Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_SPLICEOSOME |
| Enrichment Score (ES) | -0.4208839 |
| Normalized Enrichment Score (NES) | -1.7321924 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.03362989 |
| FWER p-Value | 0.178 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | LSM2 | NA | LSM2 Entrez, Source | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 1574 | 1.705 | -0.0664 | No |
| 2 | HSPA1A | NA | HSPA1A Entrez, Source | heat shock 70kDa protein 1A | 1614 | 1.675 | -0.0472 | No |
| 3 | HSPA1B | NA | HSPA1B Entrez, Source | heat shock 70kDa protein 1B | 2020 | 1.411 | -0.0518 | No |
| 4 | PQBP1 | NA | PQBP1 Entrez, Source | polyglutamine binding protein 1 | 2611 | 1.131 | -0.0704 | No |
| 5 | THOC3 | NA | THOC3 Entrez, Source | THO complex 3 | 3138 | 0.951 | -0.0877 | No |
| 6 | DHX16 | NA | DHX16 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 16 | 3286 | 0.917 | -0.0842 | No |
| 7 | TRA2B | NA | 3701 | 0.830 | -0.0968 | No | ||
| 8 | SNRPC | NA | SNRPC Entrez, Source | small nuclear ribonucleoprotein polypeptide C | 3710 | 0.828 | -0.0867 | No |
| 9 | HSPA1L | NA | HSPA1L Entrez, Source | heat shock 70kDa protein 1-like | 3713 | 0.828 | -0.0762 | No |
| 10 | PPIL1 | NA | PPIL1 Entrez, Source | peptidylprolyl isomerase (cyclophilin)-like 1 | 4573 | 0.643 | -0.1161 | No |
| 11 | BUD31 | NA | BUD31 Entrez, Source | BUD31 homolog (yeast) | 4666 | 0.626 | -0.1132 | No |
| 12 | HSPA8 | NA | HSPA8 Entrez, Source | heat shock 70kDa protein 8 | 4884 | 0.579 | -0.1180 | No |
| 13 | RBM22 | NA | RBM22 Entrez, Source | RNA binding motif protein 22 | 5107 | 0.534 | -0.1236 | No |
| 14 | ZMAT2 | NA | ZMAT2 Entrez, Source | zinc finger, matrin type 2 | 5446 | 0.484 | -0.1364 | No |
| 15 | SNRNP40 | NA | 5715 | 0.441 | -0.1457 | No | ||
| 16 | PRPF40A | NA | PRPF40A Entrez, Source | PRP40 pre-mRNA processing factor 40 homolog A (yeast) | 6243 | 0.408 | -0.1700 | No |
| 17 | ACIN1 | NA | ACIN1 Entrez, Source | apoptotic chromatin condensation inducer 1 | 6702 | 0.334 | -0.1914 | No |
| 18 | SLU7 | NA | SLU7 Entrez, Source | - | 7041 | 0.282 | -0.2067 | No |
| 19 | SF3B1 | NA | SF3B1 Entrez, Source | splicing factor 3b, subunit 1, 155kDa | 7083 | 0.277 | -0.2055 | No |
| 20 | PRPF3 | NA | PRPF3 Entrez, Source | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 7195 | 0.258 | -0.2084 | No |
| 21 | HSPA6 | NA | HSPA6 Entrez, Source | heat shock 70kDa protein 6 (HSP70B') | 7340 | 0.236 | -0.2135 | No |
| 22 | PLRG1 | NA | PLRG1 Entrez, Source | pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) | 7612 | 0.196 | -0.2261 | No |
| 23 | CRNKL1 | NA | CRNKL1 Entrez, Source | Crn, crooked neck-like 1 (Drosophila) | 7991 | 0.147 | -0.2454 | No |
| 24 | DDX23 | NA | DDX23 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | 8026 | 0.142 | -0.2455 | No |
| 25 | DDX46 | NA | DDX46 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 8395 | 0.095 | -0.2649 | No |
| 26 | CDC5L | NA | CDC5L Entrez, Source | CDC5 cell division cycle 5-like (S. pombe) | 8506 | 0.079 | -0.2701 | No |
| 27 | BCAS2 | NA | BCAS2 Entrez, Source | breast carcinoma amplified sequence 2 | 8538 | 0.075 | -0.2709 | No |
| 28 | CWC15 | NA | 8593 | 0.067 | -0.2730 | No | ||
| 29 | DHX15 | NA | DHX15 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 15 | 8723 | 0.048 | -0.2796 | No |
| 30 | TCERG1 | NA | TCERG1 Entrez, Source | transcription elongation regulator 1 | 8854 | 0.036 | -0.2864 | No |
| 31 | NCBP2 | NA | NCBP2 Entrez, Source | nuclear cap binding protein subunit 2, 20kDa | 9125 | 0.008 | -0.3015 | No |
| 32 | SNW1 | NA | SNW1 Entrez, Source | SNW domain containing 1 | 9128 | 0.007 | -0.3015 | No |
| 33 | RBM25 | NA | RBM25 Entrez, Source | RNA binding motif protein 25 | 9166 | 0.003 | -0.3035 | No |
| 34 | DHX38 | NA | DHX38 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 38 | 9609 | -0.031 | -0.3279 | No |
| 35 | SRSF1 | NA | 9650 | -0.037 | -0.3297 | No | ||
| 36 | WBP11 | NA | WBP11 Entrez, Source | WW domain binding protein 11 | 9805 | -0.052 | -0.3376 | No |
| 37 | SNRPB | NA | SNRPB Entrez, Source | small nuclear ribonucleoprotein polypeptides B and B1 | 10268 | -0.094 | -0.3623 | No |
| 38 | U2AF2 | NA | U2AF2 Entrez, Source | U2 small nuclear RNA auxiliary factor 2 | 10355 | -0.102 | -0.3658 | No |
| 39 | PRPF18 | NA | PRPF18 Entrez, Source | PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae) | 10405 | -0.111 | -0.3671 | No |
| 40 | RBM17 | NA | RBM17 Entrez, Source | RNA binding motif protein 17 | 10570 | -0.134 | -0.3746 | No |
| 41 | CTNNBL1 | NA | CTNNBL1 Entrez, Source | catenin, beta like 1 | 10707 | -0.155 | -0.3802 | No |
| 42 | PRPF4 | NA | PRPF4 Entrez, Source | PRP4 pre-mRNA processing factor 4 homolog (yeast) | 10840 | -0.176 | -0.3854 | No |
| 43 | SF3A2 | NA | SF3A2 Entrez, Source | splicing factor 3a, subunit 2, 66kDa | 10952 | -0.191 | -0.3892 | No |
| 44 | HNRNPA3 | NA | 10990 | -0.195 | -0.3887 | No | ||
| 45 | SRSF4 | NA | 11039 | -0.204 | -0.3888 | No | ||
| 46 | SNRNP70 | NA | 11077 | -0.208 | -0.3882 | No | ||
| 47 | PPIE | NA | PPIE Entrez, Source | peptidylprolyl isomerase E (cyclophilin E) | 11322 | -0.242 | -0.3988 | No |
| 48 | SART1 | NA | SART1 Entrez, Source | squamous cell carcinoma antigen recognised by T cells | 11323 | -0.242 | -0.3957 | No |
| 49 | DDX42 | NA | DDX42 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 | 11412 | -0.256 | -0.3974 | No |
| 50 | SNRPA | NA | SNRPA Entrez, Source | small nuclear ribonucleoprotein polypeptide A | 11553 | -0.279 | -0.4016 | No |
| 51 | DDX39B | NA | 11608 | -0.285 | -0.4010 | No | ||
| 52 | SRSF10 | NA | 11655 | -0.290 | -0.3999 | No | ||
| 53 | PRPF31 | NA | PRPF31 Entrez, Source | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 11669 | -0.291 | -0.3969 | No |
| 54 | SNRPB2 | NA | SNRPB2 Entrez, Source | small nuclear ribonucleoprotein polypeptide B'' | 11723 | -0.299 | -0.3961 | No |
| 55 | SMNDC1 | NA | SMNDC1 Entrez, Source | survival motor neuron domain containing 1 | 11732 | -0.301 | -0.3926 | No |
| 56 | SF3B2 | NA | SF3B2 Entrez, Source | splicing factor 3b, subunit 2, 145kDa | 11765 | -0.307 | -0.3905 | No |
| 57 | SRSF5 | NA | 11807 | -0.312 | -0.3888 | No | ||
| 58 | SF3B4 | NA | SF3B4 Entrez, Source | splicing factor 3b, subunit 4, 49kDa | 11976 | -0.336 | -0.3939 | No |
| 59 | MAGOHB | NA | 12055 | -0.347 | -0.3939 | No | ||
| 60 | DHX8 | NA | DHX8 Entrez, Source | DEAH (Asp-Glu-Ala-His) box polypeptide 8 | 12125 | -0.358 | -0.3932 | No |
| 61 | THOC1 | NA | THOC1 Entrez, Source | THO complex 1 | 12141 | -0.360 | -0.3894 | No |
| 62 | XAB2 | NA | XAB2 Entrez, Source | XPA binding protein 2 | 12269 | -0.379 | -0.3917 | No |
| 63 | CHERP | NA | CHERP Entrez, Source | calcium homeostasis endoplasmic reticulum protein | 12283 | -0.381 | -0.3875 | No |
| 64 | PRPF38A | NA | PRPF38A Entrez, Source | PRP38 pre-mRNA processing factor 38 (yeast) domain containing A | 12425 | -0.405 | -0.3903 | No |
| 65 | SRSF8 | NA | 12721 | -0.438 | -0.4012 | No | ||
| 66 | SYF2 | NA | SYF2 Entrez, Source | SYF2 homolog, RNA splicing factor (S. cerevisiae) | 12747 | -0.444 | -0.3969 | No |
| 67 | SNRPF | NA | SNRPF Entrez, Source | small nuclear ribonucleoprotein polypeptide F | 13176 | -0.483 | -0.4147 | Yes |
| 68 | DDX5 | NA | DDX5 Entrez, Source | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 13212 | -0.491 | -0.4104 | Yes |
| 69 | TXNL4A | NA | TXNL4A Entrez, Source | thioredoxin-like 4A | 13237 | -0.494 | -0.4054 | Yes |
| 70 | SF3B5 | NA | SF3B5 Entrez, Source | splicing factor 3b, subunit 5, 10kDa | 13311 | -0.505 | -0.4030 | Yes |
| 71 | EIF4A3 | NA | 13356 | -0.510 | -0.3990 | Yes | ||
| 72 | SNRPD1 | NA | SNRPD1 Entrez, Source | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 13588 | -0.555 | -0.4048 | Yes |
| 73 | HNRNPU | NA | 13598 | -0.558 | -0.3982 | Yes | ||
| 74 | PUF60 | NA | 13663 | -0.570 | -0.3945 | Yes | ||
| 75 | PRPF6 | NA | PRPF6 Entrez, Source | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 13870 | -0.608 | -0.3983 | Yes |
| 76 | NCBP1 | NA | NCBP1 Entrez, Source | nuclear cap binding protein subunit 1, 80kDa | 13944 | -0.622 | -0.3944 | Yes |
| 77 | SNRPD2 | NA | SNRPD2 Entrez, Source | small nuclear ribonucleoprotein D2 polypeptide 16.5kDa | 13977 | -0.629 | -0.3882 | Yes |
| 78 | SNRNP200 | NA | 14287 | -0.697 | -0.3966 | Yes | ||
| 79 | RBM8A | NA | RBM8A Entrez, Source | RNA binding motif protein 8A | 14321 | -0.705 | -0.3894 | Yes |
| 80 | RBMX | NA | RBMX Entrez, Source | RNA binding motif protein, X-linked | 14340 | -0.711 | -0.3813 | Yes |
| 81 | EFTUD2 | NA | EFTUD2 Entrez, Source | elongation factor Tu GTP binding domain containing 2 | 14394 | -0.723 | -0.3750 | Yes |
| 82 | SF3A1 | NA | SF3A1 Entrez, Source | splicing factor 3a, subunit 1, 120kDa | 14398 | -0.725 | -0.3659 | Yes |
| 83 | AQR | NA | AQR Entrez, Source | aquarius homolog (mouse) | 14399 | -0.725 | -0.3567 | Yes |
| 84 | HNRNPC | NA | 14490 | -0.751 | -0.3521 | Yes | ||
| 85 | LSM4 | NA | LSM4 Entrez, Source | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 14506 | -0.755 | -0.3433 | Yes |
| 86 | HNRNPK | NA | 14564 | -0.771 | -0.3367 | Yes | ||
| 87 | SRSF7 | NA | 14575 | -0.772 | -0.3273 | Yes | ||
| 88 | LSM5 | NA | LSM5 Entrez, Source | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 14606 | -0.780 | -0.3191 | Yes |
| 89 | SRSF6 | NA | 14702 | -0.803 | -0.3141 | Yes | ||
| 90 | CCDC12 | NA | CCDC12 Entrez, Source | coiled-coil domain containing 12 | 14734 | -0.810 | -0.3055 | Yes |
| 91 | SRSF2 | NA | 14774 | -0.818 | -0.2972 | Yes | ||
| 92 | U2AF1 | NA | U2AF1 Entrez, Source | U2 small nuclear RNA auxiliary factor 1 | 14782 | -0.821 | -0.2871 | Yes |
| 93 | SF3B3 | NA | SF3B3 Entrez, Source | splicing factor 3b, subunit 3, 130kDa | 14785 | -0.823 | -0.2767 | Yes |
| 94 | PRPF38B | NA | PRPF38B Entrez, Source | PRP38 pre-mRNA processing factor 38 (yeast) domain containing B | 14800 | -0.827 | -0.2669 | Yes |
| 95 | TRA2A | NA | TRA2A Entrez, Source | - | 15037 | -0.877 | -0.2689 | Yes |
| 96 | PHF5A | NA | PHF5A Entrez, Source | PHD finger protein 5A | 15054 | -0.880 | -0.2586 | Yes |
| 97 | HNRNPM | NA | 15072 | -0.886 | -0.2482 | Yes | ||
| 98 | HSPA2 | NA | HSPA2 Entrez, Source | heat shock 70kDa protein 2 | 15081 | -0.888 | -0.2373 | Yes |
| 99 | SNRPD3 | NA | SNRPD3 Entrez, Source | small nuclear ribonucleoprotein D3 polypeptide 18kDa | 15138 | -0.898 | -0.2290 | Yes |
| 100 | PRPF8 | NA | PRPF8 Entrez, Source | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) | 15149 | -0.902 | -0.2180 | Yes |
| 101 | NAA38 | NA | 15229 | -0.923 | -0.2106 | Yes | ||
| 102 | SRSF3 | NA | 15374 | -0.963 | -0.2064 | Yes | ||
| 103 | SNRPE | NA | SNRPE Entrez, Source | small nuclear ribonucleoprotein polypeptide E | 15413 | -0.971 | -0.1961 | Yes |
| 104 | LSM6 | NA | LSM6 Entrez, Source | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 15440 | -0.979 | -0.1850 | Yes |
| 105 | LSM7 | NA | LSM7 Entrez, Source | LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 15726 | -1.069 | -0.1873 | Yes |
| 106 | U2SURP | NA | 15727 | -1.069 | -0.1737 | Yes | ||
| 107 | ISY1 | NA | 15754 | -1.079 | -0.1613 | Yes | ||
| 108 | PRPF40B | NA | PRPF40B Entrez, Source | PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae) | 15896 | -1.134 | -0.1547 | Yes |
| 109 | LSM3 | NA | LSM3 Entrez, Source | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 15910 | -1.140 | -0.1409 | Yes |
| 110 | SNRPA1 | NA | SNRPA1 Entrez, Source | small nuclear ribonucleoprotein polypeptide A' | 15964 | -1.157 | -0.1291 | Yes |
| 111 | PRPF19 | NA | PRPF19 Entrez, Source | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) | 15996 | -1.175 | -0.1158 | Yes |
| 112 | THOC2 | NA | THOC2 Entrez, Source | THO complex 2 | 16199 | -1.257 | -0.1111 | Yes |
| 113 | HNRNPA1 | NA | 16286 | -1.299 | -0.0993 | Yes | ||
| 114 | USP39 | NA | USP39 Entrez, Source | ubiquitin specific peptidase 39 | 16441 | -1.384 | -0.0902 | Yes |
| 115 | PPIH | NA | PPIH Entrez, Source | peptidylprolyl isomerase H (cyclophilin H) | 16504 | -1.416 | -0.0756 | Yes |
| 116 | SRSF9 | NA | 16623 | -1.484 | -0.0632 | Yes | ||
| 117 | CDC40 | NA | CDC40 Entrez, Source | cell division cycle 40 homolog (S. cerevisiae) | 16640 | -1.494 | -0.0450 | Yes |
| 118 | MAGOH | NA | MAGOH Entrez, Source | mago-nashi homolog, proliferation-associated (Drosophila) | 16650 | -1.501 | -0.0263 | Yes |
| 119 | SF3A3 | NA | SF3A3 Entrez, Source | splicing factor 3a, subunit 3, 60kDa | 16797 | -1.600 | -0.0141 | Yes |
| 120 | SNRNP27 | NA | 17066 | -1.829 | -0.0057 | Yes | ||
| 121 | PCBP1 | NA | PCBP1 Entrez, Source | poly(rC) binding protein 1 | 17111 | -1.891 | 0.0160 | Yes |
| 122 | SNRPG | NA | SNRPG Entrez, Source | small nuclear ribonucleoprotein polypeptide G | 17509 | -2.525 | 0.0260 | Yes |
