | MUT Entrez, Source | methylmalonyl Coenzyme A mutase | 3647 | 0.836 | 0.0348 | No |
| 7 | ALDH7A1 | NA | ALDH7A1 Entrez, Source | aldehyde dehydrogenase 7 family, member A1 | 3829 | 0.804 | 0.0468 | No |
| 8 | HSD17B10 | NA | 3848 | 0.800 | 0.0678 | No | ||
| 9 | HMGCL | NA | HMGCL Entrez, Source | 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria) | 4332 | 0.694 | 0.0600 | No |
| 10 | ACADS | NA | ACADS Entrez, Source | acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain | 4589 | 0.640 | 0.0634 | No |
| 11 | ALDH6A1 | NA | ALDH6A1 Entrez, Source | aldehyde dehydrogenase 6 family, member A1 | 5405 | 0.486 | 0.0313 | No |
| 12 | OXCT2 | NA | OXCT2 Entrez, Source | 3-oxoacid CoA transferase 2 | 5607 | 0.460 | 0.0327 | No |
| 13 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 6221 | 0.412 | 0.0099 | No |
| 14 | OXCT1 | NA | OXCT1 Entrez, Source | 3-oxoacid CoA transferase 1 | 7509 | 0.209 | -0.0561 | No |
| 15 | ACAD8 | NA | ACAD8 Entrez, Source | acyl-Coenzyme A dehydrogenase family, member 8 | 9538 | -0.020 | -0.1687 | No |
| 16 | DBT | NA | DBT Entrez, Source | dihydrolipoamide branched chain transacylase E2 | 10052 | -0.074 | -0.1953 | No |
| 17 | BCAT1 | NA | BCAT1 Entrez, Source | branched chain aminotransferase 1, cytosolic | 10271 | -0.095 | -0.2048 | No |
| 18 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 10331 | -0.100 | -0.2054 | No |
| 19 | BCAT2 | NA | BCAT2 Entrez, Source | branched chain aminotransferase 2, mitochondrial | 10623 | -0.143 | -0.2176 | No |
| 20 | ECHS1 | NA | ECHS1 Entrez, Source | enoyl Coenzyme A hydratase, short chain, 1, mitochondrial | 10958 | -0.192 | -0.2310 | No |
| 21 | ACAA2 | NA | ACAA2 Entrez, Source | acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) | 11255 | -0.232 | -0.2411 | No |
| 22 | HADHA | NA | HADHA Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit | 11436 | -0.260 | -0.2440 | No |
| 23 | ACADM | NA | ACADM Entrez, Source | acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain | 12066 | -0.348 | -0.2695 | No |
| 24 | HADHB | NA | HADHB Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 13040 | -0.461 | -0.3111 | No |
| 25 | ACADSB | NA | ACADSB Entrez, Source | acyl-Coenzyme A dehydrogenase, short/branched chain | 13801 | -0.595 | -0.3371 | Yes |
| 26 | ALDH1B1 | NA | ALDH1B1 Entrez, Source | aldehyde dehydrogenase 1 family, member B1 | 13930 | -0.620 | -0.3271 | Yes |
| 27 | DLD | NA | DLD Entrez, Source | dihydrolipoamide dehydrogenase | 13981 | -0.630 | -0.3126 | Yes |
| 28 | AUH | NA | AUH Entrez, Source | AU RNA binding protein/enoyl-Coenzyme A hydratase | 14146 | -0.668 | -0.3033 | Yes |
| 29 | PCCB | NA | PCCB Entrez, Source | propionyl Coenzyme A carboxylase, beta polypeptide | 14301 | -0.700 | -0.2927 | Yes |
| 30 | ALDH9A1 | NA | ALDH9A1 Entrez, Source | aldehyde dehydrogenase 9 family, member A1 | 14538 | -0.763 | -0.2848 | Yes |
| 31 | IVD | NA | IVD Entrez, Source | isovaleryl Coenzyme A dehydrogenase | 14550 | -0.766 | -0.2643 | Yes |
| 32 | MCEE | NA | MCEE Entrez, Source | methylmalonyl CoA epimerase | 14555 | -0.769 | -0.2434 | Yes |
| 33 | BCKDHB | NA | BCKDHB Entrez, Source | branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease) | 14814 | -0.829 | -0.2350 | Yes |
| 34 | HADH | NA | HADH Entrez, Source | hydroxyacyl-Coenzyme A dehydrogenase | 14938 | -0.852 | -0.2184 | Yes |
| 35 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 15510 | -1.001 | -0.2226 | Yes |
| 36 | PCCA | NA | PCCA Entrez, Source | propionyl Coenzyme A carboxylase, alpha polypeptide | 15637 | -1.039 | -0.2011 | Yes |
| 37 | ACAA1 | NA | ACAA1 Entrez, Source | acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) | 15691 | -1.059 | -0.1749 | Yes |
| 38 | IL4I1 | NA | IL4I1 Entrez, Source | interleukin 4 induced 1 | 15694 | -1.061 | -0.1458 | Yes |
| 39 | HIBADH | NA | HIBADH Entrez, Source | 3-hydroxyisobutyrate dehydrogenase | 16196 | -1.255 | -0.1392 | Yes |
| 40 | AOX1 | NA | AOX1 Entrez, Source | aldehyde oxidase 1 | 16202 | -1.260 | -0.1048 | Yes |
| 41 | MCCC2 | NA | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 16481 | -1.403 | -0.0816 | Yes |
| 42 | ABAT | NA | ABAT Entrez, Source | 4-aminobutyrate aminotransferase | 16644 | -1.497 | -0.0494 | Yes |
| 43 | BCKDHA | NA | BCKDHA Entrez, Source | branched chain keto acid dehydrogenase E1, alpha polypeptide | 17143 | -1.925 | -0.0242 | Yes |
| 44 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 17531 | -2.561 | 0.0247 | Yes |
