Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1gfp |
| GeneSet | KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION |
| Enrichment Score (ES) | -0.33589938 |
| Normalized Enrichment Score (NES) | -1.2879167 |
| Nominal p-value | 0.06185567 |
| FDR q-value | 0.33832934 |
| FWER p-Value | 0.998 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PIK3CA | NA | PIK3CA Entrez, Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 693 | 2.734 | 0.0037 | No |
| 2 | ADCY4 | NA | ADCY4 Entrez, Source | adenylate cyclase 4 | 1262 | 1.972 | 0.0026 | No |
| 3 | PGR | NA | PGR Entrez, Source | progesterone receptor | 1687 | 1.614 | 0.0040 | No |
| 4 | MAD2L2 | NA | MAD2L2 Entrez, Source | MAD2 mitotic arrest deficient-like 2 (yeast) | 1814 | 1.523 | 0.0206 | No |
| 5 | PIK3R1 | NA | PIK3R1 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha) | 1994 | 1.422 | 0.0327 | No |
| 6 | PIK3R3 | NA | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 2109 | 1.354 | 0.0473 | No |
| 7 | GNAI1 | NA | GNAI1 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2274 | 1.270 | 0.0579 | No |
| 8 | ADCY9 | NA | ADCY9 Entrez, Source | adenylate cyclase 9 | 2292 | 1.259 | 0.0765 | No |
| 9 | CDC25B | NA | CDC25B Entrez, Source | cell division cycle 25B | 2781 | 1.067 | 0.0658 | No |
| 10 | PDE3A | NA | PDE3A Entrez, Source | phosphodiesterase 3A, cGMP-inhibited | 3650 | 0.834 | 0.0302 | No |
| 11 | BUB1 | NA | BUB1 Entrez, Source | BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) | 3781 | 0.813 | 0.0356 | No |
| 12 | ADCY1 | NA | ADCY1 Entrez, Source | adenylate cyclase 1 (brain) | 4396 | 0.679 | 0.0118 | No |
| 13 | PIK3CB | NA | PIK3CB Entrez, Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 4450 | 0.668 | 0.0192 | No |
| 14 | MAPK14 | NA | MAPK14 Entrez, Source | mitogen-activated protein kinase 14 | 4664 | 0.626 | 0.0171 | No |
| 15 | ARAF | NA | ARAF Entrez, Source | v-raf murine sarcoma 3611 viral oncogene homolog | 5103 | 0.534 | 0.0009 | No |
| 16 | CPEB1 | NA | CPEB1 Entrez, Source | cytoplasmic polyadenylation element binding protein 1 | 5537 | 0.471 | -0.0160 | No |
| 17 | CDC23 | NA | CDC23 Entrez, Source | CDC23 (cell division cycle 23, yeast, homolog) | 5767 | 0.435 | -0.0220 | No |
| 18 | ANAPC4 | NA | ANAPC4 Entrez, Source | anaphase promoting complex subunit 4 | 6387 | 0.383 | -0.0507 | No |
| 19 | CDC25C | NA | CDC25C Entrez, Source | cell division cycle 25C | 6556 | 0.357 | -0.0545 | No |
| 20 | HSP90AB1 | NA | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 8137 | 0.128 | -0.1408 | No |
| 21 | PRKX | NA | PRKX Entrez, Source | protein kinase, X-linked | 8157 | 0.126 | -0.1399 | No |
| 22 | AKT2 | NA | AKT2 Entrez, Source | v-akt murine thymoma viral oncogene homolog 2 | 8193 | 0.120 | -0.1400 | No |
| 23 | ADCY6 | NA | ADCY6 Entrez, Source | adenylate cyclase 6 | 8197 | 0.120 | -0.1383 | No |
| 24 | SPDYA | NA | SPDYA Entrez, Source | speedy homolog A (Drosophila) | 8255 | 0.113 | -0.1398 | No |
| 25 | CCNA1 | NA | CCNA1 Entrez, Source | cyclin A1 | 8359 | 0.100 | -0.1440 | No |
| 26 | RPS6KA1 | NA | RPS6KA1 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 8552 | 0.073 | -0.1536 | No |
| 27 | MAPK9 | NA | MAPK9 Entrez, Source | mitogen-activated protein kinase 9 | 8847 | 0.036 | -0.1694 | No |
| 28 | CDC27 | NA | CDC27 Entrez, Source | cell division cycle 27 | 9473 | -0.010 | -0.2042 | No |
| 29 | KRAS | NA | KRAS Entrez, Source | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 9550 | -0.022 | -0.2081 | No |
| 30 | IGF1 | NA | IGF1 Entrez, Source | insulin-like growth factor 1 (somatomedin C) | 9670 | -0.039 | -0.2142 | No |
| 31 | HSP90AA1 | NA | HSP90AA1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 9814 | -0.054 | -0.2213 | No |
| 32 | MAPK10 | NA | MAPK10 Entrez, Source | mitogen-activated protein kinase 10 | 10350 | -0.102 | -0.2496 | No |
| 33 | MAPK8 | NA | MAPK8 Entrez, Source | mitogen-activated protein kinase 8 | 10418 | -0.113 | -0.2516 | No |
| 34 | ANAPC2 | NA | ANAPC2 Entrez, Source | anaphase promoting complex subunit 2 | 10537 | -0.129 | -0.2562 | No |
| 35 | GNAI3 | NA | GNAI3 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 10843 | -0.176 | -0.2705 | No |
| 36 | ADCY2 | NA | ADCY2 Entrez, Source | adenylate cyclase 2 (brain) | 10895 | -0.183 | -0.2705 | No |
| 37 | ANAPC7 | NA | ANAPC7 Entrez, Source | anaphase promoting complex subunit 7 | 11082 | -0.209 | -0.2777 | No |
| 38 | PIK3R5 | NA | PIK3R5 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 5, p101 | 11218 | -0.228 | -0.2817 | No |
| 39 | PRKACA | NA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 11344 | -0.246 | -0.2848 | No |
| 40 | ANAPC11 | NA | ANAPC11 Entrez, Source | APC11 anaphase promoting complex subunit 11 homolog (yeast) | 11365 | -0.248 | -0.2821 | No |
| 41 | MAPK1 | NA | MAPK1 Entrez, Source | mitogen-activated protein kinase 1 | 11524 | -0.274 | -0.2867 | No |
| 42 | MAPK13 | NA | MAPK13 Entrez, Source | mitogen-activated protein kinase 13 | 11527 | -0.275 | -0.2825 | No |
| 43 | BRAF | NA | BRAF Entrez, Source | v-raf murine sarcoma viral oncogene homolog B1 | 11539 | -0.277 | -0.2788 | No |
| 44 | PIK3CD | NA | PIK3CD Entrez, Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 11952 | -0.332 | -0.2967 | No |
| 45 | ADCY7 | NA | ADCY7 Entrez, Source | adenylate cyclase 7 | 12278 | -0.380 | -0.3090 | No |
| 46 | ANAPC13 | NA | ANAPC13 Entrez, Source | anaphase promoting complex subunit 13 | 12330 | -0.388 | -0.3058 | No |
| 47 | CCNB3 | NA | CCNB3 Entrez, Source | cyclin B3 | 12387 | -0.398 | -0.3027 | No |
| 48 | PKMYT1 | NA | PKMYT1 Entrez, Source | protein kinase, membrane associated tyrosine/threonine 1 | 12442 | -0.408 | -0.2994 | No |
| 49 | PRKACG | NA | PRKACG Entrez, Source | protein kinase, cAMP-dependent, catalytic, gamma | 12510 | -0.411 | -0.2968 | No |
| 50 | RPS6KA3 | NA | RPS6KA3 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 12674 | -0.429 | -0.2992 | No |
| 51 | RAF1 | NA | RAF1 Entrez, Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 12700 | -0.434 | -0.2939 | No |
| 52 | ANAPC10 | NA | ANAPC10 Entrez, Source | anaphase promoting complex subunit 10 | 13453 | -0.527 | -0.3277 | Yes |
| 53 | CCNB1 | NA | CCNB1 Entrez, Source | cyclin B1 | 13592 | -0.556 | -0.3268 | Yes |
| 54 | ANAPC1 | NA | ANAPC1 Entrez, Source | anaphase promoting complex subunit 1 | 13600 | -0.558 | -0.3185 | Yes |
| 55 | FZR1 | NA | FZR1 Entrez, Source | fizzy/cell division cycle 20 related 1 (Drosophila) | 13710 | -0.579 | -0.3156 | Yes |
| 56 | ADCY8 | NA | ADCY8 Entrez, Source | adenylate cyclase 8 (brain) | 13764 | -0.588 | -0.3095 | Yes |
| 57 | AKT1 | NA | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 13847 | -0.604 | -0.3046 | Yes |
| 58 | PLK1 | NA | PLK1 Entrez, Source | polo-like kinase 1 (Drosophila) | 14126 | -0.664 | -0.3099 | Yes |
| 59 | AKT3 | NA | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 14156 | -0.671 | -0.3011 | Yes |
| 60 | CCNA2 | NA | CCNA2 Entrez, Source | cyclin A2 | 14235 | -0.689 | -0.2947 | Yes |
| 61 | CDC26 | NA | CDC26 Entrez, Source | cell division cycle 26 | 14457 | -0.743 | -0.2955 | Yes |
| 62 | CDC16 | NA | CDC16 Entrez, Source | CDC16 cell division cycle 16 homolog (S. cerevisiae) | 14599 | -0.776 | -0.2914 | Yes |
| 63 | GNAI2 | NA | GNAI2 Entrez, Source | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | 14733 | -0.810 | -0.2862 | Yes |
| 64 | CDK2 | NA | CDK2 Entrez, Source | cyclin-dependent kinase 2 | 14755 | -0.815 | -0.2747 | Yes |
| 65 | PIK3R2 | NA | PIK3R2 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta) | 14983 | -0.863 | -0.2740 | Yes |
| 66 | ADCY5 | NA | ADCY5 Entrez, Source | adenylate cyclase 5 | 15022 | -0.872 | -0.2626 | Yes |
| 67 | CDC25A | NA | CDC25A Entrez, Source | cell division cycle 25A | 15209 | -0.915 | -0.2588 | Yes |
| 68 | PDE3B | NA | PDE3B Entrez, Source | phosphodiesterase 3B, cGMP-inhibited | 15330 | -0.950 | -0.2507 | Yes |
| 69 | MAD2L1 | NA | MAD2L1 Entrez, Source | MAD2 mitotic arrest deficient-like 1 (yeast) | 15344 | -0.954 | -0.2366 | Yes |
| 70 | RPS6KA6 | NA | RPS6KA6 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 15740 | -1.075 | -0.2420 | Yes |
| 71 | ADCY3 | NA | ADCY3 Entrez, Source | adenylate cyclase 3 | 16142 | -1.235 | -0.2453 | Yes |
| 72 | ANAPC5 | NA | ANAPC5 Entrez, Source | anaphase promoting complex subunit 5 | 16597 | -1.464 | -0.2479 | Yes |
| 73 | CDK1 | NA | 16637 | -1.491 | -0.2269 | Yes | ||
| 74 | MAPK3 | NA | MAPK3 Entrez, Source | mitogen-activated protein kinase 3 | 16746 | -1.562 | -0.2087 | Yes |
| 75 | IGF1R | NA | IGF1R Entrez, Source | insulin-like growth factor 1 receptor | 16802 | -1.603 | -0.1869 | Yes |
| 76 | CCNB2 | NA | CCNB2 Entrez, Source | cyclin B2 | 16828 | -1.630 | -0.1629 | Yes |
| 77 | MAP2K1 | NA | MAP2K1 Entrez, Source | mitogen-activated protein kinase kinase 1 | 16861 | -1.650 | -0.1391 | Yes |
| 78 | MAPK12 | NA | MAPK12 Entrez, Source | mitogen-activated protein kinase 12 | 16881 | -1.669 | -0.1142 | Yes |
| 79 | PRKACB | NA | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 17002 | -1.772 | -0.0934 | Yes |
| 80 | MAPK11 | NA | MAPK11 Entrez, Source | mitogen-activated protein kinase 11 | 17451 | -2.412 | -0.0810 | Yes |
| 81 | RPS6KA2 | NA | RPS6KA2 Entrez, Source | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 17664 | -2.960 | -0.0469 | Yes |
| 82 | PIK3CG | NA | PIK3CG Entrez, Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 17882 | -4.130 | 0.0051 | Yes |
