Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_TYPE_I_DIABETES_MELLITUS |
| Enrichment Score (ES) | 0.66417444 |
| Normalized Enrichment Score (NES) | 2.0330298 |
| Nominal p-value | 0.0 |
| FDR q-value | 1.4164648E-4 |
| FWER p-Value | 0.001 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0731 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.1444 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.2066 | Yes |
| 4 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.2693 | Yes |
| 5 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.3311 | Yes |
| 6 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.3873 | Yes |
| 7 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.4452 | Yes |
| 8 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.4980 | Yes |
| 9 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.5398 | Yes |
| 10 | CPE | NA | CPE Entrez, Source | carboxypeptidase E | 1027 | 2.264 | 0.5406 | Yes |
| 11 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.5668 | Yes |
| 12 | IL12A | NA | IL12A Entrez, Source | interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) | 1403 | 1.842 | 0.5788 | Yes |
| 13 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.6024 | Yes |
| 14 | HLA-E | NA | HLA-E Entrez, Source | major histocompatibility complex, class I, E | 1528 | 1.738 | 0.6244 | Yes |
| 15 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.6414 | Yes |
| 16 | FAS | NA | FAS Entrez, Source | Fas (TNF receptor superfamily, member 6) | 1716 | 1.589 | 0.6619 | Yes |
| 17 | GAD1 | NA | GAD1 Entrez, Source | glutamate decarboxylase 1 (brain, 67kDa) | 2048 | 1.394 | 0.6642 | Yes |
| 18 | HLA-C | NA | HLA-C Entrez, Source | major histocompatibility complex, class I, C | 4338 | 0.693 | 0.5468 | No |
| 19 | HLA-G | NA | HLA-G Entrez, Source | HLA-G histocompatibility antigen, class I, G | 4577 | 0.642 | 0.5431 | No |
| 20 | HLA-A | NA | HLA-A Entrez, Source | major histocompatibility complex, class I, A | 4720 | 0.613 | 0.5442 | No |
| 21 | HLA-F | NA | HLA-F Entrez, Source | major histocompatibility complex, class I, F | 4736 | 0.609 | 0.5524 | No |
| 22 | PRF1 | NA | PRF1 Entrez, Source | perforin 1 (pore forming protein) | 5383 | 0.490 | 0.5237 | No |
| 23 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.4890 | No |
| 24 | LTA | NA | LTA Entrez, Source | lymphotoxin alpha (TNF superfamily, member 1) | 6479 | 0.370 | 0.4743 | No |
| 25 | HSPD1 | NA | HSPD1 Entrez, Source | heat shock 60kDa protein 1 (chaperonin) | 6826 | 0.318 | 0.4598 | No |
| 26 | FASLG | NA | FASLG Entrez, Source | Fas ligand (TNF superfamily, member 6) | 7435 | 0.220 | 0.4291 | No |
| 27 | GAD2 | NA | GAD2 Entrez, Source | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 8203 | 0.120 | 0.3881 | No |
| 28 | PTPRN2 | NA | PTPRN2 Entrez, Source | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 8488 | 0.080 | 0.3735 | No |
| 29 | HLA-B | NA | HLA-B Entrez, Source | major histocompatibility complex, class I, B | 8759 | 0.043 | 0.3591 | No |
| 30 | IL2 | NA | IL2 Entrez, Source | interleukin 2 | 9229 | 0.000 | 0.3329 | No |
| 31 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 9956 | -0.066 | 0.2934 | No |
| 32 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 10403 | -0.111 | 0.2702 | No |
| 33 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 10856 | -0.177 | 0.2476 | No |
| 34 | IL12B | NA | IL12B Entrez, Source | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 11133 | -0.216 | 0.2354 | No |
| 35 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.2268 | No |
| 36 | PTPRN | NA | PTPRN Entrez, Source | protein tyrosine phosphatase, receptor type, N | 12112 | -0.355 | 0.1899 | No |
| 37 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 12804 | -0.445 | 0.1580 | No |
| 38 | ICA1 | NA | ICA1 Entrez, Source | islet cell autoantigen 1, 69kDa | 15635 | -1.039 | 0.0156 | No |
| 39 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 17036 | -1.802 | -0.0358 | No |
| 40 | IL1B | NA | IL1B Entrez, Source | interleukin 1, beta | 17373 | -2.282 | -0.0206 | No |
| 41 | IL1A | NA | IL1A Entrez, Source | interleukin 1, alpha | 17815 | -3.646 | 0.0089 | No |
