Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS |
| Enrichment Score (ES) | -0.6751701 |
| Normalized Enrichment Score (NES) | -1.7706921 |
| Nominal p-value | 0.004938272 |
| FDR q-value | 0.06745409 |
| FWER p-Value | 0.122 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | DHDDS | NA | DHDDS Entrez, Source | dehydrodolichyl diphosphate synthase | 1576 | 1.703 | -0.0013 | No |
| 2 | PMVK | NA | PMVK Entrez, Source | phosphomevalonate kinase | 4622 | 0.633 | -0.1387 | No |
| 3 | HMGCS2 | NA | HMGCS2 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | 6221 | 0.412 | -0.2068 | No |
| 4 | GGPS1 | NA | GGPS1 Entrez, Source | geranylgeranyl diphosphate synthase 1 | 7888 | 0.160 | -0.2914 | No |
| 5 | ACAT1 | NA | ACAT1 Entrez, Source | acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) | 10331 | -0.100 | -0.4223 | No |
| 6 | IDI2 | NA | IDI2 Entrez, Source | isopentenyl-diphosphate delta isomerase 2 | 14289 | -0.698 | -0.6072 | No |
| 7 | ACAT2 | NA | ACAT2 Entrez, Source | acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) | 15510 | -1.001 | -0.6244 | Yes |
| 8 | PDSS2 | NA | PDSS2 Entrez, Source | prenyl (decaprenyl) diphosphate synthase, subunit 2 | 16216 | -1.267 | -0.5993 | Yes |
| 9 | PDSS1 | NA | PDSS1 Entrez, Source | prenyl (decaprenyl) diphosphate synthase, subunit 1 | 16360 | -1.339 | -0.5393 | Yes |
| 10 | IDI1 | NA | IDI1 Entrez, Source | isopentenyl-diphosphate delta isomerase 1 | 16724 | -1.548 | -0.4809 | Yes |
| 11 | FDPS | NA | FDPS Entrez, Source | farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | 16738 | -1.557 | -0.4026 | Yes |
| 12 | MVK | NA | MVK Entrez, Source | mevalonate kinase (mevalonic aciduria) | 17008 | -1.778 | -0.3273 | Yes |
| 13 | HMGCR | NA | HMGCR Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | 17398 | -2.327 | -0.2309 | Yes |
| 14 | HMGCS1 | NA | HMGCS1 Entrez, Source | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) | 17531 | -2.561 | -0.1082 | Yes |
| 15 | MVD | NA | MVD Entrez, Source | mevalonate (diphospho) decarboxylase | 17563 | -2.616 | 0.0229 | Yes |
