Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | w6a_vs_wt_vs_wt.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp.w6a_vs_wt.cls #ago1w6a_versus_ago1gfp_repos |
| Phenotype | w6a_vs_wt.cls#ago1w6a_versus_ago1gfp_repos |
| Upregulated in class | ago1w6a |
| GeneSet | KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS |
| Enrichment Score (ES) | 0.62717324 |
| Normalized Enrichment Score (NES) | 1.5659907 |
| Nominal p-value | 0.028380634 |
| FDR q-value | 0.07046176 |
| FWER p-Value | 0.744 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | CH25H | NA | CH25H Entrez, Source | cholesterol 25-hydroxylase | 264 | 3.853 | 0.2156 | Yes |
| 2 | HSD3B7 | NA | HSD3B7 Entrez, Source | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | 286 | 3.766 | 0.4396 | Yes |
| 3 | CYP39A1 | NA | CYP39A1 Entrez, Source | cytochrome P450, family 39, subfamily A, polypeptide 1 | 461 | 3.300 | 0.6272 | Yes |
| 4 | HSD17B4 | NA | HSD17B4 Entrez, Source | hydroxysteroid (17-beta) dehydrogenase 4 | 4681 | 0.622 | 0.4294 | No |
| 5 | AMACR | NA | AMACR Entrez, Source | alpha-methylacyl-CoA racemase | 5406 | 0.486 | 0.4181 | No |
| 6 | BAAT | NA | BAAT Entrez, Source | bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase) | 6224 | 0.411 | 0.3972 | No |
| 7 | CYP7A1 | NA | CYP7A1 Entrez, Source | cytochrome P450, family 7, subfamily A, polypeptide 1 | 7181 | 0.261 | 0.3595 | No |
| 8 | CYP7B1 | NA | CYP7B1 Entrez, Source | cytochrome P450, family 7, subfamily B, polypeptide 1 | 7717 | 0.182 | 0.3407 | No |
| 9 | CYP27A1 | NA | CYP27A1 Entrez, Source | cytochrome P450, family 27, subfamily A, polypeptide 1 | 7891 | 0.159 | 0.3405 | No |
| 10 | SCP2 | NA | SCP2 Entrez, Source | sterol carrier protein 2 | 9491 | -0.013 | 0.2523 | No |
| 11 | ACOX2 | NA | ACOX2 Entrez, Source | acyl-Coenzyme A oxidase 2, branched chain | 11542 | -0.277 | 0.1547 | No |
| 12 | SLC27A5 | NA | SLC27A5 Entrez, Source | solute carrier family 27 (fatty acid transporter), member 5 | 12364 | -0.393 | 0.1325 | No |
| 13 | CYP8B1 | NA | CYP8B1 Entrez, Source | cytochrome P450, family 8, subfamily B, polypeptide 1 | 12661 | -0.426 | 0.1415 | No |
| 14 | AKR1D1 | NA | AKR1D1 Entrez, Source | aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) | 14645 | -0.787 | 0.0781 | No |
| 15 | AKR1C4 | NA | AKR1C4 Entrez, Source | aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4) | 15071 | -0.886 | 0.1074 | No |
| 16 | CYP46A1 | NA | CYP46A1 Entrez, Source | cytochrome P450, family 46, subfamily A, polypeptide 1 | 15171 | -0.907 | 0.1561 | No |
