Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS |
| Enrichment Score (ES) | 0.5774322 |
| Normalized Enrichment Score (NES) | 2.098993 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.0 |
| FWER p-Value | 0.0 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | HLA-DRB1 | NA | HLA-DRB1 Entrez, Source | major histocompatibility complex, class II, DR beta 1 | 8 | 4.960 | 0.0354 | Yes |
| 2 | HLA-DRA | NA | HLA-DRA Entrez, Source | major histocompatibility complex, class II, DR alpha | 27 | 4.871 | 0.0696 | Yes |
| 3 | HLA-DPA1 | NA | HLA-DPA1 Entrez, Source | major histocompatibility complex, class II, DP alpha 1 | 107 | 4.489 | 0.0977 | Yes |
| 4 | HLA-DRB5 | NA | HLA-DRB5 Entrez, Source | major histocompatibility complex, class II, DR beta 5 | 137 | 4.339 | 0.1274 | Yes |
| 5 | HLA-DMB | NA | HLA-DMB Entrez, Source | major histocompatibility complex, class II, DM beta | 164 | 4.259 | 0.1568 | Yes |
| 6 | HLA-DRB3 | NA | HLA-DRB3 Entrez, Source | major histocompatibility complex, class II, DR beta 3 | 226 | 4.018 | 0.1824 | Yes |
| 7 | HLA-DRB4 | NA | HLA-DRB4 Entrez, Source | major histocompatibility complex, class II, DR beta 4 | 242 | 3.963 | 0.2102 | Yes |
| 8 | C2 | NA | C2 Entrez, Source | complement component 2 | 271 | 3.833 | 0.2364 | Yes |
| 9 | HLA-DMA | NA | HLA-DMA Entrez, Source | major histocompatibility complex, class II, DM alpha | 294 | 3.747 | 0.2623 | Yes |
| 10 | HIST1H2AC | NA | HIST1H2AC Entrez, Source | histone cluster 1, H2ac | 322 | 3.688 | 0.2874 | Yes |
| 11 | HIST1H2BD | NA | HIST1H2BD Entrez, Source | histone cluster 1, H2bd | 385 | 3.466 | 0.3090 | Yes |
| 12 | HIST1H2BJ | NA | HIST1H2BJ Entrez, Source | histone cluster 1, H2bj | 399 | 3.436 | 0.3331 | Yes |
| 13 | HLA-DQB1 | NA | HLA-DQB1 Entrez, Source | major histocompatibility complex, class II, DQ beta 1 | 438 | 3.353 | 0.3553 | Yes |
| 14 | HIST1H2BK | NA | HIST1H2BK Entrez, Source | histone cluster 1, H2bk | 518 | 3.140 | 0.3736 | Yes |
| 15 | HIST1H4H | NA | HIST1H4H Entrez, Source | histone cluster 1, H4h | 520 | 3.136 | 0.3962 | Yes |
| 16 | HIST2H2AA3 | NA | HIST2H2AA3 Entrez, Source | histone cluster 2, H2aa3 | 596 | 2.954 | 0.4133 | Yes |
| 17 | HIST1H3H | NA | HIST1H3H Entrez, Source | histone cluster 1, H3h | 633 | 2.891 | 0.4322 | Yes |
| 18 | C1R | NA | C1R Entrez, Source | complement component 1, r subcomponent | 694 | 2.734 | 0.4486 | Yes |
| 19 | HIST1H3C | NA | HIST1H3C Entrez, Source | histone cluster 1, H3c | 850 | 2.477 | 0.4579 | Yes |
| 20 | HIST1H3B | NA | HIST1H3B Entrez, Source | histone cluster 1, H3b | 866 | 2.454 | 0.4748 | Yes |
| 21 | FCGR3B | NA | FCGR3B Entrez, Source | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 901 | 2.407 | 0.4903 | Yes |
| 22 | HIST1H2AM | NA | HIST1H2AM Entrez, Source | histone cluster 1, H2am | 992 | 2.295 | 0.5019 | Yes |
| 23 | HIST2H2BE | NA | HIST2H2BE Entrez, Source | histone cluster 2, H2be | 1048 | 2.231 | 0.5149 | Yes |
| 24 | HLA-DPB1 | NA | HLA-DPB1 Entrez, Source | major histocompatibility complex, class II, DP beta 1 | 1127 | 2.142 | 0.5260 | Yes |
| 25 | HLA-DOB | NA | HLA-DOB Entrez, Source | major histocompatibility complex, class II, DO beta | 1460 | 1.797 | 0.5204 | Yes |
| 26 | HIST1H2BC | NA | HIST1H2BC Entrez, Source | histone cluster 1, H2bc | 1555 | 1.719 | 0.5276 | Yes |
| 27 | HLA-DOA | NA | HLA-DOA Entrez, Source | major histocompatibility complex, class II, DO alpha | 1660 | 1.640 | 0.5337 | Yes |
| 28 | HIST1H2AH | NA | HIST1H2AH Entrez, Source | histone cluster 1, H2ah | 1689 | 1.613 | 0.5438 | Yes |
| 29 | HIST1H2BN | NA | HIST1H2BN Entrez, Source | histone cluster 1, H2bn | 1793 | 1.534 | 0.5491 | Yes |
| 30 | HIST1H2AE | NA | HIST1H2AE Entrez, Source | histone cluster 1, H2ae | 1935 | 1.454 | 0.5517 | Yes |
| 31 | HIST1H3A | NA | HIST1H3A Entrez, Source | histone cluster 1, H3a | 1942 | 1.450 | 0.5618 | Yes |
| 32 | HIST2H4B | NA | HIST2H4B Entrez, Source | histone cluster 2, H4b | 2279 | 1.264 | 0.5522 | Yes |
| 33 | C4B | NA | C4B Entrez, Source | complement component 4B (Childo blood group) | 2383 | 1.222 | 0.5553 | Yes |
| 34 | HIST2H2BF | NA | HIST2H2BF Entrez, Source | histone cluster 2, H2bf | 2408 | 1.212 | 0.5627 | Yes |
| 35 | HIST1H4C | NA | HIST1H4C Entrez, Source | histone cluster 1, H4c | 2437 | 1.198 | 0.5698 | Yes |
| 36 | HIST1H4B | NA | HIST1H4B Entrez, Source | histone cluster 1, H4b | 2525 | 1.169 | 0.5734 | Yes |
| 37 | C4A | NA | C4A Entrez, Source | complement component 4A (Rodgers blood group) | 2600 | 1.137 | 0.5774 | Yes |
| 38 | HIST2H3D | NA | HIST2H3D Entrez, Source | histone cluster 2, H3d | 2769 | 1.070 | 0.5758 | No |
| 39 | H2AFY2 | NA | H2AFY2 Entrez, Source | H2A histone family, member Y2 | 3351 | 0.896 | 0.5497 | No |
| 40 | HIST1H2AB | NA | HIST1H2AB Entrez, Source | histone cluster 1, H2ab | 3594 | 0.843 | 0.5423 | No |
| 41 | C1S | NA | C1S Entrez, Source | complement component 1, s subcomponent | 3847 | 0.800 | 0.5340 | No |
| 42 | FCGR2A | NA | FCGR2A Entrez, Source | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 3899 | 0.785 | 0.5368 | No |
| 43 | HIST1H2BO | NA | HIST1H2BO Entrez, Source | histone cluster 1, H2bo | 4005 | 0.761 | 0.5364 | No |
| 44 | FCGR3A | NA | FCGR3A Entrez, Source | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 4045 | 0.751 | 0.5396 | No |
| 45 | HIST1H2AG | NA | HIST1H2AG Entrez, Source | histone cluster 1, H2ag | 4617 | 0.634 | 0.5123 | No |
| 46 | HIST1H2AJ | NA | HIST1H2AJ Entrez, Source | histone cluster 1, H2aj | 4634 | 0.632 | 0.5159 | No |
| 47 | HIST1H2AK | NA | HIST1H2AK Entrez, Source | histone cluster 1, H2ak | 4793 | 0.597 | 0.5114 | No |
| 48 | SSB | NA | SSB Entrez, Source | Sjogren syndrome antigen B (autoantigen La) | 4929 | 0.572 | 0.5080 | No |
| 49 | H2AFJ | NA | H2AFJ Entrez, Source | H2A histone family, member J | 4988 | 0.560 | 0.5088 | No |
| 50 | HIST1H2BM | NA | HIST1H2BM Entrez, Source | histone cluster 1, H2bm | 5231 | 0.512 | 0.4990 | No |
| 51 | HIST1H2BE | NA | HIST1H2BE Entrez, Source | histone cluster 1, H2be | 5433 | 0.485 | 0.4912 | No |
| 52 | H2AFB2 | NA | H2AFB2 Entrez, Source | H2A histone family, member B2 | 5888 | 0.428 | 0.4689 | No |
| 53 | HIST1H3I | NA | HIST1H3I Entrez, Source | histone cluster 1, H3i | 5968 | 0.418 | 0.4675 | No |
| 54 | HIST3H3 | NA | HIST3H3 Entrez, Source | histone cluster 3, H3 | 6046 | 0.418 | 0.4662 | No |
| 55 | HIST1H4K | NA | HIST1H4K Entrez, Source | histone cluster 1, H4k | 6100 | 0.415 | 0.4662 | No |
| 56 | HLA-DQA1 | NA | HLA-DQA1 Entrez, Source | major histocompatibility complex, class II, DQ alpha 1 | 6116 | 0.415 | 0.4684 | No |
| 57 | HIST3H2BB | NA | HIST3H2BB Entrez, Source | histone cluster 3, H2bb | 6188 | 0.415 | 0.4674 | No |
| 58 | HIST1H2BL | NA | HIST1H2BL Entrez, Source | histone cluster 1, H2bl | 6548 | 0.359 | 0.4499 | No |
| 59 | HIST1H2AI | NA | HIST1H2AI Entrez, Source | histone cluster 1, H2ai | 6831 | 0.317 | 0.4364 | No |
| 60 | H2AFY | NA | H2AFY Entrez, Source | H2A histone family, member Y | 7024 | 0.286 | 0.4278 | No |
| 61 | H2AFV | NA | H2AFV Entrez, Source | H2A histone family, member V | 7297 | 0.242 | 0.4143 | No |
| 62 | C6 | NA | C6 Entrez, Source | complement component 6 | 7318 | 0.239 | 0.4149 | No |
| 63 | HIST2H2AC | NA | HIST2H2AC Entrez, Source | histone cluster 2, H2ac | 7406 | 0.224 | 0.4116 | No |
| 64 | TRIM21 | NA | TRIM21 Entrez, Source | tripartite motif-containing 21 | 7941 | 0.152 | 0.3828 | No |
| 65 | TROVE2 | NA | TROVE2 Entrez, Source | TROVE domain family, member 2 | 8102 | 0.133 | 0.3748 | No |
| 66 | ACTN4 | NA | ACTN4 Entrez, Source | actinin, alpha 4 | 8121 | 0.131 | 0.3748 | No |
| 67 | HIST1H2BG | NA | HIST1H2BG Entrez, Source | histone cluster 1, H2bg | 8142 | 0.128 | 0.3746 | No |
| 68 | C9 | NA | C9 Entrez, Source | complement component 9 | 8168 | 0.125 | 0.3741 | No |
| 69 | GRIN2B | NA | GRIN2B Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 8338 | 0.102 | 0.3654 | No |
| 70 | IL10 | NA | IL10 Entrez, Source | interleukin 10 | 8629 | 0.062 | 0.3496 | No |
| 71 | HIST1H3F | NA | HIST1H3F Entrez, Source | histone cluster 1, H3f | 9201 | 0.000 | 0.3176 | No |
| 72 | HIST1H3D | NA | HIST1H3D Entrez, Source | histone cluster 1, H3d | 9202 | 0.000 | 0.3176 | No |
| 73 | HIST1H2BI | NA | HIST1H2BI Entrez, Source | histone cluster 1, H2bi | 9303 | 0.000 | 0.3120 | No |
| 74 | H2AFZ | NA | H2AFZ Entrez, Source | H2A histone family, member Z | 9425 | -0.003 | 0.3053 | No |
| 75 | C8A | NA | C8A Entrez, Source | complement component 8, alpha polypeptide | 9500 | -0.014 | 0.3012 | No |
| 76 | C7 | NA | C7 Entrez, Source | complement component 7 | 9558 | -0.024 | 0.2982 | No |
| 77 | HIST1H2BB | NA | HIST1H2BB Entrez, Source | histone cluster 1, H2bb | 9702 | -0.043 | 0.2905 | No |
| 78 | H2AFX | NA | H2AFX Entrez, Source | H2A histone family, member X | 9779 | -0.049 | 0.2866 | No |
| 79 | FCGR1A | NA | FCGR1A Entrez, Source | Fc fragment of IgG, high affinity Ia, receptor (CD64) | 9795 | -0.051 | 0.2861 | No |
| 80 | TNF | NA | TNF Entrez, Source | tumor necrosis factor (TNF superfamily, member 2) | 9956 | -0.066 | 0.2777 | No |
| 81 | SNRPB | NA | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 10268 | -0.094 | 0.2609 | No |
| 82 | CD80 | NA | CD80 Entrez, Source | CD80 molecule | 10403 | -0.111 | 0.2542 | No |
| 83 | CD86 | NA | CD86 Entrez, Source | CD86 molecule | 10856 | -0.177 | 0.2302 | No |
| 84 | HIST1H4A | NA | HIST1H4A Entrez, Source | histone cluster 1, H4a | 11201 | -0.227 | 0.2126 | No |
| 85 | HIST1H3J | NA | HIST1H3J Entrez, Source | histone cluster 1, H3j | 11280 | -0.236 | 0.2099 | No |
| 86 | HLA-DQA2 | NA | HLA-DQA2 Entrez, Source | major histocompatibility complex, class II, DQ alpha 2 | 11354 | -0.247 | 0.2076 | No |
| 87 | C8G | NA | C8G Entrez, Source | complement component 8, gamma polypeptide | 11727 | -0.300 | 0.1890 | No |
| 88 | HIST2H3A | NA | HIST2H3A Entrez, Source | histone cluster 2, H3a | 11878 | -0.326 | 0.1829 | No |
| 89 | HIST2H2AB | NA | HIST2H2AB Entrez, Source | histone cluster 2, H2ab | 11902 | -0.327 | 0.1840 | No |
| 90 | H3F3C | NA | 11963 | -0.334 | 0.1831 | No | ||
| 91 | HIST4H4 | NA | HIST4H4 Entrez, Source | histone cluster 4, H4 | 12404 | -0.400 | 0.1613 | No |
| 92 | HIST1H4I | NA | HIST1H4I Entrez, Source | histone cluster 1, H4i | 12471 | -0.411 | 0.1606 | No |
| 93 | HIST1H4J | NA | HIST1H4J Entrez, Source | histone cluster 1, H4j | 12472 | -0.411 | 0.1636 | No |
| 94 | CD40LG | NA | CD40LG Entrez, Source | CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome) | 12489 | -0.411 | 0.1657 | No |
| 95 | H2BFM | NA | H2BFM Entrez, Source | H2B histone family, member M | 12679 | -0.431 | 0.1582 | No |
| 96 | IFNG | NA | IFNG Entrez, Source | interferon, gamma | 12804 | -0.445 | 0.1545 | No |
| 97 | ACTN1 | NA | ACTN1 Entrez, Source | actinin, alpha 1 | 12856 | -0.445 | 0.1548 | No |
| 98 | GRIN2A | NA | GRIN2A Entrez, Source | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 13568 | -0.551 | 0.1190 | No |
| 99 | SNRPD1 | NA | SNRPD1 Entrez, Source | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 13588 | -0.555 | 0.1220 | No |
| 100 | C8B | NA | C8B Entrez, Source | complement component 8, beta polypeptide | 13690 | -0.574 | 0.1205 | No |
| 101 | H2BFWT | NA | H2BFWT Entrez, Source | H2B histone family, member W, testis-specific | 13933 | -0.621 | 0.1114 | No |
| 102 | FCGR2B | NA | FCGR2B Entrez, Source | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 14756 | -0.815 | 0.0713 | No |
| 103 | H3F3B | NA | H3F3B Entrez, Source | H3 histone, family 3B (H3.3B) | 15031 | -0.875 | 0.0623 | No |
| 104 | SNRPD3 | NA | SNRPD3 Entrez, Source | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 15138 | -0.898 | 0.0628 | No |
| 105 | H3F3A | NA | H3F3A Entrez, Source | H3 histone, family 3A | 15430 | -0.977 | 0.0536 | No |
| 106 | ACTN2 | NA | ACTN2 Entrez, Source | actinin, alpha 2 | 15457 | -0.986 | 0.0593 | No |
| 107 | CTSG | NA | CTSG Entrez, Source | cathepsin G | 15787 | -1.091 | 0.0487 | No |
| 108 | ACTN3 | NA | ACTN3 Entrez, Source | actinin, alpha 3 | 16502 | -1.414 | 0.0190 | No |
| 109 | C5 | NA | C5 Entrez, Source | complement component 5 | 16535 | -1.431 | 0.0276 | No |
| 110 | CD28 | NA | CD28 Entrez, Source | CD28 molecule | 17036 | -1.802 | 0.0126 | No |
| 111 | CD40 | NA | CD40 Entrez, Source | CD40 molecule, TNF receptor superfamily member 5 | 17453 | -2.414 | 0.0068 | No |
| 112 | C3 | NA | C3 Entrez, Source | complement component 3 | 17698 | -3.089 | 0.0155 | No |
