Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_STEROID_BIOSYNTHESIS |
| Enrichment Score (ES) | -0.6453918 |
| Normalized Enrichment Score (NES) | -1.7375834 |
| Nominal p-value | 0.017369727 |
| FDR q-value | 0.038508065 |
| FWER p-Value | 0.171 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | TM7SF2 | NA | TM7SF2 Entrez, Source | transmembrane 7 superfamily member 2 | 1628 | 1.661 | -0.0106 | No |
| 2 | CEL | NA | CEL Entrez, Source | carboxyl ester lipase (bile salt-stimulated lipase) | 2370 | 1.226 | 0.0072 | No |
| 3 | SOAT1 | NA | SOAT1 Entrez, Source | sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 | 4895 | 0.578 | -0.1055 | No |
| 4 | SOAT2 | NA | SOAT2 Entrez, Source | sterol O-acyltransferase 2 | 6771 | 0.325 | -0.1942 | No |
| 5 | LIPA | NA | LIPA Entrez, Source | lipase A, lysosomal acid, cholesterol esterase (Wolman disease) | 9120 | 0.008 | -0.3246 | No |
| 6 | EBP | NA | EBP Entrez, Source | emopamil binding protein (sterol isomerase) | 9472 | -0.010 | -0.3436 | No |
| 7 | NSDHL | NA | NSDHL Entrez, Source | NAD(P) dependent steroid dehydrogenase-like | 9856 | -0.058 | -0.3621 | No |
| 8 | CYP51A1 | NA | CYP51A1 Entrez, Source | cytochrome P450, family 51, subfamily A, polypeptide 1 | 13626 | -0.563 | -0.5449 | No |
| 9 | LSS | NA | LSS Entrez, Source | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 15432 | -0.977 | -0.5983 | Yes |
| 10 | FDFT1 | NA | FDFT1 Entrez, Source | farnesyl-diphosphate farnesyltransferase 1 | 16183 | -1.251 | -0.5798 | Yes |
| 11 | HSD17B7 | NA | HSD17B7 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 7 | 16819 | -1.623 | -0.5369 | Yes |
| 12 | DHCR7 | NA | DHCR7 Entrez, Source | 7-dehydrocholesterol reductase | 17178 | -1.978 | -0.4616 | Yes |
| 13 | SQLE | NA | SQLE Entrez, Source | squalene epoxidase | 17217 | -2.029 | -0.3659 | Yes |
| 14 | MSMO1 | NA | 17243 | -2.074 | -0.2674 | Yes | ||
| 15 | DHCR24 | NA | DHCR24 Entrez, Source | 24-dehydrocholesterol reductase | 17710 | -3.134 | -0.1424 | Yes |
| 16 | CYP27B1 | NA | CYP27B1 Entrez, Source | cytochrome P450, family 27, subfamily B, polypeptide 1 | 17733 | -3.259 | 0.0134 | Yes |
